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Patent # Description
2018/0228811 GDNF INDUCTION FOR THE TREATMENT OF RETINAL DISORDERS
Methods and compositions for glial cell-derived neurotrophic factor (GDNF) induction in the eye, and for treatment and/or prevention of retinal disorders are...
2018/0228810 Nanoparticulate Meloxicam Formulations
The present invention is directed to nanoparticulate compositions comprising meloxicam particles having an effective average particle size of less than about...
2018/0228809 Nanoparticulate Meloxicam Formulations
The present invention is directed to nanoparticulate compositions comprising meloxicam particles having an effective average particle size of less than about...
2018/0228808 USE OF H3K9me3 MODULATION FOR ENHANCING COGNITIVE FUNCTION
Use of H3K9me3 modulation for enhancing cognitive function and treating anxiety related disorders is presented. A composition is administered to the subject...
2018/0228807 METHODS OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF
The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the...
2018/0228806 THERAPEUTIC STRATEGIES FOR THE TREATMENT OF PREECLAMPSIA
Compositions and methods for treating preeclampsia in a subject in need thereof are disclosed.
2018/0228805 AGENT AGAINST FUNGAL INFECTIONS
The invention relates to fungicides and can be used for treating diseases caused by fungi, and also for preventing fungal damage to various materials and...
2018/0228804 COMBINATION THERAPY OF HBV AND HDV INFECTION
The invention provides a composition comprising an inhibitor of Na+-taurocholate cotransporting polypeptide (NTCP) and a active ingredient selected from the...
2018/0228803 Piperidine-Substituted Mnk Inhibitors and Methods Related Thereto
The present invention relates to compounds according to Formula (I): ##STR00001## or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof wherein...
2018/0228802 5-BROMO-2,6-DI-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE FOR USE IN THE TREATMENT OF CANCER
The present invention relates to 5-bromo-2,6-di-(1H-pyrazol-1-yl)pyrimidin-4-amine, its pharmaceutically acceptable salts and co-crystals thereof and to...
2018/0228801 Method for Enhancing Learning Ability and Memory of Patients with Alzheimer's Disease using Mocetinostat
A method for enhancing learning ability and memory of patients with Alzheimer's disease using mocetinostat is provided. The method includes administering an...
2018/0228800 COMBINATIONS OF A PYRIMIDINE CONTAINING NNRTI WITH RT INHIBITORS
The present invention concerns combinations of a pyrimidine containing NNRTI with nucleoside reverse transcriptase inhibitors and nucleotide reverse...
2018/0228799 Treatment for Neurological and Mental Disorders
Methods for treating neurological or mental disorders in humans and the symptoms associated therewith are provided by administering eltoprazine and/or related...
2018/0228798 GASTRO-RESISTANT FORMULATION CONTAINING POSACONAZOLE
The present invention relates to a gastro-resistant pharmaceutical composition comprising a solid solution prepared by hot-melt extrusion, whereby the solid...
2018/0228797 PHARMACEUTICAL COMPOSITIONS
Provided herein are methods and compositions for effective treatment or prevention of pain, which also reduce or eliminate adverse effects associated with an...
2018/0228796 SN-38 LOADED IRON CROSSLINKED MICELLE AND METHODS THEREOF
The present invention provides SN-38 compositions for treating cancer.
2018/0228795 COMBINATION THERAPY FOR CANCER
The present invention provides a method of treating squamous histology cancers, breast cancer, prostate cancer, bladder cancer, cervical cancer, endometrial...
2018/0228794 QUINOLINE CARBOXAMIDES FOR USE IN THE TREATMENT OF MULTIPLE MYELOMA
A compound of formula (I) ##STR00001## or a pharmaceutically acceptable salt thereof, for use in the treatment of multiple myeloma.
2018/0228793 Nicotine Lozenge
A nicotine lozenge provided herein includes a body that is partially or wholly receivable in an oral cavity. The body includes a soluble-fiber matrix and...
2018/0228792 TRANSORAL DOSAGE FORMS COMPRISING SUFENTANIL AND NALOXONE
The invention pertains to methods that include administering to a subject a transoral dosage form comprising a pharmaceutical carrier and sufentanil, and...
2018/0228791 MUSCARINIC AGONISTS
This invention relates to compounds that are agonists of the muscarinic M.sub.4 receptor and/or M.sub.4 receptor and which are useful in the treatment of...
2018/0228790 Combination Therapy with Apalutamide
This disclosure provides a dosage regimen for co-administration of 4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-- ...
2018/0228789 COVALENT IRREVERSIBLE INHIBITORS OF USP7 AS ANTI-CANCER AGENTS
Compounds and pharmaceutical compositions for treating cancer by, for example, modulating immune system activity, are provided.
2018/0228788 Method and Composition For Treating Cachexia and Eating Disorders
The invention provides treating cachexia and eating disorders in humans and veterinary animals by administering a composition including: (i) cyproheptadine...
2018/0228787 AMELIORATION OF CERTAIN DEFICIENCIES DUE TO STROKE
Motor skill deficits and cognitive deficits associated with stroke and secondary neuronal cell death are ameliorated by treatment with pharmaceutically...
2018/0228786 PYRAZOLOPYRIDINE COMPOUNDS AND USES THEREOF
Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds....
2018/0228785 3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-PYRAZOLO[4,3-B]PYRIDINES AND THERAPEUTIC USES THEREOF
4-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a...
2018/0228784 3-(1H-INDOL-2-YL)-1H-PYRAZOLO[4,3-B]PYRIDINES AND THERAPEUTIC USES THEREOF
4-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a...
2018/0228783 3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-B] PYRIDINES AND THERAPEUTIC USES THEREOF
7-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a...
2018/0228782 3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINES AND THERAPEUTIC USES THEREOF
6-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a...
2018/0228781 3-(1H-INDOL-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINES AND THERAPEUTIC USES THEREOF
6-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a...
2018/0228780 3-(1H-PYRROLO[2,3-C]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole...
2018/0228779 MODIFIED RELEASE COMPOSITIONS COMPRISING TACROLIMUS
A modified release composition comprising tacrolimus releases less than 20% w/w of the active ingredient within 0.5 hours when subjected to an in vitro...
2018/0228778 COMPOSITIONS COMPRISING S1P RECEPTOR MODULATORS
Compositions comprising S1P receptor modulators and at least one compound selected from one or more of the group consisting of steroids, opioids and...
2018/0228777 COMPOSITIONS AND METHODS FOR TREATING CONDITIONS RELATED TO ELEVATED LEVELS OF EOSINOPHILS AND/OR BASOPHILS
Disclosed herein are methods of treating conditions, which may be associated with elevated levels of eosinophils and/or basophils, with a therapeutically...
2018/0228776 ISOTHIAZOLE DERIVATIVE
The present invention provides a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof or a solvate of these. A compound having...
2018/0228775 METHODS OF TREATING CANCER
The present invention provides methods of treating cancer.
2018/0228774 (2R,4R)-5-(5'-CHLORO-2'-FLUOROBIPHENYL-4-YL)-2-HYDROXY-4-[(5-METHYLOXAZOLE- -2-CARBONYL)AMINO]PENTANOIC ACID
In one aspect, the invention relates to a compound of the structure: ##STR00001## or a pharmaceutically acceptable salt thereof, and a crystalline form of this...
2018/0228773 SOLID STATE FORMS OF ELUXADOLINE
Disclosed are solid state forms of Eluxadoline, processes for their preparations, compositions comprising them and their medical use. The present invention...
2018/0228772 AMIDE DERIVATIVES OF N-UREA SUBSTITUTED AMINO ACIDS AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS
The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions...
2018/0228771 METHODS OF TREATMENT OR PREVENTION OF ACUTE BRAIN OR NERVE INJURIES
One of the aspects of the invention is directed toward a method of treating or preventing acute brain or nerve injury in a subject, comprising administering an...
2018/0228770 FORMULATION FOR SOFT ANTICHOLINERGIC ANALOGS
Topical formulations comprising soft glycopyrrolates are useful for treating excessive sweating conditions in subjects, such as humans suffering from...
2018/0228769 SYNERGISTIC AURISTATIN COMBINATIONS
This invention relates to combinations of an auristatin or an auristatin-based antibody-drug-conjugate (ADC) with second active agents including PI3K/mTOR...
2018/0228768 Macrocyclic Ghrelin Receptor Modulators and Methods of Using the Same
The present invention provides novel conformationally-defined macrocyclic compounds that can function as selective modulators of the ghrelin receptor (growth...
2018/0228767 Choline Esters
Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The...
2018/0228766 AGENT EXHIBITING ANTI-STRESS, ANXIOLYTIC AND ANTI-DEPRESSION ACTIVITY, AND COMPOSITION BASED THEREON
The agent with antistress, anxiolytic and antidepressant activity and a composition based on it. The invention relates to the field of pharmaceutics,...
2018/0228765 IRE-1ALPHA INHIBITORS
Compounds which directly inhibit IRE-1.alpha. activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are...
2018/0228764 SOLUBLE EPOXIDE HYDROLASE AS A TARGET FOR OCULAR NEOVASCULARIZATION
Methods of using compounds that inhibit soluble epoxide hydrolase (sEH) for the treatment of ocular diseases, and in particular, of wet age-related macular...
2018/0228763 METHOD FOR TREATING LEUKEMIA USING REPROGRAMMING EFFECT
The present invention provides a method for treating leukemia utilizing somatic cell reprogramming. The method includes a step of introduction of somatic cell...
2018/0228762 METHODS FOR THE TREATMENT OF SYSTEMIC DISORDERS TREATABLE WITH MAST CELL STABILIZERS, INCLUDING MAST CELL...
Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders, are provided.
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