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Patent # Description
2018/0230481 ISOLATED POLYNUCLEOTIDES AND POLYPEPTIDES, AND METHODS OF USING SAME FOR INCREASING NITROGEN USE EFFICIENCY,...
Provided are methods of increasing nitrogen use efficiency, yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality and/or abiotic stress...
2018/0230480 METHOD FOR PLANT IMPROVEMENT
The invention relates to the field of plant improvement, in particular of the improvement of yield for plants, by using a transgene containing an root-specific...
2018/0230479 PLANT REGULATORY ELEMENTS DERIVED FROM MEDICAGO TRUNCATULA 3'UTR SEQUENCES, AND USES THEREOF
The invention provides recombinant DNA molecules and constructs, as well as their nucleotide sequences, useful for modulating gene expression in plants. The...
2018/0230478 PLANT REGULATORY ELEMENTS DERIVED FROM MEDICAGO TRUNCATULA 3'UTR SEQUENCES, AND USES THEREOF
The invention provides recombinant DNA molecules and constructs, as well as their nucleotide sequences, useful for modulating gene expression in plants. The...
2018/0230477 METHOD FOR EDITING PLANT MITOCHONDRIAL GENOME
A method for inducing a structural change in a plant mitochondrial genome is provided. The invention relates to a method for inducing a structural change in a...
2018/0230476 GENERATION OF SITE-SPECIFIC-INTEGRATION SITES FOR COMPLEX TRAIT LOCI IN CORN AND SOYBEAN, AND METHODS OF USE
Compositions and methods are provided for introducing transgenic target sites for Site Specific Integration (SSI) and/or polynucleotides of interest into at...
2018/0230475 EIMERIA TENELLA ELONGATION FACTOR-1 ALPHA RECOMBINANT IMMUNOGENIC COMPOSITIONS WHICH INDUCE ACTIVE PROTECTIVE...
Provided herein are immunogenic compositions containing recombinant proteins capable of presenting all, or antigenic portions of, the Eimeria tenella...
2018/0230474 CHIMERIC POLYPEPTIDES HAVING TARGETED BINDING SPECIFICITY
Disclosed herein are chimeric polypeptides, including compositions thereof, expression vectors, and methods of use thereof, for the generation of transgenic...
2018/0230473 MODIFIED TGF-BETA OLIGONUCLEOTIDES
The invention refers to an oligonucleotide consisting of 10 to 20 nucleotides of selected regions of the TGF-beta1, TGF-beta2 or TGF-beta3 nucleic acid...
2018/0230472 METHODS OF IDENTIFYING AND TREATING POOR-PROGNOSIS CANCERS
The present invention relates generally to methods for identifying cancer patients with a poor prognosis, and to therapeutic modalities for improving prognosis...
2018/0230471 APTAMER-GUIDED GENE TARGETING
Compositions and methods for modifying genetic material are provided. One embodiment provides aptamers capable of binding to a site-specific DNA binding moiety...
2018/0230470 Compositions and Methods for Inhibiting Gene Expression of Hif2alpha
RNA interference (RNAi) triggers and RNAi trigger conjugates for inhibiting the expression of Hif2.alpha. (EPAS1) gene are described. Pharmaceutical...
2018/0230469 METHOD OF TREATING PAIN WITH AN ANTIBODY AGAINST NETRIN-4, UNC5B OR NEOGENIN
The present invention provides a screening method for pain suppressors, which method is characterized by using netrin-4 and/or a netrin-4 receptor to select a...
2018/0230468 TREATMENT OF ATONAL HOMOLOG 1 (ATOH1) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO ATOH1
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Atonal homolog 1 (ATOH1), in particular, by...
2018/0230467 BRUSH POLYMER-ASSISTED COMPACTION OF OLIGONUCLEOTIDES
The disclosed subject matter relates to brush polymer-oligonucleotide conjugates comprising oligonucleotides covalently attached to the backbone of a...
2018/0230466 METHODS FOR TREATING TUMORS
The present invention provides methods for increasing the sensitivity of a tumour to immunotherapy, chemotherapy or radiotherapy by administering an effective...
2018/0230465 METHODS AND COMPOSITIONS FOR MODULATING ALPHA-1-ANTITRYPSIN EXPRESSION
Disclosed herein are methods for decreasing A1AT mRNA and protein expression and treating, ameliorating, preventing, slowing progression, or stopping...
2018/0230464 Chemically Ligated RNAs for CRISPR/Cas9-lgRNA Complexes as Antiviral Therapeutic Agents
Provided herein are chemically ligated guide RNA oligonucleotides (lgRNA) which comprise two functional RNA modules (crgRNA and tracrgRNA) joined by...
2018/0230463 Compounds and Methods for the Treatment of Inflammatory Diseases of the CNS
Inflammatory diseases in the CNS can be treated or alleviated by the administration of an oligonucleotide in an amount sufficient to reduce the influx of...
2018/0230462 NOVEL REVERSE TRANSCRIPTASES AND USES THEREOF
Hybrid reverse transcriptases formed from portions of FLVRT and MLVRT are provided.
2018/0230461 METHODS FOR GENERATING BARCODED COMBINATORIAL LIBRARIES
Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive...
2018/0230460 METHODS FOR GENERATING BARCODED COMBINATORIAL LIBRARIES
Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive...
2018/0230459 MULTIPLEXED BINARY ASSEMBLY AND QUANTITATIVE TRACKING OF BACTERIAL POPULATIONS
Compositions and methods for tracking combinations of mutations in populations by coupling DNA assembly and paired-end sequencing technology with...
2018/0230458 METHOD AND COMPOSITIONS FOR DETECTING PATHOGENIC ORGANISMS
Some embodiments of the present invention relate to the enrichment of non-host nucleic acids in a mixture of host and non-host nucleic acids. Some embodiments...
2018/0230457 LIBRARY-BASED METHODS AND COMPOSITIONS FOR INTRODUCING MOLECULAR SWITCH FUNCTIONALITY INTO PROTEIN AFFINITY...
Methods and compositions are disclosed for introducing molecular switch functionality into a protein affinity reagent to render its binding to a target...
2018/0230456 SH3 domain derivatives
The present invention is directed to SH3 domain derivatives having a specific binding affinity to a target molecule. In this respect, the invention provides...
2018/0230455 COMPOSITIONS AND METHODS FOR POLYNUCLEOTIDE ASSEMBLY
Methods are provided for assembly of a target polynucleotide sequence comprising at least a first double stranded polynucleotide (DSP) and at least second DSP,...
2018/0230454 Dissection System of Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Section for Nucleic Acid Extraction
A dissection system has a dissection platform which has a frame, an agitation platform, a tissue section tray, a solution dispenser unit, an airflow drying...
2018/0230453 SINGLE CELL MICROFLUIDIC DEVICE
Methods of non-destructively obtaining the genotype of a plant cell from a plant sample are disclosed. The plant cell is isolated from a plant cell sample...
2018/0230452 METHOD AND KIT FOR CONCENTRATING TARGET DOUBLE-STRANDED NUCLEIC ACID MOLECULES USING A...
A method of separating a target double-stranded nucleic acid molecule from a sample including the target double-stranded nucleic acid molecule and a non-target...
2018/0230451 Systems and Processes for Rapid Nucleic Acid Extraction, Purification, and Analysis
Disclosed are processes and kits for rapid nucleic acid extraction from a nucleic acid-containing material, such as a bone, tooth or semen sample. For bone and...
2018/0230450 Cas9 Genome Editing and Transcriptional Regulation
CRISPR/Cas Systems are provided where two or more guide RNAs having different spacer sequence lengths direct an enzymatically active Cas9 having a...
2018/0230449 ARTIFICIAL NON-RIBOSOMAL PEPTIDE SYNTHETASES
The present invention concerns a novel method for the modification and/or custom-made design of artificial non-ribosomal peptide synthetases (NRPSs) from...
2018/0230448 ENGINEERED PHENYLALANINE AMMONIA LYASE POLYPEPTIDES
The present invention provides engineered phenylalanine ammonia lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the...
2018/0230447 ACTIVE LOW MOLECULAR WEIGHT VARIANTS OF ANGIOTENSIN CONVERTING ENZYME 2 (ACE2)
Disclosed are variants of ACE2, pharmaceutical compositions comprising the variants of ACE2, and treatment methods for reducing Angiotensin II (1-8) plasma...
2018/0230446 EXPRESSION OF RECOMBINANT BETA-XYLOSIDASE ENZYMES
The present invention relates to a Myceliophthora thermophila cell, which expresses a nucleotide sequence that codifies a recombinant beta-xylosidase enzyme...
2018/0230445 MANUFACTURING OF ALKALINE PHOSPHATASES
A method for producing a recombinant polypeptide, comprising: (a) providing a 100 L to 25,000 L fed-batch bioreactor comprising (i) cells capable of expressing...
2018/0230444 CELL-PERMEABLE CRE (ICP-CRE) RECOMBINANT PROTEIN AND USE THEREOF
The iCP-Cre recombinant protein of the present invention could mediate inactivation of a target genes, it may be used for the production of a conditional...
2018/0230443 NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) MUTANT AND USE THEREOF
The present invention discloses a Nicotinamide phosphoribosyltransferase (nampt) mutant and use thereof. The present invention relates to a nicotinamide...
2018/0230442 NOVEL KETOACYL ACP SYNTHASE GENES AND USES THEREOF
The present invention relates to beta-ketoacyl ACP synthase genes of the KASI/KASIV type and proteins encoded by these genes. The genes can be included in...
2018/0230441 Method for Producing Aldehyde
A method is provided for producing an objective substance, for example, an aromatic aldehyde such as vanillin. The objective substance is produced from a...
2018/0230440 MODIFICATION OF N-TERMINAL REGION OF CAPSID PROTEINS FOR ENHANCED PROPERTIES OF ADENO-ASSOCIATED VIRUSES
The present disclosure provide viral compositions and methods for modulating adeno-associated virus properties including transduction efficiency, virus capsid...
2018/0230439 ALTERED AVIAN VIRUS FOR IN-OVO INOCULATION AND METHODS OF USE THEREOF
An altered avian NDV that contains the coding sequence of avian interleukin-4 (IL-4), or a portion thereof, in the reverse orientation suppresses in-ovo IL-4...
2018/0230438 METHODS AND PRODUCTS FOR TRANSFECTION
The present invention relates in pan to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these...
2018/0230437 CELL CULTURING ARTICLE AND METHOD FOR MANUFACTURING THEREOF
The disclosure provides a cell culturing article. The cell culturing article includes a substrate having a surface, a hydrophilic copolymer layer positioned on...
2018/0230436 METHODS OF MANUFACTURING KERATIN PRODUCTS AND USES THEREOF
Methods and compositions are provided for producing synthetically-derived keratin compositions and keratin products.
2018/0230435 CANCER-ASSOCIATED FIBROBLASTS IN MAINTAINING STEMNESS OF CANCER STEM CELLS
An in vitro co-culture system comprising cancer-associated fibroblasts (CAFs) and cancer cells for producing and maintaining cancer stem cells and uses thereof...
2018/0230434 METHODS OF PREPARING A PRIMARY CELL SAMPLE
The invention provides methods of preparing a sample of viable diseased cells obtained from a human subject for clinical testing, wherein the methods inhibit...
2018/0230433 USE OF DERMATOPONTIN FOR MAINTAINING HEMATOPOIETIC STEM AND/OR PROGENITOR CELLS IN CULTURE
The present invention relates to the use of dermatopontin (DPT) or a functional fragment thereof for the maintenance of hematopoietic stem and/or progenitor...
2018/0230432 MEANS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF NEUROPSYCHIATRIC DISEASES
The present invention is related to a bone marrow-derived myeloid progenitor cell (MPC), preferably an isolated bone marrow-derived myeloid progenitor cell...
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