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Patent # Description
2018/0230228 METHOD FOR INCREASING THE GALACTOSE CONTENT OF RECOMBINANT PROTEINS
The present invention relates to a method for increasing the galactose content of a recombinant protein produced in mammalian cells, wherein during the...
2018/0230227 ANTI-OX40 ANTIBODIES AND METHODS OF USE
The invention provides anti-OX40 antibodies and methods of using the same.
2018/0230226 Method for In Vivo Expansion of T Regulatory Cells
Compositions specific for TNF-receptor superfamily member 25 (TNFRSF25, DR3) modulate the immune re-sponse by regulating T regulatory cells.
2018/0230225 CHIMERIC ANTIGEN RECEPTORS BASED ON SINGLE-DOMAIN ANTIBODIES AND METHODS OF USE THEREOF
The present application provides single-domain antibodies, and chimeric antigen receptors comprising one or more antigen binding domains each comprising a...
2018/0230224 CD70 BINDING MOLECULES AND METHODS OF USE THEREOF
The disclosure provides anti-CD70 antibodies, antigen binding fragments thereof, chimeric antigen receptors (CARs) and engineered T cell receptors (TCRs)...
2018/0230223 TREATMENT OF MOOD AND STRESS RELATED DISORDERS
A pharmaceutical composition and method for treating or attenuating a mood or stress-related disorder in a subject having normal or low inflammatory state is...
2018/0230222 SUBTYPES OF HUMANIZED ANTIBODY AGAINST INTERLEUKIN-6 RECEPTOR
An antibody subtype (1) which is a subtype of the humanized PM-1 antibody against interleukin-6 receptor (IL-6R) and in which one C-terminal of the heavy chain...
2018/0230221 Methods of Improving or Accelerating Physical Recovery After Surgery for Hip Fracture
The disclosure relates to novel uses and regimens for accelerating/improving physical recovery in a patient with disuse atrophy triggered by reduced mobility...
2018/0230220 BISPECIFIC-FC MOLECULES
Described herein is a bispecific molecule containing an Fc polypeptide chain and immunoglobulin variable regions. Also provided are pharmaceutical formulations...
2018/0230219 VEGFR-2 CAR IMMUNE CELLS TO TREAT CANCERS
Compositions and methods for treating cancer in humans are provided using CARs. The invention includes engineered CARs (chimeric receptor antigens) and...
2018/0230218 MET ANTIBODIES AND IMMUNOCONJUGATES AND USES THEREOF
MET is a receptor tyrosine kinase found on the surface of tumor cells. The present invention includes anti-MET antibodies, forms and fragments, having superior...
2018/0230217 METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH ALPHA-V BETA-8 INTEGRIN
Methods and compositions comprising integrin .beta.8 antibodies are provided.
2018/0230216 ANTIBODY
Provided is an active ingredient of a pharmaceutical composition for treating myeloma. Specifically, provided is an antibody whose epitope is present in the...
2018/0230215 ANTI-HUMAN CD19 ANTIBODIES WITH HIGH AFFINITY
The present invention relates to antibodies against human CD19 (anti-human CD19 antibodies), methods for their production, pharmaceutical compositions...
2018/0230214 ANTIGEN-BINDING PROTEINS TARGETING CD56 AND USES THEREOF
The presently disclosed subject matter provides for methods and compositions for treating cancer (e.g., multiple myeloma). It relates to anti-CD56 antibodies,...
2018/0230213 ANTI-NOTCH3 ANTIBODIES
Monoclonal antibodies that bind and inhibit activation of human Notch3 are disclosed. The antibodies can be used to treat cell proliferative diseases and...
2018/0230212 ANTIBODY
Provided is an antibody effective in the treatment of tumors and the like. An antibody that includes an N-type glycosylation site of human CD98hc and...
2018/0230211 TREATMENT OF HIDRADENITIS SUPPURATIVA
Hidradenitis suppurativa can be treated by administering a pharmaceutical composition that includes a pharmaceutically acceptable carrier and a therapeutically...
2018/0230210 ISOLATION AND PURIFICATION OF ANTI-IL-13 ANTIBODIES USING PROTEIN A AFFINITY CHROMATOGRAPHY
Disclosed herein are methods for the isolation and purification of anti-IL-13 antibodies wherein the use of an affinity chromatographic step results in an...
2018/0230209 HUMAN ANTIBODY MOLECULES FOR IL-13
Specific binding members, in particular human anti-IL-13 antibody molecules and especially those which neutralize IL-13 activity. Methods for using anti-IL-13...
2018/0230208 TREATMENT FOR RHEUMATOID ARTHRITIS
The present invention provides anti-GM-CSF antibodies for use in the treatment of rheumatoid arthritis. Anti-GM-CSF antibodies, in particular MOR103, are...
2018/0230207 NOTCH INHIBITION IN THE TREATMENT AND PREVENTION OF NONALCOHOLIC FATTY LIVER DISEASE
The present invention is directed to methods of treating or preventing nonalcoholic fatty liver disease by administering agents that inhibit the NOTCH...
2018/0230206 Refolding Process for Antibody's Fragments
A refolding process of Ranibizumab is disclosed wherein the solubilized solution of heavy chain and/or light chain of Ranibizumab treated with refolding buffer...
2018/0230205 ANTIBODIES TO ENDOPLASMIN AND THEIR USE
Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin In some embodiments these antibodies are fully human. Recombinant...
2018/0230204 Humanized anti-DKK2 antibody and uses thereof
The present invention relates to the discovery that inhibition of Dickkopf2 (DKK2) increases CD8.sup.+ cytotoxic T lymphocyte (CTL) activity, attenuates tumor,...
2018/0230203 ANTIBODIES TARGETING HIV ESCAPE MUTANTS
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) broadly neutralizing antibodies having...
2018/0230202 STABILIZED LIQUID ANTI-RSV ANTIBODY FORMULATIONS
The present invention provides liquid formulations of SYNAGIS.RTM. or an antigen-binding fragment thereof that immunospecifically bind to a respiratory...
2018/0230201 BROADLY NEUTRALIZING HUMAN ANTIBODY THAT RECOGNIZES THE RECEPTOR-BINDING POCKET OF INFLUENZA HEMAGGLUTININ
The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic...
2018/0230200 MVA-gH/gL-PC VACCINE DERIVED ANTIBODIES NEUTRALIZING HUMAN CYTOMEGALOVIRUS INFECTIVTIY AND METHODS THEREOF
Disclosed are vaccine-derived neutralizing antibodies (NAbs) for CMV infections and small peptides which define precise recognition elements of the antigens by...
2018/0230199 HYPERIMMUNIZED EGG PRODUCT FOR TREATMENT OF NECROTIC ENTERITIS IN POULTRY
In one aspect, the present invention is directed to a method for preventing or treating necrotic enteritis by administering a hyperimmunized egg product...
2018/0230198 METHODS AND COMPOSITIONS FOR PRODUCING A CHIMERIC POLYPEPTIDE
The present invention provides methods and compositions for converting a first polypeptide into a chimeric polypeptide. The invention includes two vectors: a...
2018/0230197 SOLUBLE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (SFGFR3) POLYPEPTIDES AND USES THEREOF
The invention features soluble fibroblast growth factor receptor 3 (sFGFR3) polypeptides. The invention also features methods of using sFGFR3 polypeptides to...
2018/0230196 SINGLE-CHAIN OX40-RECEPTOR AGONIST PROTEINS
Provided herein are specific OX40 receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having an OX40L-associated...
2018/0230195 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0230194 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0230193 TREATMENT OF CANCER USING CHIMERIC CD3 RECEPTOR PROTEINS
The present disclosure features the use of chimeric CD3 proteins to modulate T cell Receptor (TCR) signaling. Specifically, the disclosure is based, in part,...
2018/0230192 FIBROBLAST GROWTH FACTOR MUTANTS HAVING IMPROVED FUNCTIONAL HALF-LIFE AND METHODS OF THEIR USE
Mutant fibroblast growth factor (FGF) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the Fgf-1...
2018/0230191 COMPOUNDS, COMPOSITIONS AND USES THEREOF FOR IMPROVEMENT OF BONE DISORDERS
The present technology generally relates to peptides of IGFBP-2 that may be used to improve bone disorders. The present technology also generally relates to...
2018/0230190 FUSOGENIC PROPERTIES OF SAPOSIN C AND RELATED PROTEINS AND PEPTIDES FOR APPLICATION TO TRANSMEMBRANE DRUG...
The present invention comprises a method for delivering pharmaceutical and/or imaging agents within and/or through the dermal, mucosal and other cellular...
2018/0230189 Polypeptides Capable of Inhibiting the Binding Between Leptin and Neuropilin-1
The present invention relates to agents capable of inhibiting the binding between Leptin and Neuropilin-1 (NRP1) and uses thereof in the therapeutic field.
2018/0230188 PEPTIDES, COMPOSITIONS, AND METHODS FOR STIMULATING SUBCUTANEOUS ADIPOGENESIS
Peptides that stimulate subcutaneous adipogenesis in mammals and uses thereof are provided.
2018/0230187 INFLUENZA VACCINES
Provided herein are compositions related to vaccines, e.g., influenza vaccines, including, peptide based vaccines, nucleic acid based vaccines, recombinant...
2018/0230186 SELECTIVE RECOVERY
Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
2018/0230185 Peptidomimetics for Treating HER2-Overexpressd Cancer
Novel peptidomimetic compounds are disclosed, compounds that inhibit protein-protein interactions (PPI) of epidermal growth factor receptors (EGFR), also...
2018/0230183 MINIATURE PROTEIN SCAFFOLDS AND METHODS FOR USE THEREOF
Miniature protein scaffolds and compositions thereof (e.g., vaccine formulations) and methods of using same are described herein. In a particular embodiment,...
2018/0230182 HYPERPOLARIZATION OF AMINO ACID RESIDUES FOR PRODUCING HYPERPOLARIZED PEPTIDES
The invention relates to the field of Magnetic Resonance Imaging (MRI). More particularly, the invention relates to hyperpolarized peptides for use in MRI.
2018/0230181 ISOFORM-SELECTIVE LYSINE DEACETYLASE INHIBITORS
Isoform-selective lysine deacetylase inhibitors are described. Inhibitors of the lysine deacetylase enzyme are useful as antitumor drugs and for treating...
2018/0230180 Charged Depth Filtration of Antigen-Binding Proteins
Methods of producing an aqueous formulation of an antigen-binding protein or enhancing re-oxidation of an antigen-binding protein are disclosed. The methods...
2018/0230179 METHODS AND SYSTEMS FOR EXTRACTING REDUCED OXALIC ACID PROTEIN FROM AQUATIC SPECIES AND COMPOSITIONS THEREOF
The present disclosure relates, according to some embodiments, to methods and systems for purifying proteins having a reduced oxalic acid content from aquatic...
2018/0230178 CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
A class of polycyclic compounds of general formula (II), of general formula (II'), or of general formula (II''), wherein Base.sup.1, Base.sup.2, Y, Y.sup.a,...
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