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Patent # Description
2018/0230177 CYCLIC DI-NUCLEOTIDE COMPOUNDS AND METHODS OF USE
Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use...
2018/0230176 METHOD FOR PREPARING 2'-O-FUCOSYLLACTOSE
The present invention relates to a method for preparing 2'-O-fucosyllactose, the 2'-O-fucosyllactose obtainable by this method and the use thereof. The method...
2018/0230175 3'-DEAMINO-3'-(2"-PYRROLINE-1"-YL)-5-IMINO-13-DEOXYANTHRACYCLINES AND METHODS OF PREPARATION
2-pyrrolino-13-deoxyanthracycline derivatives, medical uses thereof, and a process for making them. A 2-pyrrolino-13-deoxyanthracycline and a ...
2018/0230174 Microwave Assisted Hydrothermal Pre-Treatment of Cellulosic Material to Produce Fermentable Mixtures
There is described a method of transformation of a cellulosic material, such as, lignocellulosic biomass material and/or cellulose, into a directly fermentable...
2018/0230173 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
According to an aspect of the present disclosure, a compound having a metal planar tetradentate coordination configuration is disclosed. In the compounds, the...
2018/0230172 NOVEL ORGANIC SILICON COMPOUND, SURFACE TREATMENT AGENT CONTAINING SAME, RESIN COMPOSITION CONTAINING SAME, AND...
An organic silicon compound is disclosed which is represented by a formula : (R.sup.1.sub.3SiO).sub.3SiR.sup.2-[SiR.sup.3.sub.2O].sub.y[SiR.- ...
2018/0230171 HALOGEN FREE SYNTHESES OF AMINOSILANES BY CATALYTIC DEHYDROGENATIVE COUPLING
Compounds and method of preparation of Si--X and Ge--X compounds (X=N, P, As and Sb) via dehydrogenative coupling between the corresponding unsubstituted...
2018/0230170 PROTECTED ORGANOBORONIC ACIDS WITH TUNABLE REACTIVITY, AND METHODS OF USE THEREOF
Disclosed are a range of protected organoboronic acid reagents useful in the modular assembly of complex organic compounds. The reactivities of the protected...
2018/0230169 FUNCTIONALIZED AMINOBENZOBOROXOLES
Disclosed are functionalized aminobenzoboroxoles compounds, method for preparing these compounds, and methods for treating cancers.
2018/0230168 Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors
Macrocyclic compounds having the structure of Formula (A), or pharmaceutically acceptable salts thereof, are provided: ##STR00001## wherein R.sup.1, R.sup.2,...
2018/0230167 CHIMERIC COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF
The present invention provides chimeric compounds that modulate protein function, to restore protein homeostasis, including cytokine, aiolos, and/or ikaros...
2018/0230166 BICYCLIC HETEROCYCLES AS INHIBITORS OF CHOLESTEROL ESTER TRANSFER PROTEIN
The invention provides compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein D.sup.1, D.sup.2,...
2018/0230165 IMIDAZOPYRIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the...
2018/0230164 CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS
The present invention provides unified synthesis of the CI-CI 9 building blocks of halichondrins and analogs theoreof using selective coupling of ...
2018/0230163 SALINOMYCIN DERIVATIVES AND THERAPEUTIC USES THEREOF
The invention relates to salinomycin derivatives such as compounds having the structure of formula (I) or a pharmaceutically acceptable salt thereof,...
2018/0230162 COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF
The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as inhibitors of cyclophilins, and for the treatment...
2018/0230161 DEUTERATED AMLEXANOX
Provided herein is technology relating to deuterated amlexanox and particularly, but not exclusively, to compositions comprising deuterated amlexanox, methods...
2018/0230160 2-AMINO-7A-PHENYL-3,4,4A,5,7,7A-HEXAHYDROFURO[3,4-B]PYRIDINES AS BACE1 INHIBITORS
Compounds of the Formula (I) are provided which compounds inhibitors of BACE1. ##STR00001##
2018/0230159 DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE
This invention is directed to compounds of formula (I): ##STR00001## where r, q, R, R.sup.2, R.sup.3, R.sup.4, R.sup.5a, R.sup.5b, R.sup.5c, R.sup.6a, R.sup.6b,...
2018/0230158 [1,2,4]TRIAZOLO[4,3-B]PYRIDAZINES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES
The invention concerns compounds of Formula (I) ##STR00001## or pharmaceutically-acceptable salts thereof, wherein R.sup.1, R.sup.2 and n have any of the...
2018/0230157 PYRROLO[1,2-b]PYRIDAZINE DERIVATIVES
Provided is a compound of Formula (I) ##STR00001## wherein the variable groups are defined herein.
2018/0230156 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
A heterocyclic compound and an organic light-emitting device including the heterocyclic compound, the heterocyclic compound being represented by Formula 1: ...
2018/0230155 PROCESS FOR PREPARING BTK INHIBITORS
Methods for preparing the Bruton's Tyrosine Kinase ("BTK") inhibitor compound 2-{3'-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-pi- ...
2018/0230154 ATROPISOMERISM FOR INCREASED KINASE INHIBITOR SELECTIVITY
The invention provides a series of conformationally stable kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on...
2018/0230153 Benzodiazepines as bromodomain inhibitors
The present invention provides novel benzodiazepine derivatives of Formula I or pharmaceutically acceptable derivatives, polymorphs, salts or prodrugs thereof....
2018/0230152 COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY
The present invention is directed to substituted certain reversed indazole compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1,...
2018/0230151 PROCESS FOR THE PREPARATION OF TRIAZOLE AND SALT THEREOF
An improved process for the preparation of Triazole and salts thereof, a key intermediate for the synthesis of Sitagliptine is disclosed.
2018/0230150 A3 ADENOSINE RECEPTOR AGONISTS
Disclosed are compounds of the formula (I) and (II): ##STR00001## which are A.sub.3 adenosine receptor agonists, pharmaceutical compositions comprising such...
2018/0230149 INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL
The present invention relates to compounds of the Formula (I), or a pharmaceutically acceptable salt, pharmaceutical preparation, or pharmaceutical composition...
2018/0230148 SPIRO-ISOQUINOLINE-4,4'-PIPERIDINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
The present invention relates to compounds having dual pharmacological activity towards both the sigma (.sigma.) receptor, and the .mu.-opiod receptor and more...
2018/0230147 HYDROXYETHYL SULFONATE OF CYCLIN-DEPENDENT PROTEIN KINASE INHIBITOR, CRYSTALLINE FORM THEREOF AND PREPARATION...
Provided are a hydroxyethyl sulfonate of a cyclin-dependent protein kinase inhibitor, a crystalline form thereof and a preparation method therefor....
2018/0230146 Triazolopyridine Compounds and Methods for the Treatment of Cystic Fibrosis
The invention relates to a compound of Formula I or IA and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective...
2018/0230145 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES
The present invention provides compounds of formula I: ##STR00001## or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the...
2018/0230144 INDOLIZINO [3,2-C] QUINOLINE-BASED FLUORESCENT PROBE
Provided is a fluorescent probe composition including an indolizino[3,2-c]quinoline-based compound, and a nucleic acid/protein/cell imaging method using the...
2018/0230143 INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION
The invention relates to inhibitors of the NHR2 tetramerization and their use as tumor therapeutics (e.g. against acute myeloid leukemia (AML)), cytostatics,...
2018/0230142 3-(1H-BENZO[D]IMIDAZOL-2-YL)-1H-PYRAZOLO[4,3-B]PYRIDINES AND THERAPEUTIC USES THEREOF
4-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of a ...
2018/0230141 PURIFICATION METHOD FOR 5-(THIAZOL-4-YL)INDOLIN-2-ONE DERIVATIVE
The present invention addresses the problem of providing a purification method for a 5-(thiazol-4-yl)indolin-2-one derivative that is useful as a medication....
2018/0230140 MULTICOMPONENT CRYSTALS OF DASATINIB WITH MENTHOL OR VANILLIN
The present invention primarily relates to multicomponent crystals comprising a compound of formula 1 and a second compound selected from the group consisting...
2018/0230139 PYRIMIDINE UREA COMPOUND CONTAINING ISOXAZOLINES AND USE THEREOF
The present invention relates to herbicide. Specifically to a kind of uracil compounds containing isoxazoline ring and the uses thereof. The present invention...
2018/0230138 CATHEPSIN K INHIBITORS AND APPLICATION THEREOF
The invention relates to capthepsin K inhibitors and uses thereof, specifically relates to a class of compounds having the formula (I) which are used for...
2018/0230137 FUMAGILLOL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods...
2018/0230136 NOVEL CRYSTAL FORM OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOLE-5-YL)CYCLOPROPANE ...
The present disclosure provides crystalline form A of 3-(6-(1-(2, 2-difluorobenzo [d] [1, 3] dioxo-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic...
2018/0230135 3-INDOLYL FURANOIDS AS INHIBITORS OF MATRIX METALLOPROTEINASE-9 FOR PREVENTION OF GASTRIC ULCER AND OTHER...
Disclosed are 3-indolyl furanoid compounds which are useful as potent anti-inflammatory agents and prevent gastric ulcer by inhibiting matrix ...
2018/0230134 5-(N-FUSED TRICYCLIC ARYL TETRAHYDROISOQUINOLIN-6-YL) PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF...
Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the...
2018/0230133 Preparation Method of Rociletinib
Disclosed is a method for preparing Rociletinib. 2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5 -(trifluoromethyl)-pyrimidin-4-one is obtained by...
2018/0230132 5-(5-(2-(3-AMINOPROPOXY)-6-METHOXYPHENYL)-1H-PYRAZOL-3-YLAMINO)PYRAZINE-2-- CARBONITRILE (S)-LACTATE MONOHYDRATE
The disclosure herein includes 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2- -carbonitrile (S)-lactate monohydrate that inhibits...
2018/0230131 PIPERAZINE DERIVATIVE
[Problem] To provide a compound which can be used as an MC.sub.4 receptor agonist. [Means for Solution] The present inventors have investigated MC.sub.4 receptor...
2018/0230130 ARYL-SUBSTITUTED DIHYDROQUINOLINONES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
This application relates to aryl-substituted dihydroquinolinones of formula (I), compositions comprising them and their uses in the treatment of diseases and...
2018/0230129 5-(N-BENZYL TETRAHYDROISOQUINOLIN-6-YL) PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN...
Disclosed are compounds of Formula (I), including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making...
2018/0230128 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
Chemical entities that are quinoxaline kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
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