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Patent # Description
2018/0237492 VESICULAR STOMATITIS VIRUSES
This document provides methods and materials related to vesicular stomatitis viruses. For example, vesicular stomatitis viruses, nucleic acid molecules...
2018/0237491 Optogenetic Inhibition of Overactive Neuronal Activity
This disclosure relates to recombinant proteins, vectors, and methods of treating neurological conditions by exposing neurons to an opsin and luciferase in the...
2018/0237490 Composition For Treating Diabetes Or Diabesity Comprising Oxyntomodulin Analog
Disclosed are a composition for preventing or treating diabetes, disbesity or diabetic complications, containing an oxyntomodulin analog as an active...
2018/0237489 INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS
Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale...
2018/0237488 METHOD FOR PRODUCING INTERLEUKIN-2 PROTEIN USING METHYLOTROPHIC YEAST
The present invention relates to a method for producing an interleukin-2 protein using methylotrophic yeast. The method for producing interleukin-2 according...
2018/0237487 LECTIN COMPOSITIONS AND METHODS FOR MODULATING AN IMMUNE RESPONSE TO AN ANTIGEN
The present invention provides a fusion polypeptide which can bind to a cell surface binding moiety (e.g., a carbohydrate) and serve as a ligand for a cell...
2018/0237486 AN ENGINEERED CCL20 LOCKED DIMER POLYPEPTIDE
The present invention provides a CCL20 locked dimer polypeptide, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of...
2018/0237485 CELL-PERMEABLE BONE MORPHOGENETIC PROTEIN (CP-BMP) RECOMBINANT PROTEIN AND USE THEREOF
The present invention provides the CP-BMP recombinant protein with technical advantages as an intracellular protein therapy for the treatment of bone defects...
2018/0237484 PHARMACEUTICAL COMPOSITION CONTAINING, AS ACTIVE INGREDIENT, FUSION PROTEIN IN WHICH TUMOR-PENETRATING PEPTIDE...
The present invention relates to a pharmaceutical composition containing, as an active ingredient, a fusion protein in which a tissue-penetrating peptide and...
2018/0237483 Compositions and Methods for Vascular Protection Against Reperfusion Injury After Myocardial Ischemia
As described herein, the present invention features compositions comprising an HGF/IgG complex and methods of using such compositions to reduce ischemic...
2018/0237482 FUSION PROTEIN OR CONJUGATED PROTEIN, INTRACELLULAR DELIVERY CARRIER, PARTIAL PEPTIDE, CELL MEMBRANE PERMEATION...
The present invention addresses the problem of providing: a fusion protein or conjugated protein having excellent cell membrane permeability, containing a...
2018/0237481 POLYPEPTIDES AND IMMUNIZING COMPOSITIONS CONTAINING GRAM POSITIVE POLYPEPTIDES AND METHODS OF USE
The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include...
2018/0237479 Heparosan-Producing Bacterium and Heparosan Manufacturing Method
A method for producing heparosan is provided. Heparosan is produced by culturing an Escherichia bacterium having a heparosan-producing ability and modified so...
2018/0237478 MINICIRCLE DNA VECTOR VACCINE PLATFORM FOR FOOT-AND-MOUTH DISEASE AND METHODS THEREOF
This application is directed generally to minicircle DNA vectors for the vaccination of foot-and-mouth disease (FMD). The transgene expression cassette in the...
2018/0237477 POLYNUCLEOTIDES FOR TREATING ONCOGENIC VIRAL POLYPEPTIDE POSITIVE TUMORS
This document relates to polynucleotides encoding antigenic polypeptides to induce an immune response to oncogenic viral polypeptides. Also provided are...
2018/0237476 PRE-FUSION RSV F ANTIGENS
The invention relates to pre-fusion RSV F protein and polypeptides that contain one or more amino acid mutations that stabilize the pre-fusion conformation or...
2018/0237475 PEPTIDE CONJUGATES
Methods and compositions related to the selective, specific disruption of multiple ligand-receptor signaling interactions, such as ligand-receptor interactions...
2018/0237474 NMDA RECEPTOR MODULATORS AND USES THEREOF
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
2018/0237473 DIPEPTIDYL KETOAMIDE COMPOUNDS AND THEIR USE FOR THE TREATMENT AND/OR PREVENTION OF FAT ACCUMULATION
The present invention relates to the use of dipeptidyl ketoamide compounds for preventing accumulation of triglycerides in adipose tissue or for reducing the...
2018/0237472 C-3 NOVEL TRITERPENONE WITH C-28 AMIDE DERIVATIVES AS HIV INHIBITORS
The invention relates to C-3 novel triterpenone with C-28 amide derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic...
2018/0237471 BILE ACID DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF
The present invention provides compounds represented by Formula I, or pharmaceutically acceptable salts, prodrugs and esters thereof, ##STR00001## The invention...
2018/0237470 NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF
Compounds are provided according to Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein...
2018/0237469 CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
A class of polycyclic compounds of general formula (I), of general formula (I'), or of general formula (I''), wherein Base.sup.1, Base.sup.2, Y, Y.sup.a,...
2018/0237468 Compounds for the Treatment of Cancer
Provided herein are compounds useful for the treatment of cancer.
2018/0237467 MODIFIED 2' AND 3'-NUCLEOSIDE PRODRUGS FOR TREATING FLAVIVIRIDAE INFECTIONS
2' and/or 3' prodrugs of 1', 2', 3' or 4'-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are...
2018/0237466 Preparation Method of Nucleoside Phosphoramidate Prodrugs and Intermediates Thereof
Provided in the present disclosure are a novel preparation method of nucleoside phosphoramidate prodrugs and the intermediates thereof. In particular, the...
2018/0237465 STEVIA EXTRACTS ENRICHED IN REBAUDIOSIDE D, E, N AND/OR O AND PROCESS FOR THE PREPARATION THEREOF
A Stevia extract made from leaves of the Stevia rebaudiana plant is described. The extract has desired levels of steviol glycosides and is useful in food,...
2018/0237464 PHOTOACTIVE ENERGETIC MATERIALS
Energetic materials that are photoactive or believed to be photoactive may include a conventional explosive (e.g. PETN, nitroglycerine) derivatized with an...
2018/0237463 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
A compound having the formula Ir(L.sub.A).sub.n(L.sub.B).sub.3-n, having the structure Formula I, ##STR00001## is disclosed. In Formula I, Z.sup.1, Z.sup.2,...
2018/0237462 PENTAAZA MACROCYCLIC RING COMPLEXES POSSESSING ORAL BIOAVAILABILITY
Aspects of the present disclosure relate to compounds which have enhanced oral bioavailability. A transition metal complex includes a transition metal...
2018/0237461 PHOSPHORIC ACID DIESTER SALT, PRODUCTION METHOD THEREFOR, NON-AQUEOUS ELECTROLYTIC SOLUTION FOR POWER STORAGE...
Disclosed is a phosphoric acid diester salt which can suppress deterioration of charge-discharge characteristics of a power storage element, and can suppress...
2018/0237460 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
An organic light-emitting device includes: a first electrode; a second electrode facing the first electrode; and an organic layer between the first electrode...
2018/0237459 METHOD FOR COUPLING AN AROMATIC OR VINYLIC COMPOUND TO A BORON-CONTAINING COMPOUND
In one aspect, there is provided a method of coupling an aromatic or vinylic compound having a fluorosulfonate substituent to a boron-containing compound. In...
2018/0237458 MELAMPOMAGNOLIDE B DIMERS
The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These...
2018/0237457 IMIDAZOPYRIDAZINE AND IMIDAZOTHIADIAZOLE COMPOUNDS
The present invention provides imidazopyridazine compounds or imidazothiadiazole compounds of Formula I having the structure: (I) wherein X.sup.1, X.sup.2,...
2018/0237456 AMINO ACID ACYLATION REAGENTS AND METHODS OF USING THE SAME
Provided herein are compounds useful for appending amino acids to nucleophiles.
2018/0237455 COT MODULATORS AND METHODS OF USE THEREOF
The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
2018/0237454 COMPOSITIONS AND METHODS FOR TREATING NEOPLASIA, INFLAMMATORY DISEASE AND OTHER DISORDERS
The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for...
2018/0237453 TRICYCLIC FUSED PYRIDIN-2-ONE DERIVATIVES AND THEIR USE AS BRD4 INHIBITORS
The present disclosure describes heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates,...
2018/0237452 ASYMMETRIC BENZOTRICHALCOGENOPHENE COMPOUND, SYNTHESIS METHOD THEREOF AND POLYMER
A synthesis method of benzotrichalcogenophene (BTC) includes using a tetrakis(triphenylphosphine)palladium (Pd(PPh.sub.3).sub.4) catalyst and a...
2018/0237451 ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF
The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of...
2018/0237450 PYRAZOLO FUSED HETEROCYCLIC COMPOUNDS AS ERK INHIBITORS
Disclosed herein is a compound of formula (I) and/or a pharmaceutically acceptable salt thereof that can serve as Erk inhibitors. They are potentially useful...
2018/0237449 FUMAGILLOL SPIROCYCLIC COMPOUNDS AND FUSED BICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods...
2018/0237448 NOVEL QUINOLINE DERIVATIVES AND PREPARATION THEREOF
The patent discloses novel quinoline derivatives of formula (I), (Formula should be inserted here) and process for preparing the same. The compounds of formula...
2018/0237447 THERAPEUTIC COMPOUNDS
and salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of...
2018/0237446 NOVEL N-ACYL-(3-SUBSTITUTED)-5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRA- ZINES AS SELECTIVE NK-3 RECEPTOR...
Novel compounds of Formula I ##STR00001## and their use in therapeutic treatments.
2018/0237445 Medical Use of Compound III
The present invention relates to compound III ##STR00001## and its use for treatment and/or prevention of diseases of the schizophrenia spectrum and other...
2018/0237444 INHIBITORS OF ERK AND METHODS OF USE
The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases...
2018/0237443 Chemical Compounds
The present disclosure concerns compounds of Formula (I) ##STR00001## or pharmaceutically-acceptable salts thereof, wherein R.sup.1, R.sup.2 and R.sup.3 have any...
2018/0237442 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS
The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic...
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