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Patent # Description
2018/0236074 THERMORESPONSIVE BIOCONJUGATES AND THEIR CONTROLLED DELIVERY OF CARGO
The present invention provides a bioconjugate. The bioconjugate comprises a first molecule comprising an elast-in-like peptide (ELP), a second molecule capable...
2018/0236073 Methods and Compositions for Improving Antiangiogenic Therapy with Anti-Integrins
Described here are methods and compositions for treating tumors and metastases that improve anti-angiogenesis therapy. By inhibiting these mechanisms in a...
2018/0236072 EXTENDING TIME TO DISEASE PROGRESSION OR SURVIVAL IN CANCER PATIENTS
The present application describes extending time to disease progression or survival in a cancer patient, where the patient's cancer displays HER activation, by...
2018/0236071 NOVEL ANTI-HUMAN GPVI ANTIBODIES AND USES THEREOF
The present invention relates to humanized anti-human GPVI antibodies and uses thereof.
2018/0236070 METHODS AND COMPOSITIONS COMPRISING A COMBINATION OF A VEGF ANTAGONIST AND AN ANTI-CTLA-4 ANTIBODY
The present invention provides pharmaceutical compositions comprising a VEGF antagonist and an anti-CTLA-4 antibody, and methods of use thereof. The...
2018/0236069 Methods for treating and/or limiting development of diabetes in subjects with amyotrophic lateral sclerosis
Methods for treating and/or limiting development of diabetes in a subject with amyotrophic lateral sclerosis (ALS) by inhibiting IgG-mediated activation of...
2018/0236068 THERAPEUTIC AGENTS FOR PANCREATIC CANCER
We achieved the present invention on the basis of the finding that an excellent therapeutic effect against pancreatic cancer can be obtained by administering...
2018/0236067 Combination Of The Application Of Antibodies For Immunostimulation Together With Glucocorticoids
The present invention relates to methods for reducing or eliminating the non-specific release of a cytokine associated with a disease comprising administering...
2018/0236066 METHODS OF TREATING CANCER USING PD-L1 AXIS BINDING ANTAGONISTS AND VEGF ANTAGONISTS
The present invention describes combination treatment comprising a PD-1 axis binding antagonist, chemotherapy and optionally a VEGF antagonist and methods for...
2018/0236065 COILED-COIL CONNECTOR
A connector of a helical coiled coil-type structure connecting a first and a second molecule, wherein the first molecule comprises a peptidic first alpha-helix...
2018/0236064 TARGETING TGR5 TO TREAT DISEASE
Materials and methods for treating cholangiopathies by targeting TGR5, including materials and methods for treating cholangiopathies such as polycystic liver...
2018/0236063 METHODS OF USING A VACCINE COMPOSITION CONTAINING SYNTHETIC ADJUVANT
Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery...
2018/0236062 USE OF INACTIVATED NONREPLICATING MODIFIED VACCINIA VIRUS ANKARA (MVA) AS MONOIMMUNOTHERAPY OR IN COMBINATION...
The present disclosure relates to infection-competent, but nonreplicative inactivated modified vaccinia Ankara (MVA) and its use as immunotherapy, alone, or in...
2018/0236061 AVIAN REOVIRUS VACCINES
The present invention relates to novel strains of avian reovirus that were isolated from clinical cases of viral arthritis/tenosynovitis in chickens in the...
2018/0236060 HUMAN ROTAVIRUS VACCINE STRAINS AND DIAGNOSTICS
A vaccine composition and method of vaccination are provided useful for immunizing a subject against a rotavirus. The vaccines include rotavirus strains CDC-9...
2018/0236059 POLYSACCHARIDE COMPOSITION AND USE THEREOF
The present invention relates to the field of food or health care product, in particular a polysaccharide composition and use thereof. In the present...
2018/0236058 REVERSE GENETICS SYSTEMS
The invention provides various reverse genetics systems for producing segmented RNA viruses, wherein the systems do not require bacteria for propagation of all...
2018/0236057 USE OF A PCV2 IMMUNOGENIC COMPOSITION FOR LESSENING CLINICAL SYMPTOMS IN PIGS
The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several...
2018/0236056 Needle-free administration of PRRSV vaccines
The invention provides novel methods and compositions for the vaccination of porcine animals against porcine reproductive and respiratory syndrome virus...
2018/0236055 VACCINE FOR INTRAUTERINE DISEASE
Provided are compositions and methods for use in prophylaxis of puerperal metritis and improving reproductive function of ruminants. The methods and...
2018/0236054 Tetanus Toxoid and CCL3 Improve DC Vaccines
Pre-conditioning a vaccine site with a potent recall antigen such as tetanus/diphtheria (Td) toxoid can significantly improve the lymph node homing and...
2018/0236053 CELLS FOR IMMUNOTHERAPY ENGINEERED FOR TARGETING CD38 ANTIGEN AND FOR CD38 GENE INACTIVATION
Methods of developing genetically engineered immune cells for immunotherapy, which can be endowed with Chimeric Antigen Receptors targeting an antigen marker...
2018/0236052 DNA Vaccines Encoding Heat Shock Proteins
A method of treating a T cell-mediated inflammatory autoimmune disease by administering to an individual in need thereof an immunogenic composition comprising...
2018/0236051 METHOD FOR PRODUCING EMBRYONIC-LIKE STEM CELLS FROM TICKS (ACARI: IXODIDAE), COMPOSITION, USES THEREOF AND...
The invention refers to a process for the production of a continuous cell line of simile embryo stem cells, such as Amblyomma sculptum (Acari: Ixodidae), known...
2018/0236050 METHOD OF TREATING DEPRESSION
Methods are disclosed herein for treating depression in the subject. A method includes the use of Botulinum toxin to cause paralysis of a facial muscle, such...
2018/0236049 UNIT DOSE FORMULATION OF ANTIDOTES FOR FACTOR XA INHIBITORS AND METHODS OF USING THE SAME
The present invention relates unit dose formulations of antidotes to anticoagulants targeting factor Xa. Disclosed herein are methods of stopping or preventing...
2018/0236048 SUBCUTANEOUS THERAPEUTIC ENZYME FORMULATIONS, USES, AND METHODS FOR GENERATING THEREOF
Provided herein are compositions containing a lysosomal storage disorder replacement enzyme (LSDRE) and a dispersing agent for subcutaneous injection for...
2018/0236047 mRNA FOR USE IN TREATMENT OF HUMAN GENETIC DISEASES
Compositions for modulating the expression of a protein in a target cell comprising at least one RNA molecule which comprises at least one modification 5...
2018/0236046 METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION
A composition for use in inactivating a proviral DNA integrated into the genome of a host cell latently infected with a retrovirus including an isolated...
2018/0236044 METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION
A personalized method of inactivating a proviral DNA integrated into the genome of a host cell latently infected with a retrovirus, by determining a nucleic...
2018/0236043 METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION
A method of treating a subject having or at risk for having a virus infection, by administering to the subject a therapeutically effective amount of a...
2018/0236042 METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION
A method of treating a subject at risk for having a virus infection, by administering to the subject a prophylactically effective amount of a composition...
2018/0236041 METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION
A method of treating a subject having or at risk for having a virus infection, by administering a therapeutically effective amount of a composition comprising...
2018/0236040 USE OF A PHARMACEUTICAL COMPOSITION CONTAINING AT LEAST ONE DIGESTIVE ENZYME IN ARTIFICIAL FEEDING
The invention relates to the use of a pharmaceutical composition in combination with a tube food provided for artificial feeding in the treatment of digestive...
2018/0236039 HIGH OSTEOCALCIN MICROCRYSTALLINE HYDROXYAPATITE FOR CALCIUM SUPPLEMENT
An improved manufacturing process produces microcrystalline hydroxyapatite with sustained gradual calcium release that avoids spiking in blood calcium levels....
2018/0236038 Liraglutide in cardiovascular conditions
The present invention relates to the GLP-1 receptor agonist liraglutide for use in medicine.
2018/0236037 FGF21 COMPOUND / GLP-1R AGONIST COMBINATIONS WITH OPTIMIZED ACTIVITY RATIO
The present invention relates to combinations, pharmaceutical compositions and fusion molecules comprising an FGF21 (fibroblast growth factor 21) compound and...
2018/0236036 USE OF THYMOSIN ALPHA FOR THE TREATMENT OF SEPSIS
The present invention provides methods for preventing, treating, or reducing the severity of sepsis, severe sepsis or septic shock, including bacterial, viral,...
2018/0236035 PROTEIN THERAPY FOR TREATMENT OF RETINAL DISEASES
The present invention encompasses methods, compositions, and devices for treating an ocular disease, disorder or condition in a mammal. The invention includes...
2018/0236034 Compositions and Methods of Using Anti-Mullerian Hormone for Treatment of Infertility
The present invention provides compositions and methods for the treatment of subjects with impaired fertility or at risk for impaired fertility. In certain...
2018/0236033 PHARMACEUTICAL COMPOSITION FOR TREATING A METABOLIC SYNDROME
The invention is directed to a pharmaceutical composition containing at least one FGF-21 (fibroblast growth factor 21) compound, at least one GLP-1R...
2018/0236032 COMBINATION COMPOSITION COMPRISING FGF-18 COMPOUND
The present invention relates to the use of an FGF-18 compound in combination with a further active ingredient, selected from the group of an inhibitor of...
2018/0236031 COMPOSITIONS AND METHODS FOR RECOMBINANT NERVE GROWTH FACTOR
The present application provides nerve growth factor (NGF) variants with improved in vivo stability, methods for producing and purifying NGF variants, as well...
2018/0236030 STABLE PHARMACEUTICAL COMPOSITION OF TNFR:FC FUSION PROTEIN
The present invention relates to the stable pharmaceutical compositions comprising tumor necrosis factor receptor Fc fusion protein (TNFR:Fc). More...
2018/0236029 ISOFORM NELL-1 PEPTIDE
This application is drawn to a method of using an isoform NELL-1 peptide, and compositions thereof for bone formation or for treating, preventing, or...
2018/0236028 REELIN RESCUES COGNITIVE FUNCTION
Disclosed are methods of influencing, and enhancing, cognitive function and memory by increasing, and/or preventing interference with, Reelin levels as well as...
2018/0236027 DOSES AND METHODS FOR ADMINISTERING TELAVANCIN
Doses and methods for administering telavancin or a pharmaceutically-acceptable salt thereof to a human patient having an infection caused by Staphylococcus...
2018/0236026 PEPTIDE REGULATORS OF JNK FAMILY KINASES
The present disclosure relates to the fields of proliferative disorders (for example, cancer) and disorders associated with excessive cell death (for example,...
2018/0236025 METHODS FOR THE PREVENTION OR TREATMENT OF HEART FAILURE
The disclosure provides methods of preventing or treating heart failure in a mammalian subject. The methods comprise administering to the subject an effective...
2018/0236024 IRGM AND PRECISION AUTOPHAGY CONTROLS FOR ANTIMICROBIAL AND INFLAMMATORY DISEASE STATES AND METHODS OF...
The present invention relates to the discovery that IRGM, encoded by a uniquely human gene which confers risk for inflammatory diseases, affects autoophagy...
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