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Patent # Description
2018/0235973 LIQUID FORMULATIONS OF FOSAPREPITANT
The present invention relates to liquid formulations of Fosaprepitant intended for parenteral administration. Further the invention also describes process for...
2018/0235972 NOVEL FORMULATION AND TREATMENT METHODS
The invention relates to pharmaceutical compositions comprising 6-thioguanidine (6-TG) wherein the composition is formulated for release of 6-TG in the distal...
2018/0235971 MGLU2/3 ANTAGONISTS FOR THE TREATMENT OF INTELLECTUAL DISABILITIES
The invention relates to compounds which are mGlu2/3 negative allosteric modulators for use in the treatment of intellectual disabilities. In another aspect,...
2018/0235970 COMPOSITIONS AND METHODS FOR INCREASING ENERGY METABOLISM
Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or...
2018/0235969 LIQUID PHARMACEUTICAL COMPOSITION COMPRISING PEMETREXED
The present invention relates to a liquid pharmaceutical composition suitable for parenteral administration comprising: a) pemetrexed diacid; b) at least one...
2018/0235968 EGFR MUTATIONS
The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and methods of detecting such mutations as well as prognostic methods...
2018/0235967 PHARMACEUTICAL COMPOSITIONS COMPRISING AFATINIB
The present invention relates to a tablet comprising Afatinib or a pharmaceutically acceptable salt thereof, wherein the tablet is obtained by direct...
2018/0235966 PHARMACEUTICAL COMPOSITION OF ALOGLIPTIN AND METFORMIN
Present invention relates to a stable pharmaceutical composition comprising intimate mixture of alogliptin and metformin, and suitable pharmaceutically...
2018/0235965 CRYSTAL FORM OF OREXIN RECEPTOR ANTAGONIST COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF
Disclosed are a preparation method of an orexin receptor antagonist compound 5-3, Crystalline forms I-IV of an orexin receptor antagonist compound 5-3 are...
2018/0235964 CXCR-2 INHIBITORS FOR TREATING CRYSTAL ARTHROPATHY DISORDERS
N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)p- yrimidin-4-yl)azetidine-1-sulfonamide (compound 3) and N-(6-(((2R,3S)-3,4-dihydroxy...
2018/0235962 ACOUSTIC MIXING FOR AUTO GRANULATION
A process for acoustically mixing a bulk drug substance involves the application of acoustic energy to drive an accelerative force in a mixing vessel...
2018/0235961 COMPOSITIONS AND METHODS FOR CANCER EXPRESSING PDE3A OR SLFN12
The present invention features improved methods of identifying patients having cancer (e.g., melanoma, adenocarcinoma, lung, cervical, liver or breast cancer)...
2018/0235960 TREATMENT OF CANCER WITH TOR KINASE INHIBITORS
Provided herein are methods for treating or preventing a solid tumor, non-Hodgkin lymphoma or multiple myeloma in a patient, comprising administering an...
2018/0235959 USE OF CRAC CHANNEL INHIBITORS FOR THE TREATMENT OF STROKE AND TRAUMATIC BRAIN INJURY
Described herein are methods of treatment of stroke and traumatic brain injury comprising administration of a CRAC channel inhibitor.
2018/0235958 PANCREATITIS TREATMENT
Compositions and methods related to the amelioration of pancreatitis through the pharmaceutical manipulation of calcium signaling are disclosed. Such...
2018/0235957 Treatment of Ophthalmic Conditions by Selectively Removing Senescent Cells from the Eye
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic...
2018/0235956 TREATING PULMONARY CONDITIONS BY SELECTIVELY REMOVING SENESCENT CELLS FROM THE LUNG USING AN INTERMITTENT...
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic...
2018/0235955 ACETATE SALT OF BUPRENORPHINE AND METHODS FOR PREPARING BUPRENORPHINE
The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts...
2018/0235954 LIPOSOMES USEFUL FOR DRUG DELIVERY
The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging...
2018/0235953 METHODS AND USES OF QUINOLINE DERIVATIVES IN THE TREATMENT OF SOFT TISSUE SARCOMAS AND PHARMACEUTICAL...
The present invention addresses methods and uses of quinoline derivatives in the treatment of tumours and pharmaceutical compositions for treatment of same....
2018/0235952 METHODS OF TREATING CANCER WITH FARNESYLTRANSFERASE INHIBITORS
The present invention relates to the field of cancer therapy. Specifically, provided are methods of treating cancer, for example, peripheral T-cell lymphoma...
2018/0235951 USE OF CERANIB-2 IN THE TREATMENT OF LUNG CANCER AND BREAST CANCER
The present invention relates to the use of ceranib-2 molecule in the treatment of lung cancer and breast cancer. At the same time, the present invention also...
2018/0235950 DEUTERATED ANALOGS OF PRIDOPIDINE USEFUL AS DOPAMINERGIC STABILIZERS
The present invention provides novel deuterated analogs of Pridopidine, i.e. 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine. Pridopidine is a drug substance...
2018/0235949 Substituted 1-Arylalkyl-4-Acylaminopiperidine Compounds and Methods of Producing and Using the Same
The present invention provides using a substituted 1-arylalkyl-4-acylaminopiperidine compound of Formula I: ##STR00001## to treat various clinical conditions...
2018/0235948 (S,E)-3-(6-AMINOPYRIDIN-3-YL)-N-((5-(4-(3-FLUORO-3-METHYLPYRROLIDINE-1-CAR- ...
The invention generally relates to substituted benzofuranyl compounds and, more particularly, to a compound represented by Structural Formula 1a: (I) or a...
2018/0235947 Liquid Pharmaceutical Composition
The present invention provides a physically and chemically stable pharmaceutical liquid composition including sodium picosulfate, magnesium oxide, citric acid...
2018/0235946 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PRESBYOPIA
The invention provides compositions and methods for the treatment of presbyopia. The compositions preferably comprise aceclidine, an alpha-adrenergic agonist,...
2018/0235945 TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: ...
2018/0235944 RIFAXIMIN
Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to...
2018/0235943 COMBINATION THERAPIES FOR TREATMENT OF SPINAL MUSCULAR ATROPHY
Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase...
2018/0235942 METHODS OF SEDATION AND PARENTERAL FORMULATION FOR USE DURING CRITICAL CARE TREATMENT
Methods of sedating a patient undergoing critical care treatment using intravenous gaboxadol or a pharmaceutically acceptable salt thereof are provided....
2018/0235941 PEDIATRIC ORAL SUSPENSION FORMULATIONS OF AMOXICILLIN AND CLAVULANATE POTASSIUM AND METHODS FOR USING SAME
The invention is directed to a pediatric oral suspension composition containing amoxicillin and clavulanate potassium where the clavulanate potassium is...
2018/0235940 TREATMENT AND MANAGEMENT OF AUGMENTATION IN RESTLESS LEGS SYNDROME
The present invention provides methods of treating Restless Legs Syndrome (RLS) including administering to a subject an effective amount of a dopamine D.sub.1...
2018/0235939 Polymorphic Forms of 2-(5-Bromo-4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-Triazol-3-ylthio)Ace- tic Acid...
Crystalline polymorph forms of 2-(5-bromo-4-(4-cyclopropyl naphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid are described. Pharmaceutical compositions...
2018/0235938 SUBSTITUTED 1,2-DIHYDRO-3H PYRROLO[1,2-c]IMIDAZOL-3 ONE ANTIBACTERIALS
The invention relates to antibacterial compounds of formula I ##STR00001## wherein M is one of the groups M.sup.A, M.sup.B and M.sup.C represented below ...
2018/0235937 COMPOUNDS AND METHODS FOR TREATING AN EPILEPTIC DISORDER
Provided, inter alia, are methods for treating an epilepsy disorder using clemizole, a clemizole analog, or pharmaceutical salts thereof.
2018/0235936 CANCER TREATMENT METHODS
Methods for treating cancer include administering and/or receiving, at a patient in need thereof, a therapeutic dose of an inhibitor of extracellular vesicle...
2018/0235935 Treatment of Cancer with Enzalutamide and a CYP3A4 Inhibitor
This disclosure provides a dosage regimen for co-administration of enzalutamide and a strong CYP3A4 inducer in the treatment of cancer.
2018/0235934 NORADRENERGIC DRUG TREATMENT OF OBSTRUCTIVE SLEEP APNEA
Aspects of the disclosure relate to methods for treating disorders using agents for promoting hypoglossal motoneuron excitability. In some instances the...
2018/0235933 CRYSTALLINE FORM OF LORLATINIB FREE BASE
This invention relates to acrystalline form of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-5-oxo-10,15,16,17-tetrahydro-2H- -8,4-(metheno)pyrazolo[4,3-h] ...
2018/0235932 METHODS OF TREATING MUSCULAR DYSTROPHY
Disclosed herein are .alpha.7.beta.1 integrin modulatory agents and methods of using such to treat conditions associated with decreased .alpha.7.beta.1...
2018/0235931 USE OF NEUROKININ-1 ANTAGONISTS AS ANTITUSSIVES
The disclosure relates to the use of neurokinin-1 (NK-1) antagonists, such as serlopitant, MK-0303 or MK-8478, in alleviating or suppressing cough (including...
2018/0235930 METHOD OF USING A COMPOSITION FOR ENHANCING NEWBORN INFANT COGNITIVE, BRAIN AND/OR CNS DEVELOPMENT
Disclosed are methods of using nutritional compositions generally, and infant formulas specifically, to improve cognitive, brain and/or central nervous system...
2018/0235929 ADMINISTRATION OF BENZODIAZEPINE COMPOSITIONS
The invention relates to pharmaceutical compositions comprising one or more benzodiazepine drugs for nasal administration, methods for producing and for using...
2018/0235928 COMPOSITIONS AND METHODS FOR SELECTIVELY INHIBITING INTESTINAL CARBOXYLESTERASE 2 ENZYME ACTIVITY
A method for treating diarrhea induced by a chemotherapy agent by administering a carboxylesterase 2 (CES2) inhibitor, i.e., hesperetin, naringenin, or...
2018/0235927 NITROXYL DONORS WITH IMPROVED THERAPEUTIC INDEX
The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and...
2018/0235926 METHODS FOR CONTROLLING THE SPREAD OF DIROFILARIOSIS
This invention relates to a method of controlling the spread of dirofilariosis, such as for example heartworm, by administering to at least one non-human...
2018/0235925 BISPHENOL COMPOUNDS AND METHODS FOR THEIR USE
Compounds having a structure of Formula I: wherein G, a, Q, L.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as defined herein are...
2018/0235924 COMPOSITIONS FOR TOPICAL APPLICATION COMPRISING BENZOYL PEROXIDE AND ADAPALENE
The invention provides compositions comprising as active agents benzoyl peroxide (BPO), adapalene and optionally clindamycin phosphate, kits and uses thereof...
2018/0235923 METHOD FOR REVERSING, PREVENTING, DELAYING OR STABILIZING SOFT TISSUE CALCIFICATION
The present invention provides methods of treating soft tissue calcification in a subject, comprising a step of administering to said subject an effective...
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