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Patent # Description
2018/0238911 BIOCHEMICAL MARKERS OF RED BLOOD CELL STORAGE AND TOXICITY
Compositions and methods for determining post-transfusion survival or toxicity of red blood cells and the suitability of red blood cell units for transfusion...
2018/0238910 METHODS FOR PROVIDING INFORMATION RELEVANT TO DIAGNOSIS OF NEURODEGENERATIVE DISORDER
A method for providing information relevant to the diagnosis of a neurodegenerative disorder. The method includes (i) obtaining a biological sample containing...
2018/0238909 MULTIPLEX BIOMARKER FOR USE IN EVALUATION OF STATE OF ACCUMULATION OF AMYLOID B IN BRAIN, AND ANALYSIS METHOD...
Provided are a biomarker for evaluating a cerebral A.beta. accumulation state using amyloid precursor protein (APP)-derived A.beta. and A.beta.-like peptides...
2018/0238908 NEURODEGENERATIVE DISORDERS
An amyloidogenic peptide biospecific agent comprises a nanoparticle which is visible under near infrared (NIR) and/or using Magnetic Resonance Imaging (MRI)...
2018/0238907 MARKERS AND THEIR USE IN BRAIN INJURY
The invention relates to a combination of biomarkers and their use in brain injury or mild traumatic brain injury (mTBI) detection.
2018/0238905 METHODS AND COMPOSITIONS FOR DIAGNOSIS OF ECTOPIC PREGNANCY
Methods and compositions are provided for diagnosing ectopic pregnancy in a mammalian subject by detecting changes in expression of ISM2, ADAM12, PST1, PSG7,...
2018/0238904 IMMUNE CHECKPOINT MOLECULAR FITNESS PROFILING BY MASS SPECTROMETRY
The present disclosure relates generally to the analysis of immune checkpoint proteins involved in cancer. In particular, the present disclosure provides...
2018/0238903 Immunoassay for Collagen Type VIII Sequences
The invention provides an immunological binding partner specifically reactive with a C-terminal epitope of the .alpha.1 chain of collagen Type VIII or with an...
2018/0238902 METHODS FOR USING ANTIBODIES AND ANALOGS THEREOF
Camelid and shark single-domain heavy chain antibodies lacking the light chains, and their analogs are disclosed. Methods for using the antibodies and their...
2018/0238901 HIGH PRECISION SPECTRAL FRET ASSAYS
Provided herein are methods for identifying a compound that alters fluorescence resonance energy transfer (FRET) of a protein. In one embodiment, the method...
2018/0238900 METHOD AND KIT FOR DETECTING GLUTATHIONE
A method for detecting glutathione includes mixing a sample including glutathione, 9-bromomethyl acridine (Br-MA) and a derivatization solvent to form a...
2018/0238899 NOVEL GLUCOSE DERIVATIVE, AND CELL IMAGING METHOD AND IMAGING AGENT USING SAID DERIVATIVE
Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an...
2018/0238898 MEANS AND METHODS FOR MONITORING INFLAMMATION
The application discloses methods, kits and a novel biomarker to detect and/or to prognose inflammation in patients. The diagnostic test is based on measuring...
2018/0238897 SELECTIVE NEAR-INFRARED OPTICAL IMAGING OF NECROTIC CELLS AND SIMULTANEOUS CELL FIXING AND COUNTER STAINING...
In an example of a method for simultaneously fixing and staining cells, the cells are initially incubated in a solution including a Ln(III)Zn.sub.16(HA...
2018/0238896 FREE NGAL AS A BIOMARKER FOR CANCER
Uncomplexed neutrophil gelatinase associated lipocalin (NGAL) is present at increased levels in individuals with atypical ductal hyperplasia (ADH), a major...
2018/0238895 ANTIBODIES RECOGNIZING A CARBOHYDRATE CONTAINING EPITOPE ON CD-43 AND CEA EXPRESSED ON CANCER CELLS AND METHODS...
The present invention provides novel antibodies specifically bind to an epitope on CD43 and CEA expressed on nonhematopoietic cancer cells, but do not...
2018/0238894 METHODS OF DETECTING DISEASES OR CONDITIONS USING CIRCULATING DISEASED CELLS
This invention provides methods of using circulating diseased cells in the diagnosis, prognosis, or monitoring of diseases or conditions. The invention also...
2018/0238893 USE OF CIRCULATING CELL BIOMARKERS IN THE BLOOD FOR DETECTION AND DIAGNOSIS OF DISEASES AND METHODS OF...
A new sensitive cell biomarker of solid tumors and viral infection is identified in blood. This biomarker can be used to determine presence of carcinomas,...
2018/0238892 METHOD OF DIAGNOSING, TREATING AND DETERMINING PROGRESSION AND SURVIVAL OF CANCER CELLS USING BCL-2 ANTAGONIST...
The present invention relates to the BAD pathway's influence on development, progression, chemo-sensitivity, and overall survival for multiple human cancers...
2018/0238891 Cancer Detection Method
The present disclosure relates to methods of determining whether a subject has cancer. More particularly, the present disclosure relates to a method of...
2018/0238890 METHODS AND MATERIALS FOR DETECTION, DIAGNOSIS AND MANAGEMENT OF OVARIAN CANCER
The subject invention concerns methods using a panel of proteins to detect, diagnose, and monitor therapy during treatment of ovarian cancer in a female...
2018/0238889 THE SCANO-miR PLATFORM IDENTIFIES A DISTINCT CIRCULATING MICRORNA SIGNATURE FOR THE DIAGNOSIS OF DISEASE
The disclosure relates to the identification of a novel molecular signature based on the differential expression of circulating microRNAs (miRNA) in serum...
2018/0238888 NEW BIOMARKER FOR OUTCOME IN AML PATIENTS
The present invention relates to a method for predicting the survival time of a patient suffering from acute myeloid leukemia (AML) comprising i) determining...
2018/0238887 PHARMACEUTICAL USE OF ACTININ-4 INVOLVED IN INDUCTION OF CERVICAL CANCER
The present invention relates to a pharmaceutical use of actinin-4 involved in the induction of cervical cancer and more specifically, characterizes actinin-4...
2018/0238886 METHODS FOR TREATING HEMATOLOGICAL CANCER AND THE USE OF BIOMARKERS AS A PREDICTOR FOR RESPONSIVENESS TO...
A method for predicting the responsiveness of a patient having a hematological cancer to a treatment compound, comprising obtaining a biological sample from...
2018/0238885 NEW METHOD FOR TREATING AND PROGNOSING CANCER
The present invention relates to an in vitro method for determine the prognosis of the survival time of a patient suffering from a cancer comprising the steps...
2018/0238884 PD-L2 BIOMARKERS PREDICTIVE OF PD-1 PATHWAY INHIBITOR RESPONSES IN ESOPHAGOGASTRIC CANCERS
The present invention is based on the identification of novel biomarkers predictive of responsiveness of esophagogastric cancers to inhibitors of the PD-1...
2018/0238883 FLUID ACTUATION OF INSTRUMENTS THROUGH A STERILE BARRIER
A robotic surgical system includes a fluid drive system and a surgical instrument removably positioned in operative engagement with the drive system. A sterile...
2018/0238882 KITS SUITABLE FOR USE IN ELECTROCHEMILUMINESCENCE METHODS AND METHODS OF EFFECTING A SPECIFIC-BINDING NON-WASH...
The invention relates to improved electrochemiluminescence assay methods for phosphorylated peptides or proteins employing phospho-specific antibodies and...
2018/0238881 RAPID IMMUNOCHROMATOGRAPHIC LATERAL FLOW ASSAY FOR EARLY ZIKA DISEASE DETECTION
The invention relates to a sensitive and specific rapid immunochromatographic lateral flow assay for Zika virus infection. The rapid assay of the invention can...
2018/0238880 CD127 EXPRESSION INVERSELY CORRELATES WITH FOXP3 AND SUPPRESSIVE FUNCTION OF CD4+ TREGS
The invention provides methods of isolating CD127.sup.lo/- immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding...
2018/0238879 METHODS AND MATERIALS FOR ASSESSING IMMUNE SYSTEM PROFILES
This document provides methods and materials involved in assessing immune system profiles. For example, methods and materials for performing flow cytometry to...
2018/0238878 ASSAYS FOR DETECTING T CELL IMMUNE SUBSETS AND METHODS OF USE THEREOF
The present disclosure provides methods for measuring the number of CD4+ OX40+ Foxp3+ lymphocytes in a sample containing cancer cells and lymphocytes obtained...
2018/0238877 ISOLATION OF ANTIGEN SPECIFIC B-CELLS
The present invention provides methods compositions and methods of isolating B-cells that produce an antibody specific for an antigen of interest.
2018/0238876 Method For Assessing Cell Surface Receptors of Blood Cells
The present invention relates to a novel method for rapid assessment of one or more subclasses of blood cells of interest (BCol), as for example CD4+ cells and...
2018/0238875 CIRCULATING ASTROCYTES AND MFSD2A AS BIOMARKERS
The invention provides the use of circulating astrocytes (cAstr) and the Major Facilitator Superfamily Domain containing Protein 2a (Mfsd2a) as biomarkers, and...
2018/0238874 PROTEINS USED FOR THE DIAGNOSIS OF LYME BORRELIOSIS
Chimera proteins includlng: (i) at least one sequence of a DbpA protein of a Borrelia species selected from B. afzelii, B. burgdorferi sensu stricto and B....
2018/0238873 DIAGNOSIS OF SYSTEMIC LUPUS ERYTHEMATOSUS USING PROTEIN, PEPTIDE AND OLIGONUCLEOTIDE ANTIGENS
Methods and kits for diagnosing or monitoring systemic lupus erythematosus (SLE) in a subject are provided. Particularly, provided is a specific antibody...
2018/0238872 IMMUNOASSAY CARTRIDGE
An immunoassay cartridge is disclosed that can enhance the reliability of an antigen-antibody reaction while increasing a speed of an antigen-antibody...
2018/0238871 REAGENT AND METHOD FOR MEASURING THROMBIN-ANTITHROMBIN COMPLEX
Provided is a reagent for assaying a thrombin-antithrombin complex (TAT) in a blood sample from a subject by latex agglutination assay. The reagent includes a...
2018/0238870 IMMUNOLOGICAL MEASUREMENT DEVICE
An immunological measurement device includes a micro fluid device. The micro fluid device includes a flowpath to move a specimen that is subjected to an...
2018/0238869 USES OF SYSTEMS WITH DEGREES OF FREEDOM POISED BETWEEN FULLY QUANTUM AND FULLY CLASSICAL STATES
Disclosed herein are systems and uses of systems operating between fully quantum coherent and fully classical states. Such systems operate in what is termed...
2018/0238868 CORE-SHELL NANOPARTICLES WITH MULTIPLE CORES AND METHOD FOR FABRICATING THEM
The present invention is directed toward core-shell nanoparticles, each comprising a ligand-capped metal shell surrounding a plurality of discrete,...
2018/0238867 DETECTION DEVICE AND TARGET DETECTION METHOD USING THE SAME
The present invention provides a new detection device and a target detection method using the same. The detection device of the present invention includes a...
2018/0238866 SUPPRESSION OF SPLA2-INTEGRIN BINDING FOR TREATING AN INFLAMMATORY CONDITION OR SUPPRESSING CELL PROLIFERATION
The present invention relates to the discovery that a secretory phospholipase A2 (sPLA2-IIA) plays an active role in mediating cellular signaling leading to an...
2018/0238865 DIGITAL IMMUNOASSAY
Methods of detecting an analyte in a sample are provided. In one embodiment, the method comprises forming a partition comprising the sample, a binding agent...
2018/0238864 MODULAR POINT-OF-CARE DEVICES, SYSTEMS, AND USES THEREOF
The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection...
2018/0238863 CHEMICAL SYNTHESIS
Herein are described methods of chemical synthesis.
2018/0238862 METHODS AND SYSTEMS FOR MEASURING GROWTH RATE IN PLANT OR AQUATIC ANIMAL SPECIES
Method and systems for measuring growth rate in plant or aquatic animal species such as embryonic or adult fish. The methods and systems utilize the...
2018/0238861 METHODS FOR ENHANCING THE SPECIFIC UPTAKE OF BOTULINUM NEUROTOXINS INTO CELLS
The present invention provides a method for enhancing the specific uptake of a neurotoxin polypeptide into cells, the method comprising: incubating cells...
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