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Patent # Description
2018/0237795 EXPRESSION OF THERMOSTABLE STARCH SYNTHASE GENES IMPROVES THE YIELD IN HEAT STRESS
Genetically-modified plants having increased tolerance to heat stress are described. Methods of producing such genetically-modified plants are also disclosed....
2018/0237794 SEQUENCE DETERMINED DNA FRAGMENTS AND CORRESPONDING POLYPEPTIDES ENCODED THEREBY
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful...
2018/0237793 TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS
This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to...
2018/0237792 COMPOSITIONS AND METHODS FOR ENGINEERING OIL CONTENT IN PLANTS
Compositions and methods for producing plants with enhanced oil content and higher seed yield are disclosed. The transgenic plant comprises a polynucleotide...
2018/0237791 TEMPORAL REGULATION OF GENE EXPRESSION BY MICRORNAS
This invention provides molecular constructs and methods for the temporally specific control of gene expression in plants or in plant pests or pathogens. More...
2018/0237790 FORMULATIONS AND COMPOSITIONS FOR DELIVERY OF NUCLEIC ACIDS TO PLANT CELLS
The present invention, in some embodiments thereof, relates to methods and compositions for delivering polynucleotides into plant cells having a cell wall,...
2018/0237789 MORTIERELLA ALPINE URACIL AUXOTROPH WITH URA5 GENE KNOCKED OUT THROUGH HOMOLOGOUS RECOMBINATION
It relates to a Mortierella alpine ATCC32222 uracil auxotroph strain and a construction method thereof. In the present invention, Mortierella alpine ATCC32222...
2018/0237788 IMPROVEMENTS IN OR RELATING TO DNA RECOMBINATION
There is provided a non-PCR based method for construction of a DNA recombination fragment with necessary flanking regions homologous to a desired site of...
2018/0237787 GENE EDITING OF PCSK9
Provided herein are systems, compositions, and methods of introducing loss-of-function mutations in to protein factors involved in the LDL-R-mediated...
2018/0237786 ARTIFICIAL NUCLEIC ACID MOLECULES
The invention relates to an artificial nucleic acid molecule comprising at least one open reading frame and at least one 3'-untranslated region element (3'-UTR...
2018/0237785 NOTCH 1 SPECIFIC siRNA MOLECULE
The present invention is related to a nucleic acid molecule comprising a double-stranded structure, wherein the double-stranded structure is formed by a first...
2018/0237784 Therapeutic Agents
The present invention relates to identification of therapeutic agents for the treatment, diagnosis, and prevention of pulmonary hypertension.
2018/0237783 METHODS AND COMPOSITIONS OF SHORT SMALL HAIRPIN RNAS AND MICRORNAS FOR WOUND HEALING
Wound healing is a complex homeostatic process in which several distinct types coordinate to repair a physical damage. Failure to close wounds contributes to...
2018/0237782 FUNCTIONAL LIGANDS TO TARGET MOLECULES
The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for...
2018/0237781 COMPOSITIONS AND METHODS FOR REGULATION OF GENE EXPRESSION WITH, AND DETECTION OF, FOLINIC ACID AND FOLATES
Aptamers that specifically bind to ligands of folinic acid, a folate, and derivatives thereof (which may be referred to herein as ligands) are provided, and...
2018/0237780 UNA OLIGOMERS FOR THERAPEUTICS WITH PROLONGED STABILITY
This invention provides UNA oligomers for therapeutics having prolonged stability. The UNA oligomers can be composed of one or more 2'-3'-seco-nucleomonomers...
2018/0237779 MIR-92 INHIBITORS AND USES THEREOF
The present invention provides oligonucleotide inhibitors of miR-92 and methods of using said inhibitors for inhibiting the function and/or activity of miR-92...
2018/0237778 ANTISENSE DESIGN
A novel class of pharmaceuticals which comprises a Locked Nucleic Acid (LNA) which can be used in antisense therapy. These novel oligonucleotides have improved...
2018/0237777 ANTISENSE DESIGN
A novel class of pharmaceuticals which comprises a Locked Nucleic Acid (LNA) which can be used in antisense therapy. These novel oligonucleotides have improved...
2018/0237776 METHODS AND COMPOSITIONS FOR MODLATING APOLIPOPROTEIN (A) EXPRESSION
Disclosed herein are antisense compounds and methods for decreasing apo(a) to treat, prevent, or ameliorate diseases, disorders or conditions related to apo(a)...
2018/0237775 ANTISENSE OLIGONUCLEOTIDES AND USES THEREOF
The present invention relates to nucleic acids, compositions and methods for the treatment of diseases, in particular for the treatment of facioscapulohumeral...
2018/0237774 METHODS OF SCREENING FOR RIBOSWITCHES AND ATTENUATORS
A method of determining a transcription termination site in bacterial DNA is disclosed. Uses of sequences comprising transcription termination sites are also...
2018/0237773 SPLICE-REGION ANTISENSE COMPOSITION AND METHOD
Antisense compositions targeted against an mRNA sequence coding for a selected protein, at a region having its 5' end from 1 to about 25 base pairs downstream...
2018/0237772 HYBRID tRNA/pre-miRNA MOLECULES AND METHODS OF USE
Provided are hybrid tRNA/pre-microRNA and tRNA/shRNA molecules and methods of making and using.
2018/0237771 Artificially-Manipulated Neovascularization Regulatory System
The present invention relates to an artificially manipulated neovascularization-associated factor for regulating neovascularization and a use thereof. More...
2018/0237770 Compositions and Methods of Nucleic Acid-Targeting Nucleic Acids
This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof. Genome engineering can refer...
2018/0237769 Method and System for Isolation of Nucleic Acids
The invention relates to a field of biochemistry, and more precisely to a method of isolation, purification, and/or concentration of nucleic acids, in...
2018/0237768 NUCLEASE-MEDIATED REGULATION OF GENE EXPRESSION
The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic cell.
2018/0237767 CAPILLARY BARRIERS FOR STAGED LOADING OF MICROFLUIDIC DEVICES
Various aspects of the present disclosure are directed toward methods and apparatuses for interacting a first liquid and a second liquid in one or more fluidic...
2018/0237766 METHODS FOR PURIFICATION OF MESSENGER RNA
The present invention provides, among other things, methods of purifying messenger RNA (mRNA) including the steps of subjecting an impure preparation...
2018/0237765 Large Volume Ex Vivo Electroporation Method
An object of the invention is to provide an electroporation method for treating vesicles with exogenous material for insertion of the exogenous material into...
2018/0237764 ELECTRIC PULSE GENERATION SYSTEMS USING CAPACITIVE COUPLING
In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments,...
2018/0237763 TETHERING CYSTEINE RESIDUES USING CYCLIC DISULFIDES
Described herein are compounds and methods for tethering proteins. For example, dimers of Protein X listed in Table 1 are described, where the dimers are...
2018/0237762 CLOTTING FACTOR-FC CHIMERIC PROTEINS TO TREAT HEMOPHILIA
The invention relates to a chimeric protein comprising at least one clotting factor and at least a portion of an immunoglobulin constant region. The invention...
2018/0237761 BACILLUS GIBSONII-CLADE SERINE PROTEASES
Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof,...
2018/0237760 A novel endolysin polypeptide
The invention relates to the field of medicine, specifically to the field of treatment of conditions associated with Staphylococcus infection. The invention...
2018/0237759 Compositions for degrading cellulosic material
The present invention relates to cellulolytic compositions for degrading or converting cellulose-containing material and methods of producing and using the...
2018/0237758 EVOLUTION OF TALENS
Engineered transcriptional activator-like effectors (TALEs) are versatile tools for genome manipulation with applications in research and clinical contexts....
2018/0237757 POLYMERASES FOR NUCLEIC ANALOGUE INCORPORATION
Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the...
2018/0237756 ENZYMES
The invention relates to a nucleic acid polymerase capable of producing a non-DNA nucleotide polymer from a DNA nucleotide template, said polymerase comprising...
2018/0237755 AMADORIASE HAVING ENHANCED ANIONIC SURFACTANT TOLERANCE
The present invention provides a composition that enables measurement of glycated hemoglobin in the presence of a stronger surfactant than conventional...
2018/0237754 FAD-CONJUGATED GLUCOSE DEHYDROGENASE GENE
An object of the present invention is to provide: a novel gene (polynucleotide) encoding an FAD-conjugated glucose dehydrogenase having excellent properties...
2018/0237753 COMPOSITIONS AND METHODS FOR ENHANCING VIRUS REPLICATION
Described herein is a method of enhancing virus replication in permissive cells that express a receptor to FGF2 protein. The method includes administering FGF2...
2018/0237752 DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS
The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present...
2018/0237751 METHOD FOR GENERATING BETA CELLS
The invention is directed to methods for generating pancreatic progenitor cells, insulin producing cells or endoderm cells using embryonic stem cells and...
2018/0237750 CELL CULTURE METHOD USING BONE MARROW-LIKE STRUCTURE, AND POROUS POLYIMIDE FILM FOR HEALING BONE INJURY SITE
The present invention relates to a method for culturing bone marrow cells, in which bone marrow cells are applied to a porous polyimide film and cultured....
2018/0237749 Improved method for ex vivo expansion CD34+HSPCs into NK cells using an aryl hydrocarbon receptor antagonist
The present invention relates to the field of medicine, specifically the field of treatment of cancer. More specifically, the invention relates to a method for...
2018/0237748 Methods for Neural Conversion of Human Embryonic Stem Cells
The present invention relates generally to the field of cell biology of stem cells, more specifically the directed differentiation of pluripotent or...
2018/0237747 COMPOSITIONS AND METHODS FOR IMPROVING THE QUALITY OF PROCESSED SPERM
The present invention generally relates to compositions and methods for the handling of processed sperm populations including samples that are freshly...
2018/0237746 Multipotential Expanded Mesenchymal Precursor Cell Progeny (MEMP) and Uses Thereof
The invention relates to multipotential expanded mesenchymal precursor progeny (MEMP's), characterised by the early developmental markers STRO-1.sup.bri and...
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