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Patent # Description
2018/0237542 TETRAVALENT BISPECIFIC AND TETRASPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF
The present invention relates to tetravalent bispecific and tetraspecific antigen binding proteins that are capable of binding to multiple targets. ...
2018/0237541 CH3 DOMAIN VARIANT PAIR INDUCING FORMATION OF HETERODIMER OF HEAVY CHAIN CONSTANT REGION OF ANTIBODY AT HIGH...
Disclosed are a CH3 domain variant pair of an antibody, a method for preparing same, and a use thereof. A mutation is induced in the CH3 domain so as to...
2018/0237540 Bi-Specific Fusion Proteins
Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using...
2018/0237539 ANTIBODY AGAINST ALOPECIA-INDUCING SUBSTANCE AS ANTIGEN, COMPOSITION AND PRODUCTION METHOD
Causes of hair loss have not been completely clarified and still remain unknown in many points. However, it appears that hair loss is partly caused by a...
2018/0237538 RECOMBINANT HUMAN IgM-ANTIBODY EFFECTIVE AGAINST CANCER CELLS
A recombinant human monoclonal pentameric IgM antibody comprising the capability of oligospecific binding to purified ganglioside epitopes GD3, GM3, GD2 and...
2018/0237537 SPECIFICALLY PURIFIED ANTI-PRESEPSIN ANTIBODY
The present invention provides anti-presepsin polyclonal antibodies specifically binding to a peptide comprising an amino acid sequence of SEQ ID NO: 1. As a...
2018/0237536 CD73 BLOCKADE
This disclosure relates to antibodies that bind an epitope present on CD73 expressed at the surface of cells, including tumor cells, and that inhibit the...
2018/0237535 PD-L1 ANTIBODIES BINDING CANINE PD-L1
The present disclosure describes antibodies including caninized antibodies against canine PD-L1 with specific properties. The document relates to epitopes of...
2018/0237534 ANTIBODIES AGAINST OX40 AND USES THEREOF
Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications,...
2018/0237533 CHIMERIC ANTIGEN RECEPTORS WITH INTEGRATED CONTROLLABLE FUNCTIONS
The present invention relates to the field of cell immunotherapy and more particularly to a new generation of chimeric antigen receptors (CAR), allowing the...
2018/0237532 METHOD FOR THE TREATMENT OF MULTIPLE SCLEROSIS
A method for treating a subject with multiple sclerosis is disclosed herein. In one embodiment, a method is provided for treating a subject with multiple...
2018/0237531 METHOD FOR THE TREATMENT OF PAIN AND OSTEOARTHRITIS WITH C-FMS ANTAGONISTS
The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA) and/or pain. In accordance with the present...
2018/0237530 TOOLS AND METHODS FOR EXPRESSION OF MEMBRANE PROTEINS
The disclosure relates cells or cellular systems that express both a membrane protein and a binding domain directed to the membrane protein. Also, methods are...
2018/0237529 Humanized anti-CCR7 receptor antibodies
The present invention provides novel humanized anti-human CCR7 antibodies and compositions comprising such antibodies. The antibodies and compositions are...
2018/0237528 IL2RBETA/COMMON GAMMA CHAIN ANTIBODIES
Anti-CD122 and/or .gamma.c antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses...
2018/0237527 ANTIBODY FRAGMENTS, COMPOSITIONS AND USES THEREOF
An isolated nucleic acid encoding a monovalent antibody fragment comprising a first polypeptide comprising a light chain variable domain and two constant...
2018/0237526 MIC-BINDING ANTIBODIES AND METHODS OF USE THEREOF
The technology described herein relates to antibodies and/or polypeptides which bind to MIC and inhibit MIC shedding. Methods of using such antibodies and/or...
2018/0237525 VISTA Agonist and Methods of Use
The present invention is directed to synergic or additive therapies comprising the administration of a VISTA antagonist and a PD-1, PD-L1 or POD-L3 antagonist;...
2018/0237524 CRYSTALS OF ANTI-HUMAN PD-1 MONOCLONAL ANTIBODIES
Crystals of pembrolizumab and structurally similar anti-PD-1 monoclonal antibodies are provided, as well as methods of producing such crystals, and uses of...
2018/0237523 HUMAN CD3 BINDING ANTIBODY
The invention is among others concerned with human CD3 binding antibodies comprising a heavy chain and light chain wherein said heavy chain comprises a...
2018/0237522 ANTI-ALPHABETATCR ANTIBODY
The present invention relates to humanized monoclonal antibodies comprising the CDRs of murine antibody BMA031, which bind to the apTCR.CD3 complex and possess...
2018/0237521 ANTIBODY MOLECULES WHICH BIND CD45
The present disclosure relates to constructs, such as antibody molecules comprising a binding domain specific to CD45, said binding domain comprising SEQ ID...
2018/0237520 METHOD FOR GENERATING ANTIBODIES AGAINST T CELL RECEPTOR
The invention relates to a method for generating an antibody binding to a cell surface protein of interest, the method comprising the following steps: (a)...
2018/0237519 BIVALENT ANTIBODY DIRECTED AGAINST NKG2D AND TUMOR ASSOCIATED ANTIGENS
A polypeptide is disclosed that binds tumor-associated antigens (TAA) on the surface of cancer cells and a NKG2D receptor. The NKG2D receptor is expressed on...
2018/0237518 ANTI-AGGRUS MONOCLONAL ANTIBODY, DOMAIN IN AGGRUS WHICH IS REQUIRED FOR BINDING TO CLEC-2, AND METHOD FOR...
A novel domain of Aggrus involved in the binding to CLEC-2 was searched for, and monoclonal antibodies recognizing the domain were obtained. The newly found...
2018/0237517 Methods of diagnosing and treating hyperproliferative disorders
The invention relates to compositions and methods for diagnosing and treating hyperproliferative disorders using ligands which specifically recognize the...
2018/0237516 ANTIBODIES THAT RECOGNIZE IAPP
The invention provides monoclonal antibody 3H6 and related antibodies. The 3H6 antibody binds to an epitope within residues 28-36 of IAPP. The antibodies of...
2018/0237515 Compositions And Methods For Treating Cancer
The disclosure generally provides compositions and methods that are useful in the treatment of cancer. More specifically, the methods and compositions may be...
2018/0237514 Compositions and Methods of Use for Treating Metabolic Disorders
A complex comprising a GDF15 polypeptide is described. Methods of treating individuals with a metabolism disorder, such as, glucose metabolism disorder and/or...
2018/0237513 METHOD OF TREATING OR PREVENTING STROKE
A method of reducing an effect of stroke in a subject, the method comprising administering to the subject a compound that inhibits VEGF-B signaling
2018/0237512 NOVEL MODULATORS AND METHODS OF USE
Novel modulators, including antibodies and derivatives thereof, and methods of such modulators to treat hyperproliferative disorders are provided.
2018/0237511 Multispecific binding molecules having specificity to dystroglycan and laminin-2
Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a...
2018/0237510 ANTI-ALPHA-SYNUCLEIN ANTIBODIES AND METHODS OF USE
The invention provides anti-human alpha-synuclein antibodies and methods of using the same.
2018/0237509 METHODS OF TREATING ADAMTS13 DEFICIENCIES AND CONGENITAL THROMBOTIC THROMBOCYTOPENIA IN PEDIATRIC PATIENTS
Provided are methods for clinical treatment of an ADAMTS 13 deficiency by administering an anti-C5 antibody, or antigen binding fragment thereof. Also,...
2018/0237508 ANTI-CK8 ANTIBODIES FOR USE IN THE TREATMENT OF CANCERS
The present disclosure relates to a human CK8 antigen peptide, an antibody, or antibody fragment thereof, or a humanized antibody, specifically binding the...
2018/0237507 SINGLE CHAIN ANTIBODY DOMAINS FOR DETECTION OF ANTI-BOTULINUM NEUROTOXIN DOMAINS AND METHODS OF THEIR USE
Provided herein, inter alia, are single chain antibody binding domains (VHHs) for use in conjunction with the Assay with a Large Immuno-sorbent Surface Area...
2018/0237506 HIGHLY ACTIVE AGONISTIC CD4 BINDING SITE ANTI-HIV ANTIBODIES (HAADS) COMPRISING MODIFIED CDRH2 REGIONS THAT...
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) potent VRC01-like (PVL) antibodies targeted...
2018/0237505 BISPECIFIC HIV-1-NEUTRALIZING ANTIBODIES
In various embodiments, the present invention relates generally to using bispecific antibodies in the prevention and treatment of HIV.
2018/0237504 NOVEL FULL SPECTRUM ANTI-DENGUE ANTIBODY
The present invention provides, among other things, antibody agents (e.g., antibodies, and/or antigen-binding fragments thereof) that bind to DV epitopes, as...
2018/0237503 MONOCLONAL ANTIBODY NEUTRALIZING INFECTIVITY OF ALL EBOLA VIRUSES
There has been a need for a neutralizing monoclonal antibody which is useful for antibody therapy effective against ebolavirus. The present invention provides a...
2018/0237502 PAN-EBOLA AND PAN-FILOVIRUS PROTECTIVE EPITOPES, ANTIBODIES, AND ANTIBODY COCKTAILS
This disclosure provides a method for preventing, treating, or managing a filovirus infection in a subject, where the method includes administering to a...
2018/0237501 LOW-VISCOSITY, HIGH CONCENTRATION EVOLOCUMAB FORMULATIONS AND METHODS OF MAKING THE SAME
Provided herein are formulations of PCSK9-binding polypeptides, such as those comprising evolocumab, that comprise N-acetyl arginine and have reduced...
2018/0237500 METHOD OF PREVENTING REPERFUSION INJURY IN REPERFUSION THERAPY
The method of preventing reperfusion injury in reperfusion therapy is a medical technique for prevention of reperfusion injury in a patient where reperfusion...
2018/0237499 Cell-Penetrating ATF5 Polypeptides and Uses Thereof
Provided are cell-penetrating ATF5 polypeptides having a cell-penetrating region and an ATF5 leucine zipper region, compositions comprising the ATF5...
2018/0237498 Hydrolyzed Jellyfish Collagen Types I, II, and V and Use Thereof
Hydrolyzed collagen types I, II, and V powder compositions, method of preparing the compositions, and use of the compositions in treating a variety of...
2018/0237497 INSULIN-LIKE GROWTH FACTOR 2 (IGF2) BINDING AGENTS
This invention relates to mutant polypeptides comprising the IGF2 binding domain of the Insulin-like Growth Factor 2 Receptor (IGF2R) with residue P1597 is...
2018/0237496 ENGINEERED POLYPEPTIDES
Provided herein are polypeptides that bind to a blood-brain barrier (BBB) receptor, methods of generating such polypeptides, and methods of using the...
2018/0237495 SINGLE-CHAIN CD137-RECEPTOR AGONIST PROTEINS
Provided herein are specific CD137 receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a CD137L-associated...
2018/0237494 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0237493 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
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