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Patent # Description
2018/0243442 POLY(VINYL ALCOHOL) NANOCARRIERS
The present invention provides a nanoparticle including at least one polyvinyl alcohol) (PVA) having a molecular weight of from about 10 kDa to about 200 kDa,...
2018/0243441 CYTOTOXIC HEXIM1 PEPTIDES AND USES THEREOF
Disclosed are isolated cytotoxic peptides having similar sequences as the basic region (BR) of Hexamethylene Bisacetamide Inducible Protein 1 (HEXIM1)....
2018/0243440 METHODS AND COMPOSITIONS FOR DRUG DELIVERY
Compositions comprising a red blood cell (RBC) having non-toxically coupled thereto a nanoparticle having a low shear modulus or low Young's modulus of less...
2018/0243439 Pharmaceutical Formulation of an Anti-Guanylyl Cyclase C Antibody Conjugate Comprising Histidine or a Salt...
Provided is a formulation containing an immunoconjugate comprising an anti-GCC antibody molecule and a therapeutic agent, which is superior in stability and...
2018/0243437 ANTI-VEGFR-2 UREASE CONJUGATES
A conjugate comprising an anti-VEGFR-2 antibody moiety conjugated to a urease moiety is described.
2018/0243436 THERAPEUTIC CELL INTERNALIZING CONJUGATES
Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein, a phosphorothioate nucleic acid, a first linker...
2018/0243435 ANTI-DLL3 ANTIBODY DRUG CONJUGATES AND METHODS OF USE
Provided are novel anti-DLL3 antibodies and antibody drug conjugates, and methods of using such anti-DLL3 antibodies and antibody drug conjugates to treat cancer.
2018/0243434 ANTIBODIES HAVING SPECIFICITY TO NECTIN-4 AND USES THEREOF
The present invention relates to antibodies having specificity to nectin-4 and uses thereof.
2018/0243433 BLOCK COPOLYMERS
Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular...
2018/0243432 CELL-TARGETING MOLECULES COMPRISING SHIGA TOXIN A SUBUNIT EFFECTORS AND CD8+ T-CELL EPITOPES
The present invention provides cell-targeting molecules which can deliver a CD8+ T-cell epitope cargo to the MHC class I presentation pathway of the cell. The...
2018/0243431 PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents....
2018/0243430 COMPOSITION FOR INTRACELLULAR DELIVERY CONTAINING ADENOVIRUS PROTEIN VI-DERIVED PEPTIDE AND ANTICANCER...
The present invention relates to a composition for intracellular delivery containing an adenovirus protein VI-derived peptide and an anti-cancer pharmaceutical...
2018/0243429 OLIGOMER-PHENOTHIAZINE CONJUGATES
The invention relates to (among other things) oligomer-phenothiazine conjugates and related compounds. A conjugate of the invention, when administered by any...
2018/0243428 PROTEIN-POLYMER-DRUG CONJUGATES
Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier...
2018/0243427 TUBULYSIN COMPOUNDS AND CONJUGATES THEREOF
A tubulysin compound conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with...
2018/0243426 COMPOUNDS AND METHODS FOR TRANS-MEMBRANE DELIVERY OF MOLECULES
A novel delivery system for drugs, and especially macromolecules such as proteins or oligonucleotides through biological membranes is provided, and...
2018/0243425 LYMPH DIRECTING PRODRUGS
The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that pro mote transport of a pharmaceutical agent...
2018/0243424 COMPOSITIONS
The disclosure describes a composition including about 4 weight percent to about 12 weight percent of povidone-iodine complex, about 0.1 weight percent to...
2018/0243423 FUNCTIONALIZED NANOPARTICLES AND METHODS OF USE THEREOF
Certain embodiments of the present invention provide functionalized nanoparticles and methods of use thereof. Certain embodiments provide nanoparticles...
2018/0243422 SUSTAINED-RELEASE FORMULATION
The present invention relates to a sustained-release formulation comprising a metastin derivative and a lactic polymer having a weight average molecular weight...
2018/0243421 IMMUNOSTIMULATING AGENT
Compounds represented by formula (I): ##STR00001## defined herein and salts thereof, and compounds represented by formula (II): ##STR00002## defined herein...
2018/0243420 PHARMACEUTICAL FORMULATIONS CONTAINING CORTICOSTEROIDS FOR TOPICAL ADMINISTRATION
Pharmaceutical compositions for topical application to skin are provided. In some embodiments, the pharmaceutical compositions comprise a corticosteroid and...
2018/0243419 LIPOSOMAL COMPOSITIONS WITH LIGHT ILLUMINATION-INDUCED DRUG RELEASE
Provided herein is a small molecule delivery system with illumination-induced small molecule release based on the binary combination of charged liposomes...
2018/0243418 SYSTEMS AND METHODS FOR TARGETED CANCER THERAPIES
Systems and methods for producing liposomes, including control liposomes and various targeted liposomes. Systems and methods for treating conditions, such as,...
2018/0243417 Methylene blue complex for treating skin disease and its use thereof
The present invention relates to complex particles using methylene blue for treating a skin disease caused by propionibacterium acnes or staphylococcus aureus...
2018/0243416 NOVEL AAV MEDIATED INFLUENZA VACCINES
A non-replicating recombinant adeno-associated associated virus (rAAV) having an AAV capsid having packaged therein a vector genome which comprises AAV...
2018/0243415 LIQUID ANTIBODY FORMULATION WITH IMPROVED AGGREGATION PROPERTIES
Disclosed here are methods and systems for improving the aggregation profile in a liquid antibody formulation. In one embodiment, the antibody is a fully...
2018/0243414 ANTIBODIES AGAINST LIF AND USES THEREOF
Described herein are antibodies that target Leukemia Inhibitory Factor (LIF). Also described herein are uses of these antibodies for the treatment of cancer.
2018/0243413 Intralesional (Intratumoral) Dinitrochlorobenzene and Associated Compounds Coadministered with Checkpoint...
Inventor seeks patents related to the use in solid cancer patients of substances, (including, for example, dinitrohalogenated compounds) injected into tumor...
2018/0243412 ANTIBODIES TO POLYPHOSPHATE DECREASE CLOT FORMATION, DECREASE INFLAMMATION, AND IMPROVE SURVIVAL
Hypercoagulable and hyperinflammatory responses can lead to a variety of diseases including but not limited to disseminated intravascular coagulation in...
2018/0243411 Toxicity Management for Anti-Tumor Activity of CARs
The present invention provides compositions and methods for treating cancer in a patient. In one embodiment, the method comprises a first-line therapy...
2018/0243410 Methods Of Treatment Of Keloid Using An Anti-VEGF Agent
Methods for treating pterygium recurrence following pterygiectomy, and for treating keloid recurrence, following surgical removal of the keloid, are disclosed....
2018/0243409 SYNTHETIC CONJUGATE OF CpG DNA AND T-HELP/CTL PEPTIDE
Highly effective vaccine compositions are constructed according to the methods of this invention. The methods are amenable to use with any peptidic antigen...
2018/0243408 TOLERANCE THERAPEUTIC FOR TREATING POLYPEPTIDE INDUCED ALLERGY
The present disclosure is directed to compositions comprising one or more components of a polypeptide allergen combined with a reovirus-derived targeting...
2018/0243407 METHODS AND COMPOSITIONS FOR ELICITING AN IMMUNE RESPONSE AGAINST HEPATITIS B VIRUS
The present invention relates to immunization of hypo-responsive groups of individuals. In particular, the present invention provides methods and compositions...
2018/0243406 INACTIVATED VIRUS COMPOSITIONS AND METHODS OF PREPARING SUCH COMPOSITIONS
The present invention is directed at a composition comprising a live swine flu virus having an infectious component and a plurality of surface antigens in...
2018/0243405 INACTIVATED VIRUS COMPOSITIONS AND METHODS OF PREPARING SUCH COMPOSITIONS
The present invention is directed at a composition comprising a live swine flu virus having an infectious component and a plurality of surface antigens in...
2018/0243404 IDNA VACCINES AND METHODS FOR USING THE SAME
Described herein are iDNA vectors and vaccines and methods for using the same. The iDNA generates live attenuated vaccines in eukaryotic cells in vitro or in...
2018/0243403 INFLUENZA HEMAGGLUTININ PROTEINS AND METHODS OF USE THEREOF
In some embodiments the present invention provides influenza hemagglutinin ("HA") polypeptides, proteins, and protein complexes that comprise a stalk domain...
2018/0243402 BIRD FLU VACCINE COMBINATION COMPRISING VIRUS-LIKE PARTICLES AND NOVEL ADJUVANTS
A vaccine composition is disclosed. The vaccine composition comprises: (a) a therapeutically effective amount of an influenza virus-like particle (VLP)...
2018/0243401 Live-Attenuated Vaccine Having Mutations in Viral Polymerase for the Treatment and Prevention of Canine...
The present invention relates to compositions and methods for the treatment and prevention of canine influenza virus (CIV) and CIV-related pathology. The...
2018/0243400 ANTIGENS AND VACCINES DIRECTED AGAINST HUMAN ENTEROVIRUSES
The instant invention provides materials and methods for producing immunologically active antigens derived from members of the Picornaviridae virus family. The...
2018/0243399 FCV RECOMBINANT VACCINES AND USES THEREOF
The present invention encompasses FCV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FCV antigens. The...
2018/0243398 PRRSV minor protein-containing recombinant viral vectors and methods of making and use thereof
The present invention encompasses recombinant porcine reproductive and respiratory syndrome virus (PRRSV) vaccines or compositions. In particular, the...
2018/0243397 NOROVIRUS VACCINE
A dry powder norovirus vaccine is provided, which comprises at least two norovirus antigens representing different genogroups. The vaccine may be produced by...
2018/0243396 COMPOSITIONS AND METHODS FOR DETECTING, TREATING, AND PROTECTING AGAINST FUSOBACTERIUM INFECTION
The present invention relates to protecting against, treating, and detecting Fusobacteria infections. Compositions and methods derived from nucleic acid and...
2018/0243395 INJECTABLE VACCINES AGAINST MULTIPLE MENINGOCOCCAL SEROGROUPS
An injectable immunogenic composition comprising capsular saccharides from at least two of serogroups A, C, W135 and Y of Neisseria meningitidis, wherein said...
2018/0243394 STAPHYLOCOCCAL COAGULASE ANTIGENS AND METHODS OF THEIR USE
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium....
2018/0243393 METHODS AND COMPOSITIONS FOR IMMUNE PROTECTION AGAINST EXTRA-INTESTINAL PATHOGENIC E. COLI
Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune...
2018/0243392 CS21 AND LNGA PROTEIN VACCINES
A vaccine composition including an LngA peptide or a fragment or variant thereof and a pharmaceutically acceptable carrier is described. The vaccine...
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