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Patent # Description
2018/0243341 Methods and Compositions for Cells Expressing a Chimeric Intracellular Signaling Molecule
The present invention relates to compositions and methods for enhancing T cell metabolism and activity for more effective adoptive T cell therapy. By...
2018/0243339 METHOD FOR TREATING MIGRAINE HEADACHES
A method for preventing and treating a headache in a patient is disclosed. The method includes locating one or more ligaments or muscle insertions that are...
2018/0243338 MEDICINE FOR TREATMENT AND/OR PREVENTION OF ISCHEMIC DISEASES, METHOD FOR IMPROVING ANGIOGENESIS-PROMOTING...
The present invention provides a sufficiently effective medicine for treatment and/or prevention of ischemic diseases, without performing isolation of...
2018/0243337 COMBINED ORGAN AND HEMATOPOIETIC CELLS FOR TRANSPLANTATION TOLERANCE OF GRAFTS
Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to a recipient, where tolerance to the graft is...
2018/0243336 ANTIMICROBIAL AND ENZYME INHIBITORY ZINC OXIDE NANOPARTICLES
In certain aspects, the present disclosure provides an enzyme inhibitory nanoparticle. The nanoparticle may comprise zinc oxide. The nanoparticle exhibits...
2018/0243335 METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISORDERS
The present invention provides methods for treating conditions that involve infection and/or inflammation, including acute and chronic inflammation, as well as...
2018/0243334 USE OF CHLORITE TO TREAT RED BLOOD CELL DISEASES AND INDICATIONS MEDIATED THEREBY
Method of treating hyperglycemia induced Red Blood Cell Disease/Dysfunction (RBCD) caused by generation of early and late glycation end products. Method of...
2018/0243333 BICARBONATE AS A POTENTIATOR FOR ANTIMICROBIAL AGENTS
Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises...
2018/0243332 METHOD OF TREATING OR AMELIORATING SKIN CONDITIONS WITH A MAGNETIC DIPOLE STABILIZED SOLUTION
The present invention is directed to methods for treating or ameliorating skin conditions, diabetic conditions, cardiovascular conditions, cancer, infections...
2018/0243331 METHOD OF INHIBITING QUORUM SENSING IN PSEUDOMONAS AERUGINOSA
A method of inhibiting quorum sensing in Pseudomonas aeruginosa is provided. The method comprises contacting Pseudomonas aeruginosa with a gold(I) thiolate...
2018/0243330 Method of Treating Severe Asthma
Methods are provided for treating corticosteroid-resistant asthma in a patient, comprising decreasing Interferon Regulatory Factor 5 (IRF5) activity in the...
2018/0243329 STABILIZATION METHOD OF FUNCTIONAL NUCLEIC ACID
This invention is intended to enhance and improve the resistance of a single- or double-stranded nucleic acid fragment comprising a base sequence of a...
2018/0243328 NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS
The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) ##STR00001## wherein the variables have the...
2018/0243327 USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION DAMAGE
The invention relates to the use of secoisolariciresinol diglucoside (SDG), other active components in flaxseed, and related compounds for treating proton...
2018/0243326 INTRACELLULAR ATP ENHANCER
A problem to be solved by the present invention is to provide a substance having an effect of increasing intracellular ATP and, particularly, a potent ATP...
2018/0243325 METHOD FOR INHIBITING ABSORPTION OF AND/OR PROMOTING EXCRETION OF LIPIDS USING D-PSICOSE
The present invention relates to a composition for preventing or treating lipid-related metabolic diseases. The composition according to the present invention...
2018/0243324 COMPOSITIONS AND METHODS FOR THE PRODUCTION OF PYRIMIDINE AND PYRIDINE COMPOUNDS WITH BTK INHIBITORY ACTIVITY
The present invention provides novel pyrimidine and pyridine compounds according to Formula (I), Formula (II), Formula (III), Formula (IV) and Formula (V)...
2018/0243323 PHOSPHOLIPID PREPARATIONS FOR THE IMPROVEMENT OF SLEEP
Phospholipid preparations for the improvement of sleep and/or treatment of sleep disorders. Methods of improving sleep and/or treating sleep disorders...
2018/0243322 Neridronic Acid for Treating Complex Regional Pain Syndrome
Oral dosage forms of osteoclast inhibitors, such as neridronic acid, in an acid form or a salt form can be used to treat or alleviate pain or related...
2018/0243321 COMPOSITION AND MEDICAL DEVICE COMPRISING ACETYLSALICYLIC ACID FOR THE TREATMENT OF HUMAN PAPILLOMA VIRUS SKIN...
A medical device for the treatment of papilloma virus (HPV) skin infections is the object of this invention, in particular for the treatment of warts and...
2018/0243320 HIGH-STRENGTH TESTOSTERONE UNDECANOATE COMPOSITIONS
The present disclosure is drawn to pharmaceutical compositions and oral dosage capsules containing testosterone undecanoate, as well as related methods. The...
2018/0243319 MODULATION OF SOLUBILITY, STABILITY, ABSORPTION, METABOLISM, AND PHARMACOKINETIC PROFILE OF LIPOPHILIC DRUGS BY...
A formulation for drug delivery, providing enhanced modulation of solubility, stability, absorption, metabolism, and/or pharmacokinetic profile of a lipophilic...
2018/0243318 PLATINUM COMPOUNDS, COMPOSITIONS, AND USES THEREOF
The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex...
2018/0243317 COMPOSITIONS COMPRISING A PI3K INHIBITOR AND AN HDAC INHIBITOR
The invention relates to a pharmaceutical composition comprising at least one PI3K inhibitor of Formula I or a pharmaceutically acceptable salt thereof and at...
2018/0243316 SALT FORM OF A HUMAN HISTONE METHYLTRANSFERASE EZH2 INHIBITOR
Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-bip- ...
2018/0243315 INHIBITORS OF HUMAN EZH2, AND METHODS OF USE THEREOF
The invention relates to inhibition of wild-type and certain mutant forms of human histone methyltransferase EZH2, the catalytic subunit of the PRC2 complex...
2018/0243314 NO-DONORS FOR THE TREATMENT OF CEREBROVASCULAR VASOSPASMS AFTER BRAIN HEMORRHAGE
The present invention relates to the combined use of NO-donors for the treatment, prevention and/or amelioration of disturbances of the cerebral macro- and...
2018/0243313 COMPOSITIONS COMPRISING PHOSPHOINOSITIDE 3-KINASE INHIBITORS AND A SECOND ANTIPROLIFERATIVE AGENT
The invention relates to a pharmaceutical composition comprising a combination of a compound of formula (I) or a pharmaceutically acceptable salt thereof, and...
2018/0243312 TGF BETA RECEPTOR ANTAGONISTS
The invention relates generally to compounds that modulate the activity of TGFBETA R-1 and TGFBETA R-2, pharmaceutical compositions containing said compounds...
2018/0243311 INHIBITORS OF BRUTON'S TYROSINE KINASE
Inhibitors for Bruton's Tyrosine Kinase (BTK) are disclosed as are compositions thereof, methods for their preparation, and methods for their use.
2018/0243310 Pharmaceutical composition containing ...
The present invention relates to a pharmaceutical composition comprising linagliptin or a pharmaceutically acceptable salt thereof as active ingredient,...
2018/0243309 TOPICAL ANTIVIRAL COMPOSITIONS
In various embodiments compositions that inactivates a virus or inhibit replication of a virus are provided where the compositions comprise a C.sub.1-C.sub.10...
2018/0243308 PHARMACEUTICAL COMBINATION
The present invention relates to a pharmaceutical combination which may be useful for the treatment of diseases which involve cell proliferation, which involve...
2018/0243307 TREATING EXTRAPYRAMIDAL SYNDROME USING TRAPIDIL
Disclosed herein are methods, pharmaceutical combinations, or kits for the prevention or treatment of extrapyramidal syndromes, for example, dyskinesia,...
2018/0243306 Dual Inhibition Of CDK And HSP90 Destabilize HIF1alpha And Synergistically Induces Cancer Cell Death
The present disclosure provides pharmaceutical compositions including a CDK inhibitor and an HSP90 inhibitor, as well as methods of treating cancer or a tumor...
2018/0243305 COMPOSITIONS AND METHODS FOR TREATING BONE DISEASES
Certain aspects of the present invention generally relate to compositions and methods for treating a bone disease, for example a genetic bone disease. In one...
2018/0243304 PHARMACEUTICAL COMBINATIONS COMPRISING (A) THE CYCLIN DEPENDENT KINASE 4/6 (CDK4/6) INHIBITOR LEE011...
The present disclosure relates to pharmaceutical combinations comprising (a) a cyclin dependent kinase 4/6 (CDK4/6) inhibitor compound, and (b) an epidermal...
2018/0243303 METHODS AND COMPOSITIONS FOR INHIBITING THE INTERACTION OF MENIN WITH MLL PROTEINS
The present disclosure provides compositions and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. The...
2018/0243302 Varlitinib for Use in the Treatment of Resistant or Refractory Cancer
The present disclosure provides a method of treating a patient with refractory or resistant cancer by administering a therapeutically effective amount of a...
2018/0243301 INHIBITION OF SGK1 IN THE TREATMENT OF HEART CONDITIONS
The present invention relates to the treatment of acquired and genetic heart conditions in a subject by the inhibition of SGK1, including Long QT syndrome and...
2018/0243300 FUNGICIDAL AGENT
The invention relates to a novel fungicidal agent in the form of a salt associate having the structural formula shown. The agent can be used for treating...
2018/0243299 COMPOSITIONS AND METHODS FOR TREATING EWING FAMILY TUMORS
A method for treating a sarcoma by administering a tyrosine kinase inhibitor and a biguanide compound. Also described is a method for treating a tumor of the...
2018/0243298 TRPV3 MODULATORS
A compound of Formula (I) having efficacy for the treatment or prevention of conditions and disorders related to TRPV3 activity, e.g. pain, atopic dermatitis,...
2018/0243297 Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases...
2018/0243296 TREATMENT AND PROGNOSTIC MONITORING OF NON-CANCEROUS PROLIFERATION DISORDERS USING HEDGEHOG PATHWAY INHIBITORS
The present invention concerns methods for treating a proliferation disorder, such as prostate cancer, basal cell carcinoma, lung cancer, and other cancers,...
2018/0243295 TREATMENT AND PROGNOSTIC MONITORING OF CANCEROUS PROLIFERATION DISORDERS USING HEDGEHOG PATHWAY INHIBITORS
The present invention concerns methods for treating a proliferation disorder, such as prostate cancer, basal cell carcinoma, lung cancer, and other cancers,...
2018/0243294 OPHTHALMIC FORMULATIONS OF TYROSINE KINASE INHIBITORS, METHODS OF USE THEREOF, AND PREPARATION METHODS THEREOF
Ophthalmic formulations containing nintedanib, or a pharmaceutically acceptable salt thereof are provided. The ophthalmic formulations can contain...
2018/0243293 Pharmaceutical combinations and their use
The present disclosure relates to a pharmaceutical combination, e.g. a product, comprising a combination of (a) a MDM2 inhibitor of formula I or formula II, or...
2018/0243292 SUSTAINED-RELEASE BUPRENORPHINE FORMULATIONS
The disclosure is directed to sustained-release buprenorphine formulations that provide long-term, therapeutic levels of buprenorphine for the treatment of...
2018/0243291 DEUTERATED MORPHINAN COMPOUNDS FOR TREATING AGITATION
This invention relates to methods of treating agitation comprising administering a morphinan compound or a pharmaceutically acceptable salt thereof. This...
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