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Patent # Description
2018/0245112 GENETICALLY MODIFIED STRAIN OF EUKARYOTIC MICROALGA HAVING IMPROVED TRIGLYCERIDE PRODUCTIVITY, AND USE THEREOF
It is an object of the present invention to provide the eukaryotic microalgae, which have been genetically modified such that larger amounts of assimilation...
2018/0245111 Method for Preparing Medium-Long-Chain Triglyceride Using Packed Bed Reactor
Disclosed is a method for preparing a medium-long-chain triglyceride using a packed bed reactor, and belongs to the technical field of deep processing and...
2018/0245110 Method of Producing Lipid
A method of producing lipids, containing the steps of: culturing a transformant in which the expression of a gene encoding the following protein (A) or (B)...
2018/0245109 COMPOSITIONS AND METHODS FOR PRODUCING LIPIDS AND OTHER BIOMATERIALS FROM GRAIN ETHANOL STILLAGE AND STILLAGE...
Lipogenic yeasts bioengineered to overexpress genes for lipid production, and methods of use thereof. The yeasts are modified to express, constitutively...
2018/0245108 Use of Oxyhydrogen Microorganisms for Non-Photosynthetic Carbon Capture and Conversion of Inorganic and/or C1...
Compositions and methods for a hybrid biological and chemical process that captures and converts carbon dioxide and/or other forms of inorganic carbon and/or...
2018/0245107 BIOCATALYTIC OXIDATION
There is provided a method of oxidising at least one organic substance in aerobic conditions to produce at least one alcohol, amine, acid, aldehyde, and/or...
2018/0245106 PROCESS FOR PRODUCING ITACONIC ACID AND ITACONIC ACID ESTERS UNDER ANAEROBIC CONDITIONS
The present invention relates to a method for the production of itaconic acid or an ester of itaconic acid, which method comprises fermenting a recombinant...
2018/0245105 PROCESSES FOR PRODUCING FERMENTATION PRODUCTS
The present invention relates to processes for producing fermentation products from starch-containing material, wherein an alpha-amylase and optionally a...
2018/0245104 DIPHOSPHOMEVALONATE DECARBOXYLASE VARIANT, AND METHOD FOR PRODUCING OLEFIN COMPOUND BY USING THE SAME
A method which enables olefin compound production with a high productivity and an enzyme used in the method, a mutation involving amino acid substitution has...
2018/0245103 METABOLIC ENGINEERING FOR MICROBIAL PRODUCTION OF TERPENOID PRODUCTS
In various aspects and embodiments, the invention relates to bacterial strains and methods for making terpene and terpenoid products. The invention provides...
2018/0245102 METHODS OF MICROBIALLY PRODUCING ACIDS AND MINERALS AND USES THEREOF
A method of producing sulfuric acid can include: obtaining a microbial culture that produces sulfuric acid; placing the microbial culture in a bioreactor in an...
2018/0245101 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific...
2018/0245100 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific...
2018/0245099 COMPOSITIONS AND METHODS OF ENGINEERED CRISPR-CAS9 SYSTEMS USING SPLIT-NEXUS CAS9-ASSOCIATED POLYNUCLEOTIDES
The present specification discloses engineered Type II CRISPR-Cas9 systems comprising split-nexus Cas9-associated polynucleotides (sn-casPNs), including...
2018/0245098 COMPOSITION AND METHODS FOR HIGHLY EFFICIENT GENE TRANSFER USING AAV CAPSID VARIANTS
Compositions and methods for AAV mediated gene therapy are disclosed. AAV vectors comprise protein capsid variants comprising therapeutically beneficial...
2018/0245097 OPTO-GENETIC MODULATOR
Provided herein are opto-genetic systems, cells, and methods thereof for modulating and regulating genetic expression in transiently active cells. The...
2018/0245096 CITRUS VARIETIES RESISTANT TO XANTHOMONAS CITRI INFECTION
The invention pertains to a plant cell or a plant having one or more mutations in the promoters of both the alleles for CsLOB1 gene, wherein the one or more...
2018/0245095 Transgenic plants with enhanced agronomic traits
This invention provides recombinant DNA constructs, transgenic plant nuclei and cells with such recombinant DNA construct for expression of proteins that are...
2018/0245094 ISOLATED POLYNUCLEOTIDES AND POLYPEPTIDES, AND METHODS OF USING SAME FOR INCREASING PLANT YIELD AND/OR...
Provided are isolated polynucleotides at least 80% identical to SEQ ID NOs: 1-479, 813-5173, 8511, 8513, 8515, 8517, 8519, 8521, 8523, 9096-9141 and 9142; and...
2018/0245093 METHOD OF IMPROVING CHLOROPLAST FUNCTION AND INCREASING SEED YIELD
Ascorbate protects tissues against damage caused by reactive oxygen species (ROS) produced through normal metabolism or generated from stress. The inositol...
2018/0245092 SUCROSE TRANSPORTER GENES FOR INCREASING PLANT SEED LIPIDS
This invention relates to polynucleotide sequences encoding SUT2 or SUT4 sucrose transporter genes. Methods for increasing seed oil content and evaluating...
2018/0245091 ENHANCED RECOMBINATION OF GENOMIC LOCI
The present disclosure provides methods to accelerate recombination at selected genomic loci, allowing recombination to occur, and selecting events with...
2018/0245090 HAPLOID INDUCER LINE FOR ACCELERATED GENOME EDITING
Provided herein are materials and in planta methods for using haploid inducer lines containing a targeted endonuclease to generate transgenic or non-transgenic...
2018/0245089 INTRACELLULAR DELIVERY OF BIOMOLECULES TO CELLS COMPRISING A CELL WALL
The present disclosure pertains to methods for delivering a compound into a cell comprising a cell wall, including passing a cell suspension through a...
2018/0245088 Antibody To Be Cross-Linked To Human SEMA3A And Use Thereof
The present invention provides an antibody having cross-linking ability against human Sema3A and mouse Sema3A. The antibody of the present invention can be...
2018/0245087 NOVEL EUKARYOTIC CELL-FREE PROTEIN EXPRESSION SYSTEM THAT DOES NOT REQUIRE AN ARTIFICIAL ENERGY REGENERATION SYSTEM
This disclosure concerns the systems, methods, and kits for the in vitro synthesis of biological macromolecules in a reaction utilizing cell lysates containing...
2018/0245086 TRANSFECTION VECTOR FOR PATHOGENIC AMOEBAE AND USES THEREOF
Disclosed herein are expression vectors suitable for transfection in amoebas. The vectors may include a promoter from a protein-encoding gene from an amoeba, a...
2018/0245085 RAPID DEPLETION AND REVERSIBLE ACCUMULATION OF PROTEINS IN VIVO
The present invention relates to a process for producing a temperature-sensitive conditionally mutant multicellular organism using a low-temperature N-terminal...
2018/0245084 COMPOSITIONS AND METHODS FOR ENHANCED INTESTINAL ABSORPTION OF CONJUGATED OLIGOMERIC COMPOUNDS
Provided herein are compositions and methods for non-parenteral delivery of conjugated oligomeric compounds. In certain embodiments, compositions and methods...
2018/0245083 RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC...
The present invention concerns methods and reagents useful modulating gene expression in a variety of applications, including use in therapeutic, diagnostic,...
2018/0245082 PARENTAL RNAI SUPPRESSION OF CHROMATIN REMODELING GENES TO CONTROL COLEOPTERAN PESTS
This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of...
2018/0245081 Polycomb-Associated Non-Coding RNAs
This invention relates to polycomb-associated long non-coding RNAs (lncRNAs), libraries and fragments of those ncRNAs, inhibitory nucleic acids and methods and...
2018/0245080 METHODS AND COMPOSITIONS TO TREAT LIVER DISEASES AND CONDITIONS
Methods and compounds useful to treat diseases and conditions are provided. Methods of administering one or more microRNA-inhibitor compounds or one or more...
2018/0245079 METHODS AND COMPOSITIONS FOR ALTERING FUNCTION AND STRUCTURE OF CHROMATIN LOOPS AND/OR DOMAINS
Chromatin 3D structure modulating agents in the context of the present invention are intended to interfere or manipulate the function of loop anchor motifs,...
2018/0245078 ANTISENSE OLIGONUCLEOTIDES TO TREAT DYSTROPHIC EPIDERMOLYSIS BULLOSA
An antisense oligonucleotide capable of preventing or reducing exon 80 inclusion into a human COL7A1 mRNA, and methods for preventing or reducing exon 80...
2018/0245077 COMPOSITIONS AND METHODS FOR TREATING HYPERTRIGLYCERIDEMIA
The present invention provides compositions comprising therapeutic nucleic acids such as siRNA that target ApoC3 and ANGPTL3 expression, lipid particles...
2018/0245076 MODULATION OF APOLIPOPROTEIN C-III (APOCIII) EXPRESSION IN LIPODYSTROPHY POPULATIONS
Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in a patient with Partial Lipodystrophy. Also...
2018/0245075 INTEGRATED SYSTEM FOR PROGRAMMABLE DNA METHYLATION
Provided herein are engineered systems and methods for establishing DNA adenine methylation at specific genomic locations and using DNA adenine methylation as...
2018/0245074 TREATING HEPATITIS B VIRUS INFECTION USING CRISPR
The present invention provides compositions comprising therapeutic nucleic acids such as gRNA that target Hepatitis B virus (HBV) gene expression, lipid...
2018/0245073 REGULATABLE EXPRESSION USING ADENO-ASSOCIATED VIRUS (AAV)
The present invention relates to CRISPR-AAV vectors and viral particles which exhibit self-regulatory or regulatable features.
2018/0245072 HIGH EFFICIENCY CONSTRUCTION OF DNA LIBRARIES
The invention provides a method for efficient DNA library construction and targeted genetic analyses of the libraries.
2018/0245071 Comprehensive In vitro Reporting of Cleavage Events by Sequencing (CIRCLE-seq)
Sensitive, unbiased methods for genome-wide detection of potential CRISPR-Cas9 off-target cleavage sites from cell type-specific genomic DNA samples.
2018/0245070 DNA DISPLAY AND METHODS THEREOF
Described herein is a method that displays RNA on the DNA from which it was encoded, enabling enhanced selection of RNA aptamers and proteins. The covalent...
2018/0245069 TAGMENTATION USING IMMOBILIZED TRANSPOSOMES WITH LINKERS
The present disclosure relates to methods, compositions, and kits for treating target nucleic acids, including methods and compositions for fragmenting and...
2018/0245068 A Method and Kit for Analyte Detection
The present invention relates to a method and kit for analyte detection. More precisely the invention relates to a method of detecting an analyte, comprising...
2018/0245067 SCAFFOLD PROTEINS DERIVED FROM PLANT CYSTATINS
The present invention relates to scaffold proteins derived from plant cystatins and to nucleic acids encoding them. The scaffolds are highly stable and have...
2018/0245066 sgRNA and knockout method of human RSPO2 gene targeted with CRISPR-Cas9 specificity and application thereof
A method for knocking out a human RSPO2 gene targeted with CRISPR-Cas9 specificity includes steps of: 1) designing the sgRNA of the human RSPO2 gene targeted;...
2018/0245065 METHODS AND COMPOSITIONS FOR ENHANCING GENE EDITING
The invention provides novel methods and compositions for enhancing gene editing.
2018/0245063 Tethering Cysteine Residues Using Cyclic Disulfides
Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers...
2018/0245062 HEXURONATE C4-EPIMERASE MUTANT WITH IMPROVED CONVERSION ACTIVITY, AND METHOD FOR PRODUCING D-TAGATOSE BY USING SAME
A hexuronate C4-epimerase with improved conversion activity and a method for producing D-tagatose using the hexuronate C4-epimerase. The hexuronate...
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