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Patent # Description
2018/0244808 METHOD FOR PRODUCING MODIFIED DIENE-BASED RUBBER, RUBBER COMPOSITION AND TIRE
Provided is a method capable of efficiently producing a modified diene-based rubber, and a rubber composition and a tire with excellent low hysteresis loss...
2018/0244807 CROSS-LINKED HYALURONIC ACID GRAFTED WITH DEXTRAN
A hyaluronic acid product is comprising a cross-linked hyaluronic acid and one or more dextran molecules. The hyaluronic acid is cross-linked by ether bonds,...
2018/0244806 RUBBER COMPOSITION
A rubber composition containing a rubber and modified cellulose fibers, wherein one or more substituents selected from substituents represented by the...
2018/0244805 CYTOTOXICITY-INDUCING THERAPEUTIC AGENT
Novel multispecific antigen-binding molecules maintaining excellent cellular cytotoxicity and high stability, which comprise a domain that contains an antibody...
2018/0244804 NON-HUMAN ANIMALS THAT SELECT FOR LIGHT CHAIN VARIABLE REGIONS THAT BIND ANTIGEN
Non-human animals, cells, methods and compositions for making and using the same are provided, wherein the non-human animals and cells comprise an...
2018/0244803 Vivo Method for Generating Diversity in a Protein Scaffold
A transgenic non-human animal is provided. In certain embodiments, the animal comprises a genome comprising an immunoglobulin heavy chain locus comprising: a)...
2018/0244802 ANTIBODY OR ANTIBODY FRAGMENT OF NON-IG SCAFFOLD BINDING TO A BINDING REGION OF AN ANTI-N-METHYL-D-ASPARTATE...
Subject matter of the present invention is an Antibody or antibody fragment or non-Ig scaffold binding to a binding region of an anti-NMDAR1 antibody and its...
2018/0244801 METHODS FOR INHIBITING ATHEROSCLEROSIS BY ADMINISTERING AN INHIBITOR OF PCSK9
The present invention provides methods and compositions for inhibiting atherosclerotic plaque formation in a subject. In certain embodiments, the methods of...
2018/0244800 ANTIBODY SUBSTITUTING FOR FUNCTION OF BLOOD COAGULATION FACTOR VIII
The present inventors produced a variety of bispecific antibodies that specifically bind to both F. IX/F. IXa and F. X, and functionally substitute for F....
2018/0244799 MONOCLONAL ANTIBODIES AGAINST ANTITHROMBIN BETA
This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin .beta....
2018/0244798 Combination Therapy with Coagulation Factors and Multispecific Antibodies
The invention relates to therapies for a patient with bleeding disorders, comprising the application of certain blood coagulation (clotting) factors in...
2018/0244797 CHIMERIC CYTOKINE RECEPTOR
The present invention provides a chimeric cytokine receptor (CCR) comprising: (i) an exodomain which binds to a ligand selected from a tumour secreted factor,...
2018/0244796 FULLY HUMAN ANTI-MESOTHELIN ANTIBODIES AND IMMUNE EFFECTOR CELLS TARGETING MESOTHELIN
The present invention provides fully human anti-mesothelin antibodies and immune effector cells targeting mesothelin.
2018/0244795 ANTIBODIES AND ASSAYS FOR DETECTION OF CD37
The invention generally relates to antibodies that bind to human CD37 and diagnostic assays for CD37-based therapies.
2018/0244794 ASSESSING AND TREATING LYMPHOMA
This document relates to methods and materials involved in assessing and treating mammals (e.g., humans) with non-Hodgkin's lymphoma (e.g., diffuse large...
2018/0244793 Anti-GITR Antibodies and Methods of Use Thereof
The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions...
2018/0244792 ANTI-FIBROTIC EFFECT OF CD70
Disclosed are methods for treating fibrosis in a subject using a CD70 agonist. In some examples, the agent is an antibody that binds CD70, an antigen biding...
2018/0244791 ANTI-IFNAR1 ANTIBODIES WITH REDUCED FC LIGAND AFFINITY
The invention provides anti-IFNAR1 antibodies with reduced affinity for Fc receptors and/or ligands and methods of making and using such antibodies.
2018/0244790 METHODS OF TREATING SKIN DISORDERS USING ANTI-IL-31RA ANTIBODIES
The present invention relates to methods of treating patients suffering from Contact dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic...
2018/0244789 ANTI-PRLR ANTIBODY-DRUG CONJUGATES (ADC) AND USES THEREOF
Provided are antibody drug conjugates that bind PRLR, in particular human PRLR, their methods of making, and uses thereof.
2018/0244788 ANTIBODIES AGAINST HUMAN CSF-1R AND USES THEREOF
The present invention relates to antibodies against human CSF-1R (anti-CSF-1R antibody), methods for their production, pharmaceutical compositions containing...
2018/0244787 ANTI-HUMAN CXCR3 ANTIBODIES FOR TREATMENT OF VITILIGO
Provided are methods and uses of anti-CXCR3 antibodies to treat CXCR3-associated disorders such as vitiligo. In certain embodiments, the anti-CXCR3 antibodies...
2018/0244786 ANTI IL-3R ALPHA AGENTS AND USES THEREOF
The present disclosure provides antibodies and antigen binding fragments thereof that bind to an epitope within an interleukin-3 receptor .alpha..
2018/0244785 ANTI-FGFR ANTIBODIES AND METHODS OF USE
Anti-FGFR antibodies which bind to particular isoforms of FGFR1-4, therapeutic compositions comprising the anti-FGFR antibodies, and methods of using such...
2018/0244784 VEGFR2 ANTIBODIES
Single domain anti-VEGFR-2 antibodies and fragments thereof and variants thereof and uses thereof, for example, for use to inhibit/decrease angiogenesis and...
2018/0244783 COMBINATION THERAPY FOR TREATMENT OF DISEASE
The present invention provides methods comprising combination therapy for modulating immune responses, for inhibiting tumor growth, and/or for treating cancer....
2018/0244782 THERAPEUTIC USE OF INTEGRIN-BINDING ANTIBODIES
This disclosure relates to therapeutic use of integrin-binding antibodies.
2018/0244781 PD-1/PD-L1 INHIBITORS FOR THE TREATMENT OF CANCER
The invention relates to methods of treating cancer in a subject, comprising administering to the subject a therapeutically effective amount of an inhibitor of...
2018/0244780 Antibodies Directed Against ICOS and Uses Thereof
The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation...
2018/0244779 IMMUNOMODULATORY AGENTS
The invention provides antibodies that specifically bind to PD-1, nucleic acid molecules encoding the same, and therapeutic compositions thereof. The agents...
2018/0244778 Humanized Antibodies to Cluster of Differentiation 3 (CD3)
Humanized monoclonal antibodies (mAbs) or fragments thereof, to human Cluster of Differentiation 3 (CD3), which confer improved immune stimulation and...
2018/0244777 Novel Treatment Methods Based on Multifunctional Molecules
The present invention relates to novel treatment methods based on multifunctional molecules, particularly bispecific molecules, wherein the multifunctional...
2018/0244776 Antibody To Be Cross-Linked To Human SEMA3A And Use Thereof
The present invention provides an antibody having cross-linking ability against human Sema3A and mouse Sema3A. The antibody of the present invention can be...
2018/0244775 Antibody To Be Cross-Linked To Human SEMA3A And Use Thereof
The present invention provides an antibody having cross-linking ability against human Sema3A and mouse Sema3A. The antibody of the present invention can be...
2018/0244774 ANTI-PVRIG ANTIBODIES AND METHODS OF USE
The present invention is directed to anti-PVRIG antibodies and methods of using same.
2018/0244773 ANTI-LAG-3 ANTIBODIES TO TREAT HEMATOLOGICAL MALIGNANCIES
Provided are methods for clinical treatment of hematological malignancies, such as relapsed or refractory chronic lymphocytic leukemia or lymphoma using an...
2018/0244772 FUSION PROTEINS OF HUMAN PROTEIN FRAGMENTS TO CREATE ORDERLY MULTIMERIZED IMMUNOGLOBULIN FC COMPOSITIONS WITH...
The current invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to...
2018/0244771 IMMUNITY ENHANCING AGENT FOR CANCER BY ALLERGIN-1 ANTAGONIST
A method for suppression of progress of, suppression of recurrence of and/or treatment of cancer, by administering an Allergin-1 antagonist in a therapy of a...
2018/0244770 ANTI-SIGLEC-7 ANTIBODIES AND METHODS OF USE THEREOF
The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments,...
2018/0244769 P2X7 RECEPTOR ANTAGONISTS AND AGONISTS
The present invention relates to biological materials against P2X7 and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods...
2018/0244768 HUMAN ANTI-THYROGLOBULIN T CELL RECEPTORS
Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG.sub.470-478. Related...
2018/0244767 ANTI-IL31 ANTIBODIES FOR VETERINARY USE
Provided are various embodiments relating to anti-IL31 antibodies binding to canine IL31. Such antibodies can be used in methods to treat IL31-induced...
2018/0244766 ANTI-IL31 ANTIBODIES FOR VETERINARY USE
Provided are various embodiments relating to anti-IL31 antibodies binding to canine IL31. Such antibodies can be used in methods to treat IL31-induced...
2018/0244765 BINDING MOLECULES
The present invention relates to the manufacture of a diverse repertoire of functional heavy chain-only antibodies that undergo affinity maturation, and uses...
2018/0244764 ANTI-CXCL13 ANTIBODIES AND METHODS OF USING THE SAME
Compositions and methods are provided for treating diseases associated with CXCL13 expression, including certain autoimmune diseases, inflammatory diseases,...
2018/0244763 ANTI-TGF-BETA ANTIBODIES AND THEIR USE
The invention provides an improved pan-TGF-.beta. antibody for treatment of conditions that are mediated by TGF-.beta., including autoimmune diseases, fibrotic...
2018/0244762 DUAL PDGF/VEGF ANTAGONISTS
The invention provides a dual VEGF/PDGF antagonist comprising a VEGF antagonist linked to a PDGF antagonist. The VEGF antagonist is an antibody to a VEGF or...
2018/0244761 NOVEL ANTIBODY AGAINST RIBOSOMAL PROTEIN S3 AND COMPOSITION FOR DIAGNOSING BIOLOGICAL STRESS
The present invention relates to an antibody acting as a stress sensor by sensing various stresses in a living organism including a human. Particularly, the...
2018/0244760 TETRA-SPECIFIC, OCTAMERIC BINDING AGENTS AND ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXIN A AND TOXIN B FOR...
Novel, antibody-based binding agents derived from human and camelid immunoglobulins are described. These binding agents recognize and bind with specificity to...
2018/0244759 NOVEL METHODS OF GENERATING ANTIBODIES
The invention describes a method of generating antibodies to a mixture of peptidogenic proteins wherein the peptidogenic protein has altered conformational...
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