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| Patent # | Description |
|---|---|
| 2018/0244758 |
MONOCLONAL ANTIBODIES AND COCKTAILS FOR TREATMENT OF EBOLA INFECTIONS Described herein are compositions and methods for the prevention and treatment of ebolavirus infection certain embodiments of the present invention, monoclonal... |
| 2018/0244757 |
MONOCLONAL ANTIBODIES SPECIFIC FOR HEARTLAND VIRUS AND METHODS OF THEIR
USE Monoclonal antibodies that specifically bind the nucleocapsid protein of Heartland virus (HRTV) are described. The monoclonal antibodies can be used, for... |
| 2018/0244756 |
MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS IMMUNOGENS, ANTIBODIES, AND
THEIR USE Methods of inducing an immune response in a subject to the Middle East respiratory syndrome coronavirus (MERS-CoV) are provided. In several embodiments, the... |
| 2018/0244755 |
TARGETED THERAPEUTICS BASED ON ENGINEERED PROTEINS THAT BIND EGFR The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain... |
| 2018/0244754 |
NOVEL HUMAN SERUM ALBUMIN MUTANT Disclosed are a human serum albumin mutant that can be linked to a physiologically active protein to increase the stability of the protein in the blood, as... |
| 2018/0244753 |
SINGLE-CHAIN TL1A RECEPTOR AGONIST PROTEINS Provided herein are specific TL1A receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TL1A-associated... |
| 2018/0244752 |
SINGLE-CHAIN GITR-RECEPTOR AGONIST PROTEINS Provided herein are specific GITR receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a GITRL-associated... |
| 2018/0244751 |
SINGLE-CHAIN CD27-RECEPTOR AGONIST PROTEINS Provided herein are specific CD27 receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a CD27L-associated... |
| 2018/0244749 |
IMMUNOMODULATORY PROTEINS WITH TUNABLE AFFINITIES Provided are immunomodulatory proteins and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of... |
| 2018/0244748 |
Modified Monocytes/Macrophage Expressing Chimeric Antigen Receptors and
Uses Thereof The present invention includes methods and compositions for treating cancer, whether a solid tumor or a hematologic malignancy. By expressing a chimeric... |
| 2018/0244747 |
COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING FUSION PROTEINS Provided herein are T-cell receptor (TCR) fusion proteins (TFPs), T-cells engineered to express one or more TFPs, and methods of use thereof for the treatment... |
| 2018/0244746 |
T CELL RECEPTORS (TCR) AND USES THEREOF FOR THE DIAGNOSIS AND TREATMENT OF
DIABETES The present invention relates to T-cell receptors (TCR) that recognize pancreatic betacell epitopes and uses thereof for the diagnosis and treatment of diabetes. |
| 2018/0244745 |
EPHA3 AND MULTI-VALENT TARGETING OF TUMORS Provided herein is a construct comprising, in combination: an EphA3, EphA2 and/or EphB2 binding ligand; and at least one effector molecule. In some... |
| 2018/0244744 |
A PROCESS FOR OBTAINING INSULIN WITH CORRECTLY FORMED DISULFIDE BONDS A process for solubilization and refolding of precursor insulin or insulin analogs from inclusion body isolates for use in the production of insulin or insulin... |
| 2018/0244743 |
Novel Insulin Derivatives and the Medical Uses Hereof The present invention is in the therapeutic fields of drugs for medical conditions relating to diabetes. More specifically the invention relates to novel... |
| 2018/0244742 |
Double-Acylated GLP-1 Derivatives The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue and a second K residue, at positions corresponding to... |
| 2018/0244741 |
NOVEL PEPTIDES AND COMBINATION OF PEPTIDES AND SCAFFOLDS THEREOF FOR USE
IN IMMUNOTHERAPY AGAINST COLORECTAL... The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates... |
| 2018/0244740 |
BH3 PEPTIDES AND METHODS OF USE THEREOF The invention provides peptides and the nucleic acid sequences that encode them. The invention further provides therapeutic, diagnostic and research methods... |
| 2018/0244739 |
PEPTIDE VACCINE FOR PREVENTION AND IMMUNOTHERAPY OF DEMENTIA OF THE
ALZHEIMER'S TYPE The present disclosure is directed to individual A.beta. peptide immunogen constructs, peptide compositions comprising these A.beta. peptide immunogen... |
| 2018/0244738 |
TUMOR SUPPRESSOR SALL1 AS A THERAPEUTIC AGENT FOR TREATING CANCER The present disclosure relates to the SALL1 tumor suppressor. Methods of employing SALL1 to treat cancer, as well as the underlying mechanism by which this... |
| 2018/0244737 |
OPSIN POLYPEPTIDES AND METHODS OF USE THEREOF The present disclosure provides opsins, including variant opsins with increased activity and/or increased trafficking to the plasma membrane. The opsins are... |
| 2018/0244736 |
EXTENDED RECOMBINANT POLYPEPTIDES AND COMPOSITIONS COMPRISING SAME The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids... |
| 2018/0244735 |
Compositions and Methods of Use for Recombinant Human Secretoglobins Methods of synthetically producing, formulating and using secretoglobins SCGB1A1, SCGB3A2, and SCGB3A1 are provided. Methods of using secretoglobins SCGB1A1,... |
| 2018/0244734 |
NOVEL PROTEINS AND DETECTION METHODS An isolated protein from Cimex lectularius comprising an amino acid sequence selected from any one of SEQ ID No. 1 or 5 or fragment thereof or an isolated... |
| 2018/0244733 |
ISOLATED POLYPEPTIDES AND POLYNUCLEOTIDES ENCODING SAME FOR GENERATING
PLANTS WITH INCREASED CUTICLAR WATER... An isolated polynucleotide is provided. The isolated polynucleotides comprising a nucleic acid sequence encoding a polypeptide having an amino acid sequence at... |
| 2018/0244732 |
HERBICIDE-RESISTANT PROTEIN, ENCODING GENE AND USE THEREOF Involved is a herbicide-resistant protein, coding gene and use thereof. The herbicide-resistant protein comprises: (a) a protein consisting of an amino acid... |
| 2018/0244731 |
COMPOSITIONS AND METHODS FOR TREATMENT OF PAIN Embodied herein are engineered fusion proteins that bind and target nociceptor neurons, compositions comprising these engineered fusion proteins, and methods... |
| 2018/0244730 |
Methods and Products for Fusion Protein Synthesis The present invention provides a method of producing a fusion protein, said method comprising: a) contacting a first protein with a second protein under... |
| 2018/0244729 |
MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES The invention discloses a polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A... |
| 2018/0244728 |
MINICIRCLE DNA VECTOR VACCINE PLATFORM FOR FOOT-AND-MOUTH DISEASE AND
METHODS THEREOF This application is directed generally to minicircle DNA vectors for the vaccination of foot-and-mouth disease (FMD). The transgene expression cassette in the... |
| 2018/0244727 |
CAPSID-MODIFIED RAAV VECTOR COMPOSITIONS HAVING IMPROVED TRANSDUCTION
EFFICIENCIES, AND METHODS OF USE Disclosed are capsid-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations that include them. Also... |
| 2018/0244726 |
Fusion Protein The present invention relates to a fusion protein for use in the treatment and/or prevention of a hepatitis B virus infection comprising at least one hepatitis... |
| 2018/0244725 |
PEPTIDE-BASED SYNTHETIC MOLECULES AND SILICA NANOSTRUCTURES Described herein are novel synthetic molecules, polymers, and compositions comprising silica-binding peptides, and their methods of production. Also described... |
| 2018/0244724 |
POLYPEPTIDE COMPOUND AND PREPARATION METHOD AND USE THEREOF The present invention discloses a polypeptide compound, a preparation method and an application thereof. The structural formula of the polypeptide compound is ... |
| 2018/0244723 |
HEME PEPTIDE MATERIALS FOR ANTI-INFLAMMATORY REGENERATIVE NANOBIOMEDICINE Heme released as a result of sustained injury leads to toxicity and triggers an inflammatory response and tissue damage. Heme oxygenase, an enzyme, recognizes,... |
| 2018/0244722 |
NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS OF THE BLOOD, IN PARTICULAR
CHRONIC LYMPHOID LEUKEMIA (CLL) The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the... |
| 2018/0244721 |
AROMATIC-CATIONIC PEPTIDES AND USES OF SAME The disclosure provides aromatic-cationic peptide compositions and methods of preventing or treating disease using the same. The methods comprise administering... |
| 2018/0244720 |
TARGETED DELIVERY SYSTEM AND METHODS OF USE THEREFOR Disclosed are peptides and peptidomimetics that in some embodiments include the amino acid sequence KRGARST or (SEQ ID NO: 1), AKRGARSTA or (SEQ ID NO: 2), or... |
| 2018/0244719 |
GAMMA-AA-PEPTIDE STAT3/DNA INHIBITORS AND METHODS OF USE STAT3 hyperphosphorylation, dimerization and DNA binding are required for its ability to contribute to malignant transformation. As such, STAT3 has been... |
| 2018/0244718 |
FOLDAMER HELIX BUNDLE-BASED MOLECULAR ENCAPSULATION The present description provides compositions and methods for producing therapeutic oligomeric compounds. In another aspect the description provides methods... |
| 2018/0244717 |
CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: ##STR00001## and the use of such peptides in making immunoconjugates (i.e... |
| 2018/0244716 |
EGG WHITE PROCESSING This disclosure relates to inexpensive and efficient methods of preparing egg white (e.g., obtained from eggs laid by transgenic chickens) for bulk ... |
| 2018/0244715 |
PROTEIN PURIFICATION A method for purifying a polypeptide by ion exchange chromatography is described in which a gradient wash is used to resolve a polypeptide of interest from one... |
| 2018/0244714 |
PROTOESCIGENIN DERIVATIVE, PROCESS OF ITS PREPARATION, USE OF SAID
COMPOUND AND PHARMACEUTICAL COMPOSITION... Described herein is compound including a protoescigenin derivative having pharmacological properties. Also described are a process of its preparation, and the... |
| 2018/0244713 |
SIALYLTRANSFERASE INHIBITORS AND USES THEREOF Disclosed herein are novel sialyltransferase inhibitors, and compositions and methods for treating diseases and/or conditions associated with the activation of... |
| 2018/0244712 |
CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS A class of polycyclic compounds of general formula (I), of general formula (I'), or of general formula (I''), wherein Base.sup.1, Base.sup.2, Y, Y.sup.a,... |
| 2018/0244711 |
CRYSTAL FORM OF FLUDARABINE PHOSPHATE, PREPARATION METHOD THEREFOR, AND
APPLICATION THEREOF Provided are a new crystal form of fludarabine phosphate, a preparation method therefor, a pharmaceutical composition containing same, and an application... |
| 2018/0244710 |
Composition Rich in Single Isomer NUC-1031 and Preparation Method and use
Thereof Provided is a preparation method of a composition enriched in compound S.sub.p-1. The method performs isomer separation on a reaction product from the first... |
| 2018/0244709 |
NON-CALORIC SWEETENER Disclosed is a steviol glycoside referred to as rebaudioside D2. Rebaudioside D2 has five .beta.-D-glucosyl units connected to the aglycone steviol. Also... |
| 2018/0244708 |
INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1 Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes... |
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