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Patent # Description
2018/0244758 MONOCLONAL ANTIBODIES AND COCKTAILS FOR TREATMENT OF EBOLA INFECTIONS
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection certain embodiments of the present invention, monoclonal...
2018/0244757 MONOCLONAL ANTIBODIES SPECIFIC FOR HEARTLAND VIRUS AND METHODS OF THEIR USE
Monoclonal antibodies that specifically bind the nucleocapsid protein of Heartland virus (HRTV) are described. The monoclonal antibodies can be used, for...
2018/0244756 MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS IMMUNOGENS, ANTIBODIES, AND THEIR USE
Methods of inducing an immune response in a subject to the Middle East respiratory syndrome coronavirus (MERS-CoV) are provided. In several embodiments, the...
2018/0244755 TARGETED THERAPEUTICS BASED ON ENGINEERED PROTEINS THAT BIND EGFR
The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain...
2018/0244754 NOVEL HUMAN SERUM ALBUMIN MUTANT
Disclosed are a human serum albumin mutant that can be linked to a physiologically active protein to increase the stability of the protein in the blood, as...
2018/0244753 SINGLE-CHAIN TL1A RECEPTOR AGONIST PROTEINS
Provided herein are specific TL1A receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TL1A-associated...
2018/0244752 SINGLE-CHAIN GITR-RECEPTOR AGONIST PROTEINS
Provided herein are specific GITR receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a GITRL-associated...
2018/0244751 SINGLE-CHAIN CD27-RECEPTOR AGONIST PROTEINS
Provided herein are specific CD27 receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a CD27L-associated...
2018/0244749 IMMUNOMODULATORY PROTEINS WITH TUNABLE AFFINITIES
Provided are immunomodulatory proteins and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of...
2018/0244748 Modified Monocytes/Macrophage Expressing Chimeric Antigen Receptors and Uses Thereof
The present invention includes methods and compositions for treating cancer, whether a solid tumor or a hematologic malignancy. By expressing a chimeric...
2018/0244747 COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING FUSION PROTEINS
Provided herein are T-cell receptor (TCR) fusion proteins (TFPs), T-cells engineered to express one or more TFPs, and methods of use thereof for the treatment...
2018/0244746 T CELL RECEPTORS (TCR) AND USES THEREOF FOR THE DIAGNOSIS AND TREATMENT OF DIABETES
The present invention relates to T-cell receptors (TCR) that recognize pancreatic betacell epitopes and uses thereof for the diagnosis and treatment of diabetes.
2018/0244745 EPHA3 AND MULTI-VALENT TARGETING OF TUMORS
Provided herein is a construct comprising, in combination: an EphA3, EphA2 and/or EphB2 binding ligand; and at least one effector molecule. In some...
2018/0244744 A PROCESS FOR OBTAINING INSULIN WITH CORRECTLY FORMED DISULFIDE BONDS
A process for solubilization and refolding of precursor insulin or insulin analogs from inclusion body isolates for use in the production of insulin or insulin...
2018/0244743 Novel Insulin Derivatives and the Medical Uses Hereof
The present invention is in the therapeutic fields of drugs for medical conditions relating to diabetes. More specifically the invention relates to novel...
2018/0244742 Double-Acylated GLP-1 Derivatives
The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue and a second K residue, at positions corresponding to...
2018/0244741 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES AND SCAFFOLDS THEREOF FOR USE IN IMMUNOTHERAPY AGAINST COLORECTAL...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0244740 BH3 PEPTIDES AND METHODS OF USE THEREOF
The invention provides peptides and the nucleic acid sequences that encode them. The invention further provides therapeutic, diagnostic and research methods...
2018/0244739 PEPTIDE VACCINE FOR PREVENTION AND IMMUNOTHERAPY OF DEMENTIA OF THE ALZHEIMER'S TYPE
The present disclosure is directed to individual A.beta. peptide immunogen constructs, peptide compositions comprising these A.beta. peptide immunogen...
2018/0244738 TUMOR SUPPRESSOR SALL1 AS A THERAPEUTIC AGENT FOR TREATING CANCER
The present disclosure relates to the SALL1 tumor suppressor. Methods of employing SALL1 to treat cancer, as well as the underlying mechanism by which this...
2018/0244737 OPSIN POLYPEPTIDES AND METHODS OF USE THEREOF
The present disclosure provides opsins, including variant opsins with increased activity and/or increased trafficking to the plasma membrane. The opsins are...
2018/0244736 EXTENDED RECOMBINANT POLYPEPTIDES AND COMPOSITIONS COMPRISING SAME
The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids...
2018/0244735 Compositions and Methods of Use for Recombinant Human Secretoglobins
Methods of synthetically producing, formulating and using secretoglobins SCGB1A1, SCGB3A2, and SCGB3A1 are provided. Methods of using secretoglobins SCGB1A1,...
2018/0244734 NOVEL PROTEINS AND DETECTION METHODS
An isolated protein from Cimex lectularius comprising an amino acid sequence selected from any one of SEQ ID No. 1 or 5 or fragment thereof or an isolated...
2018/0244733 ISOLATED POLYPEPTIDES AND POLYNUCLEOTIDES ENCODING SAME FOR GENERATING PLANTS WITH INCREASED CUTICLAR WATER...
An isolated polynucleotide is provided. The isolated polynucleotides comprising a nucleic acid sequence encoding a polypeptide having an amino acid sequence at...
2018/0244732 HERBICIDE-RESISTANT PROTEIN, ENCODING GENE AND USE THEREOF
Involved is a herbicide-resistant protein, coding gene and use thereof. The herbicide-resistant protein comprises: (a) a protein consisting of an amino acid...
2018/0244731 COMPOSITIONS AND METHODS FOR TREATMENT OF PAIN
Embodied herein are engineered fusion proteins that bind and target nociceptor neurons, compositions comprising these engineered fusion proteins, and methods...
2018/0244730 Methods and Products for Fusion Protein Synthesis
The present invention provides a method of producing a fusion protein, said method comprising: a) contacting a first protein with a second protein under...
2018/0244729 MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES
The invention discloses a polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A...
2018/0244728 MINICIRCLE DNA VECTOR VACCINE PLATFORM FOR FOOT-AND-MOUTH DISEASE AND METHODS THEREOF
This application is directed generally to minicircle DNA vectors for the vaccination of foot-and-mouth disease (FMD). The transgene expression cassette in the...
2018/0244727 CAPSID-MODIFIED RAAV VECTOR COMPOSITIONS HAVING IMPROVED TRANSDUCTION EFFICIENCIES, AND METHODS OF USE
Disclosed are capsid-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations that include them. Also...
2018/0244726 Fusion Protein
The present invention relates to a fusion protein for use in the treatment and/or prevention of a hepatitis B virus infection comprising at least one hepatitis...
2018/0244725 PEPTIDE-BASED SYNTHETIC MOLECULES AND SILICA NANOSTRUCTURES
Described herein are novel synthetic molecules, polymers, and compositions comprising silica-binding peptides, and their methods of production. Also described...
2018/0244724 POLYPEPTIDE COMPOUND AND PREPARATION METHOD AND USE THEREOF
The present invention discloses a polypeptide compound, a preparation method and an application thereof. The structural formula of the polypeptide compound is ...
2018/0244723 HEME PEPTIDE MATERIALS FOR ANTI-INFLAMMATORY REGENERATIVE NANOBIOMEDICINE
Heme released as a result of sustained injury leads to toxicity and triggers an inflammatory response and tissue damage. Heme oxygenase, an enzyme, recognizes,...
2018/0244722 NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS OF THE BLOOD, IN PARTICULAR CHRONIC LYMPHOID LEUKEMIA (CLL)
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the...
2018/0244721 AROMATIC-CATIONIC PEPTIDES AND USES OF SAME
The disclosure provides aromatic-cationic peptide compositions and methods of preventing or treating disease using the same. The methods comprise administering...
2018/0244720 TARGETED DELIVERY SYSTEM AND METHODS OF USE THEREFOR
Disclosed are peptides and peptidomimetics that in some embodiments include the amino acid sequence KRGARST or (SEQ ID NO: 1), AKRGARSTA or (SEQ ID NO: 2), or...
2018/0244719 GAMMA-AA-PEPTIDE STAT3/DNA INHIBITORS AND METHODS OF USE
STAT3 hyperphosphorylation, dimerization and DNA binding are required for its ability to contribute to malignant transformation. As such, STAT3 has been...
2018/0244718 FOLDAMER HELIX BUNDLE-BASED MOLECULAR ENCAPSULATION
The present description provides compositions and methods for producing therapeutic oligomeric compounds. In another aspect the description provides methods...
2018/0244717 CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF
Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: ##STR00001## and the use of such peptides in making immunoconjugates (i.e...
2018/0244716 EGG WHITE PROCESSING
This disclosure relates to inexpensive and efficient methods of preparing egg white (e.g., obtained from eggs laid by transgenic chickens) for bulk ...
2018/0244715 PROTEIN PURIFICATION
A method for purifying a polypeptide by ion exchange chromatography is described in which a gradient wash is used to resolve a polypeptide of interest from one...
2018/0244714 PROTOESCIGENIN DERIVATIVE, PROCESS OF ITS PREPARATION, USE OF SAID COMPOUND AND PHARMACEUTICAL COMPOSITION...
Described herein is compound including a protoescigenin derivative having pharmacological properties. Also described are a process of its preparation, and the...
2018/0244713 SIALYLTRANSFERASE INHIBITORS AND USES THEREOF
Disclosed herein are novel sialyltransferase inhibitors, and compositions and methods for treating diseases and/or conditions associated with the activation of...
2018/0244712 CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
A class of polycyclic compounds of general formula (I), of general formula (I'), or of general formula (I''), wherein Base.sup.1, Base.sup.2, Y, Y.sup.a,...
2018/0244711 CRYSTAL FORM OF FLUDARABINE PHOSPHATE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Provided are a new crystal form of fludarabine phosphate, a preparation method therefor, a pharmaceutical composition containing same, and an application...
2018/0244710 Composition Rich in Single Isomer NUC-1031 and Preparation Method and use Thereof
Provided is a preparation method of a composition enriched in compound S.sub.p-1. The method performs isomer separation on a reaction product from the first...
2018/0244709 NON-CALORIC SWEETENER
Disclosed is a steviol glycoside referred to as rebaudioside D2. Rebaudioside D2 has five .beta.-D-glucosyl units connected to the aglycone steviol. Also...
2018/0244708 INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1
Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes...
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