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Patent # Description
2018/0244707 METHOD FOR ISOLATING NUCLEIC ACIDS
The invention relates to a method and kits for isolating and/or purifying nucleic acids, in particular, short-chain nucleic acids, from a nucleic acid...
2018/0244706 ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE ORGANOMETALLIC COMPOUND, AND DIAGNOSTIC...
An organometallic compound represented by Formula 1: ##STR00001## wherein, in Formula 1, groups and variables are the same as described in the specification.
2018/0244705 PRODRUGS OF PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) INHIBITOR
Methods and compounds are disclosed for treating a disease or condition by inhibiting PSMA (Prostate Specific Membrane Antigen) using prodrugs of 2-PMPA.
2018/0244704 FORMS OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL)PYRIDIN-5-YL)-3-FLUOROPHENYL)-5- -HYDROXYMETHYL OXAZOLIDIN-2-ONE...
A crystalline form of crystalline (R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-5-hydro- xymethyl oxazolidin-2-one dihydrogen phosphate,...
2018/0244703 AMINO- OR AMMONIUM-CONTAINING SULFONIC ACID, PHOSPHONIC ACID AND CARBOXYLIC ACID DERIVATIVES AND THEIR MEDICAL USE
The present invention relates to amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of...
2018/0244702 PROCESS FOR PRODUCING PHOSPHORUS-CONTAINING CYANOHYDRIN ESTERS
The present invention primarily relates to a process for producing certain phosphorus-containing cyanohydrin esters of formula (I) and the use thereof for...
2018/0244701 Phosphoramidate Compound and Preparation Method and Crystal Thereof
The present disclosure involves a composition enriched in compound 61501b, wherein the compound 61501b has a purity of not less than 90% or more. The...
2018/0244700 METHODS OF TREATING A FATTY ACID AMIDE HYDROLASE-MEDIATED CONDITION
The present invention provides fatty acid amide hydrolase inhibitors, solid forms thereof, compositions thereof, and methods of making and using the same.
2018/0244699 1-HYDROXY-3H-2,1-BENZOXABOROLE DERIVATIVES AND THEIR USE AS MICROBIOCIDES
Compounds of formula (I) wherein R.sup.1 is fluorine, chlorine, bromine, cyano, nitro, hydroxy, C.sub.1-C.sub.4alkoxy, C.sub.1-C.sub.4haloalkoxy; G=OR.sup.2,...
2018/0244698 AMINE-BORANES BEARING BORANE-INTOLERANT FUNCTIONALITIES
Disclosed herein is the preparation of functional group containing amine-boranes from the corresponding amines. The mild reaction conditions allow for the...
2018/0244697 PROCESS FOR THE PREPARATION OF TRIMETHYL METAL COMPOUNDS
Process for the production of a trimethyl metal compound with the formula M(CH.sub.3).sub.3, said process comprising the steps of (i) reacting a metal...
2018/0244696 POLYMORPHIC FORMS AND CO-CRYSTALS OF A C-MET INHIBITOR
Provided herein are novel polymorphic forms and co-crystals of a compound useful in the treatment, prevention, or amelioration of cancer. In particular, the...
2018/0244695 QUINOLINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION, PREPARATION METHOD AND USE THEREOF
Disclosed are a quinoline derivative, and a pharmaceutical composition, a preparation method and a use thereof. The quinoline derivative of the present...
2018/0244694 THIAZOLOPYRIMIDINONES AND METHODS OF USE THEREOF
The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using...
2018/0244693 Process for the preparation of dolutegravir
Processes for the preparation of dolutegravir and pharmaceutically acceptable salts utilizing alkenylamine are disclosed. Intermediates in those synthetic...
2018/0244692 Inhibitors of Tryptophan Dioxygenases (IDO1 and TDO) And Their Use In Therapy
Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is...
2018/0244691 INDACEN-4-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND POLYMERS CONTAINING THEM
Indacen-4-one derivative having general formula (I) in which: --W and W.sub.1, which are the same or different, preferably the same, represent an oxygen atom;...
2018/0244690 OXABICYCLOHEPTANE PRODRUGS
The present invention provides a compound having the structure: ##STR00001##
2018/0244689 PROCESS FOR MAKING ISOIDIDE
A process is provided for making isoidide, wherein a dextrose feed is first converted by a combination of epimerizaton and hydrogenation to an iditol-enriched...
2018/0244688 HIV-1 PROTEASE INHIBITORS AND USES THEREOF
Various embodiments relate to a compound of the formula (I): wherein X, X.sup.1, R.sup.1-R.sup.4 and R.sup.7 are defined herein, as well as pharmaceutical...
2018/0244687 CONDENSED TRICYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS
There is provided compounds of formula I, ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3 R.sup.4, R.sup.5, R.sup.6, R.sup.7a and R.sup.7b have meanings given in...
2018/0244686 TRICYCLIC HETEROCYCLIC COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE INHIBITORS
The invention relates to a compound of formula I: (I) or a pharmaceutically acceptable salt thereof, wherein each R.sup.3 is independently selected from H,...
2018/0244685 TRICYCLIC HETEROCYCLIC COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE INHIBITORS
The invention relates to a compound of formula I: ##STR00001## or a pharmaceutically acceptable salt thereof and/or stereoisomers thereof. The compounds of the...
2018/0244684 ANTIVIRAL COMPOUNDS
The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such...
2018/0244683 ANTIVIRAL COMPOUNDS
The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such...
2018/0244682 TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKK.epsilon. inhibitors.
2018/0244681 PROCESS
This invention relates to cucurbituril and/or one or more derivatives thereof with low formaldehyde content, to a process of manufacturing said cucurbituril...
2018/0244680 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
2018/0244679 PYRAZOLOPYRIMIDONE OR PYRROLOTRIAZONE DERIVATIVES, METHOD OF PREPARING SAME, AND PHARMACEUTICAL APPLICATIONS...
Methods of preparation and pharmaceutical uses of pyrazolopyrimidone derivatives are described. Specifically, methods of preparation and pharmaceutical uses of...
2018/0244678 SMALL MOLECULE INHIBITORS OF KU70/80 AND USES THEREOF
Provided herein are methods for identifying and treating subjects having conditions involving aberrant Ku70/80 activity. In particular, the invention relates...
2018/0244677 IRAK4 INHIBITOR AND USE THEREOF
Disclosed are a compound related to inhibiting the activity of an IRAK4 kinase, a pharmaceutical composition thereof, a use thereof in preparing drugs, a...
2018/0244676 LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME
Compounds having the formula I, II, or III: ##STR00001## are provided. Compounds of the present disclosure are useful for the treatment of neurodegenerative...
2018/0244675 PURINONE DERIVATIVE HYDROCHLORIDE
The purinone derivative 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-di- hydro-8H-purin-8-one hydrochloride has Btk-selective...
2018/0244674 SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF
Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.
2018/0244673 LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS
The present application describes lactam-containing compounds and derivatives thereof of Formula I: P.sub.4--P-M-M.sub.4 I or pharmaceutically acceptable salt...
2018/0244672 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS
The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR4 enzyme and are useful in...
2018/0244671 TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE
The present invention provides compounds of Formula (I): wherein A, Y and R.sup.1 are each as defined in the specification, and compositions comprising any of...
2018/0244670 METHOD FOR THE PREPARATION OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NA- ...
The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihy- ...
2018/0244669 IMIDAZO[4,5-c] RING COMPOUNDS CONTAINING SUBSTITUTED GUANIDINE GROUPS
Imidazo[4,5-c] ring compounds, (particularly imidzao[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and...
2018/0244668 METHOD FOR THE PREPARATION OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NA- ...
The present invention relates to a novel process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-na- ...
2018/0244667 PYRIDO-AZAHETERECYDIC COMPOUND AND PREPARATION METHOD AND USE THEREOF
The present invention discloses a pyrido-azacyclic compound represented by formula I, an isomer thereof, a pharmaceutically acceptable salt or a ...
2018/0244666 DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE
Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further...
2018/0244665 XANTHINE OXIDASE INHIBITOR
Provided are a xanthine oxidase inhibitor, a drug for improving vascular endothelial function, and an excellent therapeutic or prophylactic drug for diseases...
2018/0244664 PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX
This application features pyrazol-3-one compounds that activate pro-apoptotic BAX. Also featured are methods of using such compounds, e.g., for the treatment...
2018/0244662 PROCESSES FOR PREPARING ATR INHIBITORS
The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole...
2018/0244661 PROCESS FOR THE PREPARATION OF AMORPHOUS (1S)-1,5-ANHVDRO-1-[3-[[5-(4 ...
The present invention relates to an improved process for the preparation of amorphous ...
2018/0244660 CYCLOPROPYLDERIVATIVES AND THEIR USE AS KINASE INHIBITORS
The invention generally relates to cyclic compounds and, more particularly, to a compound represented by Structural Formula I: or a pharmaceutically acceptable...
2018/0244659 HETERO RING COMPOUND AND ORGANIC LUMINESCENT ELEMENT COMPRISING SAME
The present specification provides a heterocyclic compound and an organic light emitting device including the same.
2018/0244658 Mannose Derivatives for Treating Bacterial Infections
##STR00001## The compounds represented by Formula (I) or pharmaceutically acceptable salts thereof: with U, W, X, Y, Z, p and ring A as defined in claim 1. ...
2018/0244657 RHO KINASE INHIBITORS
The invention relates to inhibitors of ROCK1 and/or ROCK2. Also provided are methods of treating diseases and disorders involving inhibiting ROCK1 and/or ROCK2.
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