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Patent # Description
2018/0244656 METALLO-BETA-LACTAMASE INHIBITORS
The present invention relates to metallo-beta-lactamase inhibitor compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein Z, R.sup.A,...
2018/0244655 Fluoroindole Derivatives as Muscarinic M1 Receptor Positive Allosteric Modulators
The present invention relates to compound of formula (I), or stereoisomers and pharmaceutically acceptable salts as muscarinic M1 receptor positive allosteric...
2018/0244654 SUBSTITUTED AROMATIC N-HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MITOGEN-ACTIVATED PROTEIN KINASE INTERACTING...
Disclosed are substituted aromatic N-heterocyclic compounds. The disclosed compounds typically exhibit kinase inhibition activity, for example, and inhibit...
2018/0244653 SELECTIVE ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND METHODS FOR MAKING AND USING THEM
In alternative embodiments, provided are selective agonists having a high affinity for the alpha7 nicotinic acetylcholine receptor (.alpha.7 nAChR), assays for...
2018/0244652 Indolyl-Pyridone Derivatives Having Checkpoint Kinase 1 Inhibitory Activity
A method of treating a mammal suffering from a cancer responsive to inhibition of protein kinase activity, by administering to the mammal an amount of a...
2018/0244651 WNT SIGNALING PATHWAY INHIBITORS AND THERAPEUTIC APPLICATIONS THEREOF
Inhibitors of Wnt signaling pathway with structures of Formula I are disclosed, together with their pharmaceutical salts. Applications of compounds of Formula...
2018/0244650 ANDROGEN RECEPTOR ANTAGONISTS
Disclosed herein are compositions and methods for modulating the androgen receptor.
2018/0244649 PYRIDINE SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITOR CRYSTAL
The present invention discloses a crystal of citrate salt of pyridine-substituted 2-aminopyridine-based protein kinase inhibitors, in particular, to crystal...
2018/0244648 INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN
Disclosed are small molecule inhibitors of .alpha.v.beta.6 integrin, and methods of using them to treat a number of diseases and conditions.
2018/0244647 CRYSTALS OF 5-CYCLOPROPYL-2-((1-(3-FLUOROBENZYL)-1H-INDOL-5-YL)AMINO)NICOTINIC ACID
Crystals of 5-cyclopropyl-2-((1-(3-fluorobenzyl)-1H-indol-5-yl)amino)nicotinic acid having diffraction peaks at diffraction angles (2.theta.) of 12.2.+-.0.2, ...
2018/0244646 BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AS IRAK4 MODULATORS
Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined...
2018/0244645 2-AMINO-3-FLUORO-3-(FLUOROMETHYL)-6-METHYL-6-PHENYL-3,4,5,6-TETRAHYDROPYRI- DINES AS BACE1 INHIBITORS
The present invention provides compounds of Formula (I) for the treatment of neurodegenerative or cognitive diseases. The method further provides for...
2018/0244644 NOVEL CATECHOL DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
The present invention relates to a compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof. The compound according to the...
2018/0244643 HIGHLY SENSITIVE DETECTION OF BIOMOLECULES USING PROXIMITY INDUCED BIOORTHOGONAL REACTIONS
There provided, inter alia, reagents and methods for modulation fluorescence of a tetrazine containing compound and/or a dienophile-containing compound. There...
2018/0244642 MIXTURES OF CANNABINOID COMPOUNDS, AND PRODUCTION AND USE THEREOF
Described are specific mixtures comprising one or more (cannabinoid) compounds of the formula (A) and/or one or more of their salts as well was methods for...
2018/0244641 TOCOPHEROL DERIVATIVES AND METHODS OF USE
Tocol derivative compounds, compositions comprising these tocol derivatives and methods of using the tocol derivatives are provided herein. Specifically the...
2018/0244640 Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use
The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions...
2018/0244639 CARBONATE-PROMOTED CARBOXYLATION REACTIONS FOR THE SYNTHESIS OF VALUABLE ORGANIC COMPOUNDS
A method for synthesizing furan-2,5-dicarboxylate (FDCA.sup.2-) is provided. Furan-2-carboxylic acid is provided. A CO.sub.3.sup.2- salt is provided to form a...
2018/0244638 SMALL MOLECULES THAT ENABLE CARTILAGE REJUVENATION
There are provided, inter alia, methods and compounds for activating a proliferative program in competent adult chondrocytes.
2018/0244637 MONOSULFONIC PHENYLTETRAZOLE COMPOUNDS WITH APPLICATIONS
A class of compounds of monosulfonic phenyltetrazole, with the structure of 2-(R1 phenyl)-5 (2-sulfonic phenyl)-2H-tetrazole. The 2-sulfonic phenyl tetrazolium...
2018/0244636 PROCESS FOR THE PREPARATION OF A DUAL-ACTING ANGIOTENSIN RECEPTOR-NEPRILYSIN INHIBITOR COMPOUND
The present invention relates to a process for preparing amorphous form of Sacubitril/Valsartan sodium salt of Formula-II and pharmaceutical composition...
2018/0244635 A PROCESS FOR THE PREPARATION OF XYLENE LINKED CYCLAM COMPOUNDS
The present invention relates to an improved process for the preparation of xylene linked cyclam compounds. More particularly the invention provides a process...
2018/0244634 PROCEDURE AND SYSTEM FOR THE EXTRACTION OF ISOCYANURIC ACID IN SOLUTION
A procedure and a system for the extraction of isocyanuric acid is disclosed. According to the invention, the water containing isocyanuric acid is passed...
2018/0244633 [4-(1,3,3-TRIMETHYL-2-OXO-3,4-DIHYDRO-1H-QUINOXALIN-7-YL)PHENOXY]ETHYLOXY COMPOUND OR SALT THEREOF
The present invention relates to a novel [4-(1,3,3-trimethyl-2-oxo-3,4-dihydro-1H-quinoxalin-7-yl)phenoxy]ethyloxy compound or a salt thereof. The compound or...
2018/0244632 HIV REPLICATION INHIBITING PYRIMIDINES
This invention concerns HIV replication inhibitors of formula ##STR00001## the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines...
2018/0244631 INHIBITION OF OLIG2 ACTIVITY
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are...
2018/0244630 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING ELEMENT USING SAME
The present specification provides a heterocyclic compound and an organic light emitting device using the same.
2018/0244629 Compounds And Compositions For The Treatment Of Cancer
Disclosed are compounds, such as pyridazinones, that can be, inter alia, used for treating cancer.
2018/0244628 CRYSTALLINE FORM OF ANDROGEN RECEPTOR INHIBITOR AND PREPARATION METHOD THEREOF
A crystalline form of an androgen receptor inhibitor and its preparation method are provided. In particular, provided are crystal form I of ...
2018/0244627 HETEROCYCLIC COMPOUNDS AND USES THEREOF
The present disclosure relates to heterocyclic compounds, and pharmaceutical compositions of the same, that are modulators/inhibitors of HDACs, such as HDAC8...
2018/0244626 AMINOINDAZOLE DERIVATIVES AS SODIUM CHANNEL INHIBITORS
The present invention relates to novel aminoindazolyl derivative compounds of Formula (I), the use of said compounds in treating diseases mediated by...
2018/0244625 FUNGICIDAL COMPOSITIONS
The present invention relates to novel fungicidal compositions for the treatment of phytopathogenic diseases of useful plants, especially phytopathogenic...
2018/0244624 NOVEL ISONITRAMINE COMPOUND AND COMPOSITION CONTAINING SAME FOR PREVENTING OR TREATING METABOLIC DISEASES
Provided are a pharmaceutical composition for preventing or treating metabolic diseases and a health food for alleviating metabolic diseases, each of which the...
2018/0244623 N-methyl-D-aspartate Receptor (NMDAR) Potentiators, Pharmaceutical Compositions, And Uses Related Thereto
This disclosure relates to tetrahydroisoquinolines, salts, and derivatives useful for managing mental or cognitive diseases or conditions of the brain or...
2018/0244622 PROCESSES FOR THE PREPARATION OF IVACAFTOR
The present invention provides processes for the preparation of ivacaftor using novel intermediates and a process for its preparation.
2018/0244621 CATALYTIC HYDROGENATION OF NITRILES
The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular ...
2018/0244620 METHOD FOR PRODUCING 5-HYDROXYPIPERIDINE-2-CARBOXYLIC ACID
A method for producing (2S,5S)/(2R,5R)-5-hydroxypiperidine-2-carboxylic acid represented by the formula (10) below: ##STR00001## the method comprising the step...
2018/0244619 METHOD FOR PRODUCING 5-HYDROXYPIPERIDINE-2-CARBOXYLIC ACID
A method for producing (2S,5S)/(2R,5R)-5-hydroxypiperidine-2-carboxylic acid represented by the formula (10) below: ##STR00001## the method including removing...
2018/0244618 METHOD FOR PREPARING STRUCTURED DIRECTING AGENT
Provided is a method for preparing a structure directing agent (SDA) for crystalline molecular sieve synthesis comprising the steps of (a) hydrolyzing analkyl...
2018/0244617 ISOINDOLINE DERIVATIVES FOR USE IN THE TREATMENT OF A VIRAL INFECTION
Compounds of Formula I are disclosed and methods of treating viral infections with compositions comprising such compounds. ##STR00001##
2018/0244616 LACTAM COMPOSITIONS
Compositions comprising a lactam. The compositions are suitable for use as anti-microbial, anti-biofilm and bacteriostatic compositions.
2018/0244615 USE OF COMPOUNDS INCLUDING A SULFOXIDE OR SULFONE FUNCTION AND AN AMIDE FUNCTION AS SOLVENTS AND NEW SOLVENTS
Provided is a composition that contains a compound a) and at least one chemical entity b) dissolved in compound a). Compound a) has at least one sulfoxide...
2018/0244614 THERAPEUTIC COMPOUNDS AND COMPOSITIONS
The present invention provides compounds and compositions that inhibit Factor XIa or kallikrein and methods of using these compounds and composition.
2018/0244613 PROCESS FOR PREPARING ALPHA-DAMASCONE
The present invention relates to a process for preparing 1-(2,6,6-trimethylcyclohex-2-en-1-yl)but-2-en-1-one, which comprises a) providing...
2018/0244612 METHOD OF PRODUCING A SODIUM SALT OF (2,6-DICHLOROPHENYL)AMIDE CARBOPENTOXYSULFANILIC ACID
The invention relates to the field of organic chemistry and medicine, and more particularly to a method of producing synthetic biologically active derivatives...
2018/0244611 Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use
The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions...
2018/0244610 N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or...
2018/0244609 METHOD FOR PRODUCING THE 2-ACRYLAMIDO-2-METHYLPROPANE SULFONIC ACID MONOMER AND POLYMER COMPRISING SAID MONOMER
The invention relates to a method for producing 2-acrylamido-2-methylpropane sulfonic acid. Said method consists in reacting together acrylonitrile, fuming...
2018/0244608 PROCESS FOR THE PREPARATION OF THE COMPOUND N-(3,5-DIMETHYLPHENYL)-N'-(2-TRIFLUOROMETHYLPHENYL) GUANIDINE
The present invention relates to a process for the preparation of the compound N-(3,5-dimethylphenyl)-N'-(2-trifluoromethylphenyl) guanidine of formula (I)...
2018/0244607 INHIBITING CPI FORMATION FROM ADIPONITRILE
Disclosed is a method for inhibiting the formation of by-products from dinitriles, such as the formation of cyclopentylideneimine (CPI) from Adiponitrile...
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