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Patent # Description
2018/0250330 TOPICAL COMPOSITIONS AND METHODS OF USING THE SAME
The present invention generally relates to topical compositions and methods of using the same. The topical compositions may comprise a hydrophilic composition...
2018/0250329 USE OF INHALED GASEOUS NITRIC OXIDE AS A MUCOLYTIC AGENT OR EXPECTORANT
Methods and devices for treating excess mucus accumulation in mammals by administering gaseous inhaled nitric oxide or nitric oxide releasing compounds as a...
2018/0250328 Metallocene-boronic acid-containing compounds and copolymers as antimicrobial agents.
Polymeric compounds for targeting broad-spectrum bacterial strains are provided. The polymeric compounds can include at least one metallocene monomeric unit...
2018/0250327 ANTIVIRAL PHARMACEUTICAL COMPOSITION FOR TOPICAL USE
The invention relates to an antiviral pharmaceutical composition for topical use against those viruses with a lipid envelope, comprising, as active ingredients...
2018/0250326 COMPOSITION AND METHOD TO ALLEVIATE JOINT PAIN USING LOW MOLECULAR WEIGHT HYALURONIC ACID AND ASTAXANTHIN
A dietary supplement composition is formulated in a therapeutic amount to treat and alleviate symptoms of joint pain. The composition includes pro-inflammatory...
2018/0250325 MIR-19 MODULATORS AND USES THEREOF
The present invention provides miR-19 modulators and uses thereof, such as for promoting angiogenesis and/or wound healing with miR-19 inhibitors alone or in...
2018/0250324 PREBIOTIC FORMULATIONS AND METHODS OF USE
The invention provides methods and compositions for treating symptoms associated with lactose intolerance and for overall improvement in gastrointestinal...
2018/0250323 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF ADAMTS-5 AND ADAM17
Provided are siRNAs or chemically-modified siRNAs targeted against ADAMTS-5 or ADAM17 for inhibiting the expression of ADAMTS-5 or ADAM17. Use of the siRNAs...
2018/0250322 ANTIBODIES WHICH BIND TYPE I CANNABINOID RECEPTOR/ANGIOTENSIS II RECEPTOR HETEROMERS
Compounds and compositions useful for the treatment of liver diseases and methods of treating liver diseases are disclosed. The compounds of the invention...
2018/0250321 COMPOSITIONS AND METHODS FOR RESTORING THE IMMUNE SYSTEM
A pharmaceutical composition for shifting a Th2 immune response to a Th1 response by natural killer T cells (NKT cells) including a therapeutically effective...
2018/0250320 COMPOSITIONS AND METHODS FOR TREATING SOLID TUMORS
The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods useful for treating solid...
2018/0250319 ANTIFUNGAL AND ANTIPARASITIC POLYENE MACROLIDES
In certain aspects, the present disclosure provides for novel, water-soluble polyene macrolides and salts or solvates thereof and methods of making the...
2018/0250318 SYNERGISTIC COMPOSITION FOR MAINTENANCE OF HEALTHY BALANCE OF MICROFLORA
The present invention relates to compositions, particularly compositions useful in maintaining and supporting healthy microflora in the female urogenital tract...
2018/0250317 MUPARFOSTAT FOR USE IN TREATING PATIENTS WITH HEPATITIS VIRUS-RELATED HEPATOCELLULAR CARCINOMA AFTER SURGICAL...
Muparfostat for use in reducing intrahepatic tumor recurrence and increasing disease-free survival period in a hepatocellular carcinoma patient with...
2018/0250316 (R)-3-((3S,4S)-3-FLUORO-4-(4-HYDROXYPHENYL)PIPERIDIN-1-YL)-1-(4-METHYLBENZ- YL)PYRROLIDIN-2-ONE AND ITS PRODRUGS...
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds...
2018/0250315 USE OF AMINOSALICYLATES IN DIARRHOEA-PREDOMINENT IRRITABLE BOWEL SYNDROME
A method for the treatment or prophylaxis of non-inflammatory bowel diseases, diarrhoea-predominant irritable bowel syndrome or other non-specific bowel...
2018/0250314 Skin Treatment System
A system for skin treatment including first, second, third, fourth, and fifth formulations that each include glycolic acid in an amount that ranges between 6...
2018/0250313 COMPOUNDS AND FORMULATIONS FOR TREATING OPHTHALMIC DISEASES
The present disclosure is directed to compositions, formulations and methods of use thereof in the treatment and prevention of ocular conditions including...
2018/0250312 TOPICAL CORTICOSTEROID COMPOSITIONS
Compositions for the topical administration of an active agent comprise a corticosteroid and a fatty alcohol as a skin penetration enhancer, in the form of...
2018/0250311 INTRAOCULAR DRUG DELIVERY DEVICE AND ASSOCIATED METHODS
An intraocular active agent delivery device can include an active agent homogenously combined with a biodegradable active agent matrix such that the entire...
2018/0250310 METHODS AND MATERIALS FOR REDUCING SUPRESSION OF IMMUNE FUNCTION
This document provides methods and materials involved in reducing suppression of immune function in mammals. For example, methods and materials for (a)...
2018/0250309 METHODS FOR TREATMENT OF MONOCYTE DYSFUNCTION AND CHRONIC INFLAMMATORY MICRO AND MACRO-VASCULAR DISEASES
Certain embodiments are directed to composition and methods related to 23 hydroxy ursolic acid and it use in attenuating the effects to monocyte ...
2018/0250308 NR2B SELECTIVE NMDA-RECEPTOR ANTAGONISTS FOR TREATMENT OF IMMUNE-MEDIATED INFLAMMATORY DISEASES
The present invention provides novel means and methods for treatment auf immunemediated inflammatory diseases.
2018/0250307 INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF
The present application relates to a-substituted amino acid compounds of the Formula (I), compositions comprising these compounds and their use, in particular...
2018/0250306 ALDEHYDE CONJUGATES AND USES THEREOF
The present invention provides compounds and methods of use thereof for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or...
2018/0250305 NITRIC OXIDE-RELEASING PRODRUG MOLECULE
Provided are a type of compounds that can be used for treating cardiovascular diseases and compositions containing the compounds. The compounds and the...
2018/0250304 Pharmaceutical compositions of Linagliptin and process for preparation thereof
Pharmaceutical compositions comprising an antidiabetic agent as an active agent are provided. The present invention relates to pharmaceutical compositions...
2018/0250303 TGF BETA RECEPTOR ANTAGONISTS
The invention relates generally to compounds of formula (I) that modulate the activity of TGF.beta.R-1 and TGF.beta.R-2, pharmaceutical compositions containing...
2018/0250302 COMBINATION OF RIBOCICLIB AND DABRAFENIB FOR TREATING OR PREVENTING CANCER
The present disclosure relates to pharmaceutical combinations comprising a cyclin dependent kinase 4/6 (CDK4/6) inhibitor compound, (b) a B-Raf inhibitor...
2018/0250300 TREATMENT OF SEXUAL DYSFUNCTION
The present invention describes novel methods for the treatment of sexual dysfunction.
2018/0250299 Use of Kinase Inhibitors to Manage Tuberculosis and Other Infectious Diseases
This disclosure relates to the use of kinase inhibitor to treat or prevent infectious diseases such as tuberculosis. In certain embodiments, this disclosure...
2018/0250298 Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, and/or a BCL-2 Inhibitor
Therapeutic combinations of a phosphoinositide 3-kinase (PI3K) inhibitor, including PI3K inhibitors selective for the .gamma.- and .delta.-isoforms and...
2018/0250297 Methods, Compositions, and Uses of Novel FYN Kinase Inhibitors
The present invention provides methods for inhibiting Fyn kinase, using 5-3-pyridin-2-amine, 6-3-imidazo[1,2-a] pyrazine, 6-3-imidazo[1,2-b] pyridazine,...
2018/0250296 REMOVING SENESCENT CELLS FROM A MIXED CELL POPULATION OR TISSUE USING A PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITOR
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic...
2018/0250295 Treatment of Motor and Movement Disorder Side Effects Associated with Parkinson's Disease Treatments
This invention provides methods of treating motor disorder side effects associated with the administration of levodopa to a subject having Parkinson's disease,...
2018/0250294 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-COMPOUNDS FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE AIRWAY DISEASES
The present invention relates to compounds for the treatment of chronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD) or...
2018/0250293 AZAINDAZOLE COMPOUNDS AND METHODS OF USE
Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl...
2018/0250292 ANTIBIOTIC GEL FORMULATION AND METHODS OF PREPARING THE ANTIBIOTIC GEL FORMULATION
Antibiotic gel formulations for use in dental applications are disclosed. More particularly, the present disclosure is directed to antibiotic gel formulations...
2018/0250291 COMPOSITION AND METHODS OF USE OF NOVEL PHENYLALANINE SMALL ORGANIC COMPOUNDS TO DIRECTLY MODULATE PCSK9...
This invention is related to the field of PCSK9 biology and the composition and methods of use of small organic compounds as ligands for modulation of PCSK9...
2018/0250290 COMPOSITIONS FOR TREATING CMT AND RELATED DISORDERS
The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders.
2018/0250289 THERAPEUTIC APPROACHES FOR TREATING CMT AND RELATED DISORDERS
Compositions and methods for the treatment of Charcot-Marie-Tooth disease and related disorders. Also provided are combination therapies for treating this...
2018/0250288 Novel Alpha-Hydroxy Carboxylic Acid And Derivatives And Other GRAS-Based Prodrugs Of Oxymorphone And Uses Thereof
The invention describes pharmaceutical compounds and compositions comprised of a ligand attached to the opioid oxymorphone, in a manner that substantially...
2018/0250287 ABUSE DETERRENT OPIOID FORMULATIONS
An abuse deterrent opioid formulation for rectal use. The formulation contains a therapeutically effective amount of the opioid buprenorphine or salts and...
2018/0250286 OPIOID FORMULATIONS
A depot precursor formulation comprising: a) a controlled-release matrix; b) at least oxygen containing organic solvent; c) at least 12% by weigh of at least...
2018/0250285 COMBINATION OF LAQUINIMOD AND PRIDOPIDINE FOR TREATING NEURODEGENERATIVE DISORDERS, IN PARTICULAR HUNTINGTON'S...
This invention provides a method of treating a patient afflicted with a neurodegenerative disorder, e.g., Huntington's disease (HD), comprising administering...
2018/0250284 QUINOLINE DERIVATIVES FOR USE IN TREATING LEUKODYSTROPHY AND TREATMENT METHOD
The present invention relates in a first aspect to compounds for use in the treatment of leukodystrophy whereby these compounds are quinoline derivatives, e.g....
2018/0250283 SELECTIVE NR2B ANTAGONISTS
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds...
2018/0250282 Novel Methyl-Piperidine Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1
The present invention provides compounds of Formula 1, or a pharmaceutically acceptable salt thereof, ##STR00001## where R, R1, and G are as described herein;...
2018/0250281 TRANSDERMAL DELIVERY OF DOXYLAMINE SUCCINATE AND PYRIDOXINE HYDROCHLORIDE
Pharmaceutical compositions for simultaneous transdermal delivery of Doxylamine and Pyridoxine comprising Doxylamine or its salts, Pyridoxine or its salts or...
2018/0250280 SUBSTITUTED OXOPYRIDINE DERIVATIVES
The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of...
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