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Patent # Description
2018/0250279 Methods for Treatment of Fabry Disease
Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological...
2018/0250278 DONEPEZIL DERIVATIVE AND USE THEREOF
The present invention relates to a donepezil derivative of general formula (I) or a pharmaceutically acceptable salt thereof, wherein R in the formula is as...
2018/0250277 POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR
The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising...
2018/0250276 Antibacterial compounds
Compounds of Formula (I), or a stereoisomer or a pharmaceutically acceptable salt thereof, their preparation, pharmaceutical compositions comprising such...
2018/0250275 MODIFIERS OF CFTR-DIRECTED THERAPY
Described herein is a genetic modifier of cystic fibrosis (CF), which may serve as a predictor of the efficacy of a CFTR-directed therapy. SNPs rs7512462 or...
2018/0250274 AGENT FOR TREATMENT OF PBC
The present invention relates to a pharmaceutical composition for the treatment of primary biliary cirrhosis (PBC), in which containing a therapeutically...
2018/0250273 SUBSTITUTED 1,2-DIHYDRO-3H-PYRROLO[1,2-c]IMIDAZOL-3-ONE ANTIBACTERIAL COMPOUNDS
The invention relates to antibacterial compounds of formula I ##STR00001## wherein M is one of the groups M.sup.A, M.sup.B and M.sup.C represented below ...
2018/0250272 PROTEIN KINASE INHIBITORS
A compound of formula (I), wherein R.sub.3, R.sub.4, G, B, M, and Z are as defined in the claims, and pharmaceutically acceptable salts thereof are disclosed....
2018/0250271 Pharmaceutical Antiretroviral Composition
A pharmaceutical composition comprises at least one integrase inhibitor or its salt, solvate, complex, hydrate, isomer, ester, tautomer, anhydrate, enantiomer,...
2018/0250270 MUSCARINIC COMBINATION AND ITS USE FOR COMBATING HYPOCHOLINERGIC DISORDERS OF THE CENTRAL NERVOUS SYSTEM
A combination of a muscarinic cholinergic receptor agonist with a non-anticholinergic antiemetic agent, and the optional addition of an acetyl choline esterase...
2018/0250269 3-(1H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINE AND THERAPEUTIC USES THEREOF
Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole...
2018/0250268 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
2018/0250267 SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
2018/0250266 COMPOSITION COMPRISING COMPOUND INHIBITING INTERACTIONS OF MBD2 AND P66A FOR ANTI-METASTASIS AND PREVENTION AND...
The present invention relates to a composition including an inhibitor against the function of an Mi-2/NuRD chromatin remodeling complex for inhibiting...
2018/0250265 METHODS AND COMPOSITIONS FOR SOFT ANTICHOLINERGIC ESTERS
Intra-oral formulations comprising soft anticholinergic alkyl esters are useful for treating excessive drooling conditions in subjects, such as humans,...
2018/0250264 COMPOSITIONS FOR IMPROVED NRF2 ACTIVATION AND METHODS OF THEIR USE
Disclosed here are compositions and methods for preventing or treating certain health conditions associated with inflammation or oxidative stress. These...
2018/0250263 THERAPEUTIC COMBINATIONS OF SESQUITERPENES AND FLAVONOIDS
Provided is a pharmaceutical formulation and a method associated therewith for treating inflammation. The pharmaceutical formulation includes therapeutically...
2018/0250262 SUSTAINED RELEASE CANNABINOID FORMULATIONS
The present invention provides modified release pharmaceutical composition comprising one or more natural or synthetic cannabinoids and one or more...
2018/0250261 METHOD FOR TREATING CANCER WITH A STAT3 PATHWAY INHIBITOR AND KINASE INHIBITOR
Methods comprising administering and kits comprising at least one compound of formula A: (A) prodrugs, derivatives, pharmaceutically acceptable salts of any of...
2018/0250260 METHODS FOR TREATING CANCER
Methods comprising administration of, and kits comprising, at least one compound of formula (I) ##STR00001## FOLFIRI, and optionally at least one angiogenesis...
2018/0250259 DENTAL COMPOSITION FOR APPLYING A PREDETERMINED DOSE OF AN AGENT TO TEETH
A therapeutic material delivered to a tooth surface in a predetermined dose. The therapeutic material is contained in an emulsion which is contained within a...
2018/0250258 REDUCED FAT, SHELF STABLE LIQUID NUTRITIONAL COMPOSITION
Liquid nutritional compositions that include functional ingredients such as beta-hydroxy-beta-methylbutyrate, docosahexaenoic acid, and lutein are disclosed....
2018/0250257 NITRATED-FATTY ACIDS MODULATION OF TYPE II DIABETES
Nitro oleic acid and related metabolites are agonists of PPAR-.gamma.. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-.gamma., relative to...
2018/0250256 LIPID FORMULATIONS CONTAINING BIOACTIVE FATTY ACIDS
Provided herein is technology relating to lipid compositions containing bioactive fatty acids and particularly, but not exclusively, to compositions and...
2018/0250255 COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATION
The present invention is directed to novel anti-inflammatory immunomodulators including creatinine or a creatinine salt, for example, creatinine hydrochloride....
2018/0250254 CREATINE ORAL SUPPLEMENTATION USING CREATINE HYDROCHLORIDE SALT
The present invention is directed to an oral supplement including creatine hydrochloride, which has an aqueous solubility that is at least 15 times greater...
2018/0250253 Glycine for Use in Tolerance Induction in Allergic Patients
The invention relates to a free glycine source for use in inducing tolerance against an allergen, or preventing the development of allergy in a human or other...
2018/0250252 POTENT PHTHALATE INHIBITORS OF ASPARTATE N-ACETYLTRANSFERASE AND SELECTIVE ASPARTATE PATHWAY INHIBITORS
Phthalate derivatives that are aspartate-P-semialdehyde dehydrogenase (ASADH) inhibitor compounds, aspartate N-acetyltransferase (ANAT) inhibitor compounds, or...
2018/0250251 Treatment of Patients with Familial Hypercholesterolemia on Lipid-Lowering Therapy
Methods for the treatment of homozygous familial hypercholesterolemia, compound heterozygous familial hypercholesterolemia, or heterozygous familial...
2018/0250250 COMPOSITIONS OF BIOACTIVE FULVATE FRACTIONS AND USES THEREOF
Compositions with fulvate fractions alone or in combination with growth factors, bioactive fragmented peptides, or combinations thereof are disclosed herein....
2018/0250249 METHODS OF TREATING NEURODEGENERATIVE DISORDERS IN A PARTICULAR POPULATION
Disclosed herein are methods for treating, ameliorating, and/or preventing Alzheimer's Disease in a specific patient population using tramiprosate,...
2018/0250248 HYPERKERATOTIC SKIN CONDITION TREATMENTS AND COMPOSITIONS
A method of treating a hyperkeratotic skin condition includes combining contents of a compounded capsule with corticosteroid cream or ointment that includes a...
2018/0250247 N,N-BIS-2-MERCAPTOETHYL ISOPHTHALAMIDE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
According to the invention there is provided N,N-bis-2-mercaptoethyl isophthalamide, or a pharmaceutically acceptable salt or derivative thereof, for use in...
2018/0250246 PAIN RELIEF COMPOSITIONS, MANUFACTURE AND USES
The present invention relates to TRPV1 selective agonist topical compositions including capsaicinoid and analgesic agent compositions and methods of...
2018/0250245 EPINEPHRINE FORMULATIONS
Pharmaceutical compositions comprising epinephrine, methods of administration, and methods of making the same. Compositions may comprise at least one of an...
2018/0250244 EXO-S-MECAMYLAMINE FORMULATION AND USE IN TREATMENT
A pharmaceutical composition includes a therapeutically effective amount of exo-S-mecamylamine or a pharmaceutically acceptable salt thereof, substantially...
2018/0250243 A PHARMACEUTICAL COMPOSITION FOR REDUCING LOCAL FAT AND USES THEREOF
The present invention provides a pharmaceutical composition for reducing localized fat, comprising drug-containing micelles made of surfactants, and curcumin...
2018/0250242 NOVEL ANALGESIC COMPOSITIONS
The present invention provides compositions useful in reducing or preventing pain in a subject in need thereof. In one embodiment, the compositions comprise a...
2018/0250241 COMPOSITIONS AND METHODS FOR THE TREATMENT OF TAUOPATHIES
Disclosed herein are compositions and methods for treating tauopathies such as Alzheimer's disease (AD). Also provided herein are methods of reducing or...
2018/0250240 METHOD OF TREATMENT AND DEVICE FOR THE IMPROVED BIOAVAILABILITY OF LEUKOTRIENE RECEPTOR ANTAGONISTS
Disclosed is a method of administration and device for the improved bioavailability of leukotriene receptor antagonists. This method and device involve an...
2018/0250239 DRUG DELIVERY SYSTEM AND METHODS OF USE
A drug delivery system (DDS) including a hydrophobic porous scaffold and a hydrogel having a hydrophilic polymer and one or more biologic drugs provides...
2018/0250238 SOLID DRUG DISPENSING APPARATUS, FORMULATIONS, AND METHODS OF USE
Embodiments provide apparatus and methods for delivering solid form medications such as drug cords (DC) to various locations in the body. The DCs may comprise...
2018/0250237 METHODS OF PREPARING STIMULI-RESPONSIVE MULTIFUNCTIONAL NANOPARTICLES
Provided is a method of preparing a stimuli-responsive multifunctional nanoparticle, including in sequence the steps of: (a) conjugating covalently an active...
2018/0250236 CONTROLLED RELEASE SYSTEM INCLUDING A GAS OR VOLATILE ENCAPSULATED IN A POLYMERIC SUPPORT AND A MATRIX SYSTEM,...
A controlled release system includes a polymeric support, wherein the polymeric support is biodegradable; a polymeric matrix, wherein the polymeric matrix...
2018/0250235 FINGOLIMOD CAPSULE COMPOSITION
The present invention relates to a pharmaceutical capsule composition comprising fingolimod or its pharmaceutically acceptable salts thereof, a cellulose...
2018/0250234 PHARMACEUTICAL FORMULATIONS OF A BRUTON'S TYROSINE KINASE INHIBITOR
Described herein are pharmaceutical formulations of Bruton's tyrosine kinase (Btk) inhibitor ...
2018/0250233 TABLETS HAVING MEDIA INDEPENDENT ACTIVE SUBSTANCE DELIVERY
The present invention relates to formulations having extended release of active ingredient, comprising an active ingredient from BCS Class I having high...
2018/0250232 PROCESS FOR PREPARING SPRAY DRIED SOLID DISPERSIONS OF ...
A process for preparing spray dried solid dispersions of (S)--N-(3-(6-isopropoxypyridin-3-yl)-1H4ndazol-5-yl)-1-(2-(4-(4-(1-methyl- ...
2018/0250231 POLYMERIC MICROSPHERES WITH SPONTANEOUS PORE-CLOSING FUNCTIONALITY AND METHODS FOR PREPARIGN THE SAME
The present invention relates to a method for preparing a polymeric microsphere and the polymeric microsphere prepared by the method, and specifically, relates...
2018/0250230 POLYMERS AND MICROSPHERES
New cationic polymers are provided that are suitable for the preparation of microspheres. The microspheres are capable of loading and eluting anionic species...
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