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Patent # Description
2018/0251797 DRIMENOL SYNTHASES II
The present invention relates to a method of producing drimenol and/or drimenol derivatives by contacting at least one polypeptide with farnesyl diphosphate....
2018/0251796 METHOD OF FERMENTATIVE ALPHA-IONONE PRODUCTION
The present invention concerns a method of producing and enantiomerically pure alpha-ionone. Further, the invention concerns a nucleic acid that comprises a...
2018/0251795 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific...
2018/0251794 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific...
2018/0251793 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific...
2018/0251792 SYSTEMS AND METHODS FOR ONE-SHOT GUIDE RNA (ogRNA) TARGETING OF ENDOGENOUS AND SOURCE DNA
Engineered nucleic acids encoding genome editing system components are provided, as are engineered RNA-guided nucleases that include inserts encoded in part by...
2018/0251791 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific...
2018/0251790 Method for Cell Line Development
The present invention relates to an improved method for cell line development which is generally applicable to production of any therapeutic protein that can...
2018/0251789 MULTILAYER GENETIC SAFETY KILL CIRCUITS BASED ON SINGLE CAS9 PROTEIN AND MULTIPLE ENGINEERED GRNA IN MAMMALIAN...
Aspects of the disclosure relate to synthetic regulatory systems composed of a multifunctional clustered regularly interspaced short palindromic repeat...
2018/0251788 ENGINEERED NUCLEIC ACID-TARGETING NUCLEIC ACIDS
The present disclosure provides engineered polynucleotide sequences that form scaffolds and nucleoprotein complexes comprising such engineered polynucleotide...
2018/0251787 CRISPR-CAS10 SYSTEMS AND METHODS FOR PHAGE GENOME EDITING
The present disclosure relates to CRISPR-Cas10 systems and methods for phage genome editing.
2018/0251786 RECOMBINANT VECTORS COMPRISING 2A PEPTIDE
This disclosure provides modified recombinant retroviruses comprisings containing a 2A-peptide or peptide-like coding sequence operably linked to a...
2018/0251785 GENE EXPRESSION SYSTEM USING ALTERNATIVE SPLICING IN INSECTS
A polynucleotide expression system is provided that is capable of alternative splicing of RNA transcripts of a polynucleotide sequence to be expressed in an...
2018/0251784 METHODS AND COMPOSITIONS FOR TARGETED GENETIC MODIFICATIONS AND METHODS OF USE
Methods and compositions are provided for generating targeted genetic modifications on the Y chromosome or a challenging target locus. Compositions include an...
2018/0251783 NON-SILENCING SELECTABLE MARKER GENES AND METHODS OF USE
Provided are nucleic acids and expression vectors having a non-silencing selectable marker gene, and methods of using the same. A subject expression vector...
2018/0251782 EXPRESSION VECTOR AND METHOD OF PREPARING A POLYPEPTIDE OF INTEREST USING THE SAME
A fusion polynucleotide including a human CMV promoter and an intron, a recombinant vector including the fusion polynucleotide and a gene encoding a...
2018/0251781 POLYEPITOPE CONSTRUCTS FOR USE IN IMMUNOTHERAPY
The present invention relates to DNA expression vector or a mixture of DNA expression vectors which encodes at least two CD4 epitopes of telomerase reverse...
2018/0251780 AXMI115 VARIANT INSECTICIDAL GENE AND METHODS FOR ITS USE
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. The toxin coding sequences can be...
2018/0251779 COPI COATOMER BETA SUBUNIT NUCLEIC ACID MOLECULES THAT CONFER RESISTANCE TO COLEOPTERAN AND HEMIPTERAN PESTS
This disclosure concerns nucleic acid molecules and methods of use thereof for control of insect pests through RNA interference-mediated inhibition of target...
2018/0251778 Glyphosate Tolerant Corn Event VCO-O1981-5 and Kit and Method for Detecting the Same
The present invention relates to the field of plant transformation with genes conferring tolerance to glyphosate. The invention particularly relates to a maize...
2018/0251777 COTTON VARIETY 16R251NRB2XF
The invention relates to the novel cotton variety designated 16R251NRB2XF. Provided by the invention are the seeds, plants, plant parts and derivatives of the...
2018/0251776 ENDOPHYTE COMPOSITIONS AND METHODS FOR IMPROVEMENT OF PLANT TRAITS
This invention relates to methods and materials for modulating the characteristics of a plant, said plant having been heterologously disposed to an endophyte...
2018/0251775 INCREASING PLANT OIL CONTENT BY ALTERING A NEGATIVE REGULATOR OF ACETYL-COA CARBOXYLASE
The present invention provides a method and means to change fatty acid and ultimately triacylglycerol production in plants and algae. Methods of the invention...
2018/0251774 Mutant xylan biosynthetic enzymes capable of dominant suppression of xylan biosynthesis
The present invention provides for a polypeptide capable of dominant suppression of a first naturally occurring IRX10, wherein the polypeptide comprises an...
2018/0251772 MICROORGANISM PRODUCING L-LEUCINE AND METHOD FOR PRODUCING L-LEUCINE USING THE SAME
The present disclosure relates to a microorganism producing L-leucine and a method for producing L-leucine using the same, and more specifically, to a...
2018/0251771 BIOSYNTHESIS OF HUMAN MILK OLIGOSACCHARIDES IN ENGINEERED BACTERIA
The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or...
2018/0251770 CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING HERPES SIMPLEX VIRUS
CRISPR/CAS-related systems, compositions and methods for editing RS1, RL2, and/or LAT genes in human cells are described, as are cells and compositions...
2018/0251769 Recombinant Influenza Virus
Disclosed herein are recombinantly engineered influenza viruses and compositions thereof.
2018/0251768 ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS
The present invention relates to antisense oligonucleotide (ASO) compositions and particularly to compositions and methods for the cytosolic delivery of...
2018/0251767 COMBINATION COMPRISING IMMUNOSTIMULATORY OLIGONUCLEOTIDES
The invention relates to a combination and its use for the treatment of diseases. The instant disclosure provides a combination of a so-called T-cell regulator...
2018/0251766 TARGETING MICRORNAS FOR METABOLIC DISORDERS
Provided herein are methods and compositions for the treatment of metabolic disorders. Also provided herein are methods and compositions for the reduction of...
2018/0251765 HIGH-THROUGHPUT SPLIT APTAMER SCREENING ASSAY
Methods and materials for development of high-throughput screening assays using split aptamers are provided by this invention.
2018/0251764 Oligonucleotide Conjugates
The invention relates to the field of oligonucleotide therapeutics, and in particular to the use of a cleavable, e.g. a phosphodiester region covalently...
2018/0251763 Compositions and Methods for Inducing Senescence in Cancer Cells
The invention relates to nucleic acid sequences as well as to modified oligonucleotides (ODNs) comprising a p52 binding site derived from the EZH2 promoter...
2018/0251762 USE OF TRINUCLEOTIDE REPEAT RNAs TO TREAT CANCER
Disclosed are compositions and methods related to RNA interference (RNAi) and the use of RNAi active sequence for treating diseases and disorders. Particular...
2018/0251761 OLIGOMERIC COMPOUNDS COMPRISING BICYCLIC NUCLEOTIDES AND USES THEREOF
The present invention provides oligomeric compounds. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including...
2018/0251760 ANTISENSE NUCLEIC ACID FOR TREATING AMYOTROPHY
There has been a demand for a novel antisense nucleic acid or the like capable of inhibiting myostatin at the mRNA level. The present invention provides a specific...
2018/0251759 AMINO ACID-MODIFIED NUCLEIC ACID AND UTILIZATION THEREOF
Provided is a method for synthesizing a protein, into which a nucleobase amino acid (NBA) is introduced at a desired position, that comprises: a step for...
2018/0251758 Microarray Based Multiplex Pathogen Analysis and Uses Thereof
Provided herein is a 3-dimensional lattice microarray system for DNA sequence detection and analysis. The system has a plurality of bifunctional polymer...
2018/0251757 Capture Methodologies for Circulating Cell Free DNA
A nucleic acid patch method for amplifying target nucleic acid sequences in circulating free DNA or residual DNA samples where the defining ends of the target...
2018/0251756 TEMPLATE DIRECTED SPLIT AND MIX SYNTHESIS OF SMALL MOLECULE LIBRARIES
The invention combines the advantages of split and mix synthesis with the advantages of template directed synthesis. The method comprises the steps of: a)...
2018/0251755 Methods For Purification of Messenger RNA
The present invention relates, in part, to methods for large-scale purification of mRNA. The method includes, at least, steps of forming an mRNA slurry,...
2018/0251754 METHODS FOR PURIFICATION OF MESSENGER RNA
The present invention relates, in part, to methods for large-scale purification of mRNA. The method includes, at least, a step of centrifuging an mRNA...
2018/0251753 ELECTROPORATION-INDUCED ELECTROSENSITIZATION
Methods of enhancing membrane permeabilization in a cell are provided. A method includes disposing the cell between a first electrode and a second electrode...
2018/0251752 PHOSPHOLIPID NANOGEL FOR ENZYME STABILIZATION
Described herein are phospholipid nanogels that can contain a low concentration (less than about 250 .mu.Units/.mu.L) of an exoglycosidase enzyme. Also...
2018/0251751 NON-NATURAL AMINO ACID tRNA SYNTHETASES FOR PYRIDYL TETRAZINE
The invention provides methods and compositions for a mutein aminoacyl-tRNA synthetase that preferentially charges a tRNA with a non-natural amino acid. Also...
2018/0251750 MUTATIONS IN IRON-SULFUR CLUSTER PROTEINS THAT IMPROVE XYLOSE UTILIZATION
There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron...
2018/0251749 Fructose to Allulose Conversion
The present disclosure describes a method of producing allulose from fructose with a novel psicose-3-epimerase enzyme from a Burkholderia species. Once...
2018/0251748 Arginine Deiminase Mutant with Improved Enzyme Activity and Temperature Stability and Application Thereof
An arginine deiminase mutant with improved enzyme activity and temperature stability and application thereof were provided, belonging to the technical field of...
2018/0251747 VARIANTS OF CHYMOSIN WITH IMPROVED PROPERTIES
Variants of chymosin with improved .alpha. S1-casein cleavage and C/P properties.
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