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Patent # Description
2018/0251544 ANTI-HUMAN FOLATE RECEPTOR BETA ANTIBODIES AND METHODS OF USE
Human anti-human folate receptor beta antibodies and antigen-binding fragments thereof are described, as well as method of using such antibodies and fragments...
2018/0251543 POLYNUCLEOTIDES ENCODING MONOCLONAL ANTIBODIES THAT BIND BOTH IL-17A AND IL-17F
The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are...
2018/0251542 Anti-IL-33 Antibodies and Uses Thereof
The present invention provides antibodies that bind to interleukin-33 (IL-33) and methods of using the same. The invention includes antibodies that inhibit or...
2018/0251541 TREATING INFLAMMATION WITH IL-17/IL-23 BISPECIFIC ANTIBODIES
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include...
2018/0251540 HUMAN MONOCLONAL ANTIBODIES AGAINST INTERLEUKIN 8 (IL-8)
Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or...
2018/0251539 BIOPHARMACEUTICAL COMPOSITIONS
The present disclosure relates to compositions, for treating interleukin 5 (IL-5) mediated diseases, and related methods.
2018/0251538 NOVEL ANTI-IL13 ANTIBODIES AND USES THEREOF
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does...
2018/0251537 ANTI-INTERLEUKIN ANTIBODY PREPARATIONS FOR DELIVERY INTO A LUMEN OF THE INTESTINAL TRACT USING A SWALLOWABLE...
Embodiments of the invention provide swallowable devices, preparations and methods for delivering therapeutic agents within the GI tract such as neutralizing...
2018/0251536 TUMOR THERAPY WITH AN ANTI-VEGF ANTIBODY
The present invention provides a method of treating a patient suffering from relapsed HER2 positive cancer with an anti-VEGF antibody during or after treatment...
2018/0251534 POLYPEPTIDES COMPRISING A MODIFIED BACTERIOPHAGE G3P AMINO ACID SEQUENCE WITH REDUCED IMMUNOGENICITY
The invention relates to polypeptides that comprise a portion of filamentous bacteriophage gene 3 protein (g3p) sufficient to bind to and/or disaggregate...
2018/0251533 METHODS AND COMPOSITIONS FOR MODULATING MONOCYTE POPULATIONS AND RELATED USES THEREOF
Method and compositions for modulating specific populations of monocytes or macrophages are disclosed. Methods include, in certain embodiments, modulating...
2018/0251532 SYNTHETIC ANTIBODIES TO BAX AND USES THEREOF
Synthetic fragment antigen-binding (Fab) antibodies are disclosed that bind to an N-terminal activation site of BCL-2-associated X-protein (BAX) and inhibit...
2018/0251531 FLAVIVIRUS NEUTRALIZING ANTIBODIES AND METHODS OF USE THEREOF
The present invention provides antibodies that neutralize flavivirus and methods of use thereof. These antibodies are derived from mAb11 which recognizes West...
2018/0251530 ANTI-HIV DUAL SPECIFICITY ANTIBODIES AND METHODS OF HIV TREATMENT
Dual variable domain immunoglobulins (DVD Igs) are provided capable of tetravalent binding to bispecific sites of the human immunodeficiency virus (HIV). The...
2018/0251529 COMPOSITE COMPRISING ANTIBODY CAPABLE OF BINDING TO INTRANUCLEAR PROTEIN OF INFLUENZA VIRUS
The present invention provides a composite comprising a novel antibody and at least one selected from the group consisting of a solid phase support and a...
2018/0251528 COMPOSITE COMPRISING ANTIBODY CAPABLE OF BINDING TO INTRANUCLEAR PROTEIN OF INFLUENZA VIRUS
The present invention provides a composite comprising a novel antibody and at least one selected from the group consisting of a solid phase support and a...
2018/0251527 SINGLE-DOMAIN VHH ANTIBODIES DIRECTED TO NOROVIRUS GI.1 AND GII.4 AND THEIR USE
Isolated V.sub.HH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I...
2018/0251526 ANTI-RSV MONOCLONAL ANTIBODY FORMULATION
The present invention provides a formulation comprising: (i) an anti-RSV monoclonal antibody; and (ii) an ionic excipient; wherein the monoclonal antibody is...
2018/0251525 PREVENTION OF N-TERMINAL TRUNCATION IN IGG LIGHT CHAINS
We discovered that recombinant antibody light chains having a murine secretory leader sequence and an SYE motif at the N-terminus are truncated during...
2018/0251524 EpCAM TARGETED POLYPEPTIDES, CONJUGATES THEREOF, AND METHODS OF USE THEREOF
Certain embodiments of the invention provide epithelial cell adhesion molecule (EpCAM) binding polypeptides, as well as conjugates and CSANs comprising such...
2018/0251523 CCR2 ANTAGONIST PEPTIDES
The invention relates to a peptide comprising the following amino acid sequence useful as a CCR2 non competitive antagonist peptide.
2018/0251522 IL-22BP COMPOSITIONS AND METHOD FOR THE TREATMENT OF DISEASE THEREWITH
Provided herein are compositions comprising interleukin-22 binding protein (IL-22BP) fusion proteins, and methods of using such fusions to inhibit IL-22 and...
2018/0251521 DE NOVO BINDING DOMAIN CONTAINING POLYPEPTIDES AND USES THEREOF
Provided herein are de novo binding domain containing polypeptides (DBDpp) that specifically bind a target of interest. Nucleic acids encoding the DBDpp, and...
2018/0251520 Novel peptides and combination of peptides for use in immunotherapy and methods for generating scaffolds for...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0251519 Novel peptides and combination of peptides for use in immunotherapy and methods for generating scaffolds for...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0251518 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0251517 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0251516 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST ESOPHAGEAL CANCER AND OTHER CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0251515 B7-H5, A Costimulatory Polypeptide
B7-H5 costimulatory polypeptides, nucleic acids encoding such polypeptides, and methods for using the polypeptides and nucleic acids to enhance a T cell...
2018/0251514 COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING FUSION PROTEINS
Provided herein are T-cell receptor (TCR) fusion proteins (TFPs), T-cells engineered to express one or more TFPs, and methods of use thereof for the treatment...
2018/0251513 T CELL RECEPTOR
The present invention provides an engineered T cell receptor (TCR) comprising at least one of the following amino acid residues: L96 of the .alpha. chain; R9...
2018/0251512 Double-Acylated GLP-1 Derivatives
The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 27 of GLP-1(7-37)...
2018/0251511 PROCESS FOR THE PREPARATION OF LIRAGLUTIDE
The present invention relates to a process for the preparation of Liraglutide, which comprises: a) synthesis of suitable fragments (protected) by solid phase...
2018/0251510 LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING AND ADMINISTERING SAME
A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human...
2018/0251509 SINGLE-CHAIN LIGHT RECEPTOR AGONIST PROTEINS
Provided herein are specific LIGHT receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a LIGHT-associated...
2018/0251508 AAV-EPO FOR TREATING COMPANION ANIMALS
Compositions and methods are provided for treating companion animals are provided. An adeno-associated viral vector is provided which includes a nucleic acid...
2018/0251507 Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0251506 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST OVARIAN CANCER AND OTHER CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0251505 KERATIN-BASED HYDROGELS
Keratin-based hydrogels and aqueous compositions and methods for forming the hydrogels and compositions are described. The compositions include solubilized...
2018/0251504 METHOD FOR EFFICIENTLY PRODUCING MYOSIN HEAVY CHAIN IN CARDIAC MUSCLE CELLS DIFFERENTIATED FROM INDUCED...
The present invention provides a method for producing a .beta. myosin heavy chain in cardiac muscle cells differentiated from induced pluripotent stem cells...
2018/0251503 MULTIMERIZATION TECHNOLOGIES
The present invention provides, among other things, dimeric multispecific binding agents (e.g., fusion proteins comprising antibody components) that have...
2018/0251502 COLON DISEASE TARGETS AND USES THEREOF
The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or...
2018/0251501 Molded Article and Method for Producing Molded Article
Provided is a molded article of a composition comprising a polypeptide which has more than 4.3 GPa of a bending elastic modulus and transparency.
2018/0251500 pH-RESPONSIVE PROTEOLYSIS PROBE
The present invention provides a tool which exhibits excellent properties in the quantification of autophagy activity. A unimolecular FRET probe of the present...
2018/0251499 Corynebacterium SP. Microorganisms having L-Lysine-Producing Ability and Method for Producing L-Lysine using Same
The present invention relates to an L-lysine-producing microorganism of the genus Corynebacterium and a method for producing L-lysine using the same.
2018/0251498 FLAGELLIN COMPOSITIONS AND USES
The present invention relates to compositions comprising improved flagellin derived constructs and methods of using the same in the treatment of various diseases.
2018/0251497 DISORDERED PROTEIN-BASED SEEDS FOR MOLECULAR CLUSTERING
A system and method for reversibly controlling clustering of proteins around an engineered multivalent nucleus is disclosed. The system and method utilize...
2018/0251496 OXADIAZOLE CYCLIC PEPTIDES
The present invention relates to cyclic amino acid molecules, in particular 1,3,4-oxadiazole containing macrocyclic peptides, and a process to produce the...
2018/0251495 Skin-Penetrating Peptides and Compositions and Methods of Use Thereof
Skin penetrating polypeptide and pharmaceutical compositions and methods of use thereof are provided. Typically, the peptides are between 3 and 100 amino...
2018/0251494 PEPTIDE COMPOUNDS TO REGULATE THE COMPLEMENT SYSTEM
The present invention provides peptide compounds that regulate the complement system and methods of using these compounds. The invention is an isolated,...
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