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| Patent # | Description |
|---|---|
| 2018/0251493 |
P3 PEPTIDYLIC INHIBITORS FOR TREATING CAG-REPEAT RNA TOXICITY IN
POLYGLUTAMINE DISEASES The present invention provides for novel peptide inhibitors and methods for treating polyglutamine (polyQ) diseases. Also disclosed are related compositions... |
| 2018/0251492 |
ANTI-ENDOTOXIN POLYPEPTIDE An anti-endotoxin polypeptide is provided. The anti-endotoxin polypeptide having the formula (I) A.sub.1-L-C.sub.1, wherein A.sub.1 and C.sub.1 independently... |
| 2018/0251491 |
Peptide Inhibitors of Telomerase Translocation and Therapeutic Uses
Thereof This disclosure provides compositions and methods for treating or preventing cardiac or vascular toxicity in a subject receiving a chemotherapeutic agent,... |
| 2018/0251490 |
ADVANTAGEOUS MU-OPIATE RECEPTOR PEPTIDE COMPOUNDS The subject invention provides advantageous new salts of mu-opiate receptor peptides. These salts have been found to have excellent properties in terms of... |
| 2018/0251489 |
MALT1 INHIBITORS AND USES THEREOF Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the... |
| 2018/0251488 |
CROSSLINKED NUCLEIC ACID GUNA, METHOD FOR PRODUCING SAME, AND INTERMEDIATE
COMPOUND The present invention provides a method for producing guanidine crosslinked artificial nucleic acid (abbreviated hereinafter as GuNA), and an intermediate... |
| 2018/0251487 |
SPINOSYN DERIVATIVES AS INSECTICIDES Compositions including derivatives of spinosyns and methods for the production of derivatives of spinosyns are provided. The spinosyn derivatives described... |
| 2018/0251486 |
LINCOMYCIN BIOSYNTHETIC INTERMEDIATES, METHOD FOR PREPARATION, AND USE
THEREOF Provided in the present invention are a class of Lincomycin biosynthetic intermediates and a preparation method and use thereof. Specifically provided are... |
| 2018/0251485 |
PYRAZOLOTRIAZOLYL NUCLEOSIDE ANALOGUES AND OLIGONUCLEOTIDES COMPRISING
THEM The present invention relates to pyrazolotriazolyl nucleoside analogues, oligonucleotide comprising them, and uses thereof. Further the invention relates to a... |
| 2018/0251484 |
ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE
ORGANOMETALLIC COMPOUND, AND DIAGNOSTIC... An organometallic compound represented by Formula 1: ##STR00001## wherein in Formula 1, groups and variables are the same as described in the specification. |
| 2018/0251483 |
THIOCYANATE SALTS FOR ANTI-INFLAMMATION Described herein, inter alia, are thiocyanate salt compositions and methods for treating or preventing inflammation using the same. |
| 2018/0251482 |
FORMS OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL)PYRIDIN-5-YL)-3-FLUOROPHENYL)-5-
-HYDROXYMETHYL OXAZOLIDIN-2-ONE... A crystalline form of crystalline (R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-5-hydro- xymethyl oxazolidin-2-one dihydrogen phosphate,... |
| 2018/0251481 |
PROCESS FOR PRODUCING PHOSPHORUS-CONTAINING CYANOHYDRIN ESTERS The present invention primarily relates to a process for producing certain phosphorus-containing cyanohydrin esters of formula (I) and the use thereof for... |
| 2018/0251480 |
PROCESS FOR PRODUCING PHOSPHORUS-CONTAINING CYANOHYDRIN ESTERS The present invention primarily relates to a process for producing certain phosphorus-containing cyanohydrin esters of formula (I) and the use thereof for... |
| 2018/0251479 |
INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: ##STR00001## where R.sup.1, R.sup.2, R.sup.3, R.sup.4,... |
| 2018/0251478 |
COMPOUNDS AS STIMULI-RESPONSIVE PROBES, METHODS AND APPLICATIONS THEREOF The present disclosure relates to the field of synthetic pharmaceutical chemistry and biology. The disclosure provides a compound of Formula I and a process of... |
| 2018/0251477 |
METHOD FOR INDUCING CYTOTOXICITY IN CANCER CELLS A method for treating a proliferative disease, disorder, or condition comprising administering a gold(III) complex such as [Au(npen)Cl.sub.2]Cl.2H.sub.2O (1)... |
| 2018/0251476 |
Oxadiazolopyridine Derivatives for Use as Ghrelin O-Acyl Transferase
(GOAT) Inhibitors The present invention relates to compounds of general formula I, ##STR00001## wherein the groups R.sup.1, R.sup.2 and n are defined as in claim 1, which have... |
| 2018/0251475 |
HETEROCYCLIC COMPOUNDS AND USES THEREOF The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the... |
| 2018/0251474 |
METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors. |
| 2018/0251473 |
COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING
SAME, AND ELECTRONIC DEVICE... The present invention provides a novel compound capable of improving the light emitting efficiency, stability and life span of a device, and an organic... |
| 2018/0251472 |
Compound Having Effect Of Inhibiting Platelet Aggregation And Salt
Thereof, And Composition For Preventing Or... The present invention relates to a novel compound having an effect of inhibiting platelet aggregation and a salt thereof and, more specifically, to: a novel... |
| 2018/0251471 |
COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 The present invention relates to compounds of formula I: ##STR00001## in which X.sub.1, X.sub.2, X.sub.3, Y.sub.1, Y.sub.2, Y.sub.3, R.sub.1, R.sub.2,... |
| 2018/0251470 |
1,5-DISUBSTITUTED 1,2,3-TRIAZOLES ARE INHIBITORS OF RAC/CDC42 GTPASES Compounds are disclosed that inhibit RhoGTPases that are useful for inhibiting hyperprofilerative and neoplastic diseases. Specifically, the compounds inhibit... |
| 2018/0251469 |
Carbon Dioxide Sensing Compounds Compounds, in particular compounds including a metal phthalocycanine, are embodied as carbon dioxide sensing compounds. A sensitivity of the metal ... |
| 2018/0251468 |
Ionic Liquid, Lubricating Agent, and Magnetic Recording Medium A lubricating agent including an ionic liquid formed from a Bronsted acid (HX) and a Bronsted base (B), wherein the Bronsted base has a linear hydrocarbon... |
| 2018/0251467 |
NOVEL COMPOUNDS AND USES THEREOF The present invention provides novel compounds of any one of Formulae (I)-(IV), and pharmaceutical compositions thereof. Also provided are particles (e.g.,... |
| 2018/0251466 |
SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS BRUTON'S TYROSINE KINASE
MODULATORS The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed... |
| 2018/0251465 |
AMINOPYRIDAZINONE COMPOUNDS AS PROTEIN KINASE INHIBITORS The present disclosure provides a compound of formula (I) and the use thereof for the therapeutic treatment of human cancers including B-cell lymphoma and... |
| 2018/0251464 |
INHIBITORS OF BRUTON'S TYROSINE KINASE Provided are forms of 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-di- hydro-8H-purin-8-one, compositions thereof, methods for their... |
| 2018/0251463 |
IBRUTINIB SOLID FORMS AND PRODUCTION PROCESS THEREFOR Provided are ibrutinib polymorphs, e.g., crystalline ibrutinib Forms III, IV, V, VI, VII, VIII and Form IX and processes for producing these crystalline forms,... |
| 2018/0251462 |
DOSAGE FORM COMPOSITIONS COMPRISING AN INHIBITOR OF BRUTON'S TYROSINE
KINASE The invention relates generally to pharmaceutical tablet compositions comprising fumaric acid and the compound ... |
| 2018/0251461 |
METHODS AND REAGENTS FOR RADIOLABELING The present invention provides methods for radiolabeling compounds useful as Hsp90 inhibitors. The present invention also provides intermediates useful in such... |
| 2018/0251460 |
COMPOUNDS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection. |
| 2018/0251459 |
COMPOSITIONS COMPRISING MACROCYCLE DERIVATIVES INCORPORATING BRIDGED
MACROCYCLES AND METHODS OF PRODUCING AND... Compositions are disclosed herein that include macrocycle derivatives incorporating bridged macrocycles. Also disclosed are methods of producing and using the... |
| 2018/0251458 |
HISTONE DEMETHYLASE INHIBITORS The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine... |
| 2018/0251457 |
COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions... |
| 2018/0251456 |
HETEROCYCLIC CONSTRAINED TRICYCLIC SULFONAMIDES AS ANTI-CANCER AGENTS A genus of arylsulfonamide derivatives of heterocyclic constrained tricyclic compounds is disclosed. The compounds are of the following genus: ##STR00001## ... |
| 2018/0251455 |
INDOLIN-2-ONE DERIVATIVES The present invention is concerned with indolin-2-one derivatives of general formula ##STR00001## wherein A is phenyl or a six membered heteroaryl group, ... |
| 2018/0251454 |
DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL Provided herein are compounds which intercalate into the DNA of a cell and are capable of crossing the blood brain barrier of a formula provided herein.... |
| 2018/0251453 |
COMPOUNDS This invention relates to compounds, as defined in the specification, useful in the treatment of mycoses, to compositions containing them and to their use in... |
| 2018/0251452 |
CRYSTALLINE PHARMACEUTICAL AND METHODS OF PREPARATION AND USE THEREOF Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed.... |
| 2018/0251451 |
INDOLIN-2-ONE DERIVATIVES The present invention is concerned with indolin-2-one derivatives of general formula ##STR00001## wherein A is phenyl or a six membered heteroaryl group,... |
| 2018/0251450 |
INDOLIN-2-ONE DERIVATIVES The present invention is concerned with indolin-2-one derivatives of general formula ##STR00001## wherein the substituents are defined in claim 1. The compounds... |
| 2018/0251449 |
INDOLIN-2-ONE DERIVATIVES The present invention is concerned with indolin-2-one derivatives of general formula ##STR00001## wherein the substituents are defined in claim 1. The compounds... |
| 2018/0251448 |
METHOD FOR REMOVING DIMETHOXYBENZYL GROUP In a method for producing a de-dimethoxybenzylated compound by removing a dimethoxybenzyl group from a compound containing a dimethoxybenzyl group bonded to a... |
| 2018/0251447 |
AMIDE-SUBSTITUTED PYRIDINYLTRIAZOLE DERIVATIVES AND USES THEREOF The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to... |
| 2018/0251446 |
Novel Carboxylic Acid Compounds Useful for Inhibiting Microsomal
Prostaglandin E2 Synthase-1 The present invention provides compounds of Formula 1, or a pharmaceutically acceptable salts, thereof, where R, X, A, E, and G are as described herein,... |
| 2018/0251445 |
1-SULFONYL PIPERIDINE DERIVATIVES AS MODULATORS OF PROKINETICIN RECEPTORS The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof ##STR00001## in which m, n, W, X, Y, Z, R.sup.1, R.sup.2,... |
| 2018/0251443 |
METHOD OF TREATING OR PREVENTING RAS-MEDIATED DISEASES Disclosed are compounds, for example, a compound of formula I, wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y', and E are as described herein, pharmaceutical... |
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