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Patent # Description
2018/0251493 P3 PEPTIDYLIC INHIBITORS FOR TREATING CAG-REPEAT RNA TOXICITY IN POLYGLUTAMINE DISEASES
The present invention provides for novel peptide inhibitors and methods for treating polyglutamine (polyQ) diseases. Also disclosed are related compositions...
2018/0251492 ANTI-ENDOTOXIN POLYPEPTIDE
An anti-endotoxin polypeptide is provided. The anti-endotoxin polypeptide having the formula (I) A.sub.1-L-C.sub.1, wherein A.sub.1 and C.sub.1 independently...
2018/0251491 Peptide Inhibitors of Telomerase Translocation and Therapeutic Uses Thereof
This disclosure provides compositions and methods for treating or preventing cardiac or vascular toxicity in a subject receiving a chemotherapeutic agent,...
2018/0251490 ADVANTAGEOUS MU-OPIATE RECEPTOR PEPTIDE COMPOUNDS
The subject invention provides advantageous new salts of mu-opiate receptor peptides. These salts have been found to have excellent properties in terms of...
2018/0251489 MALT1 INHIBITORS AND USES THEREOF
Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the...
2018/0251488 CROSSLINKED NUCLEIC ACID GUNA, METHOD FOR PRODUCING SAME, AND INTERMEDIATE COMPOUND
The present invention provides a method for producing guanidine crosslinked artificial nucleic acid (abbreviated hereinafter as GuNA), and an intermediate...
2018/0251487 SPINOSYN DERIVATIVES AS INSECTICIDES
Compositions including derivatives of spinosyns and methods for the production of derivatives of spinosyns are provided. The spinosyn derivatives described...
2018/0251486 LINCOMYCIN BIOSYNTHETIC INTERMEDIATES, METHOD FOR PREPARATION, AND USE THEREOF
Provided in the present invention are a class of Lincomycin biosynthetic intermediates and a preparation method and use thereof. Specifically provided are...
2018/0251485 PYRAZOLOTRIAZOLYL NUCLEOSIDE ANALOGUES AND OLIGONUCLEOTIDES COMPRISING THEM
The present invention relates to pyrazolotriazolyl nucleoside analogues, oligonucleotide comprising them, and uses thereof. Further the invention relates to a...
2018/0251484 ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE ORGANOMETALLIC COMPOUND, AND DIAGNOSTIC...
An organometallic compound represented by Formula 1: ##STR00001## wherein in Formula 1, groups and variables are the same as described in the specification.
2018/0251483 THIOCYANATE SALTS FOR ANTI-INFLAMMATION
Described herein, inter alia, are thiocyanate salt compositions and methods for treating or preventing inflammation using the same.
2018/0251482 FORMS OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL)PYRIDIN-5-YL)-3-FLUOROPHENYL)-5- -HYDROXYMETHYL OXAZOLIDIN-2-ONE...
A crystalline form of crystalline (R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-5-hydro- xymethyl oxazolidin-2-one dihydrogen phosphate,...
2018/0251481 PROCESS FOR PRODUCING PHOSPHORUS-CONTAINING CYANOHYDRIN ESTERS
The present invention primarily relates to a process for producing certain phosphorus-containing cyanohydrin esters of formula (I) and the use thereof for...
2018/0251480 PROCESS FOR PRODUCING PHOSPHORUS-CONTAINING CYANOHYDRIN ESTERS
The present invention primarily relates to a process for producing certain phosphorus-containing cyanohydrin esters of formula (I) and the use thereof for...
2018/0251479 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS
Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: ##STR00001## where R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
2018/0251478 COMPOUNDS AS STIMULI-RESPONSIVE PROBES, METHODS AND APPLICATIONS THEREOF
The present disclosure relates to the field of synthetic pharmaceutical chemistry and biology. The disclosure provides a compound of Formula I and a process of...
2018/0251477 METHOD FOR INDUCING CYTOTOXICITY IN CANCER CELLS
A method for treating a proliferative disease, disorder, or condition comprising administering a gold(III) complex such as [Au(npen)Cl.sub.2]Cl.2H.sub.2O (1)...
2018/0251476 Oxadiazolopyridine Derivatives for Use as Ghrelin O-Acyl Transferase (GOAT) Inhibitors
The present invention relates to compounds of general formula I, ##STR00001## wherein the groups R.sup.1, R.sup.2 and n are defined as in claim 1, which have...
2018/0251475 HETEROCYCLIC COMPOUNDS AND USES THEREOF
The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the...
2018/0251474 METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
2018/0251473 COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING SAME, AND ELECTRONIC DEVICE...
The present invention provides a novel compound capable of improving the light emitting efficiency, stability and life span of a device, and an organic...
2018/0251472 Compound Having Effect Of Inhibiting Platelet Aggregation And Salt Thereof, And Composition For Preventing Or...
The present invention relates to a novel compound having an effect of inhibiting platelet aggregation and a salt thereof and, more specifically, to: a novel...
2018/0251471 COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2
The present invention relates to compounds of formula I: ##STR00001## in which X.sub.1, X.sub.2, X.sub.3, Y.sub.1, Y.sub.2, Y.sub.3, R.sub.1, R.sub.2,...
2018/0251470 1,5-DISUBSTITUTED 1,2,3-TRIAZOLES ARE INHIBITORS OF RAC/CDC42 GTPASES
Compounds are disclosed that inhibit RhoGTPases that are useful for inhibiting hyperprofilerative and neoplastic diseases. Specifically, the compounds inhibit...
2018/0251469 Carbon Dioxide Sensing Compounds
Compounds, in particular compounds including a metal phthalocycanine, are embodied as carbon dioxide sensing compounds. A sensitivity of the metal ...
2018/0251468 Ionic Liquid, Lubricating Agent, and Magnetic Recording Medium
A lubricating agent including an ionic liquid formed from a Bronsted acid (HX) and a Bronsted base (B), wherein the Bronsted base has a linear hydrocarbon...
2018/0251467 NOVEL COMPOUNDS AND USES THEREOF
The present invention provides novel compounds of any one of Formulae (I)-(IV), and pharmaceutical compositions thereof. Also provided are particles (e.g.,...
2018/0251466 SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS BRUTON'S TYROSINE KINASE MODULATORS
The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed...
2018/0251465 AMINOPYRIDAZINONE COMPOUNDS AS PROTEIN KINASE INHIBITORS
The present disclosure provides a compound of formula (I) and the use thereof for the therapeutic treatment of human cancers including B-cell lymphoma and...
2018/0251464 INHIBITORS OF BRUTON'S TYROSINE KINASE
Provided are forms of 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-di- hydro-8H-purin-8-one, compositions thereof, methods for their...
2018/0251463 IBRUTINIB SOLID FORMS AND PRODUCTION PROCESS THEREFOR
Provided are ibrutinib polymorphs, e.g., crystalline ibrutinib Forms III, IV, V, VI, VII, VIII and Form IX and processes for producing these crystalline forms,...
2018/0251462 DOSAGE FORM COMPOSITIONS COMPRISING AN INHIBITOR OF BRUTON'S TYROSINE KINASE
The invention relates generally to pharmaceutical tablet compositions comprising fumaric acid and the compound ...
2018/0251461 METHODS AND REAGENTS FOR RADIOLABELING
The present invention provides methods for radiolabeling compounds useful as Hsp90 inhibitors. The present invention also provides intermediates useful in such...
2018/0251460 COMPOUNDS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION
The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.
2018/0251459 COMPOSITIONS COMPRISING MACROCYCLE DERIVATIVES INCORPORATING BRIDGED MACROCYCLES AND METHODS OF PRODUCING AND...
Compositions are disclosed herein that include macrocycle derivatives incorporating bridged macrocycles. Also disclosed are methods of producing and using the...
2018/0251458 HISTONE DEMETHYLASE INHIBITORS
The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine...
2018/0251457 COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES
Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions...
2018/0251456 HETEROCYCLIC CONSTRAINED TRICYCLIC SULFONAMIDES AS ANTI-CANCER AGENTS
A genus of arylsulfonamide derivatives of heterocyclic constrained tricyclic compounds is disclosed. The compounds are of the following genus: ##STR00001## ...
2018/0251455 INDOLIN-2-ONE DERIVATIVES
The present invention is concerned with indolin-2-one derivatives of general formula ##STR00001## wherein A is phenyl or a six membered heteroaryl group, ...
2018/0251454 DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL
Provided herein are compounds which intercalate into the DNA of a cell and are capable of crossing the blood brain barrier of a formula provided herein....
2018/0251453 COMPOUNDS
This invention relates to compounds, as defined in the specification, useful in the treatment of mycoses, to compositions containing them and to their use in...
2018/0251452 CRYSTALLINE PHARMACEUTICAL AND METHODS OF PREPARATION AND USE THEREOF
Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed....
2018/0251451 INDOLIN-2-ONE DERIVATIVES
The present invention is concerned with indolin-2-one derivatives of general formula ##STR00001## wherein A is phenyl or a six membered heteroaryl group,...
2018/0251450 INDOLIN-2-ONE DERIVATIVES
The present invention is concerned with indolin-2-one derivatives of general formula ##STR00001## wherein the substituents are defined in claim 1. The compounds...
2018/0251449 INDOLIN-2-ONE DERIVATIVES
The present invention is concerned with indolin-2-one derivatives of general formula ##STR00001## wherein the substituents are defined in claim 1. The compounds...
2018/0251448 METHOD FOR REMOVING DIMETHOXYBENZYL GROUP
In a method for producing a de-dimethoxybenzylated compound by removing a dimethoxybenzyl group from a compound containing a dimethoxybenzyl group bonded to a...
2018/0251447 AMIDE-SUBSTITUTED PYRIDINYLTRIAZOLE DERIVATIVES AND USES THEREOF
The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to...
2018/0251446 Novel Carboxylic Acid Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1
The present invention provides compounds of Formula 1, or a pharmaceutically acceptable salts, thereof, where R, X, A, E, and G are as described herein,...
2018/0251445 1-SULFONYL PIPERIDINE DERIVATIVES AS MODULATORS OF PROKINETICIN RECEPTORS
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof ##STR00001## in which m, n, W, X, Y, Z, R.sup.1, R.sup.2,...
2018/0251443 METHOD OF TREATING OR PREVENTING RAS-MEDIATED DISEASES
Disclosed are compounds, for example, a compound of formula I, wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y', and E are as described herein, pharmaceutical...
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