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Patent # Description
2018/0305390 C,O-SPIRO ARYL GLYCOSIDE COMPOUNDS, PREPARATION THEREFOR AND USE THEREOF
C, O-spiro aryl glycoside compounds are provided. Specifically provided are C, O-spiro aryl glycoside compounds represented by the formula (I), wherein the...
2018/0305389 BRANCHED ALCOHOL-BASED SUGAR SURFACTANTS
Prepare a branched alcohol-based sugar surfactant by: (a) providing an ether alcohol and a fully acetylated sugar where the ether alcohol has the structure of...
2018/0305388 CRYSTAL OF 6'-SIALYLLACTOSE SODIUM SALT, AND PROCESS FOR PRODUCING SAME
An object of the present invention is to provide a crystal of 6'-sialyllactose (hereinafter, referred to as 6SL) sodium salt, which is easily handled, and has...
2018/0305387 METHOD OF MAKING COBALT AND PLATINUM BASED SURFACTANTS AND USING FOR CANCER THERAPY
A method of making benzidine hydrogen selenite complex with Cobalt and Platinum as surfactants is discussed. The resultant benzidine hydrogen selenite complex...
2018/0305386 ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME, AND DIAGNOSTIC COMPOSITION INCLUDING...
An organometallic compound represented by Formula 1: ##STR00001## wherein in Formula 1, A.sub.1 to A.sub.4, M, and T.sub.1 to T.sub.3 are the same as described...
2018/0305385 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICE
A compound having a formula: ##STR00001## Formula I useful as emitters in OLEDs is disclosed.
2018/0305384 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
An organometallic complex including a ligand L.sub.A having a structure represented by one of the following formulas ##STR00001## useful as emitters in OLEDs is...
2018/0305383 KINASE INHIBITORS
There are provided compounds of: ##STR00001## wherein T, A, Q, Z, R.sup.4, R.sup.5a, R.sup.5b, n, r, Het.sup.1 and R.sup.x have meanings given in the...
2018/0305382 HYDROGENATION OF ESTERS WITH FE/TRIDENTATE LIGANDS COMPLEXES
The present invention relates to certain iron complexes that have utility in the field of catalytic hydrogenation and, more particularly, to certain iron...
2018/0305381 STEREORETENTIVE CROSS-COUPLING OF BORONIC ACIDS
The present disclosure provides tri-orthoalkylphenyl phosphine catalysts that are tuned electrically and sterically. Method of using the catalyst for...
2018/0305380 PROTEASOME INHIBITORS
The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the...
2018/0305379 PREPARATION METHOD BASED ON SIMULTANEOUS PACKAGE OF TARGET SUBSTANCE AND SYNTHESIS OF MOFS WITH REDOX ACTIVITY
A preparation method based on simultaneous package of a target substance and synthesis of MOFs with redox activity, wherein methylene blue is selected as an...
2018/0305378 METAL ION COMPLEXES
The present invention provides a process for the preparation of metal ion complexes, the process comprising contacting a metal in the form of particles with a...
2018/0305377 EPIDITHIODIOXOPIPERAZINE COMPOUND OR ITS DERIVATIVES, AND THE USE THEREOF
The present invention relates to an epidithiodioxopiperazine derivative represented by the following Chemical Formula 1 or its reduced derivative; a method for...
2018/0305376 IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR4 (PAR4) INHIBITORS FOR...
The present invention provides thiazole compounds of Formula I wherein W, Y, R.sup.0, R.sup.2, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X.sup.1, X.sup.2, X.sup.3...
2018/0305375 ARYL, HETEROARYL, AND HETEROCYCLIC COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS
Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or...
2018/0305374 HETEROCYCLE-SUBSTITUTED BICYCLIC AZOLE PESTICIDES
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein Q is ##STR00002## and A,...
2018/0305373 ALPHA HELIX MIMETICS AND METHODS RELATING THERETO
Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the...
2018/0305372 USE OF ASARININ IN PREPARATION OF MEDICINES FOR TREATING VARIOUS COUGHS METHOD AND USE THEREOF
The invention discloses a use of asarinin in preparation of medicines for treating various coughs. The asarinin is used for preparing medicines for treating...
2018/0305371 NOVEL LACTONES
The present disclosure relates to novel lactones such as dihydropyrrole-fused furanones, a novel palladium-catalyzed carbonylation method to make the novel...
2018/0305370 ETHYLENE GLYCOL ETHER OF BUPRENORPHINE
A novel ethylene glycol ether of buprenorphine for oral administration and its the treatment of chronic pain.
2018/0305369 MORPHINAN DERIVATIVE AND MEDICAL USAGE THEREOF
The purpose of the present invention is to provide a compound useful as a prophylactic or therapeutic agent for various diseases and symptoms related to orexin...
2018/0305368 ARTIFICIAL METALLOENZYMES CONTAINING NOBLE METAL-PORPHYRINS
The present invention is drawn to artificial metalloenzymes for use in cyclopropanation reactions, amination and C--H insertion.
2018/0305367 SUBSTITUTED 4-METHYL-PYRROLO[1,2-A]PYRIMIDINE-8-CARBOXAMIDE COMPOUNDS AND USES THEREOF FOR MODULATING...
Disclosed are new small molecules having a 4-methylpyrrrolo[1,2-a]pyrimidine-8-carboxamide core structure and the uses thereof for modulating...
2018/0305366 SOLUBLE GUANYLATE CYCLASE STIMULATORS
The invention provides compounds of the Formula (I) ##STR00001## or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R.sup.1, R.sup.2, R.sup.4,...
2018/0305365 COMPOUND
The present invention relates to a salt form of a benzodiazepine derivative, in particular crystalline solid state forms, to pharmaceutical compositions...
2018/0305364 PRODRUGS OF IMIDAZOTRIAZINE COMPOUNDS AS CK2 INHIBITORS
PRODRUGS OF IMIDAZOTRIAZINE COMPOUNDS AS CK2 INHIBITORS The invention provides pharmaceutically active compounds of formula (I) and prodrugs thereof. The...
2018/0305363 KINASE INHIBITOR, AND PREPARING METHOD AND PHARMACEUTICAL USE THEREOF
The invention provides a compound of Formula I, or its tautomer, mesomer, racemate, enantiomer, diastereoisomer or a mixture thereof, or a pharmaceutically...
2018/0305362 EP4 ANTAGONISTS
We provide compounds given by Formula I, which is shown in FIG. 3, or pharmaceutically acceptable salts thereof, as well as formulations thereof and methods of...
2018/0305361 CRYSTAL FORM OF 4H-PYRAZOLO[1,5-alpha]BENZOIMIDAZOLE COMPOUND, PREPARATION METHOD THEREOF AND INTERMEDIATE THEREOF
The invention discloses a crystal form A of a compound (I) and a preparation method thereof, and further discloses an application of the crystal form A as a...
2018/0305360 COMT Inhibiting Methods and Compositions
The present inventions include a method of inhibiting COMT enzyme in a subject as well as compounds of formula I, or a pharmaceutically acceptable salt...
2018/0305359 BICYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND BETA-LACTAMASE INHIBITORS
A compound of formula (I): ##STR00001## wherein: M is hydrogen or a pharmaceutically acceptable salt-forming cation; Y is OR.sup.1 or NR.sup.2R.sup.3, and...
2018/0305358 SYNTHESIS OF A COMPOUND THAT MODULATES KINASES
The present disclosure provides processes for the preparation of a compound of formula I: ##STR00001## or a salt thereof, active on the receptor protein kinases...
2018/0305357 IMMUNE RESPONSE MODIFIER COMPOSITIONS AND METHDOS
The present invention provides an immune response modifier (IRM) composition that includes an IRM moiety and a second active moiety covalently linked to the...
2018/0305356 NOVEL KINASE INHIBITORS
The present invention relates to novel compounds of formula (I) ##STR00001## that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine...
2018/0305355 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS,COMPOSITIONS AND METHODS OF USE THEREOF
Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.
2018/0305354 COMT Inhibiting Methods and Compositions
Compounds that inhibit COMT enzyme and pharmaceutical compositions comprising the same are provided herein. Methods of treating various psychiatric and...
2018/0305353 FUSED BICYCLIC HETEROCYCLE DERIVATIVES AS PESTICIDES
The invention relates to novel compounds of the formula (I) or (I') ##STR00001## in which R.sup.1, R.sup.2, R.sup.3, Aa, Ab, Ac, Ad, Ae, Q and n have the ...
2018/0305352 NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES
The present invention is directed to tricyclic compounds of formula (I), (Ia) or (Ib) which are inhibitors of one or more mutant IDH enzymes. The present...
2018/0305351 6-[5-AMINO-6-(2-ETHOXYETHOXY)-IMIDAZO[4,5-B]PYRIDIN-3-YL]-NICOTINONITRILE DERIVATIVES AND THEIR USE AS IRAK...
The present invention discloses compounds according to Formula I: ##STR00001## wherein R.sup.1, R.sup.2, and Cy are as defined herein. The present invention relates...
2018/0305350 TYROSINE KINASE INHIBITORS
The present disclosure provides compounds of formula (I) that are tyrosine kinase inhibitors, in particular Bruton tyrosine kinase ("BTK") inhibitors, and are...
2018/0305349 1, 3, 4-Thiadiazole Compounds and Their Use in Treating Cancer
The specification relates to compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, where Q, R, R.sup.1 and R.sup.2 have any of...
2018/0305348 INHIBITORS OF BRUTONS TYROSINE KINASE
Disclosed herein are reversible and irreversible inhibitors of Bruton's tyrosine kinase (Btk). Also disclosed are pharmaceutical compositions that include the...
2018/0305347 METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL
Provided herein are novel compounds, pharmaceutical compositions for use, inter alia, in methods of reducing Wnt-mediated effects and treating cancer.
2018/0305346 PIPERIDINE COMPOUNDS AS PCSK9 INHIBITORS
One aspect of the invention relates to a series of new PCSK9 inhibitor compounds comprising piperidine ring structures, including compounds of formula (I)...
2018/0305345 COMPOSITIONS AND METHODS FOR ENHANCING ONCOLYTIC VIRUS EFFICACY
Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing...
2018/0305344 BICYCLIC BET BROMODOMAIN INHIBITORS AND USES THEREOF
The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, to processes for preparing...
2018/0305343 SUBSTITUTED MORPHOLINE DERIVATIVES HAVING ACTIVITY AGAINST PAIN
The present invention relates to substituted morpholine derivatives having pharmacological activity towards the sigma (.sigma.) receptor, to processes of...
2018/0305342 ARYL ACYLSULFONAMIDES AS BLT1 ANTAGONISTS
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof are antagonists of leukotriene B.sub.4 receptor 1 (BLT1) and...
2018/0305341 IMIDAZOLINONE DERIVATIVES AS TRPM8 ANTAGONISTS
The present invention relates to imidazolinone derivatives of the formula (I) or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for...
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