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Patent # Description
2018/0303871 THERAPEUTIC IMMUNE MODULATION USING NOBLE GAS COMPOSITIONS
Described are compositions of matter and protocols useful for treatment of neurological and other disorders associated with inflammatory activities. In some...
2018/0303870 MULTI-FUNCTIONAL HEMOCOMPATIBLE POROUS POLYMER BEAD SORBENT FOR REMOVING PROTEIN BASED TOXINS AND POTASSIUM...
The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt...
2018/0303869 METHODS OF USING OPHTHALMIC COMPOSITIONS COMPRISING POVIDONE-IODINE
A topical ophthalmic composition comprised of povidone-iodine 0.01% to 10.0% combined with a steroid or non-steroidal anti-inflammatory drug. This solution is...
2018/0303868 A TEAT SEAL FORMULATION
A seal formulation for forming a physical barrier in the teat canal of a non-human animal for prophylactically controlling infection of a mammary gland by a...
2018/0303867 SUPPRESSION OR REDUCTION OF THE PATHOGENICITY OR VIRULENCE OF A CLOSTRIDIUM BACTERIA
The invention relates to the use of an adsorbent to reduce or suppress the pathogenicity or virulence of Clostridium bacteria in vitro, ex vivo or in vivo. The...
2018/0303866 VETERINARY COMPOSITIONS FOR USE IN TREATING MASTITIS, AND ASSOCIATED METHODS
The present disclosure relates generally to sol-gel polymer composites that comprise chitosan, a hydrophilic polymer, a polysiloxane, and a gelation agent in a...
2018/0303865 Therapeutic Use of a Sterile Aqueous Ophthalmic Solution
The present invention relates to a sterile aqueous ophthalmic solution comprising N--(N-acetylcysteinyl-)chitosan or a pharmaceutically acceptable salt thereof...
2018/0303864 POLYNUCLEOTIDES HAVING BIOREVERSIBLE GROUPS
The disclosure provides methods and compositions for delivering polynucleotides into cells. The disclosure provides transiently protected polynucleotides...
2018/0303863 Pharmaceutical Composition for Treating STK11-Mutation Cancer Using Cardiac Glycosides
The present invention relates to a pharmaceutical composition for treating STK11-mutation cancer, containing, as an active ingredient, a material inhibiting a...
2018/0303862 ALTERING CANCER CELLULAR FUNCTIONS THROUGH PROTON MOPPING
Proton mopping is a new anti-cancer therapeutic approach that disrupts cancer's immunologic balance. It results in the alteration of the pHi/pHe ratio...
2018/0303860 CUCURBITANE TETRACYCLIC TRITERPENOID COMPOUNDS FOR APPLICATION IN TREATING PULMONARY FIBROSIS
An application of cucurbitane tetracyclic triterpenoid compounds in preparation of drugs and/or health products for preventing and/or treating pulmonary...
2018/0303859 Agent For Preventing And/Or Treating Scleroderma
The present invention aims to provide a prophylactic and/or therapeutic agent for scleroderma. The present invention also aims to provide a Th2 promotion...
2018/0303858 SYNTHETIC COMPOSITION AND METHOD FOR MODULATING EMOTION AND MOOD DISORDERS
A synthetic composition for use in treating or improving one or more emotion and/or mood disorders in a patient, characterised in that the composition contains...
2018/0303857 Prebiotic Composition and its Methods of Production
The present invention relates to a prebiotic composition comprising a galacto oligosaccharide (GOS) produced from Lactobacillus plantarum, wherein the GOS acts...
2018/0303856 INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE 1 (DGAT-1) AND USES THEREOF
This invention pertains to the use of fused bicycle heterocyclic adducts of thiohydroxy pyridines or pyrimidines as diacylglycerol O-acyltransferase 1 (DGAT-1)...
2018/0303855 COMPOSITION AND METHODS OF USE OF SMALL MOLECULES AS BINDING LIGANDS FOR THE MODULATION OF PROPROTEIN...
This invention is related to the field of PCSK9 biology and the composition and methods of use of small molecule ligands for modulation of PCSK9 biological...
2018/0303854 EFFERVESCENT FORMULATION BASED ON PYRIDOXAL-5-PHOSPHATE
Provided is a fast-dissolving effervescent pharmaceutical formulation of pyridoxal-5-phosphate, and to the use thereof in the treatment of neonatal epilepsy...
2018/0303853 COMPOSITIONS AND METHODS FOR TREATING BACTERIAL INFECTIONS USING CEFTAROLINE
The present invention relates to compositions comprising ceftaroline or a prodrug thereof (e.g., ceftaroline fosamil) and methods for treating bacterial...
2018/0303852 Method For Making Bismuth Containing Liquid Pharmaceutical Suspensions
A method of producing a liquid pharmaceutical suspension by mixing magnesium aluminum silicate, gellan gum, bismuth subsalicylate, and methyl cellulose.
2018/0303851 USE OF SUSTAINED RELEASE DEXAMETHASONE IN POST-CATARACT SURGERY INFLAMMATION
The present embodiments provide for a treatment regimen and use of a short-term sustained release liquid formulation of dexamethasone in citrate, wherein a...
2018/0303850 PROLIPOSOMAL TESTOSTERONE FORMULATIONS
Novel testosterone formulations are disclosed where testosterone is incorporated into a phospholipid/cholesterol system to produce a proliposomal powder...
2018/0303849 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF INCREASED INTRAOCULAR PRESSURE
The invention provides novel pharmaceutical compositions for the treatment of increased intraocular pressure based on semifluorinated alkanes which are useful...
2018/0303848 SUBSTITUTED TRIAZOLOBENZODIAZEPINES
This invention relates to novel substituted triazolobenzodiazepines of the Formula I: ##STR00001## wherein each of the variables are defined herein and...
2018/0303847 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR ANESTHESIOLOGICAL APPLICATIONS
Pharmaceutical compositions and methods for inducing conscious sedation using such compositions are described, the compositions comprising a ...
2018/0303846 BISMUTH-THIOLS AS ANTISEPTICS FOR BIOMEDICAL USES, INCLUDING TREATMENT OF BACTERIAL BIOFILMS AND OTHER USES
Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating natural surfaces that contain bacterial biofilm,...
2018/0303845 USE OF TLR8 AGONISTS TO TREAT CANCER
The application relates to methods of inducing antitumor immune responses in a subject having cancer. In some embodiments, methods are provided for ...
2018/0303844 APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS
The present invention relates to compounds of Formula (I): ##STR00001## Wherein variables are as defined above. The compounds have apoptosis signal-regulating...
2018/0303843 CONTROLLED-RELEASE TOZADENANT FORMULATIONS
The present invention provides a controlled-release composition containing tozadenant, at least one cellulose ether, and one or more pharmaceutically...
2018/0303842 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES
Pleuromutilin derivative compounds of the following formula (I), and uses thereof for the treatment of diseases mediated by microbes, are disclosed: ...
2018/0303841 HETEROCYCLIC COMPOUND
The present invention provides a compound which has a cholinergic muscarinic M1 receptor positive allosteric modulator activity and may be useful as a...
2018/0303840 COMBINATION THERAPY FOR TREATING MALIGNANCIES
Provided are methods and compositions for treating cancers in patients carrying an IDH2 mutation using a combination of an inhibitor of a mutant IDH2 enzyme...
2018/0303839 Methods and Devices for Renal Nerve Blocking
Methods for treating a hypertensive human patient are disclosed herein. A method in accordance with one embodiment comprises delivering a neuromodulatory agent...
2018/0303838 TRANSIENT PROTECTION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS AGAINST IONIZING RADIATION
This invention is in the area of improved compounds and methods for transiently protecting healthy cells, and in particular hematopoietic stem and progenitor...
2018/0303837 THERAPEUTIC REGIMEN
The present invention relates to dosing regimen of a new antimalarial drug, as monotherapy or combination therapy.
2018/0303836 PYRIMIDINE COMPOUNDS AS JAK KINASE INHIBITORS
The invention provides compounds of formula (I): ##STR00001## wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt...
2018/0303835 METHOD OF TREATING HYPERTENSION
Disclosed herein are compositions and methods for the treatment of pulmonary hypertension, including pulmonary arterial hypertension. The methods include...
2018/0303834 PYRROLOPYRIMIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS
Disclosed are chemical entities of formula I: ##STR00001## wherein X, Y, Z, R.sup.1, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined herein, as NR2B subtype...
2018/0303833 METHOD OF PREVENTING OR TREATING OSTEOPOROSIS BY NEDDYLATION INHIBITOR
Disclosed herein is a method of preventing and/or treating abnormal bone resorption and/or osteoporosis in a subject in need thereof. The method comprises...
2018/0303832 PYRROLOPYRIMIDINE COMPOUNDS USED AS TLR7 AGONIST
The present invention relates to a pyrrolopyrimidine compound as TLR7 agonist, and particularly relates to a compound of formula (I) or a pharmaceutically...
2018/0303831 2,3-DISUBSTITUTED 1 -ACYL-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS
The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.
2018/0303830 CANCERS EXPRESSING CCR5 AND METHODS OF TREATMENT OF SAME
Embodiments disclosed herein provide for methods of treating cancer and detecting CCR5 on circulating tumor cells and uses thereof based upon the same.
2018/0303829 METHOD FOR TREATING CANCER USING A COMBINATION OF DNA DAMAGING AGENTS AND ATR INHIBITORS
Described herein are methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a DNA damaging agent and between about 12 and...
2018/0303828 Unit Dose of an MDM2 Inhibitor that Provides Long-Lasting Relief from Idiopathic Pulmonary Fibrosis and other...
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic...
2018/0303827 TRANSDERMAL DOSAGE FORM
The disclosure generally relates to tamper-resistant transdermal dosage forms. The dosage forms can comprise an active agent and more than one antagonist...
2018/0303826 ABUSE RESISTANT DRUG FORMULATION
A pharmaceutical composition may include a coated particulate which may include at least one active pharmaceutical ingredient, particularly one susceptible to...
2018/0303825 POLYMORPHIC FORMS OF NALTREXONE
This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and...
2018/0303824 Compositions for deterring abuse of pharmaceutical products and alcohol
The invention enables the formation of prescription drugs less likely to be abused. Different approaches are employed that can potentially deter abuse by...
2018/0303823 PHARMACEUTICAL SALT FORMS OF CEPHARANTHINE AND TETRANDRINE
The present disclosure relates to the preparation of polymorphic mixtures of Cepharanthine.2HCl. Mixtures of at least two polymorphic forms can be formed into...
2018/0303822 PRMT5 INHIBITORS AND USES THEREOF
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
2018/0303821 MEMBRANE ACTIVE MOLECULES
A method of inducing anesthesia, sedation, and a method for treating disorders including central nervous system disorder, peripheral nervous system disorder,...
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