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Patent # Description
2018/0303820 USE OF HEXOKINASE 2/MITOCHONDRIA-DETACHING COMPOUNDS FOR TREATING HEXOKINASE-2 (HK2)-EXPRESSING CANCERS
The present invention provides methods of use of hexokinase 2 (HK2)/mitochondria-detaching compounds, including jasmonate derivatives and piperazine...
2018/0303819 USE OF HEXOKINASE 2/MITOCHONDRIA-DETACHING COMPOUNDS FOR ACTIVATING IMMUNE RESPONSES
The present invention provides methods of use of hexokinase 2 (HK2)/mitochondria-detaching compounds, including jasmonate derivatives and piperazine...
2018/0303818 COMPOSITIONS COMPRISING NICOTINIC AGONISTS AND METHODS OF USING SAME
The disclosure is directed at least in part to compositions and methods comprising nicotinic agonists for treating e.g., nervous system disorders, in...
2018/0303817 THERAPEUTIC AGENT FOR BREAST CANCER
The present application discloses a therapeutic agent for breast cancer, comprising 5-((2-(4-(1-(2-hydroxyethyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-- ...
2018/0303816 SALTS AND COMPOSITIONS USEFUL FOR TREATING DISEASE
The invention provides a combination or salt of lipoic acid and a compound of formula (I): ##STR00001## The combinations and salts are useful for treating diabetes.
2018/0303815 COMBINATION OF BCL-2 INHIBITOR AND MEK INHIBITOR FOR THE TREATMENT OF CANCER
The present invention is directed to a combination therapy involving a selective Bcl-2 inhibitor and a MEK inhibitor for the treatment of a patient in need of...
2018/0303814 METHODS AND COMPOSITIONS FOR ENHANCING FEMALE SEXUAL AROUSAL AND TREATING FEMALE SEXUAL DYSFUNCTION
Methods and compositions for enhancing female sexual arousal and treating female sexual dysfunction utilize L-arginine or equivalents and/or derivatives...
2018/0303813 SUBLINGUAL FENTANYL SPRAY
The present invention is directed to sublingual formulations containing fentanyl, a pharmaceutically acceptable salt thereof, or derivative thereof, suitable...
2018/0303812 PHARMACEUTICAL COMPOSITION FOR USE IN TREATING AML AND METHOD OF TREATING AML IN A SUBJECT IN NEED THEREOF
The present invention provides a pharmaceutical composition for use in treating acute myeloid leukemia (AML) and a method of treating AML in a patient in need...
2018/0303811 ORAL SOLUTION OF DIHYDROPYRIDINE DERIVATIVES
The present invention pertains to the field of oral pharmaceutical composition of dihydropyridine derivatives. In particular, present invention relates to oral...
2018/0303810 Nimodipine Water-Soluble Derivative, And Preparation Method And Use Thereof
Provided are a nimodipine water-soluble derivative, and a preparation method and a use thereof, belonging to the field of pharmaceutical chemistry. The...
2018/0303809 TREATMENT OF BURN PAIN BY TRPV1 MODULATORS
The present invention is directed to a method for treating pain associated with a burn injury originating from a thermal exposure, from a radiation exposure,...
2018/0303808 COMBINATION THERAPY FOR TREATING MALIGNANCIES
Provided are methods and compositions for treating cancers in patients carrying an IDH1 mutation using a combination of an inhibitor of a mutant IDH1 enzyme...
2018/0303807 ANDROGEN RECEPTOR LIGANDS
Described are compounds that inhibit androgen receptor action, pharmaceutical compositions including the compounds, and methods of using the compounds and...
2018/0303806 NOVEL DOSAGE AND FORMULATION
The present disclosure relates to pharmaceutical compositions for inhalation comprising aclidinium in the form of a dry powder of a pharmaceutically acceptable...
2018/0303805 METHODS OF INCREASING TONIC INHIBITION AND TREATING SECONDARY INSOMNIA
Methods of increasing tonic inhibition in a subject in need thereof, for example a subject with Fragile X syndrome or Angelman syndrome are disclosed. Methods...
2018/0303804 METHODS OF TREATING HEPATIC ENCEPHALOPATHY
The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific...
2018/0303803 MACROLIDE PARTICULATES, METHODS FOR PREPARATION, AND MEDICAL DEVICES ASSOCIATED THEREWITH
The disclosure provides macrolide particulates including a macrolide therapeutic agent such as rapamycin at high concentration in the particulate. In one...
2018/0303802 METHODS FOR TREATING SYNOVIAL SARCOMA
Methods useful in the treatment of synovial sarcoma are provided. The methods comprise administering to a subject suffering from synovial sarcoma a compound as...
2018/0303801 UNIT ORAL SOLID DOSE COMPOSITIONS COMPOSED OF IBUPROFEN AND NIZATIDINE
Described herein are unit oral solid dose compositions composed of ibuprofen and nizatidine. The compositions described herein are useful in improving the...
2018/0303800 SUBSITUTED ALIPHANES, CYCLOPHANES, HETERAPHANES, HETEROPHANES, HETERO-HETERAPHANES AND METALLOCENES USEFUL FOR...
The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula I D-M-D ...
2018/0303799 An Oral Preparation for the Treatment of Cardiovascular Disease and Its Preparation Method
The invention provides an oral preparation containing compound 1 used for cardiovascular disease, the oral preparation is prepared to ribbon via dry...
2018/0303798 USE OF N-ACETYL-5-METHOXYTRYPTAMINE OR ANALOGUES THEREOF, FOR PROMOTING THE MECHANISM OF IMPLANTATION OF THE...
The present invention refers to the use of N-acetyl-5-methoxytryptamine (melatonin) and/or an analogue thereof, for use in the medical or veterinary field in...
2018/0303797 Chalcone Compounds
This disclosure relates to the compounds of formula (I) [INSERT FORMULA], in which A and R1-R12 are defined in the Specification. The compounds of formula (I)...
2018/0303796 Compositions And Methods For Treating Traumatic Brain Injury
The present invention relates, in certain embodiments, to methods for preventing and/or treating neurodegenerative damage (e.g., secondary cascade of...
2018/0303795 METHOD OF TREATING ROSACEA
A method of treating, preventing, and/or managing rosacea in a subject includes the steps of administering intravenously to the subject a therapeutically...
2018/0303794 COMPOSITIONS AND METHODS FOR IMPROVING MITOCHONDRIAL FUNCTION AND TREATING NEURODEGENERATIVE DISEASES AND...
Provided are compositions comprising compounds or precursors to compounds which may be used for a variety of therapeutic applications including, for example,...
2018/0303793 METHODS AND COMPOSITIONS FOR TREATING TRAUMATIC BRAIN INJURY
Methods and compositions for treating traumatic brain injury in a subject are provided.
2018/0303792 METHOD FOR PRODUCING A CONCENTRATE OF POLYMER PROANTHOCYANIDINS WITH A CONCENTRATION OF MORE THAN 40% BY MEANS...
The invention relates to a method for producing a concentrate of polymer proanthocyanidins with a concentration of more than 40%, characterised by the use of...
2018/0303791 SYNERGISTIC USE OF CANNABIS FOR TREATING MULTIPLE MYELOMA
The present invention discloses a pharmaceutical composition comprising therapeutically effective amount of, or an extract consisting essentially ...
2018/0303790 PHARMACEUTICAL FORMULATIONS FOR SUBCUTANEOUS ADMINISTRATION OF FUROSEMIDE
The present teachings relate to liquid pharmaceutical formulations of furosemide, where the pharmaceutical formulations include a molar excess of...
2018/0303789 METHOD OF TREATING CONDITIONS RELATED TO THE PGI2 RECEPTOR
Provided in some embodiments are titration packages, kits, and methods of treating pulmonary arterial hypertension comprising prescribing and/or administering...
2018/0303788 Entacapone for treatment of obesity
Obesity is inhibited by administering to a person in need thereof an effective amount of entacapone ...
2018/0303786 INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR
A method for reducing macrophage migration inhibitory factor (MIF or MMIF) cytokine or its biological activity, including the step of administering an...
2018/0303785 METHOD FOR TREATING BENIGN PROSTATIC HYPERPLASIA (BPH), PROSTATITIS, AND PROSTATE CANCER
A method for treating benign prostatic hyperplasia (BPH), prostatitis, and/or prostate cancer, including the step of administering an isothiocyanate functional...
2018/0303784 OMEGA-3 COMPOSITIONS, DOSAGE FORMS, AND METHODS OF USE
Omega-3 compositions, dosage forms, and methods of use are disclosed herein. The omega-3 compositions and dosage forms disclosed herein may comprise DHA and...
2018/0303783 COMPOSITIONS AND METHODS FOR TREATING RETINOPATHY
The present invention provides methods, compositions, and kits for treating retinopathy, including diabetic retinopathy and macular degeneration, in a subject...
2018/0303782 Oral Microbiota Promotion For Oral and/or Sinus Infections
A method of promoting a desired oral microbiota to treat an oral and/or sinus infection condition in a subject in need of such treatment including providing a...
2018/0303781 Oral Microbiota Promoting Composition
A composition useful for promoting a desired oral microbiota to treat an allergy related respiratory condition in a subject in need of such treatment, the...
2018/0303780 DERIVATIVES USED IN THE TREATMENT OF MUSCLE ATROPH
This invention relates to a derivative of the general formula (I), as follows: or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture...
2018/0303779 Methods of Reducing Risk of Cardiovascular Disease
Methods of lowering the plasma LDL-C levels in a patient on a stable dose of statin where the patient has an LDL-C level above treatment goal. Methods of...
2018/0303778 SUPPORTING IMMUNOMODULATORY AGENT
The invention relates to a combination therapy for the prevention and/or treatment of immune-mediated chronic inflammatory and autoimmune diseases comprising a...
2018/0303777 Hyaluronate Compositions
The present invention provides compositions suitable for topical administration to a mammalian subject including sodium hyaluronate and a pharmaceutically...
2018/0303776 LIPOSOMAL REHYDRATION SALT FORMULATION FOR TREATMENT OF ALCOHOL RELATED DISORDERS
A liposomal rehydration salt formulation includes phospholipids at a concentration of about 1.0 g/L to 10.0 g/L, salts, water, oleoylethanolamide, and a...
2018/0303775 HAIR-GROWTH PROMOTING COMPOSITION AND USAGE THEREOF
Novel compositions that promote hair growth or hair restoration, and compositions that prevent hair loss. Compositions including an iNOS inhibitor as an active...
2018/0303774 COMPOSITION FOR TREATMENT OF INFLAMMATORY BOWEL DISEASE AND ATOPIC DERMATITIS
The present invention relates to a compound for inhibiting thymic stromal lymphopoietin (TSLP) secretion from mast cells and use thereof. The compound of the...
2018/0303773 COMBINATION COMPRISING AN AMINOTHIOLESTER COMPOUND OR A HARMACEUTICALLY ACCEPTABLE SALT THEREOF AND A COMPOUND...
The present invention relates to a combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof, in particular the S-methyl...
2018/0303772 5-HYDROXYTRYPTAMINE 1B RECEPTOR-STIMULATING AGENT FOR THE TREATMENT OF MYOCARDIAL INFARCTION
The present invention relates to the field of myocardial infraction (MI). It more specifically relates to an agent stimulating, either directly or indirectly,...
2018/0303771 INTRAVENOUS ADMINISTRATION OF TRAMADOL
A method of treating pain, e.g., acute post-operative pain, by administering to a human patient(s) a therapeutically effective dose of tramadol intravenously...
2018/0303770 TREATMENT OF METHYLMALONIC ACIDURIA, ISOVALERIC ACIDURIA, AND OTHER ORGANIC ACIDURIAS WITH TOCOTRIENOL QUINONES
The present invention relates to methods of treating methylmalonic aciduria and other organic acidurias with tocotrienol quinones, including alpha-tocotrienol...
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