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Patent # Description
2018/0305694 PARENTAL RNAI SUPPRESSION OF HUNCHBACK GENE TO CONTROL HEMIPTERAN PESTS
This disclosure concerns nucleic acid molecules and methods of use thereof for control of hemipteran pests through RNA interference-mediated inhibition of...
2018/0305693 TREATMENT OF DOWN SYNDROME GENE RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO A DOWN...
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a Down Syndrome Gene, in particular, by...
2018/0305692 ANTISENSE OLIGONUCLEOTIDES FOR THE TREATMENT OF LEBER CONGENITAL AMAUROSIS
The present invention relates to the fields of medicine and immunology. In particular, it relates to novel antisense oligonucleotides that may be used in the...
2018/0305691 MicroRNA Compounds and Methods for Modulating MIR-21 Activity
Described herein are compositions and methods for the inhibition of miR-21 activity. The compositions have certain nucleoside modification patterns that yield...
2018/0305690 Targeting MicroRNAs for the Treatment of Fibrosis
Provided herein are compositions and methods for the modulation of miR-214 for the treatment and/or prevention of fibrosis and fibroproliferative conditions.
2018/0305689 SARNA COMPOSITIONS AND METHODS OF USE
The invention relates to oligonucleotides, e.g., saRNAs useful in upregulating the expression of a target gene and therapeutic compositions comprising such...
2018/0305688 Chemically Ligated RNAs for CRISPR/Cas9-lgRNA Complexes as Antiviral Therapeutic Agents
Provided herein are chemically ligated guide RNA oligonucleotides (1gRNA) which comprise two functional RNA modules (crgRNA and tracrgRNA) joined by...
2018/0305687 LINKAGE MODIFIED OLIGOMERIC COMPOUNDS
The present invention provides oligomeric compounds comprising at least one neutral methoxypropyl phosphonate modified internucleoside linkage. Such oligomeric...
2018/0305686 Enhanced Gene Expression
The present disclosure is directed to a novel, unexpected approach of expressing exogenous gene(s) at increased levels by predictably, optionally irreversibly,...
2018/0305685 METHOD FOR CONSTRUCTING HIGH-RESOLUTION SINGLE CELL HI-C LIBRARY WITH A LOT OF INFORMATION
Provided in the present invention is a method for constructing a high-resolution single cell Hi-C library with a large amount of information, comprising the...
2018/0305684 Scavenger Compounds for Improved Sequencing-by-Synthesis
The present invention discloses methods of applications of indole-3-propionic acid, L-carnitine and O-acetyl-L-carnitine in one or more different reactive...
2018/0305683 MULTIPLEXED TAGMENTATION
Described herein, among other things, is a method for amplifying a nucleic acid sample. In some embodiments this method may comprise (a) tagmenting the nucleic...
2018/0305682 MICROFLUIDIC DEVICE FOR EXTRACTING, ISOLATING, AND ANALYZING DNA FROM CELLS
The present invention relates to a microfluidic device for extracting and isolating DNA from cells. The device includes a support having an inlet port for...
2018/0305681 METHOD AND APPARATUS FOR ENCODING CELLULAR SPATIAL POSITION INFORMATION
A system, methods, and apparatus are described to collect and prepare single cells and groups of cells from microsamples of specimens and encode spatial...
2018/0305680 GENETIC TOOL FOR THE TRANSFORMATION OF CLOSTRIDIUM BACTERIA
The present invention relates to a genetic tool comprising at least two different nucleic acids allowing the transformation, by homologous recombination, of a...
2018/0305679 NEAR-INFRARED RAY EXPOSURE SYSTEM FOR BIOLOGICAL STUDIES
An apparatus and methods of using the same for conducting photonic and optical treatments on biological samples with additional functions including temperature...
2018/0305678 BETA-LACTAMASES WITH IMPROVED PROPERTIES FOR THERAPY
This invention relates to, in part, compositions of beta-lactamases and methods of using these enzymes in, for example, gastrointestinal tract (GI tract)...
2018/0305677 RECOMBINANT PROTHROMBIN ANALOGUES AND USES THEREOF
During the process of coagulation, prothrombin is activated to .alpha.-thrombin by prothrombinase. Key residues in the structure of prothrombin allow for...
2018/0305676 BACTERIAL TOXINS AND USES THEREOF AS RAS SPECIFIC PROTEASES FOR TREATING CELL PROLIFERATION DISEASES AND DISORDERS
Disclosed are bacterial toxins and uses thereof as specific proteases for Ras sarcoma oncoproteins (Ras proteins). The bacterial toxins may be modified for use...
2018/0305675 INTEIN-MODIFIED PROTEASES, THEIR PRODUCTION AND INDUSTRIAL APPLICATIONS
Methods for producing intein-modified proteases are provided. Expression cassettes and vectors for using to genetically engineer hosts are described. Hosts...
2018/0305674 Polypeptides Having Beta-Xylosidase Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having beta-xylosidase activity and polynucleotides encoding the polypeptides. The invention also...
2018/0305673 POLYMERASE COMPOSITIONS, METHODS OF MAKING AND USING SAME
The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified...
2018/0305672 MODIFIED GLUCOSYLTRANSFERASES FOR PRODUCING BRANCHED ALPHA-GLUCAN POLYMERS
Glucosyltransferase enzymes are disclosed herein that produce branched alpha-glucan polymer. Also disclosed, for example, are polynucleotides encoding these...
2018/0305671 DERIVATION OF HUMAN SKIN ORGANOIDS FROM PLURIPOTENT STEM CELLS
Provided herein are methods for directing differentiation of human pluripotent stem cells into a three-dimensional multilayered skin composition comprising an...
2018/0305670 Method and System for Monitoring Nutritional Uptake as a Function of Hydrogen Gas Levels
Systems and methods for monitoring nutritional uptake of an individual are disclosed. The method can include monitoring microflora intestinal gas concentration...
2018/0305669 MICROTISSUE FORMATION USING STEM CELL-DERIVED HUMAN HEPATOCYTES
Provided herein are methods of producing three-dimensional (3-D) microtissue from a starting cell suspension of pluripotent stem cell (PSC)-derived...
2018/0305668 METHOD OF OSTEOGENIC DIFFERENTIATION IN MICROFLUIDIC TISSUE CULTURE SYSTEMS
Microfluidic "organ-on-a-chip" devices have been developed with the aim to replicate human tissues in vitro. However, there is no option to quantitatively...
2018/0305667 METHODS AND COMPOSITIONS FOR GENERATING AN IMMUNE RESPONSE BY INDUCING CD40 AND PATTERN RECOGNITION RECEPTOR...
Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter,...
2018/0305666 METHODS FOR GENERATING ENGINEERED HUMAN PRIMARY BLOOD DENDRITIC CELL LINES
Provided are engineered primary blood and monocyte-derived dendritic cells, wherein the dendritic cell expresses a functional Tax protein from a T cell...
2018/0305665 Method for Enrichment and Expansion of Virus Antigen-Specific T Cells
The present invention relates to a method for inducing and proliferating target virus antigen-specific dual activated T cells, and can produce target virus...
2018/0305664 METHODS FOR DIRECTED DIFFERENTIATION OF PLURIPOTENT STEM CELLS TO IMMUNE CELLS
Provided herein are methods for the efficient in vitro differentiation of somatic cell-derived pluripotent stem cells to hematopoietic precursor cells, and the...
2018/0305663 METHOD FOR HIGHLY EFFICIENT CONVERSION OF HUMAN STEM CELLS TO LINEAGE-SPECIFIC NEURONS
The present invention relates to the field of stem cells. More specifically, the present invention provides methods and compositions useful for the highly...
2018/0305662 Method for Generating Human Multipotent Mammary Stem Cells From Normal Primary Breast Luminal Cells
The invention relates to methods for generating multipotent mammary stem cells from isolated and cultured human breast luminal cells. The method comprises the...
2018/0305661 ISOLATION, EXPANSION AND USE OF CLONOGENIC ENDOTHELIAL PROGENITOR CELLS
A hierarchy of endothelial colony forming cells (EPCs) was identified from mammalian cord blood, umbilical vein and aorta. A newly isolated cell named high...
2018/0305660 TARGETED MUTAGENESIS IN SPIRULINA
This disclosure describes techniques for creating stable, targeted mutations in Spirulina (Athrospiria) and Spirulina having stable, targeted mutations.
2018/0305659 Compositions and Methods for Treatment of Bacterial Infections
A cell, isolated nucleic acid, vector, isolated polypeptide, and method of treating a bacterial infection are provided. The cell includes a modified...
2018/0305658 Composition of Bacterial Mixture and Uses Thereof
The disclosure provides bacterial compositions and methods of use thereof for ameliorating malodor in fabrics. More specifically, the invention provides...
2018/0305657 Bioactive Fungi
The present invention relates to fungi, in particular fungal endophytes of Daldinia spp., compounds produced by the fungi, uses of the fungi, uses of compounds...
2018/0305656 METHODS OF PRESERVING A MICROALGAE BIOMASS AND A PRESERVED MICROALGAE BIOMASS
A method of preserving a biomass. The method comprises adding an acid solution to a biomass comprising microalgae to form an acidified microalgae biomass...
2018/0305655 Bone Marrow Adipose Portion Isolation Device and Methods
The embodiments disclosed herein generally relate to systems, devices and methods for the fractionation, isolation, extraction and processing of the adipose...
2018/0305654 BUBBLE-JETTING CHIP, LOCAL ABLATION DEVICE AND LOCAL ABLATION METHOD, AND INJECTION DEVICE AND INJECTION METHOD
A bubble-jetting chip capable of jetting bubbles upward from a substrate is provided. Bubbles can be jetted upward from a substrate by a bubble-jetting chip ...
2018/0305653 FERMENTER FOR A LIQUID MEDIUM WITH GAS CIRCULATION STIRRING, COMPRISING AN AUTOMATIC DEVICE FOR ESTABLISHING A...
The invention relates to a digester for a liquid medium, comprising a container, a dividing wall between two spaces, and a device for injecting gas into the...
2018/0305652 COATING AGENT FOR FLOW PASSAGE
The invention provides a coating agent for a flow passage which comprises a copolymer containing a recurring unit which contains an organic group of the...
2018/0305651 MICROFLUIDIC MODEL OF THE BLOOD BRAIN BARRIER
The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic...
2018/0305650 Culture Bag and Culture Device
A culture bag includes a culture portion which has a culture space configured to contain and culture a culture fluid. The culture space is an endless...
2018/0305649 ALCOHOLIC BEVERAGE AND METHOD OF MAKING THE SAME
The present invention is an alcoholic beverage having the sensory characteristics of a traditionally aged distilled spirit. The method for making the alcoholic...
2018/0305648 Systems and methods for distilling food grade ethanol from food waste
A system and method for producing food-grade ethanol from food waste. A method of producing ethanol or vodka from food waste includes the steps of selecting...
2018/0305647 Beer Making Machine with Direct Steam Injection
A beer making system may use direct steam injection during wort manufacturing. Steam may be added directly to the wort, and may be part of a recirculating mash...
2018/0305646 FERMENTATION
The present invention is directed to a method for decreasing the lag time in a fermentation of a culture medium to prepare a target substance, wherein the...
2018/0305645 WASHING METHOD
An aqueous detergent solution in a device for cleaning soiled textile substrates is disclosed. The solution contains a plurality of water-insoluble solid...
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