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Patent # Description
2018/0319887 CANCER IMMUNOTHERAPY BY DISRUPTING PD-1/PD-L1 SIGNALING
The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a...
2018/0319886 Use of pentoxifylline with immune checkpoint-blockade therapies for the treatment of melanoma
Methods of treating a PD-1-resistant cancer are provided and comprise administering to a subject in need thereof a therapeutically effective amount of a c-Rel...
2018/0319885 ANTI-CD3-FOLATE CONJUGATES AND THEIR USES
Described herein are novel anti-CD3 antibodies conjugated to folate and uses thereof treatment of diseases or conditions that would benefit from such conjugate...
2018/0319884 NOVEL T CELL RECEPTORS AND IMMUNE THERAPY USING THE SAME
The present invention pertains to antigen recognizing constructs against COL6A3 antigens. The invention in particular provides novel T cell receptor (TCR)...
2018/0319883 Anti SIRP-alpha Antibodies and Bi-specific Macrophage Enhancing Antibodies
Anti-SIRP.alpha. antibodies, including multi-specific anti-SIRP.alpha. antibodies, are provided, as are related compositions and methods. The antibodies of the...
2018/0319882 PLEXIN D1 AS A TARGET FOR TUMOR DIAGNOSIS AND THERAPY
The present invention relates to plexin D1 for use as a targetable protein in the treatment or diagnosis of disorders that involve expression of plexin D1....
2018/0319881 METHODS OF SELECTIVELY TREATING ASTHMA USING IL-17 ANTAGONISTS
The disclosure relates to methods, treatment regimens, uses, kits and therapies for treating asthma, such as severe asthma, by employing IL-17 antagonists to a...
2018/0319880 ANTI-CGRP/ANTI-IL-23 BISPECIFIC ANTIBODIES AND USES THEREOF
IgG bispecific antibodies are provided that bind human Calcitonin Gene Related Peptide (CGRP) and human Interleukin-23 (IL-23) and are characterized as having...
2018/0319879 ANTI-CANINE TARC ANTIBODY USED FOR TREATMENT AND DIAGNOSIS OF CANINE ATOPIC DERMATITIS
Provided are an anti-canine TARC antibody for use in the treatment and diagnosis of canine atopic dermatitis, and a method for treating or diagnosing canine...
2018/0319878 Angiopoietin-Like 4 and Its Use in Modulating Cell Leakiness
Vascular disruption induced by interactions between tumor-secreted permeability factors and adhesive proteins on endothelial cells facilitates metastasis. The...
2018/0319877 ANTI-MYOSTATIN ANTIBODIES, POLYPEPTIDES CONTAINING VARIANT FC REGIONS, AND METHODS OF USE
The disclosure provides anti-myostatin antibodies and methods of making and using the same. Nucleic acids encoding the anti-myostatin antibodies and host cells...
2018/0319876 ANTI-MYOSTATIN ANTIBODIES, POLYPEPTIDES CONTAINING VARIANT FC REGIONS, AND METHODS OF USE
The disclosure provides anti-myostatin antibodies and methods of making and using the same. Nucleic acids encoding the anti-myostatin antibodies and host cells...
2018/0319875 NOVEL ANTI-NODAL ANTIBODIES AND METHODS OF USING SAME
The present invention relates to anti-Nodal antibodies and use of the anti-Nodal antibodies for diagnosing, preventing, and treating a Nodal-related disorder...
2018/0319874 Single Chain Intrabodies that Alter Huntingtin Mutant Degradation
Compositions and methods of use are provided for intrabodies that bind and alter the effects of poly-glutamate protein aggregation in poly-glutamate associated...
2018/0319873 Antibodies Against Infectious Diseases
Anti-CaENO1 antibodies and humanized antibodies are provided as an effective diagnostic agent or a therapeutic treatment against infections caused by Candida...
2018/0319872 YEAST-BASED IMMUNOTHERAPY AGAINST CLOSTRIDIUM DIFFICILE INFECTION
Antibody-based binding agents derived from human and camelid immunoglobulins are described, as well as strains of yeast engineered to secrete the binding...
2018/0319871 Antibody Preparations
An antibody preparation suitable for intravenous administration in humans includes IgG, IgA and at least 5% IgM antibodies by weight of the total amount of...
2018/0319870 METHODS TO CREATE CHEMICALLY-INDUCED DIMERIZING PROTEIN SYSTEMS FOR REGULATION OF CELLULAR EVENTS
Methods to create chemically-induced dimerizing (CID) protein systems and uses thereof are described. The methods utilize antibody binding domain dimerizing...
2018/0319869 METHOD FOR MASS HUMANIZATION OF RABBIT ANTIBODIES
The present invention relates to a method for producing a population of 20 or more nucleic acids, each encoding at least one protein comprising at least one...
2018/0319868 SERPIN REACTIVE CENTER LOOP PEPTIDES AND METHODS OF USE
Disclosed here are peptides derived from a serpin reactive center loop that have anti inflammatory, anti-atherogenic and anti-sepsis activity. Compositions...
2018/0319867 POLYMERIZED PEPTIDE AND GEL HAVING COLLAGEN-LIKE STRUCTURE
The present invention is produced as a polymerized peptide prepared by oxidatively cross-linking collagen-like peptides having the triple-helical structure...
2018/0319866 HYDROLYZED COLLAGEN COMPOSITIONS AND METHODS OF MAKING THEREOF
Disclosed herein are hydrolyzed collagen compositions. The compositions are inexpensive to make and can be produced without the use of proteolytic enzymes,...
2018/0319865 Identification of Novel Small Molecule Beta2 Integrin Agonists
The application describes small molecules capable of modulating activity of beta2 family of integrins, such as integrin CD11b/CD18 (also known as Mac-1, CR3...
2018/0319864 METHODS AND COMPOSITIONS FOR MODIFICATION OF A HLA LOCUS
Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA...
2018/0319863 ANTI-HLA ASSAY AND METHODS
Anti-MHC assay methodologies utilize functionally active, recombinantly produced, truncated individual soluble MHC trimolecular complexes that are linked to a...
2018/0319862 CHIMERIC RECEPTORS CONTAINING TRAF-INDUCING DOMAINS AND RELATED COMPOSITIONS AND METHODS
Provided are chimeric receptors for engineering cells for adoptive therapy, including T cells, and the genetically engineered cells. In some aspects, also...
2018/0319861 COMBINATION THERAPY FOR MALIGNANT DISEASES
A new approach for the treatment of a malignant disease is provided. The new method comprises administering a traditional anti-cancer therapy in combination...
2018/0319860 ISLET AMYLOID POLYPEPTIDES WITH IMPROVED SOLUBILITY
Isolated non-naturally occurring, mutant-human islet amyloid polypeptides (hIAPP) are disclosed. These polypeptides can be formulated or co-formulated at...
2018/0319859 INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS
Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale...
2018/0319858 PHARMACEUTICAL COMPOSITION COMPRISING IMMUNOGLOBULIN FC-FUSED INTERLEUKIN-7 FUSION PROTEIN FOR PREVENTING OR...
The present invention relates to a pharmaceutical composition comprising an immunoglobulin Fc region and an IL-7 fusion protein. Specifically, when a fusion...
2018/0319857 FGF2 TRUNCATIONS AND MUTANTS AND USES THEREOF
The present disclosure provides FGF2 mutant proteins, such as those having an N-terminal deletion, point mutation(s), or combinations thereof, which can reduce...
2018/0319856 EPITOPES IN AMYLOID BETA MID-REGION AND CONFORMATIONALLY-SELECTIVE ANTIBODIES THERETO
The disclosure pertains to conformational epitopes in A-beta, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.
2018/0319855 GENETICALLY MUTATED AEQUORIN-BASED BIOSENSORS WITH EXTRA SENSITIVITY TO CALCIUM AND IMPROVED BIOLUMINESCENCE...
Disclosed is an apoaequorin mutant protein, wherein the apoaequorin mutant protein includes an amino acid substitution in position, position, position,...
2018/0319854 EXPRESSION IN MAMMALIAN CELLS WITH GAUSSIA LUCIFERASE SIGNAL PEPTIDE
The present invention relates to in vitro expression of proteins and particularly, although not exclusively, to expression of proteins in mammalian cell lines....
2018/0319853 METHODS AND COMPOSITIONS FOR RED-SHIFTED CHROMOPHORE SUBSTITUTION FOR OPTOGENETIC APPLICATIONS
The present disclosure provides compositions and methods used for optogenetics, wherein the composition comprises an optogenetic device and a retinoid...
2018/0319852 Increased production of ginsenosides through yeast cell organelle improvement
Provided are a recombinant yeast having improved ability to produce ginsenoside, which is prepared by overexpressing INO2 and INO4 or deleting OPT1 in a yeast...
2018/0319851 WAP GENES AND PROTEINS THAT IMPROVE BACILLUS COMPETITIVENESS
Disclosed are WapA and WapI proteins from Bacillus amyloliquefaciens, genes that encode the proteins, vectors that express the proteins, and cells constructed...
2018/0319850 CRISPR-ASSOCIATED (Cas) PROTEINS WITH REDUCED IMMUNOGENICITY
The invention relates to methods of reducing the immunogenicity of CRISPR-associated (Cas) proteins and the modified Cas proteins produced therefrom. In...
2018/0319849 METHODS OF ANALYZING CELL MEMBRANES
A method of precipitating cell membrane fragments from a cell lysate is disclosed. The method comprises contacting the cell lysate with a hydrophobic chelator...
2018/0319848 MODIFICATIONS OF CUPREDOXIN DERIVED PEPTIDES AND METHODS OF USE THEREOF
The present invention provides modified cupredoxin derived peptides with pharmacologic activity that have improved pharmacokinetic properties, and methods to...
2018/0319847 COMPOSITIONS AND METHODS FOR TREATING CONDITIONS RELATED TO EPHRIN SIGNALING WITH CUPREDOXINS
The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that...
2018/0319846 PREFUSION RSV F PROTEINS AND THEIR USE
Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are...
2018/0319845 VACCINES AGAINST HEPATITIS B VIRUS
The present application provides immunotherapies for Hepatitis B virus infections. Provided herein are genetically modified arenaviral vectors suitable as...
2018/0319844 CYCLIC PEPTIDE BINDER AGAINST ONCOGENIC K-RAS
Cyclic peptides represented by (Formula 1) ##STR00001## selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each...
2018/0319843 COMPOSITIONS AND METHODS FOR TREATING CENTRAL NERVOUS SYSTEM (CNS) DISORDERS AND MOOD DISORDERS
Compositions and methods of treating a central nervous system (CNS) disorder or mood disorder in a subject in need of such treatment are described. A...
2018/0319842 COMPOUNDS AND METHODS FOR TREATING PAIN
The present disclosure relates to, among other things, compounds and methods for treating neuropathic pain, ocular pain, ocular inflammation, and/or dry eye...
2018/0319841 AGONIST OF SPEXIN-BASED GALANIN TYPE 2 RECEPTOR AND USE THEREOF
The present invention relates to spexin-based agonists specific for galanin receptor type 2 and use thereof. More specifically, the present invention provides...
2018/0319840 NOVEL ANTIMICROBIAL PEPTIDE AND USE THEREOF
The present invention relates to a novel peptide having both an antimicrobial effect and an immunocyte activity regulatory function, and a use thereof. The...
2018/0319839 GELATINASE INHIBITORS AND USE THEREOF
New gelatinase inhibitors, processes for their preparation, pharmaceutical compositions comprising them, and their use in therapy and/or prophylaxis of...
2018/0319838 CONJUGATION METHODS FOR MODIFYING OR IMMOBILIZING PROTEINS
The present disclosure relates, in some aspects, to protein-ligand localized conjugation technology with respect to immobilized functional proteins for...
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