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Patent # Description
2018/0319836 BILE ACID DERIVATIVES AND METHODS FOR SYNTHESIS AND USE
Provided herein, inter alia, are methods for the preparation of modulators of farnesoid X receptor (FXR), and compositions and uses of the modulators of FXR.
2018/0319835 METHOD OF PREPARING NUCLEASE-RESISTANT DNA-INORGANIC HYBRID NANOFLOWERS
A method of preparing nucleic acid-inorganic hybrid nanoflowers is described, in which a nucleic acid is allowed to react with a solution of a metal...
2018/0319834 THIONUCLEOSIDE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION
Disclosed are a compound and a pharmaceutical composition that exhibit an excellent drug efficacy against a tumor, in particular a tumor which has acquired...
2018/0319833 Method of preparation of 6-azido-2,4-diacetamido-2,4,6-trideoxy-D-mannose
Disclosed is a method of preparation of 6-azido-2,4-diacetamido-2,4,6-trideoxy-D-mannose. This method includes the chemical reaction of compound of formula X: ...
2018/0319832 Design, Synthesis, and Biological Activity of Platinum-benz[c]acridine Hybrid Agents and Methods Associated...
The present invention relates to the compounds of formula (I), pharmaceutically acceptable salts, and solvates thereof, wherein the various substituents are as...
2018/0319831 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
A compound comprising a first ligand L.sub.A having the formula ##STR00001## Formula I, is disclosed. In Formula I, ring A is a five- or six-membered carbocyclic...
2018/0319830 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
The present invention includes novel hexadentate metal complexes. The complexes hexadentate ligands of the present invention may be useful as improved emitters...
2018/0319829 PHOSPHINIC PEPTIDE DERIVATIVES FOR USE AS MMP-12 INHIBITORS
This invention relates to compounds that are selective inhibitors of Matrix Metalloprotease-12 (MMP-12), to cosmetic and pharmaceutical compositions containing...
2018/0319828 PREPARATION METHOD FOR TEDIZOLID, TEDIZOLID INTERMEDICATE, AND PREPARATION METHOD THEREFOR
The present invention relates to a preparation method for a tedizolid compound in Formula I. In Formula I, R is selected from hydrogen, formula A, formula B,...
2018/0319827 PROCESS FOR PRODUCING PHOSPHORUS-CONTAINING CYANOHYDRIN ESTERS
The present invention primarily relates to a process for producing certain phosphorus-containing cyanohydrin esters of formula (I) and the use thereof for...
2018/0319826 PROCESS FOR ISOLATING A (THIO)PHOSPHORIC ACID DERIVATIVE
Provided herein is a process for isolating at least one (thio)phosphoric acid derivative, which has a boiling point of at least 70.degree. C., from a product...
2018/0319825 CELL-PENETRATING, GUANIDINIUM-RICH OLIGOPHOSPHOTRIESTERS FOR DRUG AND PROBE DELIVERY
Guanidinium-rich oligophosphotriesters transporter compounds and methods of making and using the same are provided. Also provided are pharmaceutical...
2018/0319824 MOISTURE AND ROOM TEMPERATURE-CURABLE ORGANOPOLYSILOXANE RESIN COMPOSITION AND METHOD FOR PRODUCING CURED...
The present invention provides: a novel organic titanium compound having an effect as an adhesion promoter by itself; a production method of such organic...
2018/0319823 MIXTURES OF CYCLIC BRANCHED SILOXANES OF THE D/T TYPE AND CONVERSION PRODUCTS THEREOF
Mixtures of cyclic branched siloxanes having exclusively D and T units, with the proviso that the cumulative proportion of the D and T units having Si-alkoxy...
2018/0319822 Functionalized Mesoporous Silica via an Aminosilane Surfactant Ion Exchange Reaction: Controlled Scaffold...
Nitric oxide-releasing mesoporous silica nanoparticles (MSNs) were prepared using an aminosilane-template surfactant ion exchange reaction. Initially, bare...
2018/0319821 COVALENT ORGANIC FRAMEWORKS WITH A WOVEN STRUCTURE
The disclosure provides for covalent organic frameworks (COFs) that constructed from weaving a plurality of long organic threads together. In particular, the...
2018/0319820 Novel 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative
There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and...
2018/0319819 HETEROCYCLIC COMPOUND
The present invention provides a heterocyclic compound having an RIP1 kinase inhibitory action, which is useful for the prophylaxis or treatment of Gaucher's...
2018/0319818 ACTIVATORS OF AUTOPHAGIC FLUX AND PHOSPHOLIPASE D AND CLEARANCE OF PROTEIN AGGREGATES INCLUDING TAU AND...
The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further...
2018/0319817 Derivatized 3-Styryl-Cephalosporins
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the...
2018/0319816 PRODUCTION METHOD OF THIENOPYRIMIDINE DERIVATIVE
The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH)...
2018/0319815 HETERO-SUBSTITUTED CYCLIC LACTONE ANALOGUES AND USES THEREOF
The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure...
2018/0319814 CORTISTATIN ANALOGUES AND SYNTHESES AND USES THEREOF
Provided herein are compounds of Formula (A), (B), (C), (D) and (E), pharmaceutically acceptable salts, quaternary amine salts, and N-oxides thereof, and...
2018/0319813 BENZIMIDAZOLE FUSED HETEROARYLS
A compound of general formula (I): wherein A.sup.1, A.sup.2, A.sup.3, A.sup.4, B.sup.1, B.sup.2, B.sup.3, B.sup.4, C.sup.1, C.sup.2, C.sup.3, C.sup.4, X.sup.1...
2018/0319812 HETEROCYCLIC COMPOUND
The present invention relates to compound (I) or a salt thereof which has a ROR.gamma.t inhibitory action. ##STR00001## wherein each symbol is as defined in the...
2018/0319811 DERIVATIVES OF PORPHYRINS, THEIR PROCESS OF PREPARATION AND THEIR USE FOR TREATING VIRAL INFECTIONS
The present invention concerns metallated porphyrin derivatives as ligands of G-quadruplex and their novel use as anti-viral agents.
2018/0319810 SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS
The present invention relates to novel substituted bridged urea analog compounds of Formula (I) or pharmaceutically acceptable salts thereof, corresponding...
2018/0319809 FUSED QUADRACYCLIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
Provided herein are substituted fused quadracyclic compounds useful as inhibitors of MK2. The invention further provides pharmaceutical compositions of the...
2018/0319808 METHOD FOR PRODUCING A SPIROOXINDOLE DERIVATIVE
The present disclosure provides a method for efficiently producing and providing compounds having a spirooxindole skeleton, for example compounds having a...
2018/0319807 [8-(PHENYLSULFONYL)-3,8-DIAZABICYCLO[3.2.1]OCT-3-YL](1H-1,2,3-TRIAZOL-4-YL- )METHANONES
The present invention covers [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-y- l)methanone compounds of general formula (I): ...
2018/0319806 CRYSTALLINE FORMS OF A BRUTON'S TYROSINE KINASE INHIBITOR
Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pi- ...
2018/0319805 CRYSTALLINE FORMS OF A BRUTON'S TYROSINE KINASE INHIBITOR
Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4d]pyrimidin-1-yl)pip- ...
2018/0319804 NOVEL COMPOUNDS THAT ARE ERK INHIBITORS
Disclosed are the ERK inhibitors of formula (1): ##STR00001## and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer...
2018/0319803 SALT AND POLYMORPHIC FORMS OF (3R,4S)-L-((4-AMINO-5H-PYRROLO[3,2,-D]PYRIMIDIN-7-YL)METHYL)-4(METHYLTHIO- ...
The invention relates to salt forms of (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(methyl-thi- omethyl)pyrrolidin-3-ol, as well as...
2018/0319802 Method Of Stabilizing Riboflavin
A method of stabilizing riboflavin by affixing the riboflavin to at least one substrate for the riboflavin by covalent bonding, hydrogen bonding, Van der Waals...
2018/0319801 INHIBITORS OF CYCLIN-DEPENDENT KINASES
The present invention provides novel compounds of Formula (I), (II), or (III), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs,...
2018/0319800 (1R,4R) 7-OXO-2-AZABICYCLO[2.2.2]OCT-5-ENE AND DERIVATIVES THEREOF
This invention provides novel (1R,4R) 7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof, preferably in substantially enantiomerically enriched forms,...
2018/0319799 PYRIDO[1,2-A]PYRIMIDONE ANALOG, CRYSTAL FORM THEREOF, INTERMEDIATE THEREOF AND PREPARATION METHOD THEREFOR
Disclosed in the present invention are a crystalline Form of pyrido[1,2-a]pyrimidone analog, a preparation method therefor and an intermediate thereof, ...
2018/0319798 1,3,4,8-Tetrahydro-2H-Pyrido[1,2-a]Pyrazine Derivative and Use of the Same as HIV Integrase Inhibitor
[Problem] Provided is a novel 1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine derivative or a pharmaceutically acceptable salt thereof, or a solvate thereof, which...
2018/0319797 NOVEL SUBSTITUTED PYRIDO-PIPERAZINONE DERIVATIVES AS GAMMA SECRETASE MODULATORS
The present invention is concerned with novel substituted pyrido-piperazinone derivatives of Formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
2018/0319796 JAK Kinase Inhibitor Compounds for Treatment of Respiratory Disease
The invention provides compounds of formula (I): ##STR00001## wherein X is ##STR00002## and the variables are defined in the specification, or a ...
2018/0319795 THERAPEUTIC TARGETING OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 (IRAK4) IN CANCERS CHARACTERIZED BY...
Disclosed are methods for treating cancers associated with rearrangements in the mixed lineage leukemia gene (MLL-r), including MLL-r leukemia. The methods...
2018/0319794 AMINO-SUBSTITUTED IMIDAZO[1,2-A] PYRIDINECARBOXAMIDES AND THEIR USE
The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in...
2018/0319793 HISTONE DEMETHYLASE INHIBITORS
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted ...
2018/0319792 PYRROLOQUINOLINE QUINONE B CRYSTAL FORM AND PREPARATION METHOD THEREFOR
The present invention relates to the technical field of chemical drugs and crystal form processes, and to a pyrroloquinoline quinine B crystal form and a...
2018/0319791 4,5,6,7-TETRAHYDRO-1H-IMIDAZO[4,5-C]PYRIDINE AND 1,4,5,6,7,8-HEXAHYDROIMIDAZO[4,5-D]AZEPINE DERIVATIVES AS...
There are provided compounds of formula (I), wherein X, Ak, s, L, Q, R.sup.1 and R.sup.2 have meanings given in the description, which compounds have...
2018/0319790 PREPARATION METHODS FOR PALBOCICLIB FREE BASE CRYSTAL FORM A AND CRYSTAL FORM B
Disclosed is a preparation method for a Palbociclib free base crystal form A as shown in Formula I, comprising the following steps: treating a Palbociclib free...
2018/0319789 PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAININGSUBSTITUENTS
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers...
2018/0319788 N-PYRIDINYL ACETAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALING PATHWAY
Disclosed are compounds useful as inhibitors of the Wnt signalling pathway. Specifically, inhibitors of Porcupine (Porcn) are contemplated by the invention. In...
2018/0319787 BACE1 INHIBITORS
The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and...
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