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Patent # Description
2018/0319786 INHIBITOR OF THE P2X7 RECEPTOR
The present invention provides (S)-N-(2-(4-chlorophenyl)-2-morpholinoethyl)-2-(pyrimidin-2-yl)-4-(triflu- oro-methyl)thiazole-5-carboxamide as P2X7 inhibitor,...
2018/0319785 4-HYDROXY-2-PHENYL-1,3-THIAZOL-5-YL METHANONE DERIVATIVES AS TRPM8 ANTAGONISTS
The invention relates to compounds acting as antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I): ...
2018/0319784 PHENYLTHIAZOLES AND USES THEREOF
Series of 2-phenyl-4-methylthiazole analogues are disclosed as potential therapeutic agents for the treatment of bacterial infections, especially ...
2018/0319783 Novel Ferroportin Inhibitors
The invention relates to novel compounds of the general formula (A-I), with Het-2 being an optionally substituted bicyclic heteroaryl of the formula (AA)...
2018/0319782 N-((HET) ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS
The present invention provides compounds of formula (I): (I) compositions comprising such compounds; the use of such compounds in therapy (for example in the...
2018/0319781 NEW BENZIMIDAZOLES DERIVATIVES AS TEC KINASES FAMILY INHIBITORS
The present invention relates to a novel family of covalent kinases inhibitors. Compounds of this class have been found to have inhibitory activity against...
2018/0319780 INHIBITORS OF JUN N-TERMINAL KINASE
The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: ##STR00001## or a salt or...
2018/0319779 SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF
The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by...
2018/0319778 PHENYL INDOLE ALLOSTERIC INHIBITORS OF P97 ATPASE
The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be...
2018/0319777 CRYSTALLINE FORMS OF POSACONAZOLE INTERMEDIATE AND PROCESS FOR THE PREPARATION OF AMORPHOUS POSACONAZOLE
The present invention provides an industrial method production of amorphous posaconazole. The present invention also relates to a method for production of the...
2018/0319776 NOVEL ORGANIC HETEROCYCLIC COMPOUND AND LIHGHT-EMITTING DIODE COMPRISING SAME
The present disclosure relates to an organic compound represented by Chemical Formula A or B, and an organic light-emitting diode comprising the same.
2018/0319775 INHIBITORS OF KRAS G12C MUTANT PROTEINS
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I) or a pharmaceutically...
2018/0319774 IRIDIUM (III) COMPLEXES WITH CYCLIC QUINOXALINE-FUSED LIGANDS AND ORGANIC LIGHT-EMITTING DIODES USING THE SAME
An iridium (III) complex compound with cyclic quinoxaline-fused dibenzosuberene ligand is shown in General Formula (1), ##STR00001## wherein m is 1 or 2, n is...
2018/0319773 TRIAZOLE AGONISTS OF THE APJ RECEPTOR
Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the...
2018/0319772 INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7)
The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers,...
2018/0319771 HETEROARYLCARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS
The present invention relates to compounds of general formula (I), wherein D.sup.1 to D.sup.3, -A-, n, R.sup.1, R.sup.2, Y.sup.1, L and .sup.y2 are defined as...
2018/0319770 EGFR INHIBITOR AND PHARMACEUTICALLY ACCEPTABLE SALT AND POLYMORPH THEREOF, AND USE THEREOF
Provided is an EGFR inhibitor and a pharmaceutically acceptable salt and a polymorph thereof, and a use thereof. In particular, provided is a polymorph, a...
2018/0319769 HISTONE DEMETHYLASE INHIBITORS
The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine...
2018/0319768 ANTIFUNGAL COMPOUNDS AND PROCESSES FOR MAKING
The present invention relates to polymorphic forms of compound 1 or 1a and processes for preparing compound 1 and 1a polymorphs, which are useful as antifungal...
2018/0319767 COMPOSITIONS COMPRISING AN INHIBITOR OF LYSINE SPECIFIC DEMETHYLASE-1
Described herein are amorphous and crystalline forms of pharmaceutically acceptable salts of the lysine specific demethylase-1 inhibitor ...
2018/0319766 CO-CRYSTALS OF BENZIMIDAZOLE COMPOUNDS
The invention relates to a cocrystal comprising a) at least bilastine and, b) at least a cocrystal forming compound selected from the group consisting of...
2018/0319765 DIBENZOTHIOPHENE COMPOUNDS
The present invention generally relates to various dibenzothiophene compounds, processes for preparing these compounds, and use of these compounds in organic...
2018/0319764 TRICYCLIC SPIRO COMPOUND
A medicinal agent for the prevention and/or treatment of diseases caused by EP.sub.4 receptor activation. A compound having antagonistic activity against the...
2018/0319763 PROCESS FOR THE PRODUCTION OF CANNABIDIOL AND DELTA-9-TETRAHYDROCANNABINOL
The present disclosure relates to the preparation of a cannabidiol compound or a derivative thereof. The cannabidiol compound or derivatives thereof can be...
2018/0319762 5-deoxy-irilin B Having Angiotensin-I-converting enzyme Inhibition Activity derived from Salicornia SPP. and...
A compound having antihypertensive activity, especially 5-deoxy-irilin B having angiotensin-I-converting enzyme inhibition activity, derived from Salicornia...
2018/0319761 PYRONE BASED COMPOUNDS FOR TREATING BACTERIAL INFECTIONS
The present teachings relate to pyrone derivatives, pharmaceutical compositions thereof, and methods of using such compounds to treat bacterial infections.
2018/0319760 METHOD FOR PRODUCING 5-HYDROXYMETHYLFURFURAL IN THE PRESENCE OF CATALYSTS OF THE FAMILY OF HOMOGENEOUS SULFONIC...
The invention relates to a novel process for the conversion of a feedstock comprising at least one sugar to 5-hydroxymethylfurfural, in which said feedstock is...
2018/0319759 A PROCESS FOR PREPARING A MIXTURE COMPRISING 5-(HYDROXYMETHYL) FURFURAL AND SPECIFIC HMF ESTERS
Provided herein is a process for preparing a mixture including 5-(hydroxy-methyl)furfural (HMF) and one or more HMF esters of formula (I), the process...
2018/0319758 A PROCESS FOR PREPARING FURAN-2,5-DICARBOXYLIC ACID
Provided herein is a process for preparing furan-2,5-dicarboxylic acid. The process includes the following steps: (A-1) preparing a starting mixture comprising...
2018/0319757 METHOD FOR PRODUCING FURAN COMPOUND AND FURFURAL COMPOSITION
The present invention is aimed to provide an industrially advantageous method for producing a furan compound, in which a furan compound can be efficiently...
2018/0319756 GLYCIDOL SYNTHESIS METHOD
The invention relates to a method for obtaining glycidol in a semi-continuous or continuous manner by decarboxylating glycerol carbonate at reduced pressure,...
2018/0319755 POLYMERIZABLE COMPOUND AND OPTICALLY ANISOTROPIC BODY
There is provided a polymerizable composition, by which discoloration or alignment defects are less likely to occur when a filmy polymer, which is obtained by...
2018/0319754 THERMODYNAMICALLY STABLE CRYSTAL MODIFICATION OF 2-METHYL-N-(5-METHYL-1, 3,...
A thermodynamically stable crystal modification of 2-methyl-N-(5-methyl-1,3,4-oxadiazol-2-yl)-3-(methylsulfonyl)-4-(trifluor- omethyl)benzamide is described....
2018/0319753 MICROBIOCIDAL OXADIAZOLE DERIVATIVES
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides. ##STR00001##
2018/0319752 P2X4 RECEPTOR ANTAGONIST
Compounds represented by the following general formula (I), which has a P2X4 receptor antagonistic activity (in the formula, R.sup.1, R.sup.2 and R.sup.3...
2018/0319751 THERAPEUTIC COMPOUNDS
Compounds of formula (I) and salts are disclosed. Also disclosed are isotopes of compounds of formula I of the salts thereof. Pharmaceutical compositions...
2018/0319750 PROCESSES FOR THE PREPARATION OF 4-ALKOXY-3-(ACYL OR ALKYL)OXYPICOLINAMDES
A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic...
2018/0319748 KINASE INHIBITORS
There are provided compounds of formula IIb, ##STR00001## wherein: LG.sup.1 represents imidazolyl, chloro, or aryloxy; and Z.sup.1 represents a structural...
2018/0319747 PROCESS FOR THE SYNTHESIS OF PIRFENIDONE
Disclosed is a process for the synthesis of Pirfenidone (1) from 5-methyl-2(1H)-pyridinone and chlorobenzene in the presence of a catalytic system consisting...
2018/0319746 STERICALLY HINDERED AMINES
An intermediate of the formula (I) ##STR00001## wherein the radicals R.sub.1 are independently of one another methyl, ethyl or n-propyl, is suitable for...
2018/0319745 PEROXYHEMIACETAL PROFRAGRANT AND PROFLAVOR COMPOUNDS
Provided herein is a compound of Formula I: ##STR00001## wherein R represents a terpene hydroperoxyl selected from the group consisting of ##STR00002## ...
2018/0319744 FLUORINATED COMPOUNDS CONTAINING A -OSF5 GROUP AND PROCESS FOR THEIR PREPARATION
A process for the preparation of fluorinated compounds having at least one --OSF.sub.5 group, said method comprising the step of reacting SOF.sub.4 with a...
2018/0319743 TETRALIN AND INDANE DERIVATIVES AND USES THEREOF
The applicaton discloses pharmaceutical compounds of formula I useful for treating CNS diseases wherein m, s, R.sup.1R.sup.5, R.sup.6 and R.sup.7 are as...
2018/0319742 N-(4-HYDROXY-4-METHYL-CYCLOHEXYL)-4-PHENYL-BENZENESULFONAMIDES AND N-(4- ...
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted...
2018/0319741 NOVEL SULFONYLAMINOBENZAMIDE COMPOUNDS AS ANTHELMINTICS
The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt...
2018/0319740 RADIATION-SENSITIVE RESIN COMPOSITION, RESIST PATTERN-FORMING METHOD, AND COMPOUND
A radiation-sensitive resin composition includes a first polymer including a first structural unit that includes a first acid-labile group; a...
2018/0319739 PROCESS FOR PURIFYING ALKANESULFONIC ACIDS
The invention relates to a process for purifying alkanesulfonic acids which comprises the steps of: (a) distilling a melt comprising crude alkanesulfonic acid...
2018/0319738 PROCESS FOR THE SYNTHESIS OF (+) AND (-)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE
The present invention is concerned with novel processes for the preparation of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically...
2018/0319737 PHENYL-(AZA)CYCLOALKYL CARBOXYLIC ACID GPR120 MODULATORS
The present invention provides compounds of Formula (I): ##STR00001## or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the...
2018/0319736 L-ORNITHINE PHENYL ACETATE AND METHODS OF MAKING THEREOF
Disclosed herein are forms of L-ornithine phenyl acetate and methods of making the same. A crystalline form may, in some embodiments, be Forms I, II, III and...
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