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Patent # Description
2018/0318469 COMPOSITION COMPRISING HYALURONIC ACID AND MEPIVACAINE
Compositions and methods for the surface appearance of the skin a subject are provided. An injectable composition comprising at least hyaluronic acid or a salt...
2018/0318468 METHODS OF MAKING THERAPEUTIC POLYMERIC MATERIAL
Therapeutic polymeric materials, therapeutic polymeric materials containing medical implants and methods for making the same, and related materials are...
2018/0318467 SUPER-HYDROPHOBIC MATERIALS AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS
Superhydrophobic materials are disclosed and described, along with devices, surfaces, and associated methods. Such materials can be coated onto device...
2018/0318466 METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The...
2018/0318465 BONE GRAFT
The present invention relates to a novel bone graft and methods for producing said graft. Said bone graft can be used for surgical, plastic and/or cosmetic...
2018/0318464 INTRAOCULAR LENS MATERIAL
An intraocular lens material disclosed in the present description includes an aromatic ring-containing acrylate structural unit, an alkoxyalkyl methacrylate...
2018/0318463 SYSTEM AND METHOD FOR INTRAOPERATIVE JOINT CONTACT MECHANICS MEASUREMENT
A method for intraoperatively measuring joint contact mechanics of a patient's joint is provided. The method includes inserting a sensor between first and...
2018/0318462 SCENT DIFFUSER WITH INTEGRATED AIR CIRCULATOR
A scent diffuser (e.g., air freshener) configured to automatically circulate fragrant air throughout a surrounding environment comprises a powered air...
2018/0318460 Fragrance Emitter
An emitter including a charcoal composition, a flat base section disposed on a bottom portion of the charcoal composition, a scented configuration piece is...
2018/0318459 APPARATUS FOR STERILIZING AN INSTRUMENT CHANNEL OF A SURGICAL SCOPING DEVICE
Sterilization apparatus comprising a sterilization instrument configured to be inserted through the instrument channel of a surgical scoping device and a...
2018/0318458 A FACILITY, AN UNMANNED VEHICLE AND METHOD FOR PROCESSING OF DIRTY SURGICAL INSTRUMENTS
The invention relates to a facility which has a dirty facility area and an adjacent clean facility area, baskets for receiving the dirty articles, and a wall...
2018/0318457 DEVICE FOR DISINFECTING CPAP COMPONENTS AND METHOD OF USING THE SAME
This disclosure relates to a device for disinfecting CPAP components and a method of using the same. An example device includes a chamber, an ultraviolet (UV)...
2018/0318456 COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS
The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods...
2018/0318455 COMPLEXES BETWEEN BLOCK POLYMERS AND IONS AS CONTRAST AGENTS FOR MEDICAL IMAGING
The invention relates to a complex between block polymers comprising a first hydrophilic block and a second block comprising at least one ionised function, and...
2018/0318454 CONJUGATED POLYCATIONIC POLYMERS, METHODS OF USING THE SAME AND METHODS OF TREATING AUTOIMMUNE DISEASES,...
Disclosed herein are polycationic polymers and methods of using the same. The polycationic polymer comprises a dendrimer or dendron, the dendrimer or the...
2018/0318453 COMPOSITIONS AND METHODS FOR ASSESSING EYE VASCULATURE
Compositions and methods for assessing blood vessels and organs of the body are disclosed herein, specifically methods for assessing the vasculature of the eye.
2018/0318452 Fluorescent Fluid For Detecting Fluid Injection
A fluorescent solution is disclosed for use in a hydraulic or diesel fluid to facilitate detection of injection of the hydraulic of diesel fluid into a human....
2018/0318451 NOVEL PSMA-SPECIFIC BINDING PROTEINS
The present invention relates to a prostate-specific membrane antigen (PSMA)-specific binding protein, wherein the PSMA-specific binding protein is a lipocalin...
2018/0318450 ENHANCED SURGICAL VISUALIZATION OF VIABLE TISSUE WITH SELECTIVE DYE
The various embodiments relate to the identification of non-viable tissue for debridement using a ph low insertion peptide conjugate. ph low insertion peptide...
2018/0318449 OLIG1 MINI-PROMOTERS: Ple305
Isolated polynucleotides comprising an OLIG1 mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter...
2018/0318448 METHOD FOR DETERMINING PRESENCE OR ABSENCE OF SUFFERING FROM MALIGNANT LYMPHOMA OR LEUKEMIA, AND AGENT FOR...
An object of the present invention is to provide a method for determining whether a subject suffers from malignant lymphoma or leukemia and an agent for...
2018/0318447 COMPOSITIONS AND METHODS FOR IMPROVING VIRAL VECTOR EFFICIENCY
The present invention relates to peptides and compositions for use in improving transduction efficiency of viruses into target cells.
2018/0318446 ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF
Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of viruses....
2018/0318445 AMPHIPHILIC CYCLODEXTRIN-BASED GLYCODENDRIMERS
The present application provides an amphiphilic cyclodextrin-based compound of the formula I: R-G-D-A (I) wherein R is one or more hydrophilic groups; G is one...
2018/0318444 GLYPICAN 2 AS A CANCER MARKER AND THERAPEUTIC TARGET
The present disclosure is directed to antibodies binding to Glypican 2 and methods of using such antibodies to treat cancers that express or overexpress the
2018/0318443 HETEROMULTIVALENT PARTICLE COMPOSITIONS
A composition for use in diagnostic and therapeutic applications includes a heteromultivalent nanoparticle or microparticle having an outer surface and a...
2018/0318442 FORMULATION OF NANOSTRUCTURED GELS FOR INCREASED AGENT LOADING AND ADHESION
A gel formulation has been developed which provides high loading, e.g., between about 5% and about 50% wt/wt agent/total gel weight, of a wide range of agents,...
2018/0318441 NOVEL ANTIBODY CONJUGATES AND USES THEREOF
Provided are novel antibody drug conjugates (ADCs), and methods of using such ADCs to treat proliferative disorders.
2018/0318440 MONOCLONAL ANTIBODIES SPECIFIC FOR FIBROBLAST GROWTH FACTOR RECEPTOR 4 (FGFR4) AND METHODS OF THEIR USE
Monoclonal antibodies selected from immunized mice, immunized rabbits and a human scFv library that specifically bind fibroblast growth factor receptor 4...
2018/0318439 Immunoconjugates with an Intracellularly-Cleavable Linkage
The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an...
2018/0318438 ANTIBODY DRUG CONJUGATES OF KINESIN SPINDEL PROTEIN (KSP) INHIBITORS WITH ANTI-TWEAKR-ANTIBODIES
The present application relates to novel binder drug conjugates (ADCs), to active metabolites of these ADCs, to processes for preparing these ADCs, to the use...
2018/0318437 ANTIBODY DRUG CONJUGATES OF KINESIN SPINDEL PROTEIN (KSP) INHIBITORS WITH ANTI-CD123-ANTIBODIES
The present application relates to novel binder drug conjugates (ADCs), to active metabolites of these ADCs, to processes for preparing these ADCs, to the use...
2018/0318436 METHODS AND MEANS FOR INDUCING AN IMMUNE RESPONSE
The present invention relates to a method for inducing an immune response manifested by type I interferon production in a synergistic manner comprising the...
2018/0318435 ANTI-BCMA POLYPEPTIDES AND PROTEINS
Polypeptides and proteins that specifically bind to and immunologically recognize B-Cell Maturation Antigen (BCMA) are disclosed. Chimeric antigen receptors...
2018/0318434 COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF
The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein...
2018/0318433 Composition Comprising a Biocompatible and Biodegradable Polymer, Nanocarriers and a Drug and Methods of Making...
The present invention pertains to a composition comprising at least one biocompatible and biodegradable polymer, said polymer further comprising nanocarriers...
2018/0318432 THERAPEUTIC PROTEINS WITH INCREASED HALF-LIFE AND METHODS OF PREPARING SAME
The present disclosure relates to materials and methods of conjugating a water soluble polymer to a therapeutic protein.
2018/0318431 METHODS OF TREATING AN OCULAR DISEASE OR DISORDER
The present disclosure provides methods of treating an ocular disease or disorder. The methods involve direct administration into the eye of a conjugate...
2018/0318430 COMPLEX COMPRISING RNAI MOLECULE AND N-ACETYLATED CHITOSAN
Provided is a composition comprising an RNAi molecule which suppresses expression of CHST15 gene and successfully used for less invasive administration. A...
2018/0318429 USE OF HYDROPHOBIC ORGANIC ACIDS TO INCREASE HYDROPHOBICITY OF PROTEINS AND PROTEIN CONJUGATES
Examples may include a method of making a protein-PEG conjugate salt with increased hydrophobicity. The method may include providing an aqueous protein...
2018/0318428 POLYAMINATED POLYGLUTAMIC ACID-CONTAINING COMPOUNDS AND USES THEREOF FOR DELIVERING OLIGONUCLEOTIDES
Polymers useful for associating therewith oligonucleotides and for delivering the oligonucleotides into a cell, conjugates comprising these polymers and an...
2018/0318427 PHARMACEUTICAL FORMULATIONS COMPRISING INSULIN OR INSULIN ANALOGS CONJUGATED TO FUCOSE
Disclosed is a pharmaceutical formulation comprising an insulin or insulin analog molecule covalently attached to at least one branched linker having a first...
2018/0318426 PHARMACEUTICAL FORMULATIONS COMPRISING INSULIN OR INSULIN ANALOGS CONJUGATED TO FUCOSE FOR PROVIDING A BASAL...
Disclosed is a pharmaceutical formulation comprising an insulin or insulin analog molecule covalently attached to at least one branched linker having a first...
2018/0318425 Bortezomib Conjugates and Methods Using Same
The present invention provides compositions and methods for providing controllable local delivery of a conjugate of bortezomib (Btz) and a bisphosphonate to...
2018/0318424 NANOSTRUCTURE COATED WITH A TWIST-STRAINED DOUBLE-STRANDED CIRCULAR DEOXYRIBONUCLEIC|ACID (DNA), METHOD FOR...
A nanostructure coated with a twist-strained double-stranded circular deoxyribonucleic acid (DNA) is provided, together with methods for preparing the coated...
2018/0318423 NANOSTRUCTURED GELS CAPABLE OF CONTROLLED RELEASE OF ENCCAPSULATED AGENTS
Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The...
2018/0318422 Method for Suppressing Bitterness of Quinoline Derivative
The present invention provides a method for suppressing bitterness of a quinoline derivative.
2018/0318421 METHODS FOR THE TREATMENT OF RECURRENT GLIOBLASTOMA (RGBM)
Methods for the treatment of cancer, including glioblastoma multiforme (GBM) and recurrent glioblastoma multiforme (RGBM). The method includes administering to...
2018/0318420 BORON NEUTRON CAPTURE THERAPY SYSTEM
A boron neutron capture therapy system has a neutron beam irradiation device, a patient restraint/placement portion, a three-dimensional diagnostic device, an...
2018/0318419 COMPOSITIONS AND METHODS FOR TREATING AUTOIMMUNE DISEASES AND CANCERS
The present invention provides methods and compositions for treating a cancer, methods for increasing an immune response against a tumor, methods for treating...
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