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Patent # Description
2018/0318418 ANTI-BARF1 MONOCLONAL ANTIBODY
The present invention relates to a new anti-BARF1 monoclonal antibody.
2018/0318417 MULTISPECIFIC IMMUNOMODULATORY ANTIGEN-BINDING CONSTRUCTS
Provided herein are multispecific immunomodulatory antigen-binding constructs (MIACs) and compositions comprising the constructs. Also provided are methods of...
2018/0318416 BINDING MOLECULES SPECIFIC FOR IL-21 AND USES THEREOF
This disclosure provides IL-21 binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof. In certain aspects the anti-IL-21...
2018/0318415 NOVEL ADJUVANT FORMULATIONS
The invention relates to a composition comprising solid lipid nanoparticles (SLNs), wherein the SLNs comprise an aminoalkyl glucosaminide phosphate (AGP).
2018/0318414 Pro-Inflammatory and Adjuvant Functions of Toll-Like Receptor 4 Antagonists
The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). ...
2018/0318413 ALLERGEN DESENSITIZATION METHOD
The present application relates to a method for desensitization of allergic patients. More specifically it relates to an epicutaneous desensitization method,...
2018/0318412 INACTIVATED VARICELLA ZOSTER VIRUS VACCINES, METHODS OF PRODUCTION, AND USES THEREOF
The invention provides an inactivated varicella zoster virus (VZV), and compositions and vaccines comprising said inactivated VZV, wherein the infectivity of...
2018/0318411 METHOD OF VACCINATION WITH AN ATTENUATED RSV VACCINE FORMULATION
Respiratory syncytial virus (RSV) infection may lead to severe respiratory illness in young children. Thus, there is a need for a live attenuated vaccine,...
2018/0318410 COMBINATION VACCINES WITH SEROGROUP B MENINGOCOCCUS AND D/T/P
Serogroup B meningococcus antigens can successfully be combined with diphtheria, tetanus and pertussis toxoids ("DTP") to provide effective combination...
2018/0318409 CANCER VACCINES
The disclosure relates to cancer ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
2018/0318408 IMMUNOTHERAPY OF CANINE LEISHMANIASIS
The present invention provides a method for treating canine leishmaniasis by immunotherapy.
2018/0318407 PCSK9 VACCINE
The present invention relates to the provision of novel immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention,...
2018/0318406 KEXIN-DERIVED VACCINES TO PREVENT OR TREAT FUNGAL INFECTIONS
A vaccine is disclosed that promotes CD4+ T cell-independent host defense mechanisms to defend against infection by fungi such as Pneumocystis spp. The vaccine...
2018/0318405 TARGETING CAPN9/CAPNS2 ACTIVITY AS A THERAPEUTIC STRATEGY FOR THE TREATMENT OF MYOFIBROBLAST DIFFERENTIATION...
Provided herein are, inter alia, compositions and methods for identifying and using agents capable of inhibiting myofibroblast transition as well as methods...
2018/0318404 COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA
Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria...
2018/0318403 HEMOSTATIC COMPOSITIONS
The invention relates to a hemostatic composition in powder form comprising collagen of the fibrillar type comprising a content of fibrous collagen and/or...
2018/0318402 COMPOSITIONS AND METHODS COMPRISING SERRATIA PEPTIDASE FOR INHIBITION AND TREATMENT OF BIOFILMS RELATED TO...
Physiologically acceptable anti-biofilm compositions comprising Serratia peptidase and optionally one or more of bromelain, papain and a fibrinolytic enzyme....
2018/0318401 Compositions and Methods for Treating Pathological Calcification and Ossification
The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological...
2018/0318400 METHODS OF TREATING TISSUE CALCIFICATION
The present invention provides a method of treating NPP1 deficiency or NPP1-associated disease such as idiopathic infantile arterial calcification (IIAC),...
2018/0318399 ANTIMICROBIAL COMPOSITIONS AND FORMULATIONS RELEASING HYDROGEN PEROXIDE
Compositions for generating antimicrobial activity are described. The compositions comprise: a first phase; a second phase; an enzyme that is able to convert a...
2018/0318398 METHODS AND COMPOSITIONS USING AMPK ACTIVATORS FOR PHARMACOLOGICAL PREVENTION OF CHRONIC PAIN
Methods and compositions using a combination of adenosine monophosphate protein kinase (AMPK) activators for treating pain such as post-surgical pain or...
2018/0318397 Method of Treating Pulmonary Hypertension by Administration of Natriuretic Peptide Receptor C Signaling Pathway...
The present invention is based upon the observation that inhibition of NPR-C Signaling pathway leads to the development of pulmonary arterial hypertension...
2018/0318396 METHODS OF TREATING OR PREVENTING PRURITIS BY BLOCKING NATRIURETIC POLYPEPTIDE B
Disclosed is a method of treating, reducing, or preventing pruritis in a mammal, the method comprising administering at least one natriuretic polypeptide b...
2018/0318395 THERAPEUTIC AGENT FOR RHINITIS
The problem to be solved by the present invention is to provide an effective and safe therapeutic preparation for rhinitis, which not only has significant...
2018/0318394 IMMUNOMODULATION FOR THE LONG TERM PREVENTION AND TREATMENT OF AUTOIMMUNE DISEASES AND FOREIGN TISSUE REJECTION
Described herein are pharmaceutical compositions, medicaments and methods for providing effective immunomodulation with chimeric proteins including FasL...
2018/0318393 METHOD FOR THE TREATMENT OF MALIGNANCIES
The present invention provides for the intratumoral delivery of at least one immunostimulatory cytokine in combination with at least one checkpoint inhibitor....
2018/0318392 Use of Angiopoietins in Promoting Blood Coagulation and in the Treatment of Blood Coagulation Disorders
The present invention provides methods for promoting blood coagulation and/or treating blood coagulation disorders in a subject in need thereof. The methods of...
2018/0318391 USE OF NEUREGULIN-4 FOR TREATMENT OF INFLAMMATORY BOWEL DISEASE AND NECROTIZING ENTEROCOLITIS
The invention provides methods, pharmaceutical compositions and kits for treating, inhibiting and/or reducing the severity of inflammatory bowel disease and...
2018/0318390 METHODS FOR TREATMENT OF BILE ACID-RELATED DISORDERS
Provided herein are variants of fibroblast growth factor 19 (FGF19) proteins and peptide sequences (and peptidomimetics) and fusions of FGF19 and/or fibroblast...
2018/0318389 NMDAR ANTAGONISTS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH ANGIOGENISIS
The present invention relates to an N-Methyl-D-aspartate (NMDA) receptor antagonist, for use in the treatment of diseases associated with angiogenesis such as...
2018/0318388 COMPOSITIONS AND METHODS FOR SENSITIZING LOW RESPONSIVE TUMMORS TO CANCER THERAPY
The present invention relates to the AAAPT bioconjugate of general Formula 1 or 2, wherein ##STR00001## A may be a small molecule such as, but is not limited to ...
2018/0318387 METHODS FOR DIAGNOSING AND TREATING SYSTEMIC LUPUS ERYTHEMATOSUS
Described herein are peptides and antibodies for prevention and/or therapeutic treatment of mammals, including humans, against systemic lupus erythematosus, as...
2018/0318386 PEPTIDES AND METHODS OF TREATING ENDOMETRIOSIS USING THE SAME
Embodiments are directed to methods of examining preimplantation factor (PIF) binding to a subject's circulating immune cells as a marker for immune...
2018/0318384 Strengthened t-cell modulator that can modulate the immune response, specifically designed for therapeutic use...
The invention relates to a strengthened T-cell modulator with a strength of 10.sup.12 leukocytes/mm.sup.3, produced from a dialysed extract of leukocytes from...
2018/0318383 PEPTIDE HAVING NEURONAL LOSS PREVENTION AND REGENERATION EFFECTS, AND COMPOSITION CONTAINING SAME
The present invention relates to a composition for neuronal loss prevention and regeneration and, more specifically, to a composition for neuronal loss...
2018/0318382 THERAPY AND KIT FOR THE PREVENTION AND TREATMENT OF CYSTIC FIBROSIS
Compositions, kits and methods for preventing or treating cystic fibrosis are provided, which include the use of a peptidomimetic that inhibits the interaction...
2018/0318381 Methods of Treatment of Rhabdomyolysis
Provided herein are methods of treating long-chain fatty acid disorders, conditions, such as rhabdomyolysis, associated with inflammation and/or long-chain...
2018/0318380 METHODS OF TREATING MUSCULAR DYSTROPHY
Disclosed herein are .alpha.7.beta.1 integrin modulatory agents and methods of using such to treat conditions associated with decreased .alpha.7.beta.1...
2018/0318379 INHIBITION OF TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1 (TREM1) TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS
Aspects of the present invention include treating a subject having an acute of chronic central nervous system disorder, such as a brain disorder or spinal cord...
2018/0318378 A METHOD FOR REGULATING CANCER STEM CELL GROWTH BY INHIBITING PHOSPHORYLATION OF 120TH THREONINE RESIDUE OF...
The present invention relates to a peptide suppressing the phosphorylation of threonine(T120), the 120th residue of TSPYL5 (testis-specific Y-like protein 5),...
2018/0318377 COMPOSITION COMPRISING THE EXTRACT OF HERBAL COMBINATION FOR PREVENTING OR TREATING DIABETIC PERIPHERAL NEUROPATHY
Disclosed are a pharmaceutical composition and a health functional food for the prevention and treatment of diabetic peripheral neuropathy, comprising an herb...
2018/0318376 MULTIDIMENSIONAL APPROACH FOR CANCER TREATMENT
Method of treating/managing Cancer is disclosed in various embodiments herein. The disclosed method includes the use of a combination of formulations and...
2018/0318375 HERBAL PREPARATION FOR ACCELERATING WOUNDS AND SKIN INFLAMMATIONS HEALING AND ITS APPLICATION
The invention relates to a herbal preparation which can be applied in a wound and skin inflammation healing. The herbal preparation is characterized in that...
2018/0318374 HERBAL FORMULATION FOR MANAGEMENT OF METABOLIC DISORDERS AND METHOD OF PREPARATION THEREOF
Herbal formulation for treatment/management of metabolic disorders and related complications are disclosed herein. The disclosed herbal formulation includes...
2018/0318373 METHODS OF USING EXTRACTS OF MELISSA OFFICINALIS AGAINST FILOVIRUSES
The present disclosure relates to methods of using Melissa officinalis extracts in inhibiting viral replication of a filovirus and in treating or preventing a...
2018/0318372 Method for Production of an Antimalarial Compound
A method for the production of an antimalarial compound from a quantity of plant matter obtained from the plant species Cassia Nigricans. Active ingredients...
2018/0318371 BAUHINIA EXTRACT AND USES THEREOF
Disclosed herein is the novel use of use of a Bauhinia spp. extract, which may upregulate neprilysin, induce autophagy, protect neuron from amyloidopathy or...
2018/0318370 COMPOSITIONS COMPRISING SIRAITIA GROSVENORI EXTRACTS AND METHODS FOR THE TREATMENT OF INFECTION
A method for the treatment and/or prophylaxis of a viral infection in a subject is provided wherein the method comprises the steps of providing a ...
2018/0318369 TRANSFER FACTOR PREPARATIONS AND ASSOCIATED METHODS
A drink includes an edible liquid or semisolid preparation and transfer factor. The drink may also include lactoferrin and one or more preservatives. An edible...
2018/0318368 A METHOD FOR PRODUCING A MEDIUM CONTAINING STEROIDAL GLYCOSIDES FROM PLANT CELLS OF THE GENUS HOODIA
A method for producing an active ingredient-containing medium from cultured plant cells, selected from the Hoodia genus, is provided. The method comprises the...
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