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Patent # Description
2018/0318317 NON-BIOCONVERTIBLE C3-SUBSTITUTED PREGNENOLONE DERIVATIVES FOR USE IN THE TREATMENT OF SUBSTANCE USE DISORDERS
The present invention relates to the use of non-bioconvertible C.sub.3-substituted pregnenolone derivatives of formula (I), with no significant affinity for...
2018/0318316 DOSING REGIMEN FOR SEDATION WITH CNS 7056 (REMIMAZOLAM)
The invention relates to a dosing regimen for sedation with the fast-acting benzodiazepine CNS 7056 in combination with an opioid, in particular fentanyl,...
2018/0318315 Prostaglandin Receptor EP2 Antagonists, Derivatives, Compositions, and Uses Related Thereto
The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the...
2018/0318314 ANTITUMOR AGENT
To provide a pharmaceutical agent or an antitumor agent useful for the treatment and/or prevention of gastrointestinal cancer, leukemia, pituitary tumor, small...
2018/0318313 TREATMENTS FOR RESISTANT ACNE
The present disclosure relates generally to novel molecules, compositions, and formulations for treatment of bacterial infections in general and more...
2018/0318312 SPLICE VARIANTS ASSOCIATED WITH NEOMORPHIC SF3B1 MUTANTS
Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice...
2018/0318311 TRICYCLIC 2-QUINOLINONES AS ANTIBACTERIALS
This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof that are useful as antibacterial...
2018/0318310 MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR
Compounds, compositions, and methods for modulation of Hec1/Nek2 interaction are provided. Such compounds disrupt Nek2/Hec1 binding and may be useful as...
2018/0318309 ARYL-OR HETEROARYL-SUBSTITUTED BENZENE COMPOUNDS
The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions...
2018/0318308 PYRAZOLONE DERIVATIVES AS NITROXYL DONORS
The disclosed subject matter provides pyrazolone derivative compounds, pharmaceutical compositions comprising such compounds, kits comprising such compounds,...
2018/0318307 METHODS OF USE OF INHIBITORS OF PHOSPHODIESTERASES AND MODULATORS OF NITRIC OXIDE, REACTIVE OXYGEN SPECIES, AND...
The present methods and compositions are of use for treatment of conditions involving fibrosis, such as Peyronie's disease plaque, penile corporal fibrosis,...
2018/0318306 METHODS OF TREATING TRANSPLANT REJECTION
The present invention provides the use of protein kinase inhibitors, in particular JAK2 inhibitors of formula (I), as set forth in the specification, in the...
2018/0318304 Methods of Using BTK Inhibitors to Treat Dermatoses
In certain embodiments, the invention includes therapeutic methods of using a BTK inhibitor to treat dermatoses, such as psoriasis, atopic dermatitis, contact...
2018/0318303 METHODS FOR TREATING MYELOPROLIFERATIVE DISORDERS
In part, the disclosure relates to methods of treating myeloproliferative disorders by administering one or more Serum Amyloid Protein (SAP) proteins. In...
2018/0318302 METHOD OF TREATMENT AND CLINICAL TRIAL DESIGN FOR GEOGRAPHIC ATROPHY DUE TO AGE-RELATED MACULAR DEGENERATION
Methods of treating or slowing the growth of a lesion associated with geographic atrophy and methods of evaluating a drug or agent for use in treating,...
2018/0318301 FORMULATIONS OF AZAINDOLE COMPOUNDS
A pharmaceutical composition comprises: a) 5 wt % to 95 wt % of a HCl salt of Compound (1).xH.sub.2O by the weight of the pharmaceutical composition, wherein x...
2018/0318300 TREATMENT OF AUTOIMMUNE DISEASE
Provided herein are compositions and methods for the treatment of autoimmune and alloimmune diseases and conditions, including rheumatoid arthritis, multiple...
2018/0318299 HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF
The present invention relates to pyrimidine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
2018/0318298 Method of Treating Obesity
A method of treating obesity and obesity-related disorders in a mammal is provided. The method comprises the step of administering to the mammal a compound or...
2018/0318297 Imidazopyrazine Inhibitors of Bruton's Tyrosine Kinase
In some embodiments, the invention relates to a BTK inhibitor or a pharmaceutically acceptable salt, cocrystal, ester, prodrug, solvate, hydrate or derivative...
2018/0318296 Sortilin-Binding Small Molecules for Increasing Glucose Uptake
Various scaffolds of small molecules capable of binding to the active site of sortilin are identified by in silico methods. These scaffolds include norbornene...
2018/0318295 PHARMACEUTICAL COMPOSITION FOR CANCER IMMUNOTHERAPY AND/OR IMMUNOLOGICAL ACTIVATION CONTAINING DIAMINO...
[Problem] A compound useful as an active ingredient of a pharmaceutical composition, for example, a pharmaceutical composition for cancer immunotherapy, and/or...
2018/0318294 PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS
Provided is a superior, novel heterocyclic compound with improved solubility in oil such as sesame oil and benzyl benzoate, which has a broader treatment...
2018/0318293 ARIPIPRAZOLE PRODRUG COMPOSITION
Described is a composition comprising (a) a population of particles of an aripiprazole prodrug having a volume based particle size (Dv50) of less than 1000 nm...
2018/0318292 2-(1H-INDAZOL-3-YL)-3H-IMIDAZO[4,5-C]PYRIDINES AND THEIR ANTI-INFLAMMATORY USES THEREOF
Indazole compounds for treating various diseases and pathologies are provided. More particularly, the use of an indazole compound or analogs thereof, in the...
2018/0318291 USE OF AMINOTHIAZOLE MYD88 SPECIFIC INHIBITOR TJM2010-5
MyD88 inhibitor can be used to prevent, for example, post myocardial infarction ischemia reperfusion injury, post severed limb replantation ischemia...
2018/0318290 USE OF NALMEFENE IN NON-ALCOHOLIC STEATOHEPATITIS
The present invention relates to morphinans selected from nalmefene and naltrexone and their related derivatives of formula (I), and pharmaceutical...
2018/0318289 TREATMENTS FOR DEPRESSION AND OTHER DISEASES WITH A LOW DOSE AGENT
The present invention relates to improved compositions and methods for the treatment or prevention of various diseases, including forms of depression,...
2018/0318288 GLUTAMATE AGENTS IN THE TREATMENT OF MENTAL DISORDERS
Methods of treating mental disorders, including anxiety disorders such as obsessive-compulsive disorder, are provided. The methods comprise administering an...
2018/0318287 Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer
The specification generally relates to compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, where x, R.sup.1, R.sup.2,...
2018/0318286 FUSED HETEROCYCLIC COMPOUND DERIVATIVE AND APPLICATION THEREOF
The present invention relates to the field of pharmaceutical chemistry, and specifically relates to a fused heterocyclic compound derivative and an application...
2018/0318285 METHODS FOR TREATMENT OF AUTISM SPECTRUM DISORDERS
We have determined that MeCP2 protein mediates modulation of long-gene expression in the brain and results in neurological dysfunction associated with autism...
2018/0318284 BENZOPIPERIDINE DERIVATIVE, PREPARATION METHOD THEREOF AND MEDICAL USE THEREOF
The present invention relates to a benzopiperidine derivative, a preparation method thereof and a medical use thereof. In particular, the present invention...
2018/0318283 PHARMACEUTICAL COMPOSITION, USE OF MEFLOQUINE IN A FIXED DOSE, AND METHOD FOR TREATING TUBERCULOSIS
This invention concerns the use of mefloquine in relation to Mycobacterium tuberculosis. This invention also concerns the combination of mefloquine with drugs...
2018/0318282 Phosphonate-Chloroquine Conjugates and Methods Using Same
The present invention provides compositions and methods for providing controllable local delivery of a conjugate of chloroquine (CQ) and a bisphosphonate to...
2018/0318281 Methods for the Treatment of Abnormal Involuntary Movement Disorders
Disclosed herein are new dosage regimens for deuterium-substituted benzoquinoline compounds, and methods for the treatment of abnormal muscular activity,...
2018/0318280 MODIFIED RELEASE NICOTINAMIDE
The present invention relates to a pharmaceutical preparation comprising modified release nicotinamide, as well as its use in a method of preventing and/or...
2018/0318279 TOPICAL COMPOSITIONS PROVIDING PAIN RELIEF AND METHODS OF USE THEREOF
The present invention generally relates to a topical composition including loperamide and a pharmaceutically acceptable carrier and to a method of using such a...
2018/0318278 Methods for Treating Disorders or Diseases Associated with Hyperlipidemia and Hypercholesterolemia While...
The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an...
2018/0318277 Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer
Described herein are methods of treating non-metastatic castrate-resistant prostate cancer with anti-androgens.
2018/0318276 ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES
Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders.
2018/0318275 COMBINATION THERAPY USING PI3K INHIBITOR AND MDM2 INHIBITOR
The present disclosure pertains to a pharmaceutical combination comprising (a) an alpha-isoform specific PI3K inhibitor, (b) an MDM2 inhibitor, and optionally...
2018/0318274 CYCLOHEXENE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING...
The present invention relates to a cyclohexene derivative, a preparation method thereof, and a pharmaceutical composition for preventing or treating metabolic...
2018/0318273 Immunoresponsive Methods of Treating Tumors
Within the scope of the present invention is a new pharmacological strategy for the treatment of tumors based on anti-tumoral immune responses.
2018/0318272 METHODS OF TREATING TUMORS AND CANCER, AND IDENTIFYING CANDIDATE SUBJECTS FOR SUCH TREATMENT
The present invention relates to methods of treating a tumor or treating cancer in a subject having a p53 DNA contact mutation that involve administering, to...
2018/0318271 Use of PDE4 Inhibitors for the Prophylaxis and/or Therapy of Dyslipoproteinaemia and Related Disorders
The present invention discloses new medical uses of phosphodiesterase 4 (PDE 4) inhibitors for treating dyslipoproteinaemia and of diseases when respectively...
2018/0318270 Selective High Affinity Alpha3Beta4 Nicotinic Acetycholine Receptor Antagonists
Provided herein are novel and selective high affinity .alpha.3.beta.4 nicotinic acetycholine receptor ligands and pharmaceutical compositions thereof. In other...
2018/0318269 METHOD FOR TREATING OBESITY, DIABETES, CARDIOVASCULAR AND KIDNEY DISEASES BY REGULATING GPR30/GPER ACTIVITY
The current invention is in the field of molecular biology/pharmacology and provides methods of using compounds that modulate the effects of GPR30/GPER for...
2018/0318268 AMINE PRODRUGS OF PHARMACEUTICAL COMPOUNDS
Disclose are amine prodrugs and methods of synthesis thereof. In particular, the amine prodrug comprises a drug molecule and at least one or more prodrug...
2018/0318267 METHOD FOR IMPROVING PHARMACOKINETICS
The object of the present invention is to inhibit oxidative metabolism of a compound of formula I by co-administration with ritonavir, a cytochrome P450...
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