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Patent # Description
2018/0320194 PYL9 AND USES THEREOF
The present invention provides for transgenic plants and methods of producing such transgenic plants, wherein the transgenic plants express an increased...
2018/0320193 METHODS OF INCREASING RESISTANCE OF CROP PLANTS TO HEAT STRESS AND SELECTING CROP PLANTS WITH INCREASED...
Methods of increasing the resistance of a crop plant to heat stress and in particular methods of improving the grain yield and quality of crop plants grown...
2018/0320192 METHOD FOR IMPROVING STRESS TOLERANCE OF PLANTS
The present invention relates to a method of improving stress tolerance and/or preventing growth reduction of a plant by introducing a polynucleotide encoding...
2018/0320191 DISEASE RESISTANT PLANTS
The present invention relates to a plant, which is resistant to a pathogen of viral, bacterial, fungal or oomycete origin, wherein the plant has a reduced...
2018/0320190 METHODS AND COMPOSITIONS FOR INCREASING EFFICIENCY OF TARGETED GENE MODIFICATION USING OLIGONUCLEOTIDE-MEDIATED...
Provided herein include methods and compositions for effecting a targeted genetic change in DNA in a cell. Certain aspects and embodiments relate to improving...
2018/0320189 REGULATED EXPRESSION OF ANTIGEN AND/OR REGULATED ATTENUATION TO ENHANCE VACCINE IMMUNOGENICITY AND/OR SAFETY
The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated...
2018/0320188 COMPOSITIONS AND METHODS FOR MODULATING GROWTH HORMONE RECEPTOR EXPRESSION
The present embodiments provide methods, compounds, and compositions for treating, preventing, or ameliorating a disease associated with excess growth hormone...
2018/0320187 TOXIC RNAi ACTIVE SEED SEQUENCES FOR KILLING CANCER CELLS
Disclosed are polynucleotides, compositions, and methods related to RNA interference (RNAi). The disclosed polynucleotides, compositions, and methods may be...
2018/0320186 METHOD FOR SITE-SPECIFIC INSERTION OF FOREIGN DNA INTO A GENOME IN AN ANIMAL CELL AND A CELL OBTAINED USING SAME
A method is provided for site-specific insertion of foreign DNA into a genome in an animal cell, including (1) a step of constructing a donor plasmid in which...
2018/0320185 METHODS RELATING TO CIRCULATING TUMOR CELL CLUSTERS AND THE TREATMENT OF CANCER
Described herein are methods and assays relating to the presence and/or level of circulating tumor cells (CTCs). These CTC-Cs represent a highly metastatic...
2018/0320184 SPHERICAL NUCLEIC ACID-BASED CONSTRUCTS AS IMMUNOSTIMULATORY AGENTS FOR PROPHYLACTIC AND THERAPEUTIC USE
Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof. The compositions of the invention are...
2018/0320183 FUNCTIONAL TRANSFER tRNA-APTAMER MOLECULES
The present invention provides functional aptamer-comprising tRNA molecules, useful in the study of tRNA and ribosomal activity.
2018/0320182 Methods and Compositions for Selecting siRNA of Improved Functionality
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize...
2018/0320181 CHIMERIC DOUBLE-STRANDED NUCLEIC ACID
A method of reducing the level of a transcription product in a cell comprising contacting with the cell a composition comprising a double-stranded nucleic acid...
2018/0320180 AGE-RELATED MACULAR DEGENERATION TREATMENT
This invention is directed to an RNA interference (RNAi) agent and the use of that RNAi agent to treat Age-related Macular Degeneration, as well as...
2018/0320179 LANOSTEROL 14-ALPHA DEMETHYLASE (CYP51) NUCLEIC ACID MOLECULES THAT CONTROL PATHOGENS
This disclosure concerns nucleic acid molecules and methods of use thereof for control of pathogens through RNA interference-mediated inhibition of target...
2018/0320178 STEM CELL WITH SUPPRESSED SOCS AND IMPROVED IMMUNOSUPPRESSIVE ABILITY AND USE THEREOF
The present invention relates to a stem cell having an immunosuppressive ability in which the expression or activity of a suppressor of cytokine signaling...
2018/0320177 COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER FIBROSIS
Described herein are methods of treating a subject in need of treatment for liver fibrosis by administering a therapeutically effective amount of an inhibitor...
2018/0320176 INTRATHECAL DELIVERY OF NUCLEIC ACID SEQUENCES ENCODING ABCD1 FOR TREATMENT OF ADRENOMYELONEUROPATHY
Methods of the invention encompass delivery of nucleic acid sequences encoding ABCD1 for the treatment of X-linked Adrenoleukodystrophy (X-ALD), e.g., for...
2018/0320175 The RNA Interactome of Polycomb Repressive Complex 1 (PRC1)
This invention relates to polycomb-associated RNAs, libraries and fragments of those RNAs, inhibitory nucleic acids and methods and compositions for targeting...
2018/0320174 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING LUPUS
The present disclosure provides methods for inhibiting and/or reducing self-reactive IgE and/or basophils, thereby treating or preventing lupus, lupus...
2018/0320173 METHODS FOR TRAPPING AND BARCODING DISCRETE BIOLOGICAL UNITS IN HYDROGEL
Disclosed are methods for trapping and barcoding discrete biological units in a hydrogel. Also disclosed are methods for analyzing gene expression, genotype,...
2018/0320172 LIGATION-BASED RNA AMPLIFICATION
Methods of amplification, purification and detection of nucleic acid sequences especially RNA are described. One aspect of the method involves the...
2018/0320171 COMBINATORIAL SETS OF NUCLEIC ACID BARCODES FOR ANALYSIS OF NUCLEIC ACIDS ASSOCIATED WITH SINGLE CELLS
Provided herein are methods of identifying the origin of a nucleic acid sample. The methods include forming a reaction mixture comprising a nucleic acid sample...
2018/0320170 PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING
The present disclosure provides compositions and methods for genomic engineering.
2018/0320169 METHOD FOR CONSTRUCTING DNA LIBRARY FOR SEQUENCING
Provided is a method for constructing a DNA library for sequencing. The method comprises A-tailing of a single 3' end to at least a portion of blunt-end DNA...
2018/0320168 Methods of Producing Size-Selected Nucleic Acid Libraries and Compositions and Kits for Practicing Same
Provided are methods of producing size-selected nucleic acid libraries. The methods include contacting a nucleic acid sample and a nucleic acid binding reagent...
2018/0320167 METHODS AND SYSTEMS FOR IDENTIFYING PATIENT SPECIFIC DRIVER MUTATIONS
Methods for identifying patient specific driver mutations are provided. The methods provided identify specific patient derived markers associated with aberrant...
2018/0320166 MULTIPLEX PAIRWISE ASSEMBLY OF DNA OLIGONUCLEOTIDES
The present invention provides methods for multiplex assembly of oligonucleotides.
2018/0320165 COUPLING ENDONUCLEASES WITH END-PROCESSING ENZYMES DRIVES HIGH EFFICIENCY GENE DISRUPTION
The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the...
2018/0320164 DNA SEQUENCE MODIFICATION-BASED GENE DRIVE
Described herein are embodiments relating to manipulation of populations and sex ratio in populations through DNA sequence modifications.
2018/0320163 NOVEL CRISPR ENZYMES AND SYSTEMS
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or...
2018/0320162 ENGINEERED LIGASE VARIANTS
The present invention provides engineered ligase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered ligase polypeptides....
2018/0320161 BACTERIA ENGINEERED TO REDUCE HYPERPHENYLALANINEMIA
Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating diseases associated with hyperphenylalaninemia are...
2018/0320160 LYOPHILIZED FORMULATIONS FOR FACTOR XA ANTIDOTE
The present disclosure relates to solutions and methods of preparing lyophilized formulations of factor Xa (fXa) antidotes. A suitable aqueous formulation...
2018/0320159 Processable Single Chain Molecules and Polypeptides Made Using Same
The present invention features inter alia nucleic acid molecules which encode polypeptides comprising a single chain Fc region and the polypeptides they...
2018/0320158 PAENIBACILLUS AND BACILLUS SPP. MANNANASES
Disclosed herein are mannanases from Paenibacillus or Bacillus spp, polynucleotides encoding the mannanases, compositions containing the mannanases, and...
2018/0320157 ENGINEERED HEME-BINDING COMPOSITIONS AND USES THEREOF
Described herein are heme-binding compositions and methods relating to their use, e.g. methods of treatment of, for example, sepsis and rhabdomyolysis.
2018/0320156 ENZYME VARIANTS
The invention relates to a variant polypeptide having lactase activity. The invention also relates to a nucleic acid sequence encoding such a variant...
2018/0320155 Polypeptides Having Cellulolytic Enhancing Activity And Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides, catalytic domains,...
2018/0320154 RECOMBINANT NUCLEOSIDE-SPECIFIC RIBONUCLEASE AND METHOD OF PRODUCING AND USING SAME
A recombinant ribonuclease is disclosed. The recombinant ribonuclease is produced by introducing a recombinant DNA sequence into a host; activating expression...
2018/0320153 DIRECTED DIFFERENTIATION OF PLURIPOTENT STEM CELLS BY BACTERIAL INJECTION OF TALEN PROTEINS
In some aspects, the disclosure relates to methods and compositions for delivery of proteins into mammalian cells. In some embodiments, the disclosure provides...
2018/0320152 MODIFIED SULFAMIDASE AND PRODUCTION THEREOF
Disclosed herein are a modified sulfamidase, a composition comprising a modified sulfamidase, as well as methods for preparing a modified sulfamidase and...
2018/0320151 MODIFIED PLANTS CONTAINING COMBINATION OF APYRASE GENES AND METHOD FOR MAKING MODIFIED PLANTS WITH COMBINATION...
The present disclosure is directed to a modified plant cell, plant tissue, plantlet, plant part, plant, and progeny thereof containing a combination of apyrase...
2018/0320150 HIGHLY SENSITIVE OPTICAL SENSOR FOR POLYMERASE SCREENING
The present invention is directed to a polymerase activity assay that produces a strong optical signal when a primer-template complex is extended to...
2018/0320149 HIGH YIELDS OF ISOMELEZITOSE FROM SUCROSE BY ENGINEERED GLUCANSUCRASES
Provided herein are compositions and methods for the synthesis of the trisaccharide, isomelezitose, using genetically modified glucansucrase enzymes from...
2018/0320148 Acute Respiratory Distress Syndrome Therapeutic Agent
An agent for treating acute respiratory distress syndrome includes, as an active ingredient, a lecithinized superoxide dismutase represented by the general...
2018/0320147 STABLE CELL LINES FOR RETROVIRAL PRODUCTION
The invention relates to retroviral producer cells comprising nucleic acid sequences encoding: gag and pol proteins; envelope protein or a functional...
2018/0320146 ENGINEERED RESPIRATORY SYNCYTIAL VIRUSES WITH CONTROL OF CELL-TO-CELL VIRUS TRANSMISSION FOR ENHANCED SAFETY OF...
Highly antigenic yet safe vaccines against diseases caused by Paramyxoviridae viruses such as respiratory syncytial virus (RSV) are provided. The vaccines...
2018/0320145 COMPOSITIONS AND METHODS FOR ENHANCED GENE EXPRESSION IN CONE CELLS
The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in cone cells.
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