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Patent # Description
2019/0161558 Acylation Process
A process for the manufacture of an acylated polymer composition including amylose and/or amylopectin, including a pre-treatment step in the presence of an...
2019/0161556 Fusion Protein Construct
The disclosure provides constructs comprising a first fusion protein, a second fusion protein, and a linker, wherein the first fusion protein and the second...
2019/0161555 Bispecific Antibodies Directed Against OX40 and a Tumor-Associated Antigen
The invention provides bispecific polypeptides comprising a first binding domain, designated B1, which is capable of binding specifically to OX40, and a second...
2019/0161552 ANTI-BCMA ANTIBODIES
This invention provides antibodies that recognize the B Cell Maturation Antigen (BCMA) and that bind naive B cells, plasma cells, and/or memory B cells. The...
2019/0161551 ANTI-TRKB MONOCLONAL ANTIBODIES AND METHODS OF USE
The present invention provides antibodies that bind specifically to TrkB and methods of using the same. According to certain embodiments, the antibodies of the...
2019/0161550 ANTIBODIES AGAINST MAC-1
The present invention provides an isolated monoclonal antibody or an antigen-binding portion thereof which a) binds to Mac-1, b) specifically inhibits the...
2019/0161549 COMBINATION THERAPY WITH A MEK INHIBITOR, A PD-1 AXIS INHIBITOR, AND A VEGF INHIBITOR
A combination therapy comprising a MEK inhibitor, a PD-1 axis inhibitor, and a VEGF inhibitor is provided for the treatment of colorectal cancer and metastatic...
2019/0161548 Bispecific Molecules Having Immunoreactivity with PD-1 and CTLA-4, and Methods of Use Thereof
The present invention is directed to bispecific molecules (e.g., diabodies, bispecific antibodies, trivalent binding molecules, etc.) that possess at least one...
2019/0161547 METHODS FOR REGULATING ENDOGENOUS PRODUCTION OF CHECKPOINT MOLECULE ANTAGONISTS
The present disclosure relates to one or more agents, therapies, treatments, and methods of use of the agents and/or therapies and/or treatments for decreasing...
2019/0161545 JAML Specific Binding Agents, Antibodies, and Uses Related Thereto
Certain embodiments of the disclosure relate to targeted binding agents that specifically bind to JAM-like protein and therein inhibit epithelial damage....
2019/0161542 TREATMENT OF CANCER USING A CHIMERIC ANTIGEN RECEPTOR IN COMBINATION WITH AN INHIBITOR OF A PRO-M2 MACROPHAGE...
The invention provides compositions and methods for treating diseases associated with expression of an antigen, e.g., a solid tumor antigen or antigen...
2019/0161541 ANTIBODY FORMULATIONS
The invention provides stable aqueous pharmaceutical formulations comprising a therapeutic antibody, trehalose, a buffer, and optional surfactant, and having a...
2019/0161537 SYNTHETIC ANTIBODIES TO BAX AND USES THEREOF
Synthetic fragment antigen-binding (Fab) antibodies are disclosed that bind to an N-terminal activation site of BCL-2-associated X-protein (BAX) and inhibit...
2019/0161535 COMPOSITIONS AND METHODS FOR TREATING SPINAL MUSCULAR ATROPHY
The present disclosure relates generally to methods of preventing, reducing risk of developing, or treating spinal muscular atrophy, comprising administering...
2019/0161534 ANTI-GALACTAN II MONOCLONAL ANTIBODIES TARGETING KLEBSIELLA PNEUMONIAE
A cross-neutralizing monoclonal antibody that specifically recognizes a cross-reactive epitope of the lipopolysaccharide (LPS) antigen structure of Klebsiella...
2019/0161531 Cell
The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR at the cell surface, each CAR comprising an...
2019/0161530 CHIMERIC ANTIGEN RECEPTOR T CELL COMPOSITIONS
The invention provides improved compositions for adoptive immune effector cell therapies for treatment, prevention, or amelioration of numerous conditions...
2019/0161529 COMPOSITIONS AND METHODS FOR NEUROLOGICAL DISEASES
Compositions and methods are provided for modulating the activity of cells using engineered receptors, polynucleotide encoded engineered receptors, and gene...
2019/0161528 CLAUDIN-6 PEPTIDES
The present invention relates to novel peptides derived from Claudin-6 (CLDN6), complexes comprising such peptides bound to recombinant MHC molecules, and...
2019/0161526 Novel peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2019/0161525 Method for treating Alzheimer's disease and method for downregulating protein aggregation in brain
A method for treating Alzheimer's disease and a method for downregulating protein aggregation in brain are disclosed, which respectively comprises: ...
2019/0161524 NOVEL ALPHA-1-MICROGLOBULIN DERIVED PROTEINS AND THEIR USE
This invention relates to an alpha-1-microglobulin derived protein for medical use.
2019/0161522 ARTICLES COMPRISING A SILK POLYPEPTIDE FOR ANTIGEN DELIVERY
The present invention relates to a polypeptide comprising a silk polypeptide and an antigen. Further, the present invention relates to an article comprising...
2019/0161521 ANTIBODY BINDING NANOFIBRILS
The present embodiments relate to antibody binding nanofibrils obtainable by co-fibrillation of carrier proteins and carrier-Z fusion proteins at a molar ratio...
2019/0161520 MSA2 AFFINITY-ENHANCED BIOTIN-BINDING CHIMERIC ANTIGEN RECEPTOR (CAR)
A chimeric antigen receptor is disclosed that includes: (a) an extracellular high affinity streptavidin;(b) a hinge domain from CD8; (c) a CD28 transmembrane...
2019/0161519 ENGINEERED INFLUENZA ANTIGENIC POLYPEPTIDES AND IMMUNOGENIC COMPOSITIONS THEREOF
The present invention provides, among other things, a novel and improved method for generating "mosaic" influenza antigenic polypeptides including ...
2019/0161518 PHARMACEUTICAL COMPOSITION AND THE USE THEROF IN THE TREATMENT OF AUTOIMMUNE DISEASES
The present invention relates to compounds comprising formula I: Amino Acid Sequence-(L).sub.n-DMARD wherein the amino acid sequence comprises ...
2019/0161517 NOVEL PEPTIDE AND USE THEREOF
The present invention provides a peptide consisting of the amino acid sequence of SEQ ID NO:1 or the amino acid sequence of SEQ ID NO:2, or a pharmaceutically...
2019/0161513 SYNTHESIS OF THIOLATED OLIGONUCLEOTIDES WITHOUT A CAPPING STEP
The invention herein describes a synthetic method for preparing thiolated oligonucleotides without needing a capping step, as the sulfurization agent caps the...
2019/0161511 METHOD FOR SEPARATION OF ACIDS AND SUGARS TO REDUCE ENERGY CONSUMPTION
The present disclosure relates to a method for separating sugars and acids with reduced energy consumption, including a step of diffusively dialyzing a first...
2019/0161510 METAL COMPLEXES FOR USE AS EMITTERS IN ORGANIC ELECTROLUMINESCENCE DEVICES
The present invention relates to metal complexes and electronic devices, in particular organic electroluminescent devices containing said metal complexes.
2019/0161507 TITANIUM-CONTAINING FILM FORMING COMPOSITIONS FOR VAPOR DEPOSITION OF TITANIUM-CONTAINING FILMS
Titanium-containing film forming compositions comprising titanium halide-containing precursors are disclosed. Also disclosed are methods of synthesizing and...
2019/0161504 CARBENE COMPOUNDS AND ORGANIC ELECTROLUMINESCENT DEVICES
A compound selected from the group consisting of Formula I, Formula II, and Formula III, ##STR00001## wherein ring A, ring B, and ring C are independently a ...
2019/0161503 XANTHINE DERIVATIVES, THEIR USE AS A MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THE SAME
The invention relates to a xanthine derivative defined by chemical formula I or a salt thereof, its use as a medicament, especially for use in the treatment of...
2019/0161501 NITROGEN-CONTAINING CONDENSED RING COMPOUNDS HAVING DOPAMINE D3 ANTAGONISTIC EFFECT
Novel compounds having D3 receptor antagonistic activity are provided. A compound represented by formula (I): ##STR00001## wherein ring A is a heterocycle, X.sup.1...
2019/0161499 PESTICIDALLY ACTIVE 1,2,4-TRIAZOLE DERIVATIVES
The present invention relates to 1,2,4-triazole derivatives, to processes for preparing them, to intermediates for preparing them, to pesticidli, in particular...
2019/0161497 SPECIFICALLY SUBSTITUTED BENZOFURO- AND BENZOTHIENOQUINOLINES FOR ORGANIC LIGHT EMITTING DIODES
Specifically substituted benzofuro- and benzothienoquinolines and their use in electronic devices, especially electroluminescent devices. When used as charge...
2019/0161496 HYDROXYESTER DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Compounds of formula (I): ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.13, R.sub.a, R.sub.b, A and n are as defined...
2019/0161494 EPOXY COMPOUND, CURABLE COMPOSITION CONTAINING THE SAME, AND CURED PRODUCT OBTAINED BY CURING CURABLE COMPOSITION
The present invention discloses a composition comprising at least one or more stereoisomers of a compound represented by the following Formula (1), wherein, in...
2019/0161493 NOVEL HARRINGTONINES SALTS IN THE CRYSTALLINE STATE, THEIR USE FOR THE PURIFICATION OF THE CORRESPONDING DRUG...
The present invention concerns harringtonines salts never described in the crystalline state exhibiting a protonated nitrogen seen in solid state analysis and...
2019/0161489 SUBSTITUTED PYRROLO [2, 3-D] PYRIDAZIN-4-ONES AND PYRAZOLO [3, 4-D] PYRIDAZIN-4-ONES AS PROTEIN KINASE INHIBITORS
Provided are certain compounds or pharmaceutically acceptable salts thereof which can inhibit kinase activity of Bruton's tyrosine kinase (BTK) and may be...
2019/0161486 CHIRAL HETEROCYCLIC COMPOUND WITH HEDGEHOG PATHWAY ANTAGONIST ACTIVITY, METHOD AND USE THEREOF
A chiral heterocyclic compound with hedgehog pathway antagonist activity, method and use thereof are provided. The chiral heterocyclic compound with hedgehog...
2019/0161484 SOLID FORMS OF A COMPOUND FOR MODULATING KINASES
Forms of 4-(6-(3,5-dimethylisoxazol-4-yl)-1-[(1S)-1-(2-pyridyl)ethyl]pyrr- olo[3,2-b]pyridin-3-yl)benzoic acid (Compound I) were prepared and characterized in...
2019/0161482 SUBSTITUTED ISOSELENAZOLONE ANTI-INFECTIVE, ANTI-INFLAMMATORY, ANTI-CANCER, CYTOPROTECTIVE, NEUROPROTECTIVE,...
Compounds, compositions, and methods for the treatment of infections, inflammation, cancers, tinnitus, Meniere's disease, hearing loss, or bipolar disorder, or...
2019/0161481 Novel (Cyano-Dimethyl-Methyl)-Isoxazoles and -[1,3,4]Thiadiazoles
This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical...
2019/0161479 NOVEL COMPOUNDS
The present invention provides compounds of the formula (I) and their use as Kv3 modulators. ##STR00001##
2019/0161478 PLANTS HAVING INCREASED TOLERANCE TO HERBICIDES
The present invention refers to a method for controlling undesired vegetation at a plant cultivation site, the method comprising the steps of providing, at...
2019/0161477 1-TETRAHYDROPYRANYLCARBONYL-2,3-DIHYDRO-IH-INDOLE COMPOUNDS FOR TREATING CANCER
The present invention relates to certain novel 2,3-dihydro-1H-indole compounds, pharmaceutical compositions comprising the compounds, and methods of using the...
2019/0161476 Pyrimidine Derivative, Method For Preparing Same And Use Thereof In Medicine
The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates...
2019/0161475 METHOD FOR PRODUCING INDOLE COMPOUND
The present invention aims to provide a new method for producing an indole compound or a salt thereof, which has an ITK inhibitory action, and is useful for...
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