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Patent # Description
2019/0169249 CSF1R-BASED CHIMERIC PROTEINS
The present invention relates, in part, to, chimeric proteins which include the extracellular domain of colony stimulating factor 1 receptor (CSF1R) and their...
2019/0169248 METHODS FOR PROTECTING DOPAMINERGIC NEURONS FROM STRESS AND PROMOTING PROLIFERATION AND DIFFERENTIATION OF...
The invention features methods of treatment and diagnosis using NRG-2 polypeptides, nucleic acid molecules, and antibodies. The invention also provides novel...
2019/0169247 RETINAL CAPILLARY REGENERATION WITH SYNTHETIC PROTEIN
A method is provided for capillary stabilization and vascular regeneration in retinal tissue. Capillary regeneration is accomplished with a protein that is a...
2019/0169246 REELIN COMPOSITIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS
Changes in Reelin levels as well as Reelin signaling alter cognitive function. This can be accomplished by administering a therapeutically effective amount of...
2019/0169245 CTLA4-BINDING PROTEIN PEPTIDE-LINKER MASKS
Provided herein are recombinant CTLA-4 binding proteins, which are, inter alia, useful for the treatment of cancer. The recombinant proteins provided herein...
2019/0169244 Compositions And Methods For Enhancing Visual Function
The present disclosure provides a method of restoring or enhancing visual function in an individual, the method comprising administering to the individual a...
2019/0169243 SILK-DERIVED PROTEIN FOR TREATING INFLAMMATION
Described herein are methods for reducing inflammation by administration of an effective amount of silk-derived proteins (SDP) or a fraction thereof to a...
2019/0169242 Methods of Generating Recombinant Spider Silk Protein Fibers
Provided herein are scalable methods of generating a recombinant silk polypeptide with a coefficient of friction sufficient to form mechanical interactions...
2019/0169241 KIF13B-DERIVED PEPTIDE AND METHOD OF INHIBITING ANGIOGENESIS
A construct composed of a Kinesin-derived Angiogenesis Inhibitor peptide and one or more carrier moieties and/or stabilizing moieties is provided as are...
2019/0169240 DNA-BINDING PROTEIN USING PPR MOTIF, AND USE THEREOF
The object of the present invention is to, by analyzing PPR proteins that act to bind to DNA with a prediction that RNA recognition rules of PPR motifs can...
2019/0169239 Mutant Strain of Filamentous Fungus and Use Therefor
A filamentous fungus mutant strain showing improved secretory protein production and a method of producing a protein using the filamentous fungus are provided....
2019/0169238 Improved Filamentous Fungal Host
The instant invention relates to filamentous fungal host cells producing and secreting a heterologous polypeptide of interest, said mutant host cell comprising...
2019/0169237 MUTANT ADENO-ASSOCIATED VIRUS VIRIONS AND METHODS OF USE THEREOF
The present invention provides mutant adeno-associated virus (AAV) that exhibit altered capsid properties, e.g., reduced binding to neutralizing antibodies in...
2019/0169236 PURIFICATION OF VIRUS LIKE PARTICLES
Methods of purifying virus-like particles (VLPs) that are substantially free of process contaminants and infectious agents. The methods incorporate, for...
2019/0169235 MODIFIED PROTEIN ENCODING SEQUENCES HAVING INCREASED RARE HEXAMER CONTENT
This invention provides a modified protein encoding sequence containing nucleotide substitutions at multiple locations in the protein encoding sequence,...
2019/0169234 PEPTIDE INHIBITORS OF PHOSPHOGLYCERATE MUTASE AND METHODS OF USE
Disclosed herein are isolated peptides inhibit activity of a cofactor-independent phosphoglycerate mutase. In some examples, the isolated peptide is 6-20 amino...
2019/0169233 IMMUNOTHERAPY AGAINST SEVERAL TUMORS, SUCH AS LUNG CANCER, INCLUDING NSCLC
A method of treating a patient who has glioblastoma and/or gastric cancer includes administering to said patient a composition containing a population of...
2019/0169232 C1q AND HMGB1 FUSION PROTEINS AND USES THEREOF
Fusion proteins of C1q peptides and HMBG1 A-box or HMBG1 B-box, or C1q peptides and DWESY peptide are provided, and methods of use thereof.
2019/0169231 COMPOSITIONS CONTAINING HC-HA/PTX3 COMPLEXES AND METHODS OF USE THEREOF
Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of...
2019/0169230 Use of Quaternary and Tertiary Ammonium Cations to Denature Proteins
Ammonium cation detergents comprising a quaternary or tertiary ammonium cation can be used as detergents to denature proteins and are particularly useful in...
2019/0169229 TANGENTIAL FLOW FILTRATION BASED PROTEIN REFOLDING METHODS
Provided herein are methods for refolding proteins that are denatured. Exemplary methods comprise solubilizing the denatured protein with a denaturing agent,...
2019/0169228 SELECTIVE DISULFIDATION REAGENT USING NITROGEN-CONTAINING COMPOUND AND METHOD FOR PRODUCING...
The present invention provides a means capable of selectively introducing a disulfide bond with respect to two free thiol groups located in a molecule of an...
2019/0169227 METHOD FOR PRODUCTION OF NOVEL GALETERONE ANALOGS AND USES THEREOF
Galeterone and its C-3 analogs are of substantial interest because of their multi-target anticancer activities, including AR and Mnk degrading activities....
2019/0169226 NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
Described herein are steroids of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof; wherein R.sup.1, R.sup.2a, R.sup.2b, R.sup.3, R.sup.4,...
2019/0169225 Nuclear Sulfated Oxysterol, Potent Regulator of Lipid Homeostasis, for Therapy of Hypercholesterolemia,...
The sulfated oxysterol 5-cholesten-3.beta., 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol...
2019/0169224 PREPARATIONS OF HYDROPHOBIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE AND USE THEREOF
The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic agent such as fluticasone or triamcinolone, pharmaceutical...
2019/0169223 OLIGONUCLEOTIDE PRODUCTION METHOD
The invention provides a novel method for producing an oligonucleotide using a nucleoside or oligonucleotide that is easy to isolate and has high storage...
2019/0169222 NOVEL 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-D]PYRIMIDINE-2, 7-DIONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS...
The present invention relates to compounds of formula (I), ##STR00001## wherein R.sup.1, R.sup.2 and R.sup.3 are as described herein, and their prodrugs or...
2019/0169221 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Picornaviridae...
2019/0169220 CRYSTALLIZATION OF STEVIOL GLYCOSIDES
A method for purifying rebaudioside A, which method comprises: (a) providing a solution comprising rebaudioside A; (b) concentrating the said solution; and (c)...
2019/0169219 NEW CRYSTAL FORM OF SODIUM-GLUCOSE CO-TRANSPORTER INHIBITOR PROCESSES FOR PREPARATION AND USE THEREOF
The present disclosure relates to novel crystalline forms of a sodium-glucose co-transporter inhibitor drug (Sotagliflozin), processes for preparation and use...
2019/0169218 AMPHIPATHIC COMPOUND HAVING NOVEL PENTA-SACCHARIDE HYDROPHILIC GROUP AND USE THEREOF
Disclosed are an amphipathic compound having a penta-saccharide hydrophilic group, a method of preparing the same, and a method of extracting, solubilizing,...
2019/0169217 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF HYPERCHOLEMIA AND CHOLESTATIC LIVER DISEASE
Provided herein are methods of treating or ameliorating hypercholemia or a cholestatic liver disease by administering to an individual in need thereof a...
2019/0169216 PURIFICATION OF STAPHYLOCOCCUS AUREUS TYPE 5 AND TYPE 8 CAPSULAR SACCHARIDES
The invention provides a method for releasing capsular polysaccharide from S. aureus type 5 or type 8 cells, comprising the step of treating the cells with...
2019/0169215 ARYL IMIDAZOLES FOR TREATMENT OF CANCER
The present invention relates to a method of preventing, reducing, or treating cancer in a subject, comprising administering a therapeutically effective amount...
2019/0169214 BISPHOSPHONATE QUINOLONE CONJUGATES AND USES THEREOF
Described herein are bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof that can include a bisphosphonate and a quinolone,...
2019/0169213 LIMONENE-BASED, NON-HALOGENATED FLAME RETARDANTS FOR POLYMERIC APPLICATIONS
A limonene-based flame-retardant compound, a method of making a flame-retardant polymer, and an article of manufacture comprising a material that includes a...
2019/0169212 AMINOCHLOROHYDRIDODISILANES
Disclosed is a Silicon Precursor Compound for deposition, the Silicon Precursor Compound comprising a compound which is a disilane and which comprises at least...
2019/0169211 NOVEL TETRACARBOXYLIC DIANHYDRIDE, POLYIMIDE RESIN AND METHOD FOR PRODUCING THE SAME, PHOTOSENSITIVE RESIN...
The present invention has been made in view of the circumstances herein. An object of the present invention is to provide: a tetracarboxylic dianhydride which...
2019/0169210 Coordinative alignment of molecules in chiral metal-organic frameworks
Coordinative alignment uses x-ray diffraction to precisely and unambiguously determine the structure of molecules bound or crystallized within chiral metal...
2019/0169209 NEW SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS
The present invention encompasses compounds of formula (I) wherein the groups R.sup.1 to R.sup.7, A, V, W, X, Y, n, r and q are defined in claim 1, their use...
2019/0169208 MACROCYCLE KINASE INHIBITORS
The present disclosure relates to certain macrocyclic kinase inhibitors, pharmaceutical compositions containing the same, and methods of using the same to...
2019/0169207 DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES
The present invention relates to certain diaryl inacrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including...
2019/0169206 PHARMACEUTICAL COMPOSITIONS CONTAINING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUG THEREOF
The present invention provides a pharmaceutical composition containing the following compound having antiviral action: ##STR00001## wherein each of the symbols...
2019/0169205 SOLID CATALYST FOR DEHYDRATION OF MANNITOL, AND METHOD FOR PRODUCING 2, 5-SORBITAN AND/OR ISOMANNIDE USING THIS...
Provided is a solid acid catalyst which enables the production of isomannide and/or 2,5-sorbitan from mannitol with high yield and high safety at low cost. The...
2019/0169204 BENZIMIDAZOLE DERIVATIVES AS ERBB TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER
Provided herein are benzimidazole derivatives, for example, of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their...
2019/0169203 NITROGEN-CONTAINING TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE
A nitrogen-containing tricyclic compound which acts as modulator of FXR, or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a...
2019/0169202 VASOPRESSIN RECEPTOR ANTAGONISTS AND PRODUCTS AND METHODS RELATED THERETO
Compounds are provided that antagonize vasopressin receptors, particularly the V1a receptor products containing such compounds, as well as to methods of their...
2019/0169201 CRYSTALLINE FORM OF (S)-7-(1-ACRYLOYLPIPERIDIN-4-YL)-2-(4-PHENOXYPHENYL)-4,5,6,7-TETRA-HYDROP- ...
The present invention relates to a crystalline form of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetr ...
2019/0169200 NOVEL METHOD OF MANUFACTURING 4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE
The present invention discloses a method of manufacturing 4-chloro-7H-pyrrolo[2,3-d]pyrimidine comprising the steps: a) Preparing ethyl...
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