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Patent # Description
2019/0169148 METHOD FOR TREATING PAIN OR ASSOCIATED CONDITION OR SYMPTOM
Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated...
2019/0169147 Vortioxetine pamoic acid salt and crystal form thereof
The present application provides a vortioxetine pamoic acid salt, which includes a crystal form, a solvate or an amorphous substance of the vortioxetine pamoic...
2019/0169146 Acesulfame Potassium Compositions and Processes for Producing Same
Improved processes for producing high purity acesulfame potassium. In one embodiment, the process comprises the steps of contacting a solvent, e.g.,...
2019/0169145 Acesulfame Potassium Compositions and Processes for Producing Same
A process for producing acesulfame potassium, the process comprising the steps of providing a cyclizing agent composition comprising a cyclizing agent and a...
2019/0169144 Acesulfame Potassium Compositions and Processes for Producing Same
Compositions and processes for producing high purity acesulfame potassium are described. One process comprises the steps of forming a cyclic sulfur trioxide...
2019/0169143 Acesulfame Potassium Compositions and Processes for Producing Same
Compositions and processes for producing high purity acesulfame potassium are described. One process comprises the steps of providing a crude acesulfame...
2019/0169142 SULFONAMIDES AS GPR40- AND GPR120-AGONISTS
The invention relates to compounds acting as agonists of G-protein coupled receptor 120 (GPR120) and/or 40 (GPR40), and having formula (I): ##STR00001## Said...
2019/0169141 SMALL MOLECULES THAT ENABLE CARTILAGE REJUVANATION
There are provided, inter alia, methods and compounds for activating a proliferative program in competent adult chondrocytes.
2019/0169140 IDO1 INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF
A compound as an indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor, and an application thereof in the field of IDO1-related diseases, and in particular a compound...
2019/0169139 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES
The present invention relates to fluorene derivatives and to electronic devices in which these compounds are used as matrix material in the emitting layer...
2019/0169138 SMALL MOLECULE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE THEREOF
Compositions comprising small molecule mitofusin agonists are described. The mitofusin modulating agents are useful for treating diseases or disorders...
2019/0169137 SUBSTITUTED TRIAZOLES AND METHODS RELATING THERETO
Substituted 1,2,3-triazole compounds are disclosed which have utility in the treatment of a variety of neurological disorders. The compounds provided herein...
2019/0169136 Heterocyclic Naphthoquinones Derivatives for Use in the Treatment of Cancers Including Cushing Disease
The present invention concerns heterocyclic naphthoquinones derivatives for use in the treatment of Cushing disease and other cancers, in particular via the...
2019/0169135 Formation of N-Protected 3,6-bis-(4-aminoalkyl)-2,5,diketopiperazine
The disclosed embodiments detail improved methods for the synthesis of diketopiperazines from amino acids. In particular improved methods for the...
2019/0169134 NOVEL CLASS OF QUINOLONE HETEROCYCLIC AROMATIC MOLECULES FOR CANCER TREATMENT
The invention is directed to new class of quinolone heterocyclic aromatic molecules (Renotinibs) and their use in the treatment of cancer, in particular,...
2019/0169133 METHOD FOR MANUFACTURING NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND INTERMEDIATE OF SAME
An object of the present invention is to provide a method for industrially manufacturing a nitrogen-containing heterocyclic compound which shows excellent FLT3...
2019/0169132 Methods of Forming Carbene-Functionalized Composite Materials
Deposition of carbene monolayers that excluded starting anions, such as iodide ions, has been achieved. Anions such as iodide are a typical contaminant in...
2019/0169131 LIVER X RECEPTOR (LXR) MODULATORS
Described herein are liver X receptor (LXR) modulators and methods of utilizing LXR modulators in the treatment of LXR-associated diseases, disorders or...
2019/0169130 MULTIPLE-COMPONENT SOLID PHASES CONTAINING AT LEAST ONE ACTIVE PHARMACEUTICAL INGREDIENT
The subject invention concerns a method for identifying complementary chemical functionalities to form a desired supramolecular synthon. The subject invention...
2019/0169128 SUBSTITUTED 1-HYDROXY-PYRIDIN-2(1H)-ONES, AND METHODS OF MAKING AND USING SAME
The present invention includes novel substituted 1-hydroxy-pyridin-2(1H)-ones, which can be used to treat or prevent hepatitis B virus (HBV) infections in a...
2019/0169127 TUBULIN INHIBITORS
Provided herein are compounds, pharmaceutical compositions, and methods of treatment for various diseases, such as cancer. In one aspect, the method comprises...
2019/0169126 POLYMERIC METAL CHELATING COMPOSITIONS AND METHODS OF PREPARING SAME FOR CONTROLLING GROWTH AND ACTIVITIES OF...
Disclosed are chelating co-polymer compositions that are soluble in aqueous media and chelate essential metals, methods of preparation and uses thereof. The...
2019/0169125 CONCISE PROCESS FOR PREPARING 3-PYRROLIDINE CARBOXYLIC ACID DERIVATIVES
The present invention relates to a process for preparing 3-pyrrolidine carboxylic acid derivatives, and particularly a simple process for preparing...
2019/0169124 NEW DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES
The present invention relates to a new class of indole derivatives, having a particular MKlp2 inhibition profile and useful as a therapeutic agent, in...
2019/0169123 CRYSTAL FORMS AND PRODUCTION METHODS THEREOF
The various aspects present inventions provide various crystalline forms of (S)-(-)-amisulpride, (R)-(+)-amisulpride, and solvates thereof and methods of...
2019/0169122 COMPOSITIONS AND METHODS FOR TREATMENT OF PROSTATE CARCINOMA
Disclosed herein are 1,4-naphthoquinone analogs, pharmaceutical compositions that include one or more of such 1,4-naphthoquinone analogs, and methods of...
2019/0169121 METHOD FOR PREPARING N-[4-(2-{[2-(4-METHANE SULFONAMIDOPHENOXY) ...
A method for preparing 1-(4-methanesulfonamidophenoxy)-2-[N-(4-methanesulfonamidophenethyl)-N-me- thylamino]ethane (Dofetilide) of formula I by sulfonylation...
2019/0169120 SULFONIC ACID ESTER COMPOUND AND USE THEREFOR
Provided is a sulfonic acid ester compound represented by formula (1). ##STR00001## (In the formula, R.sup.1 and R.sup.2 each independently represent a hydrogen...
2019/0169119 Process for the preparation of Isosulfan Blue
Isosulfan blue and processes for the preparation thereof are provided. A process is also provided for preparation of the intermediate, ...
2019/0169118 USE OF AN ALCOHOL HYBRID TO MODIFY THE RHEOLOGY OF POLYETHOXYLATED ALCOHOL SULFATES
In one embodiment, a polyethoxylated alcohol sulfate composition is provided which includes a polyethoxylated alcohol sulfate, such as sodium laureth ether...
2019/0169117 TOPICAL COMPOSITIONS FOR THE TREATMENT OF DERMATOLOGICAL DISORDERS
The present invention relates to pharmaceutical compositions and methods useful for the treatment of dermatological disorders, and in particular acne vulgaris...
2019/0169116 PROCESS FOR PREPARATION OF CARMUSTINE
The present invention relates to an improved process for preparation of carmustine (I). The present invention also relates to preparation of ...
2019/0169115 IMPROVED PROCESS FOR THE PREPARATION OF CARBAMATES
A process for the preparation of N-(dialkylaminoalkyl)-carbamic acid esters, in particular (propyl N-[3-(dimethylamino)propyl] carbamate) comprising an...
2019/0169114 Benzoylglycine Derivatives and Methods of Making and Using Same
Disclosed are compounds of formulae: ##STR00001## and pharmaceutically acceptable salts thereof, wherein the variables, R.sub.1, R.sub.2, R.sub.3, R.sub.4,...
2019/0169113 Ketamine Derivatives
pa The present invention relates to ketamine derivatives of the formula (I), pharmaceutical compositions comprising them, and methods for treating pain...
2019/0169112 METHOD FOR HYDROGENATING NITRILES IN THE PRESENCE OF A RUTHENIUM CATALYST CARRIED ON ZrO2
The present invention relates to a process for hydrogenating nitriles with hydrogen in the presence of a ZrO.sub.2-supported ruthenium catalyst.
2019/0169111 WARMING SENSATION COMPOUNDS
Novel compounds for use in flavor, fragrance, or topical compositions are provided. Specifically, the compounds of the presently disclosed subject matter...
2019/0169110 CO-CRYSTALS OF SODIUM BENZOATE AND USES THEREOF
Provided are co-crystals of a sodium benzoate compound and a co-former compound of Formula (I) ##STR00001## Also provided herein are methods of preparing the...
2019/0169109 METHOD OF PRODUCING TEREPHTHALIC ACID
A method of terephthalic acid production in which slurry of crude terephthalic acid obtained through liquid-phase oxidation of a p-phenylene compound or a...
2019/0169108 1-HYDROXYMETHYL-1,2,2,6-TETRAMETHYL-CYCLOHEXANE AND DERIVATIVES THEREOF AND THEIR USE AS AROMA CHEMICALS
The invention relates to compounds of formula (A) as defined herein, and esters of the compound of formula (A), and ketones of the compound of formula (A). The...
2019/0169107 PREPARATION PROCESS OF PERFLUOROALKYL COMPOUND WITH MONOHYDROPERFLUOROALKANE AS STARTING MATERIAL
A simple production process is provided of a perfluoroalkyl compound that uses monohydroperfluoroalkane as a starting material, the perfluoroalkyl compound...
2019/0169106 Method for obtaining alcohols from aldehydes
The present invention relates to a method for preparing saturated C.sub.n- and C.sub.2n-alcohols, wherein the separation of the C.sub.n-alcohols and the...
2019/0169105 Method for obtaining alcohols from aldehydes III
The present invention relates to a method for preparing saturated C.sub.n- and C.sub.2n-alcohols, wherein the ratio of C.sub.n- to C.sub.2n-alcohols is...
2019/0169104 Method for obtaining alcohols from aldehydes II
The present invention relates to a method for preparing saturated C.sub.n- and C.sub.2n-alcohols, wherein the ratio of C.sub.n- to C.sub.2n-alcohols is...
2019/0169103 STORAGE CONTAINER AND STORAGE METHOD OF Z-1-CHLORO-3,3,3-TRIFLUOROPROPENE
A storage method of HCFO-1233zd (Z) according to an embodiment of the present invention, includes using a storage container having a liquid-contact portion...
2019/0169102 COMPOSITIONS OF CHROMIUM OXYFLUORIDE OR FLUORIDE CATALYSTS, THEIR PREPARATION AND THEIR USE IN GAS-PHASE PROCESSES
The present invention relates to a process for modifying the fluorine distribution in a hydrocarbon compound in the presence of a catalyst, characterized by...
2019/0169101 METHOD FOR PRODUCING 1-CHLORO-1,2-DIFLUOROETHYLENE
The present invention provides a method for efficiently producing 1-chloro-1,2-difluoroethylene at low cost. Specifically, the present invention provides a...
2019/0169100 PROCESS FOR THE DEHYDROCHLORINATION OF A CHLOROALKANE
A process for the production of a chloroalkene that includes contacting a liquid phase chloroalkane with a solid catalyst, a catalyst deposited on a solid...
2019/0169099 PROCESS FOR THE PREPARATION OF FLUOROOLEFIN COMPOUNDS
The subject of the invention is a process for the preparation of fluoroolefin compounds. It relates more particularly to a process for manufacturing a...
2019/0169098 PROCESS FOR THE PREPARATION OF 3,3,3-TRIFLUOPROPENE
The present invention provides a process for preparing 3,3,3-trifluoropropene (1243zf), the process comprising: (a)fluorinating CCI.sub.3CH.sub.2CH.sub.2CI...
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