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Patent # Description
2019/0169605 AUTOMATED CELL PROCESSING METHODS, MODULES, INSTRUMENTS, AND SYSTEMS
In an illustrative embodiment, automated multi-module cell editing instruments are provided to automate multiple edits into nucleic acid sequences inside one...
2019/0169604 METHODS AND COMPOSITIONS RELATED TO BARCODE ASSISTED ANCESTRAL SPECIFIC EXPRESSION (BAASE)
Disclosed herein are methods and platforms related to modulating expression of a gene of interest within a select population of cells comprising: providing a...
2019/0169603 Compositions and Methods for Labeling Target Nucleic Acid Molecules
Provided herein are methods and compositions for labeling target nucleic acid molecules with molecular barcodes.
2019/0169602 COMPOSITIONS AND METHODS FOR SEQUENCING NUCLEIC ACIDS
The invention provides compositions, including tethered synaptic complexes (TSCs), artificial nucleic acids, molecular constructs that include artificial...
2019/0169601 RECOGNITION TAGS FOR TGASE-MEDIATED CONJUGATION
The present application relates to methods for the functionalization of antibodies using transglutaminase, in particular antibodies lacking Fc regions. Also...
2019/0169600 RIBOSOME DISPLAY COMPLEX AND PRODUCTION METHOD THEREFOR
A method for producing a ribosome display complex includes obtaining a ribosome complex including an unmodified polypeptide chain, an mRNA molecule and a...
2019/0169599 SYSTEM AND METHOD FOR SEQUESTERING SUBSTANCES IN BULK LIQUIDS
Systems and methods for detecting and sequestering target analytes in a fluid sample. The system comprises a bulk specimen reservoir for receiving a liquid...
2019/0169598 METHODS AND COMPOSITIONS FOR ISOLATING SMALL RNA
The present invention concerns the use of methods and compositions for the isolation of small RNA molecules (100 nucleotides or fewer), such as microRNA and...
2019/0169597 GENOME EDITING ENHANCERS
The invention provides improved compositions for gene therapy compositions for treatment, prevention, or amelioration of numerous diseases, disorders, and...
2019/0169596 METHODS AND COMPOSITIONS FOR GENOME EDITING VIA HAPLOID INDUCTION
Methods and compositions for improved plant breeding using gene editing and haploid induction are provided.
2019/0169595 RNA TARGETING METHODS AND COMPOSITIONS
Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
2019/0169594 MAGNETIC CELL ISOLATION TECHNIQUES
Provided are techniques that may include a disposable magnetic cell isolation holder having one or more passages that accommodate a magnetic retention material...
2019/0169593 PRODUCTS AND METHODS FOR ASSESSING AND INCREASING KLOTHO PROTEIN LEVELS
Disclosed are products and methods for monitoring Klotho protein levels and for stabilizing Klotho protein in a mammalian blood sample, especially at room...
2019/0169592 Expression system for psicose epimerase and production for psicose using the same
A gene expression cassette capable of producing psicose at high yield with high stability, a GRAS (Generally recognized as safe) microorganism, a method of...
2019/0169591 Expression system for psicose epimerase and production for psicose using the same
A gene expression cassette capable of producing psicose at high yield with high stability, a GRAS (Generally recognized as safe) microorganism, a method of...
2019/0169590 MODIFIED BETA-LACTAMASES AND METHODS AND USES RELATED THERETO
The present invention relates to pharmaceuticals and modified beta-lactamases. Specifically, the invention relates to novel recombinant beta-lactamases and...
2019/0169589 Modified L-Asparaginase
The disclosure provides a modified protein that is a combination of (i) an L-asparaginase and (ii) one or more (poly)peptide(s), wherein the (poly)peptide...
2019/0169588 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The...
2019/0169587 VARIANT ENZYMES
Disclosed are glycosyl hydrolase enzyme variants, particularly variants of certain oxidoreductases of glycosyl hydrolase family 61. Nucleic acids encoding the...
2019/0169586 LACTIC ACID-UTILIZING BACTERIA GENETICALLY MODIFIED TO SECRETE POLYSACCHARIDE-DEGRADING ENZYMES
Lactic acid (LA)-utilizing bacteria are provided, genetically modified to express and optionally secrete polysaccharide-degrading enzymes, such as cellulases,...
2019/0169585 NOVEL GLYCOSYL HYDROLASE ENZYMES AND USES THEREOF
The present disclosure is generally directed to glycosyl hydrolase enzymes, compositions comprising such enzymes, and methods of using the enzymes and...
2019/0169584 Promoter useful for high expression of a heterologous gene of interest in Aspergillus niger
The present invention provides for an Asperigillus niger host cell comprising a gene of interest operatively linked to an ecm33 promoter of an ascomycete...
2019/0169583 STEP-Derived Peptide for Brain Injury Treatment
A novel peptide sequence that is a modified derivative of a neuron-specific tyrosine phosphatase is shown and described. Specifically, the novel peptide...
2019/0169582 Compositions and Methods for Pesticide Degradation
Compositions and methods related to anucelate cells (e.g., bacterial minicells) for pesticide degradation applications including related cells, polypeptides,...
2019/0169581 Human Serum Albumin Binding Compounds and Fusion Proteins Thereof
The present invention relates to a polypeptide binding to human serum albumin and comprising or consisting of an amino acid sequence selected from the group...
2019/0169580 VARIANT LovD POLYPEPTIDE
The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin. In particular, the...
2019/0169579 Respiratory Syncytial Virus Expression Vectors
In certain embodiments, the disclosure relates to vectors containing bacterial nucleic acid sequences and a paramyxovirus gene. Typically, the expression...
2019/0169578 METHODS AND COMPOSITIONS FOR PRODUCTION OF VACCINA VIRUS
Certain embodiments are directed to viral production processes for the large scale production of vaccinia virus.
2019/0169577 RESPIRATORY SYNCYTIAL VIRUS HAVING ALTERED NS1 PROTEIN FUNCTION AND RELATED MATERIALS AND METHODS
Embodiments disclosed herein provide compositions, methods, and uses for respiratory syncytial viruses (RSV) and immunogenic compositions thereof. Certain...
2019/0169576 GENERATION OF MIDBRAIN-SPECIFIC ORGANOIDS FROM HUMAN PLURIPOTENT STEM CELLS
The present disclosure provides a method of deriving and maintaining a midbrain-like organoid in culture, comprising (a) culturing pluripotent stem cells to...
2019/0169575 SC-BETA CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME
Disclosed herein are methods, compositions, kits, and agents useful for inducing .beta. cell maturation, and isolated populations of SC-.beta. cells for use in...
2019/0169574 IN VITRO PRODUCTION OF PANCREATIC BETA CELLS
Use of isoxazole 9 (ISX-9) for producing a beta cell in vitro.
2019/0169573 CELLS DERIVED FROM ADIPOSE TISSUE AND METHODS OF ISOLATING AND USING THE SAME
Methods of producing stem cell conditioned media to treat mammalian injuries or insults. In at least one embodiment of a method for isolating non-endothelial...
2019/0169572 END-TO-END CELL THERAPY AUTOMATION
The present disclosure provides an automated method of producing genetically modified immune cells, including chimeric antigen receptor T (CAR T) cells,...
2019/0169571 METHOD FOR PRODUCING CULTIVATED EPITHELIAL CELL SHEET
A method for producing an epithelial cell sheet, comprising culturing cells derived from oral mucosal epithelial cells on a substrate in a serum-free medium,...
2019/0169570 METHOD FOR MANUFACTURING CILIARY MARGINAL ZONE-LIKE STRUCTURE
The present invention provides a method for producing a cell aggregate containing a ciliary marginal zone-like structure, including a step of culturing a cell...
2019/0169569 METHOD FOR REPRODUCIBLE DIFFERENTIATION OF CLINICAL-GRADE RETINAL PIGMENT EPITHELIUM CELLS
Provided herein are methods of producing an RPE cell population from a starting cell suspension, such as a single cell suspension, of pluripotent stem cells...
2019/0169567 NOVEL GRAFT POLYMER, TEMPERATURE-RESPONSIVE SUBSTRATE FOR CELL CULTURE USING THE SAME AND PRODUCTION METHOD...
By using a graft polymer comprising a dendritic polymer with a styrene skeleton and a hydrophilic polymer grafted to a terminal thereof, a ...
2019/0169566 BIOREACTOR SYSTEM
Disclosed herein are bioreactor systems and methods of utilizing said systems.
2019/0169565 MEDIUM AND METHOD FOR CULTURING ANTRODIA CINNAMOMEA
A medium for culturing Antrodia cinnamomea includes a carbon source, a nitrogen source, vitamin A, agar and a solvent. The medium includes 8-16 grams/liter of...
2019/0169564 METHODS OF CULTURING MICROORGANISMS IN NON-AXENIC MIXOTROPHIC CONDITIONS
Methods of culturing microorganisms in non-axenic mixotrophic conditions are disclosed. A method of culturing microalgae mixotrophically and controlling...
2019/0169563 OXYGEN GRADIENT HYDROGEL DRUG SCREENING
The present invention describes methods for quantifying and analyzing cell migration and drug screening. Such methods include a gel (or a hydrogel) comprising...
2019/0169562 SCREENING OF IMMUNO-MODULATORY THERAPIES
Embodiments provide methods of preparing a platform, which entails, among others, contacting a) a culture comprising a medium or growth matrix comprising an...
2019/0169561 IN-SITU CELL RETENTION PERFUSION BIOREACTORS
The bioreactor may include a single-use, rigid-sided bioreactor vessel containing a fluid to be mixed and a vertical mixing wheel. A perfusion dip tube with a...
2019/0169560 An Apparatus and a Method for Transferring Material
The present invention relates to an apparatus and a method for transferring materials such as cells or microbial colonies during sample preparation. The...
2019/0169559 CELL RETENTION DEVICE AND METHOD
The subject technology relates to a cell retention device and method for use in a perfusion cell culture system where the cell retention device includes a...
2019/0169558 THREE-DIMENSIONAL STRUCTURING METHOD AND THREE-DIMENSIONAL STRUCTURING SYSTEM OF CELLS
Proposed are a three-dimensional structuring method of cells and a three-dimensional structuring system of cells capable of efficiently bonding multiple cell...
2019/0169557 PERFUSION MANIFOLD ASSEMBLY
A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells...
2019/0169556 Automated Cell Culture System with Heated, Angled Adapter and Method
An automated method for culturing stem cells using a robotic liquid handling system including a translatable bed and a movable multi-channel pipette. The...
2019/0169555 APPARATUS AND METHOD FOR PRESERVING THE AROMA OF A FERMENTABLE BEVERAGE
A fermentation apparatus for preserving the aroma of a fermentable beverage is provided. The fermentation apparatus comprises a flow passage fluidly...
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