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Patent # Description
2019/0169300 COMBINATION OF GLUCAGON RECEPTOR ANTAGONISTS AND PI3K PATHWAY INHIBITORS FOR THE TREATMENT OF CANCER
The present disclosure relates to combination therapy methods of treating a subject having cancer, comprising administering to the subject a) an effective...
2019/0169299 METHODS FOR TREATING OR PREVENTING ASTHMA BY ADMINISTERING AN IL-4R ANTAGONIST
The invention provides methods for treating or preventing asthma and associated conditions in a patient. The methods featured in the invention comprise...
2019/0169298 RECOMBINANT MONOVALENT ANTIBODIES AND METHODS FOR PRODUCTION THEREOF
The present invention provides monovalent antibodies with a long half-life when administered in vivo, methods of making such monovalent antibodies,...
2019/0169297 TARGETING THE COFILIN PATHWAY
The present disclosure provides a method of restoring immune reconstitution, immune control of viremia, and one or more T cell functions in a subject infected...
2019/0169296 TARGETING PD-L1 ON TUMOR CELLS
This document relates to materials and methods for treating cancer. For example, this document provides materials and methods for using PD-L1 targeting domains...
2019/0169295 LONG LIFE POLYPEPTIDE BINDING MOLECULES
The present invention relates to a binding molecule comprising at least three domains comprised in at least one polypeptide chain, wherein the first binding...
2019/0169294 ANTI-LAG-3 ANTIBODY
The present invention provides an anti-LAG-3 antibody capable of repeated administration even to animals other than rat. An anti-LAG-3 antibody comprising (a)...
2019/0169293 HANP-FC-CONTAINING MOLECULAR CONJUGATE
The present invention provides a conjugate comprising a hANP peptide bonded via a polyethylene glycol linker to a glycan attached to Asn297 of a Fc-containing...
2019/0169292 Covalently Bonded Diabodies Having Immunoreactivity with PD-1 and LAG-3, and Methods of Use Thereof
The present invention is directed to bi-specific diabodies that comprise two or more polypeptide chains and which possess at least one Epitope-Binding Site...
2019/0169291 Antibodies to MAdCAM
The present disclosure relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to MAdCAM, preferably human...
2019/0169290 COMPOSITIONS AND METHODS FOR MODULATING AN IMMUNE RESPONSE
Described herein are compositions for increasing IL-12 production comprising IgG or a fragment thereof or a variant thereof and uses of said compositions for...
2019/0169289 OPTIMIZED PNE-BASED CHIMERIC RECEPTOR T CELL SWITCHES AND USES THEREOF
Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more...
2019/0169288 ANTAGONISTS OF IL-6 TO PREVENT OR TREAT THROMBOSIS
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to...
2019/0169287 TREATMENT OF CANCER WITH ANTI-IL-1 ALPHA ANTIBODIES
Treating a patient with anti-IL-1.alpha. antibody or anti-IL-1.alpha. immunization s a cancer treatment.
2019/0169286 COMPOSITION FOR PROPHYLAXIS OR TREATMENT OF IL-8 RELATED DISEASES
For example, therapeutic methods and the like for novel IL-8-related diseases using an IL-8 signal inhibitor are provided. Alternatively, for example,...
2019/0169285 Anti-IL31 Antibodies for Veterinary Use
Provided are various embodiments relating to anti-IL31 antibodies binding to canine IL31. Such antibodies can be used in methods to treat IL31-induced...
2019/0169284 SOLUBILITY OPTIMIZATION OF IMMUNOBINDERS
The invention provides methods of using sequence based analysis and rational strategies to improve the solubility of immunobinders, and in particular of single...
2019/0169283 ANTI-CXCR5 ANTIBODIES AND COMPOSITIONS AND USES THEREOF
The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to CXCR5. The antibodies can be afucosylated and exhibit...
2019/0169282 Antigen Binding Proteins that Bind DLL-4
There is disclosed compositions and methods relating to or derived from anti-DLL-4 antibodies. More specifically, there is disclosed fully human antibodies...
2019/0169281 ANGPTL8-BINDING AGENTS AND METHODS OF USE THEREOF
The present disclosure provides binding agents, such as antibodies, that specifically bind Angiopoietin-like protein 8 (ANGPTL8), including human ANGPTL8, and...
2019/0169280 COMPOSITIONS FOR TREATING AMYLOIDOSIS
Antibody formulations and methods useful for treatment of peripheral neuropathy in patients with AL amyloidosis.
2019/0169279 COMPOSITIONS AND METHODS OF TREATING OCULAR DISEASES
A method of treating a complement mediated ocular inflammation, hemorrhaging and fibrosis, and the pathological consequences thereof, in a subject in need...
2019/0169278 Anti-Polyubiquitin Multispecific Antibodies
The invention provides antibodies having greater avidity for a mixed-topology polyubiquitin than a single-topology polyubiquitin and multispecific...
2019/0169277 MODIFIED ANTI-TENASCIN ANTIBODIES AND METHODS OF USE
The present invention relates to improved antibodies specific for Tenascin-C (TnC), in particular domain specific anti-TnC antibodies with improved...
2019/0169276 HUMANIZED TAU ANTIBODIES IN ALZHEIMER'S DISEASE
The present invention is in the fields of biochemistry, molecular biology, and Alzheimer's disease diagnosis, prevention, and treatment. Provided herein are...
2019/0169275 Methods of Treating a Tauopathy
The present disclosure provides methods of treating a tauopathy, involving administering an anti-Tau antibody. The present disclosure also provides anti-Tau...
2019/0169274 HUMAN ANTI-TAU ANTIBODIES
Provided are novel human tau-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and...
2019/0169273 MONOCLONAL ANTIBODIES DIRECTED AGAINST TRIMERIC FORMS OF THE HIV-1 ENVELOPE GLYCOPROTEIN WITH BROAD AND POTENT...
The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for...
2019/0169272 REMOVAL OF SERINE PROTEASES BY TREATMENT WITH FINELY DIVIDED SILICON DIOXIDE
The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition....
2019/0169271 Use of a Long Acting GLP-1/Glucagon Receptor Dual Agonist for the Treatment of Non-Alcoholic Fatty Liver Disease
The present invention relates to a pharmaceutical composition for the prevention or treatment of non-alcoholic fatty liver disease including a long-acting...
2019/0169270 COMPOSITIONS AND METHODS FOR INHIBITING ENDOGENOUS IMMUNOGLOBULIN GENES AND PRODUCING TRANSGENIC HUMAN IDIOTYPE...
The invention relates to transgenic animals lacking endogenous Ig and capable of producing transgenic antibodies, as well as methods of making the same. The...
2019/0169269 POLYPEPTIDE DERIVED FROM TROPOELASTIN AND BIOCOMPATIBLE MATERIAL COMPRISING SAME
The present invention provides a tropoelastin-derived polypeptide and an elastic composite biocompatible material comprising the polypeptide. The object of the...
2019/0169268 GLYCOSYLATED VWF FUSION PROTEINS WITH IMPROVED PHARMACOKINETICS
The invention relates to a fusion protein comprising a main protein and one or more extension peptides, wherein the amino acid sequence of the main protein is...
2019/0169267 FACTOR VIII COMPLEX WITH XTEN AND VON WILLEBRAND FACTOR PROTEIN, AND USES THEREOF
The present invention provides a chimeric protein comprising a VWF protein comprising the D' domain and D3 domain of VWF, one or more XTEN sequence, and a...
2019/0169266 CONSTRUCTS HAVING A SIRP-ALPHA DOMAIN OR VARIANT THEREOF
The present disclosure features signal-regulatory protein a (SIRP.alpha.) polypeptides and constructs that are useful, e.g., to target a cell (e.g., a cancer...
2019/0169265 SOLUBLE GLYCOPROTEIN V FOR TREATING THROMBOTIC DISEASES
A soluble polypeptide comprising a modified glycoprotein V (GPV) lacking a functional transmembrane domain for use in the treatment or prevention of a...
2019/0169264 MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE
This document relates to materials and methods for modulating ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC...
2019/0169263 MHC CLASS IA OPEN CONFORMERS
The invention relates to MHC-Ia open conformers as immunomodulatory agents, particularly in the treatment or prevention of cancer. The open conformer comprises...
2019/0169262 SLC45A2 PEPTIDES FOR IMMUNOTHERAPY
Provided are SLC45A2 peptides that bind to MHC I (HLA-A2) on melanoma cells or other antigen-presenting cells and are recognized by T-cell receptors on T...
2019/0169261 T CELL RECEPTORS AND USES THEREOF
The present invention relates to the field of biotechnology. Specifically, the invention provides antigen-specific T-cell receptors (TCRs). Further, the...
2019/0169260 Human Leukocyte Antigen Restricted Gamma Delta T Cell Receptors and Methods of Use Thereof
Disclosed herein are compositions and methods of treating a subject with cancer. The compositions and methods utilize immunoresponsive cells to effect killing...
2019/0169259 BTNL3 PROTEINS, NUCLEIC ACIDS AND ANTIBODIES AND USES THEREOF
The invention provides novel BTNL3 proteins, including multimers, fragments, fusion proteins, and variants. In addition, antibodies that can bind to BTNL3...
2019/0169258 Bi-Specific Therapeutic Proteins for Tissue Repair
Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using...
2019/0169257 ACYLATED DERIVATIVE OF HUMAN INSULIN OR ANALOGUE THEREOF
Provided is an acylated derivative of human insulin or an analogue thereof. Specifically disclosed is an acylated derivative of a human insulin analogue, or...
2019/0169256 ANTAGONISTS OF FISH REPRODUCTION
Peptide-based neurokinin antagonists of fish reproduction are disclosed. Compositions comprising antagonists of fish neurokinin and methods of inhibiting or...
2019/0169255 IL-2 MUTEINS AND USES THEREOF
The present application provides for IL-2 muteins, compositions comprising the same, and methods of using the same.
2019/0169254 IL-2 MUTEINS AND USES THEREOF
The present application provides for IL-2 muteins, compositions comprising the same, and methods of using the same.
2019/0169253 ONCOLYTIC HERPES SIMPLEX VIRUS VECTORS EXPRESSING IMMUNE SYSTEM-STIMULATORY MOLECULES
An HSV vector comprising an expression cassette for one or more of IL12, IL15, and hIL15Receptor alpha subunit is provided.
2019/0169252 CYTOKINE FUSED TO IMMUNOGLOBULIN FC HETERODIMER AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
The present invention relates to a heterodimeric Fc-fused protein comprising a first Fc region and a second Fc region of an immunoglobulin Fc pair and a...
2019/0169250 IL22 IMMUNOCONJUGATES
The application relates to a conjugate comprising interleukin-22 (IL22) and an antibody molecule. The antibody molecule preferably binds an antigen associated...
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