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| Patent # | Description |
|---|---|
| US-5,688,810 |
Steroid receptor modulator compounds and methods Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions... |
| US-5,688,809 |
5-heteroarylindole derivatives The present invention relates to compounds of the formula ##STR1## The present invention also relates to intermediates for the preparation of compounds of... |
| US-5,688,808 |
Steroid receptor modulator compounds and methods Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions... |
| US-5,688,807 |
Method for treating 5HT.sub.2B receptor related conditions The present invention provides methods for binding a 5-HT.sub.2B receptor in mammals using a both known and novel compounds. Further, the invention provides a... |
| US-5,688,806 |
Spiroazacyclic derivatives as substance P antagonists The present invention relates to novel spirocyclic piperidine derivatives and related compounds and, specifically, to compounds of the formula ##STR1## ... |
| US-5,688,805 |
Tricyclic derivatives, compositions and methods of use Disclosed are compounds of Formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof. Also disclosed are pharmaceutical compositions... |
| US-5,688,804 |
3-Benzylamino-2-phenyl-piperidine derivatives as substance P receptor
antagonists The present invention relates to the derivatives of the compound of formula (I), which are useful in the treatment of inflammatory and central nervous system... |
| US-5,688,803 |
Tricyclic dicarbonyl derivatives Compounds of general formula (Ia), (Ib) and (II), wherein R.sup.1 and R.sup.2 each independently signify hydrogen, lower alkyl, lower alkoxy, nitro,... |
| US-5,688,802 |
Bornyl xanthine derivatives with adenosine-antagonistic activity The invention relates to new xanthine derivatives of general formula I, processes for preparing them and their use as pharmaceutical compositions. |
| US-5,688,801 |
Method of inhibiting neurotransmitter activity using microencapsulated
3-piperidiny2-substituted... A pharmaceutical composition comprising a biodegradable and biocompatible composition comprising a 1,2 benzazole within a polymeric matrix. The 1,2 benzazole... |
| US-5,688,800 |
Condensed pyrimidine derivative A novel pyrimidine derivative having an excellent antitumor activity, which is represented by the following general formula (I) or a pharmacologically acceptable... |
| US-5,688,799 |
9-Hydroxy-pyrido[1,2-a]pyrimidin-4-one ether derivatives The present invention is concerned with novel compounds having the formula ##STR1## the pharmaceutically acceptable acid addition salts thereof and the ... |
| US-5,688,798 |
Pyrimidine compounds Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 each individually are lower-alkyl or amino, A is ##STR2## B is hydrogen in A.sup.4,... |
| US-5,688,797 |
Treatment of acute central nervous system injury with piperazine
derivatives A method of treating patients suffering from acute trauma of the central nervous system is described. The method comprises identifying such patient and... |
| US-5,688,796 |
Heterocyclic substituted benzothiophenes, compositions, and methods The present invention provides class of compounds of formula I ##STR1## and their pharmaceutically acceptable salts in which R.sup.1 is hydrogen, hydroxy,... |
| US-5,688,795 |
[3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy]-pyridine,
pyrimidine and benzene derivatives as... The present invention relates to novel .alpha..sub.1 -adrenoceptor antagonists of Formula I: ##STR1## in which: p is 0 or 1; t is 0, 1 or 2; X is O, S or... |
| US-5,688,794 |
Method for modifying or regulating lipid metalolism in an animal or
human subject with a proclactin stimulating... A process for the long term modification and regulation of lipid and glucose metabolism--generally to reduce obesity, insulin resistance, and hyperinsulinemia or... |
| US-5,688,793 |
Pyridazino[4',5':3,4]pyrrolo-[2,1-a]-isoquinolines and the use thereof
for preparing pharmaceutical preparations The invention relates to new pyridazino[4',5':3,4]-pyrrolo[2,1-a]isoquinolines of the formula ##STR1## and the physiologically acceptable salts thereof with... |
| US-5,688,792 |
Substituted oxazine and thiazine oxazolidinone antimicrobials A compound of structural Formula I: ##STR1## or pharmaceutically acceptable salts thereof wherein: X is O, S, SO, SO.sub.2, SNR.sup.10 or S(O)NR.sup.10 ; R... |
| US-5,688,791 |
Aryl group-or aromatic heterocyclic group-substituted aminoquinolone
derivatives and anti-hiv agent Disclosed are an aryl group- or heterocyclic group-substituted aminoquinolone compound represented by the formula (Ia), (Ib) or (Ic): ##STR1## wherein each... |
| US-5,688,790 |
Phenylpyrrole derivatives and their use as antipsychotic agents This invention relates to compounds of formula (I): ##STR1## wherein R.sup.1 represents C.sub.1-4 alkyl; and R.sup.2, R.sup.3, R.sup.4 and R.sup.5 each... |
| US-5,688,789 |
PCP receptor ligands and the use thereof The invention relates to 5-(iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene and derivatives thereof. The invention also relates to the use of such... |
| US-5,688,788 |
N-substituted azaheterocyclic carboxylic acids and esters thereof The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the... |
| US-5,688,787 |
Substituted .beta.-lactam compounds useful as hypochlesterolemic agents
and processes for the preparation thereof Novel compounds of the formula ##STR1## wherein A is --CH.dbd.CH--B; --C.tbd.C--B; --(CH.sub.2).sub.p --X--B, and X is a bone, --NH-- or --S(O).sub.0-2 --;... |
| US-5,688,786 |
.beta.-lactam antibiotics The present invention includes novel compounds or their pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms... |
| US-5,688,785 |
Substituted azetidinone compounds useful as hypocholesterolemic agents Substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: Ar.sup.1 is aryl or... |
| US-5,688,784 |
Method of suppressing appetite with vanadium complexes There are provided vanadium compositions for use in the treatment of hypertension, obesity and diabetes, in particular improved oral compositions comprising... |
| US-5,688,783 |
Salinamides Salinamides A and B are disclosed. These two bicyclic depsipeptides are produced by fermentation of a specific marine actinomycete, a Streptomyces sp, (CNB-091)... |
| US-5,688,782 |
Medicaments for treating respiratory disorders This invention relates to aerosol formulations of use for the administration of medicaments by inhalation, in particular a pharmaceutical aerosol formulation... |
| US-5,688,781 |
Method for treating vascular leak syndrome A novel method for preventing, stabilizing or causing regression of vascular leak syndrome is disclosed. The method comprises administering to a patient in need... |
| US-5,688,780 |
Antihypercholesterolemic compounds and related pharmaceutical
compositions and methods of use Novel antihypercholesterolemic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R is a C-17 side chain,... |
| US-5,688,778 |
Nucleoside analogs Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula ##STR1## wherein X and X' are... |
| US-5,688,777 |
Inhibition of C. difficile infections by indigestible oligosaccharides The primary etiology of antibiotic-associated diarrhea (which may lead to pseudomembranous colitis) has been recognized as Clostridium difficile. It is believed... |
| US-5,688,776 |
Crosslinked polysaccharides, process for their preparation and their use The invention relates to polysaccharides which are crosslinked with bifunctional crosslinkers and are no longer water-soluble but are still biodegradable, have a... |
| US-5,688,775 |
.beta.-1,3-glucan polysaccharides, compositions, and their preparation
and uses Irradiated or nonirradiated substantially pure .beta.-1,3-glucan polysaccharides, derivatives and coprocessed mixtures thereof with other hydrocolloids, methods... |
| US-5,688,774 |
A.sub.3 adenosine receptor agonists The present invention provides A.sub.3 selective agonists, particularly, adenine compounds having selected substituents at the 2, 6, and 9 positions, and related... |
| US-5,688,773 |
Method of selectively destroying neoplastic cells A method for selectively killing nervous system and peripheral neoplastic cells is provided. Viral vectors are used to selectively express a cytochrome P450 gene... |
| US-5,688,772 |
Quinoa saponin compositions and methods of use Novel Quinoa saponin pharmaceutical compositions are disclosed. The compositions are useful for enhancing mucosal absorption of a drug administered therewith. |
| US-5,688,771 |
Lipophilic oligopeptides with immunomodulating activity New, small and structurally simple immunomodulating oligopeptides are disclosed. The oligopeptides of this invention possess a long, lipophilic alkyl chain.... |
| US-5,688,770 |
Antiglaucoma compositions and methods The present invention relates to ophthalmo-logical pharmaceutical compositions comprising a renin inhibitor and to methods for using said composition in the... |
| US-5,688,769 |
Treatment method A method for inhibiting ovarian steroidogenesis in women comprising administering to women an ovarian steroidogenesis inhibitorilly effective amound of D Ser... |
| US-5,688,768 |
Recombinant thrombin receptor and related pharmaceuticals The DNA encoding the cell surface receptor for thrombin has been cloned and sequenced. The availability of this DNA permits the recombinant production of... |
| US-5,688,767 |
Treatment of endotoxin-associated disorders with cationic peptides A method for the microbial production of a cationic peptide having anti-microbial activity is provided, wherein the cationic peptide is first produced as a... |
| US-5,688,766 |
Anticaries compositions The present invention relates to oral and edible compositions intended to provide an anticaries benefit. The primary active ingredient in these compositions is a... |
| US-5,688,765 |
Ocular therapy in Sjogren's syndrome using topically applied androgensor
TGF-.beta. The topical application to the ocular surface or adjacent regions of the eye of a preparation containing a therapeutic amount of an androgen or androgen analogue... |
| US-5,688,764 |
Insecticidal peptides from spider venom This invention relates to the purification of a family of insecticidally effective peptides isolated from the spider, Calisoga sp., characterized by their... |
| US-5,688,763 |
Compositions and methods for the synthesis of growth hormone receptor
and growth hormone binding protein Growth hormone receptor and growth hormone binding protein are purified enabling amino acid sequence and DNA isolates coding for growth hormone receptor and... |
| US-5,688,762 |
Method of treating hypertension using animal stomach mucosa extract and
endogenous protease-inhibitor peptides A process of inhibiting the renin angiotensinogen angiotensin mechanism and treating hypertension administers a blood pressure lowering amount of a protease... |
| US-5,688,761 |
Convertible microemulsion formulations There is provided a water-in-oil (w/o) micro emulsion which readily converts to an oil-in-water (o/w) emulsion by the addition of aqueous fluid to the w/o... |
| US-5,688,760 |
Polypeptides having bone resorption inhibitory activity comprising
PTHrP-derived sequences Polypeptides comprising an N-terminal amino acid sequence corresponding to amino acids 107-111 of parathyroid hormone related protein (PTHrP) having bone... |
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