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| Patent # | Description |
|---|---|
| US-7,550,474 |
Substituted phenyl acetamides and their use as protease inhibitors Phenyl acetamide compounds are described, including compounds of Formula I: ##STR00001## or a solvate, hydrate or pharmaceutically acceptable salt thereof;... |
| US-7,550,473 |
Pyrimidine derivatives useful as inhibitors of PKC-theta Disclosed are novel compounds of formula (I): ##STR00001## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined herein, which are useful as inhibitors of... |
| US-7,550,472 |
Substituted pteridines for the treatment of inflammatory diseases The invention relates to new pteridines which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases... |
| US-7,550,471 |
5-alkyl-7-aminotriazolopyrimidines, methods and intermediary product
necessary for the production thereof,... The invention relates to 5-alkyl-7-aminotriazolopyrimidines of the formula (I) and to the salts thereof. In said formula substituents have the following... |
| US-7,550,470 |
Substituted pyrazolo[1,5-A]pyrimidines as tyrosine kinase inhibitors The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these... |
| US-7,550,469 |
Heterocyclic amide derivatives and their use as dopamine D3 receptor
ligands The invention relates to heterocyclic substituted amide derivatives that display selective binding to dopamine D.sub.3 receptors. In another aspect, the... |
| US-7,550,468 |
Theophylline and 3-isobutyl-1 methylxanthine based N-7 substituted
derivatives displaying inhibitory activities... A variety of N-substituted derivatives are based upon the base chemicals of ##STR00001## that provide for the induction of cavernosal relaxation in animals. R2... |
| US-7,550,467 |
Bicyclic compounds as selective melanin concentrating hormone receptor
antagonists for the treatment of obesity... The present invention discloses compounds of Formula I ##STR00001## wherein V, W, Y, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4, d, m, n, p and r are herein defined,... |
| US-7,550,466 |
Alpha and/or .beta.-adrenergic antagonists and agonists to treat pain The present disclosure provides for improved methods for treating pain, including pain associated with chronic inflammatory diseases, neuropathic pain and cancer... |
| US-7,550,465 |
Pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10,
and processes for preparing them The invention relates to pyrido[3,2-e]pyrazines, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the... |
| US-7,550,464 |
Condensed polycyclic compounds The present invention provides a novel a condensed polycyclic compound useful as a phosphodiesterase 4 inhibitor, which is shown by the formula [I]: ##STR00001##... |
| US-7,550,463 |
Carbamoylpyridone derivatives having inhibitory activity against HIV
integrase An object of the present invention provides a novel compound having the anti-viral activity, particularly, the HIV integrase inhibitory activity, and a drug... |
| US-7,550,462 |
Piperazinediones as oxytocin receptor antagonists Compounds of formula (I) ##STR00001## wherein R.sub.1 is 2-indanyl, R.sub.2 is 1-methylpropyl, R.sub.3 is a group selected from 2,6-dimethyl-3-pyridyl or... |
| US-7,550,461 |
Benzofuran and benzothiophene compounds useful in treating cytokine
mediated diseases Disclosed are amide compounds of formula (I): ##STR00001## wherein Ar.sup.1, Q, Y and R.sup.3-R.sup.6 of formula (I) are defined herein. The compounds inhibit... |
| US-7,550,460 |
2,4-pyrimidinediamine compounds and their uses The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical... |
| US-7,550,459 |
Tetrahydroquinoline analogues as muscarinic agonists The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an... |
| US-7,550,458 |
Tricycloundecane compounds useful as modulators of nuclear hormone
receptor function Tricycloundecanes compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune... |
| US-7,550,457 |
Pharmaceutically effective compounds The subject invention relates to carboxamidine derivatives, to pharmaceutical compositions containing the carboxamidine derivatives of the invention, and the use... |
| US-7,550,456 |
Substituted aryl cycloalkanoyl derivatives and methods of their use The present invention is directed to substituted aryl cycloalkanoyl derivatives, compositions containing these derivatives, and methods of their use for the... |
| US-7,550,455 |
8-(piperazin-1yl)- and 8-([1,4]diazepan-1yl)-xanthines, the preparation
thereof and their use as pharmaceutical... The present invention relates to substituted xanthines of the general formula ##STR00001## in which R.sup.1 to R.sup.3 and n are as defined in claims 1 to 8,... |
| US-7,550,454 |
Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists
and methods of treatment of... Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and... |
| US-7,550,453 |
2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions
containing them and use thereof The invention relates particularly to 2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof as a medicament,... |
| US-7,550,452 |
Cationic lipids and use thereof The present invention relates to cationic lipids, methods for preparing some and methods for effectively transporting anionic molecular substances into cell by... |
| US-7,550,451 |
Progesterone receptor modulators with increased antigonadotropic activity
for female birth control and hormone... The invention relates to new compounds of general formula I, ##STR00001## their production and pharmaceutical preparations that contain these compounds.The... |
| US-7,550,450 |
Prostate cancer treatment The instant invention provides potent antiandrogen compounds, such as 3.beta.-acetoxyandrost-1,5-diene-17-ethylene ketal and ... |
| US-7,550,449 |
Carba cyclic phosphatidic acid derivative It is an object of the present invention to synthesize a carba cyclic phosphatidic acid derivative having a novel structure by substituting O at position sn-2 of... |
| US-7,550,448 |
Therapeutic compounds Disclosed herein is a compound having a structure ##STR00001## or a pharmaceutically acceptable salt, or a prodrug thereof. Therapeutic methods, compositions,... |
| US-7,550,447 |
Method for precipitating nucleic acid with visible carrier A suitable carrier molecule useful in a nucleic acid precipitation method is modified by coupling a suitable visualizable indicator molecule to the carrier... |
| US-7,550,446 |
Highly branched, unsubstituted or low-substituted starch products,
dialysis solution and plasma expander... Known hydroxyethylated and -propylated starch types for use as colloid osmotic agent in peritoneal dialysis or as volume replacement composition (plasma... |
| US-7,550,445 |
Aripiprazole complex formulation and method An aripiprazole formulation is provided which includes the antipsychotic agent aripiprazole in the form of an inclusion complex in a .beta.-cyclodextrin,... |
| US-7,550,444 |
Composition and method for preparing biocompatible surfaces The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible... |
| US-7,550,443 |
Process and systems for biocompatible surfaces The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible... |
| US-7,550,442 |
Nucleoside analog inhibitors of reverse transcriptase Compounds of formula (XXIII), or pharmaceutically acceptable salts or esters thereof, are inhibitors of reverse transcriptase: ##STR00001## R.sub.4 is a... |
| US-7,550,441 |
Controlled release polymer nanoparticle containing bound nucleic acid
ligand for targeting The present invention relates to a conjugate that includes a nucleic acid ligand bound to a controlled release polymer system, a pharmaceutical composition that... |
| US-7,550,440 |
Topical application of ivermectin for the treatment of dermatological
conditions/afflictions Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic... |
| US-7,550,439 |
Methods for reducing oxidative damage The invention provides a method for reducing oxidative damage in a mammal, a removed organ, or a cell in need thereof. The method comprises administering an... |
| US-7,550,438 |
Methods for production of growth-promoting proteins and peptides for
kidney epithelial cells Novel growth peptides derived from protein factors having molecular weights of about 22 and 45 kDa stimulate mitogenic activity of epithelial, but not... |
| US-7,550,437 |
Compositions for preventing and treating digestive organs diseases The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal... |
| US-7,550,436 |
Compositions containing peptide and electrolyte excretion promoter and
foods containing the same A composition containing a peptide and an electrolyte excretion promoter, which comprises a peptide or a peptide mixture which is obtained by lysing a... |
| US-7,550,435 |
Method of modifying glucose activity using polypeptides selectively
expressed in fat tissue Isolated omentin polypeptides that selectively express in omental fat tissue and methods for the use of the polypeptides. The polypeptides can be used in a... |
| US-7,550,434 |
Stabilized teriparatide solutions A stabilized pharmaceutical composition in the form of a solution for parenteral administration of a parathyroid hormone is described wherein the therapeutically... |
| US-7,550,433 |
Erythropoietin receptor peptide formulations and uses The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods... |
| US-7,550,432 |
Recombinant fusion proteins to growth hormone and serum albumin The invention describes albumin fusion proteins comprising growth hormone and serum albumin. The invention also describes nucleic acid molecules encoding the... |
| US-7,550,431 |
Spatially-defined macrocycles incorporating peptide bond surrogates Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or... |
| US-7,550,430 |
Cationic antimicrobial peptides and compositions The invention described herein relates to compositions of novel antimicrobial peptides. The peptides of the present invention exhibit high antibacterial activity... |
| US-7,550,429 |
Glycoproteins having lipid mobilising properties and therapeutic
applications thereof A biologically active lipid mobilising agent for use in therapy is disclosed which has the properties and characteristics of a Zn-.alpha..sub.2-glycoprotein, or... |
| US-7,550,428 |
Echinocandin/carbohydrate complexes A complex of an echinocandin compound with a carbohydrate is described having improved thermal stability and water solubility. A process for making the... |
| US-7,550,427 |
Poly-pegylated protease inhibitors Disclosed are compounds that comprise: (i) a Kunitz domain polypeptide that comprises a Kunitz domain that binds to and inhibits a protease; and (ii) a plurality... |
| US-7,550,426 |
Acetylated therapeutic procytotoxins A class of procytotoxic agents is characterized by a capability to kill with target cell-specificity. Such an aspect can be a pore-forming protein which has at... |
| US-7,550,425 |
Diuretic peptide conjugates Disclosed are a variety of peptide conjugates represented by the following general formula: R.sub.1-Z-X-Z'-R.sub.2 including methods of making and using such... |
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