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Patent # Description
US-9,562,118 Transition metal complexes supported on metal-organic frameworks for heterogeneous catalysts
A robust mesoporous metal-organic framework comprising a hafnium-based metal-organic framework and a single-site zirconium-benzyl species is provided. The...
US-9,562,117 Preparation of derivatives of isobutene copolymers
A process for producing an isobutene copolymer derivative by: (I) free-radically copolymerizing (a) 10-90 mol % of a monoethylenically unsaturated C.sub.4- to...
US-9,562,116 Method for preparation of ruthenium-based metathesis catalysts with chelating alkylidene ligands
The invention relates to a method for preparation of ruthenium-based carbene catalysts with a chelating alkylidene ligand ("Hoveyda-type catalysts") by reacting...
US-9,562,115 Dispersion stabilizer for suspension polymerization and method for producing vinyl resin
The present invention provides an easy-to-handle dispersion stabilizer for suspension polymerization that meets the following requirements: even if the amount...
US-9,562,114 Cyclic carbonate azide
Cyclic carbonate azide having a structure according to the following formula (A) wherein R.sup.1-R.sup.5 are independently selected from the group consisting of...
US-9,562,113 Labeled alginate conjugates for molecular imaging applications
Described are bifunctional NOTA-based derivatives capable of conjugating with alginate and with metal ions, as well as NOTA-alginate conjugates which can be...
US-9,562,112 Carboxy-functionalized alternan
Functionalized alternan, comprising carboxy groups as functional groups, wherein the alternan can be described by the following formula (I) Alternan (I) wherein...
US-9,562,111 Soluble hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using...
The present invention relates to a soluble hydrophobic-core carrier composition comprising (i) a linear polymeric backbone; (ii) a plurality of hydrophilic...
US-9,562,110 Bispecific antibody
Provided are bispecific antibodies comprised of a single-chain unit having specificity to an immune cell and a monovalent unit having specificity to a tumor...
US-9,562,109 Stable heterodimeric antibody design with mutations in the Fc domain
The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g. CH2 and CH3) to accomplish selectivity between the various Fc...
US-9,562,108 Carrier immunoglobulins
Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions...
US-9,562,107 Carrier immunoglobulins
Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions...
US-9,562,106 Anti-complement C1s antibodies and methods of inhibiting complement C1s activity
The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. In some embodiments, such...
US-9,562,105 Human monoclonal antibody
The invention provides a method for the prophylaxis, improvement, or treatment of inflammatory bowel disease, multiple sclerosis, and psoriasis by administering...
US-9,562,104 Anti-CD40 antibodies
The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen...
US-9,562,103 Chronic rejection inhibitor
The present inventors assessed the effect of anti-IL-6 receptor antibodies in suppressing chronic rejection reaction. They assessed the effect of anti-mouse...
US-9,562,102 Specific binding proteins and uses thereof
The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally...
US-9,562,101 Lectin-like oxidized LDL receptor 1 antibodies and methods of use
The present invention relates to monoclonal antibodies binding to human lectin-like oxidized LDL (low density lipoprotein) receptor 1 (hereinafter, sometimes...
US-9,562,100 Molecules with extended half-lives, compositions and uses thereof
The present invention provides molecules, including IgGs, non-IgG immunoglobulins, proteins and non-protein agents, that have increased in vivo half-lives due...
US-9,562,099 Anti-B7-H4 antibodies and immunoconjugates
The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
US-9,562,098 Anti-CD28 humanized antibodies
The invention relates to humanized antibodies directed against the human lymphocyte receptor CD28. When used in a monovalent form these antibodies are...
US-9,562,097 Use of anti-CD83 agonist antibodies for treating autoimmune diseases
This invention relates to compositions comprising anti-CD83 agonist antibodies and methods of treating autoimmune disorders (such as inflammatory bowel disease)...
US-9,562,096 Anti-ROBO4 antibody
Problem to be Solved The present invention relates to an antibody having an anti-angiogenesis activity. More specifically, the present invention relates to an...
US-9,562,095 Method for treating tumors that possess the CCK-C receptor with the 3B9.1 monoclonal antibody
Human pancreatic cancer cells possess a distinct plasma membrane CCK receptor variant that can be differentiated from the classic CCK-B receptor with selective...
US-9,562,094 Companion animal treatments
The invention relates to minimizing the progression of cancer in a companion animal using P2X7 immunotherapy.
US-9,562,093 Antibodies or antigen-binding fragments thereof specifically binding to VEGF-C and use thereof
An antibody or antigen-binding fragment thereof that specifically binds to and inhibits VEGF-C and uses thereof in a method of inhibiting angiogenesis and a...
US-9,562,092 Methods of inhibiting complement C4 activation with anti-complement C1s antibodies
The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. The present disclosure also...
US-9,562,091 Humanized anti-Tau(pS422) antibodies and methods of use
The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.
US-9,562,090 Polypeptides, antibody variable domains and antagonists
The invention relates to anti-TNFR1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as...
US-9,562,089 Fibronectin based scaffold proteins having improved stability
The present application provides fibronectin based scaffold proteins associated with improved stability. The application also relates to stable formulations of...
US-9,562,088 Pegylated CD154 peptides and methods of inhibiting CD40 interacations with CD154
The present invention provides methods and materials for treating and preventing autoimmune diseases. In particular, the present invention relates to the...
US-9,562,087 High affinity PD-1 agents and methods of use
High affinity PD-1 mimic polypeptides are provided, which (i) comprise at least one amino acid change relative to a wild-type PD-1 protein; and (ii) have an...
US-9,562,086 Vitronectin:keratinocyte growth factor chimeras
Isolated protein complexes are provided comprising keratinocyte growth factor and vitronectin, or at least domains thereof that enable binding to and activation...
US-9,562,085 Antimicrobial peptide
The disclosure relates to antimicrobial peptides, pharmaceutical compositions comprising the peptides and to uses thereof for treatment or prevention of...
US-9,562,084 Peptides derived from NCAPG2 and their use
NCAPG2, a component of condensin complex II, protein and novel peptides derived from the protein are provided. The peptide may include a fragment of the NCAPG2...
US-9,562,083 Peptides and methods for inducing cell death
The invention provide isolated peptides, protides and conjugates having novel peptide sequences which are able to induce antimicrobial, anti-cancer,...
US-9,562,082 Production of glycoproteins with low N-glycolylneuraminic acid (Neu5Gc) content
The present invention relates to a medium for the cultivation of eukaryotic cells, the medium comprising as (an) additive(s) DMSO, N-acetylmannosamine (NAcMan),...
US-9,562,081 Sugar transporters
A novel class of transporter protein, referred to as SWEET, GLUE or Glu, is disclosed. These transporters provide a novel system for the transportation of...
US-9,562,080 Lyme disease vaccine, genetic construct, recombinant protein, method for designing genetic construct, method...
The present invention relates to a Lyme disease vaccine, a genetic construct, recombinant protein, method for genetic construct design, method for vaccine...
US-9,562,079 Vaccines and methods to treat lyme disease in dogs
The instant invention provides an immunogenic composition comprising an antigenic fragment of OspA protein of Borrelia burgdorferi and a chimeric protein...
US-9,562,078 Methods for identifying broadly neutralizing antibodies utilizing recombinant HIV-1 envelope glycoproteins...
The present application relates to novel HIV-1 envelope glycoproteins which may be utilized as an HIV-1 vaccine immunogens, antigens for crystallization and for...
US-9,562,077 Protein complex system for increased immunogenicity and functionality, and methods making and use
Genes for proteins which spontaneously form dimers and/or oligomers can be recombinantly linked together, which upon expression in E. coli produces stable...
US-9,562,076 Hydrophobic modified pres-derived peptides of hepatitis B virus (HBV) and their use as HBV and HDV entry inhibitors
The present invention relates to hydrophobic modified preS-derived peptides of hepatitis B virus (HBV) which are derived from a HBV preS consensus sequence and...
US-9,562,075 Intradermal HPV peptide vaccination
The invention relates to the use of a peptide derived from HPV-E2, E6 and/or E7 protein for the manufacture of a medicament for the treatment or prevention of...
US-9,562,074 Self-assembling peptide cages from coiled-coil peptide modules
This invention relates to protein structures, to methods of producing those protein structures, and to peptides used in the formation of the protein structures.
US-9,562,073 Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof
The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and...
US-9,562,072 Compositions and methods for regulating glucose metabolism
The present disclosure provides compositions for regulating glucose metabolism. The compositions provide for reduced levels of p75.sup.NTR and/or reduced...
US-9,562,071 Method for preparing eptifibatide
Provided is a method for preparing eptifibatide, wherein the method comprises: obtaining an eptifibatide refined peptide solution; and obtaining and...
US-9,562,070 Induction of tumor immunity by variants of folate binding protein
The present invention is directed to variants of antigens comprising folate binding protein epitopes as a composition associated with providing immunity against...
US-9,562,069 Selective caspase inhibitors and uses thereof
The present invention relates to compounds of Formula I, IA, II, HA, III, or IHA and their pharmaceutical uses. Particular aspects of the invention relate to...
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