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Patent # Description
US-9,562,068 Process for the preparation of 7 .alpha.-(methoxycarbonyl)-3-OXO-17alpha-pregn-4,9(11)-dien-21,17-carbolac- ...
An improved process for the preparation of intermediate (V) through the elimination of a molecule of water from intermediate (IV) is described. ##STR00001## ...
US-9,562,067 Process for the production of 19-norpregn-4-en-3,20-dione-17.alpha.-ol(gestonorone) and intermediates therefor
The present invention relates to a new stereoselective process for the synthesis of 17(.alpha.)-17-acetyl-17-hydroxy-estr-4-en-3-one of formula (I), as well as...
US-9,562,066 Oral therapy of necrotizing enterocolitis
The present invention relates to methods of treating or reducing the risk of necrotizing enterocolitis (NEC) in an infant comprising orally administering an...
US-9,562,065 Sucrose octasulfates of magnesium, preparation method thereof and pharmaceutical cosmetic uses of same
The invention relates to a sucrose octasulfate of magnesium, having general formula I, the preparation method thereof and the use of same in the pharmaceutical...
US-9,562,064 High-purity steviol glycosides
Methods of preparing highly purified steviol glycosides, particularly Rebaudioside D, are described. The methods include purification from the extraction stage...
US-9,562,063 Process for the preparation of DOPO-derived compounds and compositions thereof
This invention relates to a process for producing compounds derived from 9,10-Dihydro-9-Oxa-10-Phosphaphenantrene-10-oxide (DOPO). In particular, the invention...
US-9,562,062 Ligand compound, organic chromium compound, catalyst system for ethylene oligomerization, and method for...
The present invention relates to a ligand compound, a catalyst system for ethylene oligomerization, and a method for ethylene oligomerization using the same....
US-9,562,061 Compounds that inhibit MCL-1 protein
Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using...
US-9,562,060 Heterocyclic pyridone compound, and intermediate, preparation method and use thereof
The present invention relates to a heterocyclic pyridone compound represented by General Formula (I), where the heterocyclic pyridone compound is used as a...
US-9,562,059 Anticancer maytansinoids with two fused macrocyclic rings
This invention provides maytansinoids having improved tumor inhibition activity. In particular, the present invention provides a method of treatment of cancer,...
US-9,562,058 Crystalline forms of an antiviral compound
Crystalline forms of the anti-HCV compound (1aR,5S,8S,9S,10R,22aR)-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1- ...
US-9,562,057 (Thieno[2,3-b][1,5]benzoxazepin-4-yl)piperazin-1-yl compounds as dual activity H1 inverse agonists/5-HT.sub.2A...
A dual H1 inverse agonist/5-HT.sub.2A receptor antagonist of the formula: ##STR00001## its uses, and methods for its preparation are described.
US-9,562,056 Imidazopyridines Syk inhibitors
Certain imidazopyridines (I) and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and...
US-9,562,055 Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as TrkA kinase inhibitors
Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R.sup.1, R.sup.2, R.sup.a,...
US-9,562,054 Process for preparing isosorbide ethoxylate di(meth)acrylate
A process for preparing isosorbide ethoxylate di(meth)acrylate by transesterifying alkyl (meth)acrylate with isosorbide ethoxylate, comprising the steps of: (i)...
US-9,562,053 Benzo-fused heterocyclic derivatives useful as agonists of GPR120
The present invention is directed to benzo-fused heterocyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of...
US-9,562,052 Bicyclicpyridine derivatives
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7,...
US-9,562,051 Methylenedioxybenzo [I] phenanthridine derivatives used to treat cancer
The invention provides compounds of formula I: wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical...
US-9,562,050 Crystalline forms of pemetrexed diacid and processes for the preparation thereof
Provided are crystalline forms of N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]- ben-zoyl]-L-glutamic acid, pemetrexed diacid, and...
US-9,562,049 Pyrrolobenzodiazepines and conjugates thereof
A compound with the formula I: ##STR00001## and salts and solvates thereof.
US-9,562,047 Pyrazolopyrimidine compounds for the treatment of cancer
Compounds of Formula I are described, along with pharmaceutically acceptable salts thereof, compositions containing the same, and methods of use thereof.
US-9,562,046 Means and method for treating solid tumors
In a cytotoxic compound of the general formula (I) R is H or methyl or methylene substituted by C.sub.1-C.sub.4 straight or branched alkyl, R.sup.1 is selected...
US-9,562,045 Process for preparation of indolizine based derivatives as potential phosphodiestrase 3 (PDE3) inhibitors
The present invention provides compounds of general formula 1 useful as potential phosphodiesterase3 (PDE3) inhibitory agents and a process for the preparation...
US-9,562,044 2-acylaminothiazole derivative or salt thereof
Thiazole derivatives having pyrazine-2-carbonylamino substituted at the 2-position of the following formula (I): ##STR00001## are excellent muscarinic M.sub.3...
US-9,562,043 Heterocyclic amide derivative and pharmaceutical product containing same
The present invention aims to provide a novel compound having a TRPA1 antagonist activity, and a medicament containing the compound. Moreover, the present...
US-9,562,042 .alpha.-oxoacyl amino-caprolactam
The purpose of the present invention is to provide a pharmaceutical composition that is useful for the treatment of diseases that are caused by an increase in...
US-9,562,041 Enhancer of zeste homolog 2 inhibitors
This invention relates to novel substituted benzamides according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical...
US-9,562,040 Processes for preparing Rivaroxaban
Processes and intermediates for preparing rivaroxaban, and analogs and derivatives thereof, and pharmaceutically acceptable salts of each of the foregoing, are...
US-9,562,039 Salts of 2-amino-1-hydroxyethyl-8-hydroxyquinolin-2(1H)-one derivatives having both .beta.2 adrenergic receptor...
The present invention is directed to crystalline addition salts of (i) 8-hydroxyquinolin-2(1H)-one derivatives and (ii) a hydroxycarboxylic acid, a sulfonic...
US-9,562,038 Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human...
The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to...
US-9,562,037 Synthesis and use of amine-containing flavonoids as potent anti-leishmanial agents
The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of...
US-9,562,036 Fluoromethyl-substituted pyrrole carboxamides as CaV2.2 calcium channel blockers
The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing...
US-9,562,035 Benzamide derivative useful as FASN inhibitors for the treatment of cancer
The present invention is directed to benzamide derivatives, pharmaceutical compositions containing them, and their use as FASN inhibitors, in for example, the...
US-9,562,034 Endoparasite control agent
An object of the present invention is to provide a novel endoparasite control agent as a parasiticide, an antiprotozoal or the like. Provided is an endoparasite...
US-9,562,033 Inhibitors of viral replication, their process of preparation and their therapeutical uses
The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
US-9,562,032 Salt and photoresist composition comprising the same
A salt which has a group represented by formula (a): ##STR00001## wherein X.sup.a and X.sup.b each independently represent an oxygen atom or a sulfur group;...
US-9,562,031 Phenethyldihydrobenzodioxolones and methods of use
The present invention generally relates to phenethyldihydrobenzodioxolone compounds and compositions useful for reducing or inhibiting tumor growth. It also...
US-9,562,030 Process for the synthesis of olopatadine
The present invention provides a process for the synthesis of olopatadine. Further, the invention discloses a process that results in improved yield of the...
US-9,562,029 C-glycoside derivatives
The present invention involves a compound represented by general formula (I), a derivative thereof and a use thereof: ##STR00001## wherein R.sup.1, R.sup.2,...
US-9,562,028 Process for making 2,5-furandicarboxylic acid
A process is described for converting HMF to FDCA, comprising dissolving a quantity of HMF in water to form an aqueous solution including HMF, combining the...
US-9,562,027 Device and method for continuously preparing high-purity AKD without solvent
Device and method for continuously preparing high-purity AKD without solvent includes a reactor making continuous mixing of raw materials. The process includes:...
US-9,562,026 Neuroactive substituted cyclopent[a]anthracenes as modulators for GABA type-A receptors
The present disclosure is generally directed to neuroactive substituted cyclopent[a]anthracenes as referenced herein, and pharmaceutically acceptable salts...
US-9,562,025 Compounds with (1E, 6E)-1,7-Bis-(3,4-dimethoxyphenyl)-4-4-distributed-hepta-1,6-diene-3,5-dio- ne...
The present invention relates to compounds having at least one (substituted phenyl)-propenal moiety. The compounds are useful in treating a subject suffering...
US-9,562,024 Vortioxetine salt and crystal thereof, their preparation method, pharmaceutical compositions and usage
The present invention relates to the novel vortioxetine salts, solvates and crystalline forms thereof, specifically, vortioxetine hemihydrobromide and a...
US-9,562,023 Dipeptide mimics, libraries combining two dipeptide mimics with a third group, and methods for production thereof
Monovalent compounds having moieties comprising at least one amino acid side chain are bound to a core molecule, which also comprises a nucleophilic moiety...
US-9,562,022 Opsin-binding ligands, compositions and methods of use
Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization...
US-9,562,021 Histone deacetylase inhibitors and compositions and methods of use thereof
Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use. ##STR00001##
US-9,562,020 Dihydroxy aromatic heterocyclic compound
Provided is a compound having a D-amino acid oxidase (DAAO) inhibitory action, and useful as for example, a prophylaxis and/or therapeutic agent for...
US-9,562,019 Substituted pyridazines as EGFR and/or KRAS inhibitors
The present invention is directed to pyridazinone compounds of formula (I) and furan compounds of formula (II), pharmaceutical compositions of compounds of...
US-9,562,018 Sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imid- azol-2-amine,...
The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imid- azol-2-amine and pharmaceutically...
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