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Patent # Description
US-9,708,414 Methods and products for increasing frataxin levels and uses thereof
Methods and products (e.g., recombinant proteins) are described for increasing frataxin expression/levels in a cell, as well as uses of such methods and...
US-9,708,413 Glycosylated linker, compound containing glycosylated linker moiety and physiologically active substance moiety...
[Problem] The purpose is to provide a compound containing a carrier linker moiety and a physiologically active substance moiety or a salt of the compound,...
US-9,708,412 Trispecific binding proteins and methods of use
Provided herein are trispecific antigen-binding proteins comprising a domain binding to CD3, a half-life extension domain, and a domain binding to a target...
US-9,708,411 Modulators of acyl-CoA lysocardiolipin acyltransferase 1 (ALCAT1) and uses thereof
Compositions of modulators of acyl-CoA lysocardiolipin acyf transferase 1 (ALCAT1) expression, function or activity are provided. In particular, inhibitors of...
US-9,708,410 Anti-tissue factor antibodies and compositions
Isolated anti-tissue factor antibodies, immunoglobulins, cleavage products and other specified portions and variants thereof having enhanced ADCC activity, as...
US-9,708,409 Monoclonal antibodies with enhanced ADCC function
The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcy...
US-9,708,408 Methods for the treatment of disease using immunoglobulins having Fc Regions with altered affinities for...
The present invention relates to methods of treating or preventing cancer and other diseases using molecules, particularly polypeptides, more particularly...
US-9,708,407 Anti-CD52 antibodies
Anti-human CD52 antibodies and antigen-binding fragments thereof are provided. Also provided are isolated nucleic acids, recombinant vectors and host cells for...
US-9,708,406 Anti-transferrin receptor antibodies and methods of use
The present invention relates to anti-transferrin receptor antibodies and methods of their use.
US-9,708,405 Anti-CXCR4 antibodies and antibody-drug conjugates
The present invention provides antibodies and related molecules that bind to chemokine receptor 4 (CXCR4). The invention further provides antibody-drug...
US-9,708,404 Anti-NTB-A antibodies and related compositions and methods
Disclosed are antibodies, including antibody drug conjugates, that specifically bind to NTB-A. Also disclosed are methods for using the anti-NTB-A antibodies to...
US-9,708,403 KIR-binding agents and methods of use thereof
The present invention relates to agents and methods that are capable of augmenting NK-mediated killing of target cells by reducing inhibitory KIR signalling...
US-9,708,402 Anti-BAFF-anti-IL-17 bispecific antibodies
Bispecific antibodies are provided that specifically bind B-cell Activating Factor of the TNF Family (BAFF) and Interleukin-17A (IL-17) and are characterized as...
US-9,708,401 IL-17A/F cross-reactive monoclonal antibodies and methods of using the same
The present invention relates to antagonizing the activity of IL-17A, IL-17F and IL-23 using bispecific antibodies that comprise a binding entity that is...
US-9,708,400 Methods to modulate lysine variant distribution
The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the...
US-9,708,399 Protein purification using displacement chromatography
Disclosed herein are compositions and methods for the isolation and purification of proteins from a sample. In particular, the present invention relates to...
US-9,708,398 Anti-NGF antibodies and methods using same
The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use...
US-9,708,397 Treatment of vasculoproliferative conditions with Lrg1 antagonists
This invention relates to the field of molecular physiology. Specifically, this invention relates to the treatment of vasculoproliferative conditions,...
US-9,708,396 Bispecific anti-VEGF/anti-ANG-2 antibodies
The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions...
US-9,708,395 Anti-p40 antibodies systems and methods
The present invention is related to the anti-p40 antibodies, kits, cocktails, and use of anti-p40 antibodies for detection of cancer.
US-9,708,394 Anti-complement factor C1q antibodies and uses thereof
The present invention provides anti-C1q antibodies and methods of using the same.
US-9,708,393 Use of anti-CGRP antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in...
The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody...
US-9,708,392 Monoclonal antibodies against orthopoxviruses
The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such...
US-9,708,391 Removal of serine proteases by treatment with finely divided silicon dioxide
The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition....
US-9,708,390 Compositions and methods for inhibiting PDGFRbeta and VEGF-A
Disclosed are antagonists of PDGF receptor .beta. (PDGFR.beta.) and VEGF-A, including neutralizing anti-PDGFR.beta. and anti-VEGF-A antibodies, as well as...
US-9,708,389 Method for preparing homodimer protein mixture by using charge repulsion effect
The invention relates to a method for preparing a homodimer protein mixture by using repulsive interaction of charges. The method comprises the step of...
US-9,708,388 Antibody light chains
The present invention relates to methods for improving biophysical properties, including the stability of antibody lambda light chains, to antibody lambda light...
US-9,708,387 Methods for producing recombinant factor VIII chains from non-filamentous fungi, their functional...
A process of producing heavy chain peptide and/or light chain peptide of recombinant Factor VIII protein includes using the Pichia pastoris expression system. A...
US-9,708,386 Modified chimeric polypeptides with improved pharmacokinetic properties
The present invention provides VEGF antagonists with improved pharmacokinetic properties. According to certain embodiments, a fusion polypeptide capable of...
US-9,708,384 Universal immune receptor expressed by T cells for the targeting of diverse and multiple antigens
The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune...
US-9,708,383 Double-acylated GLP-1 derivatives
The invention relates to a derivative of a GLP-1 analog, which analog comprises a first K residue at a position corresponding to position 18 of GLP-1(7-37) (SEQ...
US-9,708,382 Peptide library
The present invention provides a peptide library comprising a plurality of mutant peptides based on the extracellular binding domain of the TACI protein. The...
US-9,708,381 Method for forming a reversible protein nanocluster using light in a cell
To efficiently analyze interaction and function between proteins, the present invention relates to a method for forming a light-induced protein nanocluster,...
US-9,708,380 Human leukolectins and uses thereof
The present invention relates to a polypeptide, described as a lectin, its encoding nucleic acid sequence and antibodies to the polypeptide and their use in...
US-9,708,379 Compositions for regulating iron homeostasis and methods of using same
The present disclosure relates to hemojuvelin-IgG Fc domain fusion proteins, variants, derivatives, fragments and peptide mimetics derived therefrom and methods...
US-9,708,378 Peptides derived from NCAPG2 and their use
NCAPG2, a component of condensin complex II, protein and novel peptides derived from the protein are provided. The peptide may include a fragment of the NCAPG2...
US-9,708,377 Scorpion toxin analogue and method for treating autoimmune diseases
A novel peptide analogue of the Heterometrus spinnifer toxin HsTX1 is disclosed along with its application as, for example, a therapeutic agent for treating an...
US-9,708,376 Spider silk fusion protein structures without repetitive fragment for binding to an organic target
A recombinant fusion protein comprising the moieties B and CT is provided. B is a non-spidroin moiety which provides the capacity of selective interaction with...
US-9,708,375 Inhibitory polypeptides specific to WNT inhibitors
The present application is directed to avimers and peptides and various combinations thereof in addition to methods of making and using them.
US-9,708,374 Modified microbial toxin receptor for delivering agents into cells
We described a novel system of targeted cell therapy with a protein toxin, such as anthrax toxin, that has been modified to re-direct it to a desired cell...
US-9,708,373 Influenza virus vaccine and uses thereof
Provided herein are influenza hemagglutinin stem domain polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use.
US-9,708,372 Agonistic autoantibodies to the alpha1-adrenergic receptor and the beta2-adrenergic receptor in Alzheimer's and...
The invention relates to means for detecting, binding, removing and/or neutralizing agonistic antibodies associated with dementia, preferably Alzheimer's...
US-9,708,371 Treatments for gastrointestinal disorders
The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to,...
US-9,708,370 Azapeptides as CD36 binding compounds
An azapeptide compound of Formula I: A-(Xaa).sub.a-N(R.sup.A)--N(R.sup.B)--C(O)-(Xaa').sub.b-B I.
US-9,708,369 Peptide for reducing the phosphate requirement and excretion from farm animals
Disclosed are methods of altering metabolism of phosphate in a livestock via an antibody. The methods involve the development of an antibody against FGF-23 for...
US-9,708,368 Linear peptide antibiotics
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in...
US-9,708,367 Agonists of guanylate cyclase and their uses
This invention provides novel guanylate cyclase C (GC-C) agonists and their therapeutic use. The agonists may be used either alone or in combination with one or...
US-9,708,366 Treatment of fragile X syndrome using glycyl-L-2-methylprolyl-L-glutamate
This invention provides compounds, compositions and methods for treating Autism Spectrum Disorders (ASD) using glycyl-2-methylprolyl-glutamic acid (G-2-MePE)...
US-9,708,365 Purification process for monoclonal antibodies
The present invention provides an improved method for the purification of monoclonal antibody from cell culture. Process of purification of the desired...
US-9,708,364 Method for forming protein crystal
A method for producing a capsule for protein crystallization is provided. The method comprises adding a solution containing a protein and a gelling agent to an...
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