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Patent # Description
US-9,708,363 Method for cross-linking peptides
The present invention relates to a method for cross-linking peptides using an activated furan-moiety. In particular, the present invention provides a method for...
US-9,708,362 Deuterated bile acids
This disclosure relates to deuterated bile acid compositions. A deuterated compound is selected from the disclosed groups of bile acids and their derivatives,...
US-9,708,361 Antisense nucleic acids
The present invention provides an oligomer which efficiently enables to cause skipping of the 53rd exon in the human dystrophin gene. Also provided is a...
US-9,708,360 Phosphorodiamidate backbone linkage for oligonucleotides
This invention relates to antisense oligonucleotides comprising at least one N3'.fwdarw.P5' phosphorodiamidate linkage (NPN) in the backbone, and kits and...
US-9,708,358 Massive parallel method for decoding DNA and RNA
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide...
US-9,708,357 4'-azido, 3'-fluoro substituted nucleoside derivatives as inhibitors of HCV RNA replication
The present invention relates to the use of 3'-fluoro, 4'-azido nucleoside phosphoramidate prodrug derivatives of formula I ##STR00001## wherein the symbols...
US-9,708,356 Method for manufacturing monosaccharides, oligosaccharides, and furfurals from biomass
The present invention provides a method for efficiently producing monosaccharides, oligosaccharides, and furfurals from biomass. A biomass is hydrolyzed under...
US-9,708,355 First-row transition metal hydrogenation and hydrosilylation catalysts
Transition metal compounds, and specifically transition metal compounds having a tetradentate and/or pentadentate supporting ligand are described, together with...
US-9,708,354 Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the...
US-9,708,353 Heterobicyclic sphingosine 1-phosphate analogs
Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can...
US-9,708,352 Echothiophate iodide process
The present invention relates to a process for preparation of Echothiophate Iodide (I). Echothiophate Iodide (I) obtained by the process of the present...
US-9,708,351 Alkenes as alkyne equivalents in radical cascades terminated by fragmentations
Disclosed are methods for rerouting radical cascade cyclizations by using alkenes as alkyne equivalents. The reaction sequence is initiated by a novel 1,2...
US-9,708,350 Method for producing polyalkylene glycol derivative having amino group at end, polymerization initiator for use...
A method for producing a narrowly distributed and high-purity polyalkylene glycol derivative having an amino group at an end, a polymerization initiator for use...
US-9,708,349 Borates for photoactivated chemical bleaching
A borate compound for use as photoinduced chemical bleaching reagent is disclosed having improved bleaching performance under certain conditions, compared to...
US-9,708,348 Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
Trisubstituted bicyclic heterocyclic compounds (e.g., chromenones and quinolines) and pharmaceutical compositions,that modulate kinase activity, including PI3...
US-9,708,347 Heterobicyclo-substituted [1,2,4]triazolo[1,5-C]quinazolin-5-amine compounds with A.sub.2A antagonist properties
Disclosed are compounds of Formula G1 (structurally represented): where "RG3" "Rd1" to "Rd4", "n", "m", "p", "W", "X", "Y", and "Z" are defined herein which...
US-9,708,346 Semiconducting compounds and related devices
The present teachings relate to new semiconducting compounds including one or more moieties represented by formula (I): ##STR00001## wherein X is a chalcogen;...
US-9,708,344 Inhibitors of UDP-galactopyranose mutase
Compounds and salts thereof which inhibit microbial growth or attenuate the virulence of pathogenic microorganisms and which inhibit UDP-galactopyranose mutase...
US-9,708,343 Process for preparing rifaximin .kappa.
The present invention relates to a process for obtaining rifaximin .kappa. comprising the following steps: a) reacting rifamycin O with 2-amino-4-picoline in...
US-9,708,342 Sodium (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,- ...
The present invention relates to sodium (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzyl) ...
US-9,708,341 Method for producing pyridine compound
A pyridine compound represented by formula (1) that is useful as an insecticide is produced by reacting a compound represented by formula (2) and a compound...
US-9,708,340 Urea derivatives and their use as fatty-acid binding protein (FABP) inhibitors
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, W, A and B are as described...
US-9,708,339 1,3-benzothiazinone, sulfoxide, and sulfone compounds with electrophilic substituent
A compound, having the following formula: ##STR00001## or resonance form thereof, or salt thereof, or salt of resonance form thereof is provided, wherein E...
US-9,708,338 Aromatic heterocyclylamine derivative having TRPV4-inhibiting activity
The present invention is related to a compound represented by formula (I) ##STR00001## wherein --X-- is --NH-- or --S--; --Z-- is --O-- or --S--; R.sup.3,...
US-9,708,337 Aryl amide-based kinase inhibitors
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and...
US-9,708,336 Metallo-beta-lactamase inhibitors
The present invention relates to compounds of formula (I) that are metallo-.beta.-lactamase inhibitors, the synthesis of such compounds, and the use of such...
US-9,708,335 Spiro-lactam NMDA receptor modulators and uses thereof
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
US-9,708,334 Substituted 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole and 4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine...
The invention provides a chemical entity of Formula (I), wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and X have any of the values described herein, and...
US-9,708,333 Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors
This application relates to compounds of Formula I: ##STR00001## or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are...
US-9,708,332 Respiratory syncytial virus inhibitors
Compounds of Formula (I), wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n are defined herein, are useful as inhibitors of RSV. ##STR00001##
US-9,708,331 Metabotrophic glutamate receptor 5 modulators and methods of use thereof
Compounds that modulate GluR5 activity and methods of using the same are disclosed.
US-9,708,330 2,3-dihydroimidazol[1,2-C]pyrimidin-5(1-H)-one based ipoprotein-associated phospholipase A2 (Lp-PLA.sub.2)...
The present invention relates to novel compounds that inhibit Lp-PLA.sub.2 activity, processes for their preparation, to compositions containing them and to...
US-9,708,328 Pteridines useful as HCV inhibitors and methods for the preparation thereof
The present invention relates to the use of pteridines as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or...
US-9,708,327 Polymorphic forms of a hydrochloride salt of ...
Polymorphs of a hydrochloride salt of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-on- e, compositions thereof, methods for their...
US-9,708,326 Inhibitors of bruton's tyrosine kinase
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition,...
US-9,708,325 Sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of virus infection
The present invention relates to compounds of formula (I), ##STR00001## wherein R.sup.1, R.sup.2 and R.sup.3 are as described herein, and their prodrugs or...
US-9,708,324 Macrocyclic compounds as IRAK1/4 inhibitors and uses thereof
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
US-9,708,323 Tricyclic compounds as alpha-7 nicotinic acetylcholine receptor ligands
The disclosure provides compounds of formula I including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for...
US-9,708,322 Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity
The invention relates to substituted heterocycle fused gamma-carbolines of the Formula Q as described herein, in free base or pharmaceutically acceptable salt...
US-9,708,321 Spiro-quinazolinone derivatives and their use as positive allosteric modulators of mGluR4
The present invention relates to novel spiro-quinazolinone derivatives as positive allosteric modulators for modulating metabotropic glutamate receptor subtype...
US-9,708,320 .beta.-lactamase inhibitor and process for preparing the same
A diazabicyclooctane compound, which is a beta-lactame inhibitor, represented by the following formula (I): ##STR00001## wherein A represents Ra(Rb)N-- or...
US-9,708,319 Synthesis of PARP inhibitor talazoparib
Provided is a new method for preparing PARP inhibitor talazoparib.
US-9,708,318 Bicyclic heterocycles as FGFR4 inhibitors
The present disclosure relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR3 and/or FGFR4 enzyme and...
US-9,708,317 Process for the preparation of 8-(4-aminophenoxy)-4H-pyrido[2,3-B]pyrazin-3-one derivatives
The present invention pertains generally to the field of organic chemical synthesis, and in particular to certain methods for the synthesis of ...
US-9,708,316 TGF.beta.R antagonists
The invention relates generally to compounds that modulate the activity of TGF.beta.R-1 and TGF.beta.R-2, pharmaceutical compositions containing said compounds...
US-9,708,315 1,2,4-triazolo[4,3-a]pyridine compounds and their use as positive allosteric modulators of MGLUR2 receptors
The present invention relates to novel 1,2,4-triazolo[4,3-a]pyridine compounds as positive allosteric modulators (PAMs) of the metabotropic glutamate receptor...
US-9,708,314 Heterocyclic amide compound
The present invention provides a heterocyclic amide compound of Formula (1), and an agricultural chemical containing it, particularly a herbicide: ##STR00001##...
US-9,708,313 Substituted pyrido[3,4-b]pyrazines as GPR6 modulators
This present invention provides compounds of formula II: ##STR00001## which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for...
US-9,708,312 Dihydropyrimidinoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory...
A compound according to Formula (Ia), ##STR00001## wherein Cy, L.sub.1, G, and R.sup.1 are as described herein. The present invention relates to novel...
US-9,708,311 Benzimidazole derivatives as EP4 antagonists
The present invention relates to novel benzimidazole derivatives of the general formula ##STR00001## processes for their preparation and their use for the...
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