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Patent # Description
US-9,708,310 Phenanthroindolizidine and phenanthroquinolizidine alkaloid having a hydroxyl group on the phenanthrene ring...
A phenanthroindolizidine and phenanthroquinolizidine alkaloid having a hydroxyl group on the phenanthrene ring thereof was synthesized, which exhibits potent...
US-9,708,309 Arylcyclopropylamine based demethylase inhibitors of LSD1 and their medical use
The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and their...
US-9,708,308 Factor IXa inhibitors
The present invention provides a compound of Formula (I) ##STR00001## wherein R.sup.1 is H or C.sub.1-6 alkyl, R.sup.2, is H or C.sub.1-6 alkyl or CH.sub.2OH,...
US-9,708,307 Heterocyclic acetamide compound
A compound which is useful as a dopamine D1 receptor positive allosteric modulator (D1 PAM) is provided. The present inventors have studied a compound which has...
US-9,708,306 Benzimidazole derivatives and preparation process and pharmaceutical uses thereof
The invention belongs to the technical field of pharmaceutical chemistry, and particularly pertains to benzimidazole derivatives, and preparation process and...
US-9,708,304 Salt polymorph of thioxanthene-9-ylidene-1-methyl piperidine acid addition salts as antimigraine compounds
The present invention relates to novel crystal forms of 4-(6-ethoxy-1-methoxy-thioxanthene-9-ylidene)-1-methyl piperidine salts and...
US-9,708,303 LFA-1 inhibitor and methods of preparation and polymorph thereof
Methods of preparation and purification of a compound of Formula I, intermediates thereof, a polymorph thereof, and related compounds are disclosed....
US-9,708,302 Flouro-naphthyl derivatives
The present invention relates to compounds of formula ##STR00001## wherein R.sup.1 is C.sub.4-6-cycloalkyl or C.sub.4-6-heterocycloalkyl, which are optionally...
US-9,708,301 Crystalline forms of afatinib monomaleate, preparation methods and pharmaceutical compositions thereof
The present invention relates to the novel solid forms of Afatinib monomaleate and preparation methods thereof; the solid forms of Afatinib monomaleate of the...
US-9,708,300 Amorphous form of vilazodone hydrochloride and process for its preparation
The present invention relates to an amorphous form of vilazodone hydrochloride and process for the preparation of amorphous form of vilazodone hydrochloride....
US-9,708,299 Hedgehog antagonists having zinc binding moieties
The present invention provides compounds which antagonize hedgehog signaling and inhibit HDAC activity. The compounds can be used in methods of treating...
US-9,708,298 Meglumine salt formulations of 1-(5,6-dichloro-1H-benzo[D]imidazol-2-yl)-1H-pyrazole-4-carboxylic acid
The meglumine salt of 1-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)-1H-pyrazole-4-carboxylic acid (compound (1)) and pharmaceutically acceptable formulations...
US-9,708,297 CGRP receptor antagonists
The present invention provides a compound of Formula II: ##STR00001## or a pharmaceutically acceptable salt thereof.
US-9,708,296 6-(5-hydroxy-1H-pyrazol-1-yl)nicotinamide inhibitors of PHD
The present invention provides compounds of the formula: ##STR00001## which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for...
US-9,708,295 Substituted 2-aminopyridine protein kinase inhibitor
The present invention discloses substituted 2-aminopyridine derivatives as protein kinase inhibitors; specifically, the invention relates to 2-aminopyridine...
US-9,708,294 Organic compounds
The invention relates to compounds and methods of treatment relating to nicotinic receptor antagonists. For example, the compounds and methods of treatment...
US-9,708,293 N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfone group
The present invention relates to N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfone group of general formula (I) as described and defined...
US-9,708,292 Cyanopyrimidine derivative
The present invention relates to a novel cyanopyrimidine compound and a pharmaceutical composition which have a safe and potent adenosine A2a receptor agonistic...
US-9,708,290 Serine/threonine kinase inhibitors
Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of...
US-9,708,289 Imidazole diketone compound and use thereof
Provided are imidazolidinedione compounds of formula (I), processes for preparation, uses and pharmaceutically compositions thereof. Said imidazolidinedione...
US-9,708,288 Pesticidal compositions and processes related thereto
This document discloses molecules having the following formula ("Formula One"): ##STR00001## and processes related thereto.
US-9,708,287 Chiral compounds, compositions, products and methods employing same
Compounds that function, alone or in combination, as inhibitors of pigmentation for the improvement of mammalian skin are described herein. Specifically, the...
US-9,708,286 Ingenol-3-acylates III and ingenol-3-carbamates
The invention relates to compounds of general formula I ##STR00001## wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or...
US-9,708,285 Dioxolane derivative, liquid crystal composition, liquid crystal element, and liquid crystal display device
A dioxolane derivative represented by formula (G1) is provided. The explanation of the substituents is given in the specification. The use of the dioxolane...
US-9,708,284 Process for the preparation of olopatadine and sylil intermediates thereof
The present invention refers to a new "one-pot" process for the preparation of olopatadine via intermediates of formula (III). ##STR00001##
US-9,708,283 Isoflavonoid compositions and methods for the treatment of cancer
Provided herein is a pharmaceutical composition comprising an isoflavonoid derivative and a cyclodextrin. Also provided herein are methods of treating cancer,...
US-9,708,282 Anti-inflammatory and antiepileptic neuroprotective statin compounds
A compound has formula (I), where R is selected from a methyl group or an ethyl group: ##STR00001## The compound can be hydroxy acid forms thereof, the...
US-9,708,281 Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof, characterized in that a...
US-9,708,280 Phenyl-piperazine derivatives as serotonin reuptake inhibitors
The invention provides compounds represented by the general formula I ##STR00001## wherein the substituents are defined in the application. The compounds are...
US-9,708,279 2-acylaminothiazoles for the treatment of cancer
The present invention relates to inhibitors of the oncogenic protein kinase ALK of formula (I): ##STR00001## as herein described and pharmaceutical...
US-9,708,277 Inhibitors of cholesterol ester transfer protein
The invention relates to novel oxazolidinones their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides...
US-9,708,276 Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer
A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein...
US-9,708,275 Heterocyclic compounds and methods for their use
The present invention relates to heterocyclic compounds useful for antagonizing angiotensin II Type 2 (AT.sub.2) receptor. More particularly the invention...
US-9,708,274 Sulfoximine substituted quinazolines for pharmaceutical compositions
This invention relates to novel sulfoximine substituted quinazoline derivatives of formula I ##STR00001## wherein Ar, R.sup.1 and R.sup.2 are as defined in...
US-9,708,273 Aryl methyl benzoquinazolinone M1 receptor positive allosteric modulators
The present invention is directed to benzoquinazilinone compounds of formula (I) ##STR00001## which are M1 receptor positive allosteric modulators and that...
US-9,708,272 Inhibitors of .alpha.-amino-.beta.-carboxymuconic acid semialdehyde decarboxylase
The present disclosure discloses compounds capable of modulating the activity of .alpha.-amino-.beta.-carboxymuconic acid semialdehyde decarboxylase (ACMSD),...
US-9,708,271 Extraction reactor and also method for extraction from granular material
The present application relates to an extraction reactor with which granular material, in particular granular polyamide, can undergo extraction, soluble...
US-9,708,270 Substituted spiropiperidinyl compounds useful as GPR120 agonists
The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or...
US-9,708,268 ROR modulators and their uses
The invention relates to ROR modulators; compositions comprising an effective amount of a ROR modulator; and methods for treating or preventing diseases...
US-9,708,267 Activators of human pyruvate kinase
Disclosed are pyruvate kinase M2 activators which are compounds of Formula (I), including those of Formula (II), wherein A.sup.1, A.sup.2, L, R, R.sup.1 to...
US-9,708,266 Cyclohexyl pyridine derivative
A problem of the present invention is to provide a new compound which has NK.sub.1 receptor antagonist activity, whose CYP3A4 inhibitory activity is reduced...
US-9,708,265 Urethanes, ureas, amidines and related inhibitors of factor Xa
The invention relates to a new class of compounds, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions that are effective as...
US-9,708,263 Synthesis of an azasugar and the intermediates thereof
Process for the preparation of intermediates useful in the synthesis of miglustat and their use in its manufacture.
US-9,708,262 Compounds for electronic devices
The present invention relates to compounds of the formula (I) and to the use thereof in organic electronic devices, and to organic electronic devices which...
US-9,708,261 Crystalline compounds
The present invention relates to crystalline forms of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride and compositions comprising the same...
US-9,708,260 Method for producing meta-xylylenediamines and method for producing bisamide compound
A method for producing meta-xylylenediamines includes a reaction step in which monohalogenated benzenes, formaldehydes, and an amide compound having a primary...
US-9,708,259 Indol and indazol derivatives
The present invention relates to compounds of formula I or pharmaceutically acceptable addition salts, racemic mixtures or the corresponding enantiomers and...
US-9,708,258 Indole 3-carbinol derivatives
The present invention relates to novel stable indole-3-carbinol derivatives of Formula-I and its pharmaceutical composition and biological activity. The present...
US-9,708,257 Photoacid compositions having extended lifetime of proton dissociation state
A photoacid includes a nucleophilic (NuH) moiety having a photodissociable proton, an electron accepting (EA) moiety, and a bridge structure (X) bonded to both...
US-9,708,256 Method for making a peroxycarboxylic acid
The present invention relates to apparatus and methods for making a peroxycarboxylic acid. The apparatus includes a reaction catalyst and a guard column for...
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