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Patent # Description
US-9,745,622 Method for detecting the methylation of colorectal-cancer-specific methylation marker genes for colorectal...
The present invention relates to a method for detecting the methylation of colorectal cancer-specific marker genes for colorectal cancer diagnosis, and more...
US-9,745,621 Temperature gradient surface plasmon resonance instrument
A system and method for sensitive measurements of molecular binding as a function of time and temperature provided by a surface plasmon resonance (SPR)...
US-9,745,620 Systems and methods for multiplex analysis of PCR in real time
The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and...
US-9,745,619 Process for detecting or quantifying nucleic acids in a library
This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes...
US-9,745,618 Photoblocked probes and methods for sequential detection of nucleic acids
Photoblocked probes are disclosed including a specific hydrolysis probe having a first nucleic acid sequence complementary to a target having a second nucleic...
US-9,745,617 Digital analyte analysis
The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of...
US-9,745,616 Methods and compositions for detecting target nucleic acids
The present invention provides compositions, apparatuses and methods for detecting one or more nucleic acid targets present in a sample. Methods of the...
US-9,745,615 Instrument for cassette for sample preparation
A parallel preceding system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel...
US-9,745,614 Reduced representation bisulfite sequencing with diversity adaptors
Described herein are methods, compositions and kits for the generation of bisulfite-converted libraries useful for conducting reduced representation bisulfite...
US-9,745,613 Compounds, substrates and methods related to histone deacetylases
The invention relates to methods for the identification of compounds, peptides and proteins that can act as substrates for histone deacetylases. The invention...
US-9,745,612 Optical method for controlling the movement of a sampling tool
The present invention relates to a method of sampling biological material on a reference surface, such as the surface of an agar medium, with the aid of a...
US-9,745,611 Methods and kits for identifying microorganisms in a sample
Disclosed herein are compositions with uniquely designed oligonucleotide primers for identifying a plurality of microorganisms in a sample, and improved methods...
US-9,745,610 Methods and compositions for controlling gene expression by RNA processing
The present disclosure provides nucleic acids encoding an RNA recognition sequence positioned proximal to an insertion site for the insertion of a sequence of...
US-9,745,609 Processing biomass
Biomass (e.g., plant biomass, animal biomass, microbial, and municipal waste biomass) is processed to produce useful products, such as food products and amino...
US-9,745,608 Processes and recombinant microorganisms for the production of cadaverine
Recombinant microorganisms comprising DNA molecules in a deregulated form which improve the production of cadaverine or N-acetylcadaverine, as well as...
US-9,745,607 Methods of producing 6-carbon chemicals using 2,6-diaminopimelate as precursor to 2-aminopimelate
This document describes biochemical pathways for producing 2-aminopimelate from 2,6-diaminopimelate, and methods for converting 2-aminopimelate to one or more...
US-9,745,606 Microalgae aurantiochytrium sp. LA3 (KCTC12685BP) and method for preparing bio-oil using the same
Provided herein are microalgae of a Thraustochytrid and a method for preparing bio-oil using the same, and more particularly, Aurantiochytrium sp. LA3...
US-9,745,605 Method for producing medium-chain .omega.-hydroxy fatty acids, .alpha.,.omega.-dicarboxylic acids, and...
The present invention relates to a transformant which is transformed to express Baeyer-Villiger monooxygenase (BVMO), a method for producing C5-C14 medium-chain...
US-9,745,604 Processing biomass
Biomass (e.g., plant biomass, animal biomass, microbial, and municipal waste biomass) is processed to produce useful products, such as food products and amino...
US-9,745,603 Biological production of multi-carbon compounds from methane
Multi-carbon compounds such as ethanol, n-butanol, sec-butanol, isobutanol, tert-butanol, fatty (or aliphatic long chain) alcohols, fatty acid methyl esters,...
US-9,745,602 Modified microorganisms and use thereof for terpene production
The present invention relates to the control of gene expression by a heterologous glucose-regulated promoter, to microorganisms in which gene expression is...
US-9,745,601 Methods and systems for producing products using engineered sulfur oxidizing bacteria
Methods and systems for producing a biofuel using genetically modified sulfur-oxidizing and iron-reducing bacteria (SOIRB) are disclosed. In some embodiments,...
US-9,745,600 Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
The present specification discloses engineered Type II CRISPR-Cas9 systems comprising split-nexus Cas9-associated polynucleotides (sn-casPNs), including systems...
US-9,745,599 Tetracycline-regulated gene expression in HSV-1 vectors
The present invention is directed to HSV-1 vectors which rely on the tetracycline repressor and operator as a means for regulating expression. The vectors...
US-9,745,598 miRNA-regulated differentiation-dependent self-deleting cassette
Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human...
US-9,745,597 Compositions and methods for controlling fungal and bacterial diseases in plants
The present invention provides a fungicidal composition comprising a strain of Bacillus subtilis or Bacillus amyloliquefaciens and one of several compounds in a...
US-9,745,596 Identification and use of KRP mutants in wheat
The invention provides a wheat cell, part, tissue culture or whole plant comprising at least one disrupted KRP gene of the present invention. The present...
US-9,745,595 Methods of increasing biomass and/or growth rate of a plant under non-stress conditions
Provided are methods of increasing yield, biomass, growth rate, vigor, and/or abiotic stress tolerance of a plant by expressing within the plant an exogenous...
US-9,745,594 Mammalian-type glycosylation in plants by expression of a zebrafish glycosyltransferase
The present invention relates to non-mammalian .beta.-1,4-galactosyltransferases that can be used in their wild-type or in modified forms. The invention further...
US-9,745,592 Engineered plant biomass for biodiesel and bioethanol production
The disclosure encompassed herein relates, in part, to a method for increasing energy density of plant biomass that can be used for production of renewable...
US-9,745,591 Plants having altered expression and activity of yield-related proteins
Transgenic plants that have enhanced yield-related traits, such as increased seed oil production, are produced by genetically engineering the plants to...
US-9,745,590 Circular nucleic acid vectors, and methods for making and using the same
Circular nucleic acid vectors that provide for persistently high levels of protein expression are provided. The circular vectors of the subject invention are...
US-9,745,589 Methods for modulating skeletal remodeling and patterning by modulating SHN2 activity, SHN3 activity, or SHN2...
This invention is based, at least in part, on the discovery that Shn2 and Shn3 play an important role in skeletal remodeling and skeletal patterning....
US-9,745,588 Transcription terminator sequences
The present invention provides new transcription termination signal sequences, especially a polynucleotide comprising at least two consecutive transcription...
US-9,745,587 Nucleic acid constructs containing orthogonal site selective recombinases (OSSRs)
The present invention provides for a recombinant nucleic acid comprising a nucleotide sequence comprising a plurality of constructs, wherein each construct...
US-9,745,586 Therapeutic polynucleotides, compositions, and methods
This disclosure describes, in one aspect, a composition that generally includes an xNA molecule comprising at least six nucleotides, in an amount effective to...
US-9,745,585 RNAi-mediated inhibition of histamine receptor H1-related conditions
RNA interference is provided for inhibition of histamine receptor H1 mRNA expression, in particular, for treating patients having an HRH1-related condition or...
US-9,745,584 Treatment of PAR4 related diseases by inhibition of natural antisense transcript to PAR4
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of PAR4, in particular, by targeting natural...
US-9,745,583 Liposome for topical administration and application thereof
This invention provides a novel delivery means that enables efficient delivery of an active ingredient to a target cell. Such novel delivery means is a liposome...
US-9,745,582 Treatment of RNASE H1 related diseases by inhibition of natural antisense transcript to RNASE H1
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of RNase H1, in particular, by targeting natural...
US-9,745,581 Methods of treating and diagnosing diseases using agents that regulate the alternative splicing pathway
A method of determining a treatment for an inflammatory disorder in a subject, is disclosed. The method comprises determining an amount of SRSF6 in a sample...
US-9,745,580 Treatment of fibroblast growth factor 21 (FGF21) related diseases by inhibition of natural antisense transcript...
The present invention relates to antisense of oligonucleotides that modulate the expression of and/or function of Fibroblast growth factor 21 (FGF21), in...
US-9,745,579 Albumin production and cell proliferation
The present invention provides short activating RNA molecules which up-regulate albumin production. The present invention also provides methods of up-regulating...
US-9,745,578 Targeting microRNA miR-409-3P to treat prostate cancer
The present invention describes methods of treating cancer, cancer metastasis, and drug resistant cancers using miRNA inhibitors; for example, inhibitors of...
US-9,745,577 Reducing intron retention
Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to...
US-9,745,576 RNA modulating oligonucleotides with improved characteristics for the treatment of neuromuscular disorders
The current invention provides an improved oligonucleotide and its use for treating, ameliorating, preventing, delaying and/or treating a human cis-element...
US-9,745,575 Antagonists of bacterial sequences
The present invention refers to antagonist molecules, particularly nucleic acid effector molecules directed against a bacterial RNA.
US-9,745,574 RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
The present invention relates to RNAi constructs and their use in gene silencing. RNAi constructs associated with the invention contain a double stranded region...
US-9,745,573 Compositions and methods for preparing oligonucleotide solutions
The present invention is directed to methods and compositions for generating a pool of oligonucleotides. The invention finds use in preparing a population or...
US-9,745,572 Method for identifying antibiotic targets
Provided are methods for identifying differentially represented genes, the method comprising the steps of generating a pool of mutant bacteria by transposon...
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