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Patent # Description
US-9,745,369 Modulation of TLR4-signaling pathway
The present invention relates to compounds for use in modulating the toll-like receptor 4 (TLR4) signaling pathway, as well as to a pharmaceutical composition...
US-9,745,368 Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
The present invention provides compositions and methods for regulating the specificity and activity of T cells. In one embodiment, the invention provides a type...
US-9,745,367 Alternative pathway specific antibodies for treating arthritis
A method of selecting a genus of therapeutic antibodies includes selecting antibodies with the following criteria; a) do inhibit cell lysis under conditions...
US-9,745,366 Compositions and methods for the prevention of microbial infections
This disclosure provides methods and compositions to inhibit or prevent infection of a cell by a bacteria that exports DNABII proteins by administering to a...
US-9,745,365 Anti-influenza B virus hemagglutinin antibodies and methods of use
The present invention provides anti-influenza B virus hemagglutinin antibodies, compositions comprising anti-influenza B virus hemagglutinin antibodies, and...
US-9,745,364 Methods and compositions for diagnosis and treatment of B cell chronic lymphocytic leukemia
This invention provides an anti-idiotype antibody that binds to the antigen-binding region of an antibody encoded by antibody genes selected from the group...
US-9,745,363 Compositions and methods for inhibiting thrombogenesis
The invention is directed to a composition comprising an (one or more) isolated peptide comprising a BF01 peptide, variants of a BF01 peptide and/or mutants of...
US-9,745,362 Seed-specific expression vector and its construction methods and applications
A seed-specific expression vector and its construction methods and applications are disclosed. A fusion protein expression cassette consisting of Arachis...
US-9,745,361 Cytokine-based fusion proteins for treatment of immune disorders
The present invention provides fusion proteins including an autoimmune antigen, an allergen antigen or an alloantigen, and an anti-inflammatory cytokine....
US-9,745,360 Dual GLP1/GIP or trigonal GLP1/GIP/glucagon agonists
The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including...
US-9,745,359 Protein and protein conjugate for diabetes treatment, and applications thereof
The present invention relates to the field of biopharmaceutics, and in particular to a protein, a protein conjugate, a pharmaceutical composition and its use...
US-9,745,358 Peptides and compositions for treatment of joint damage
The present invention provides new protease resistant polypeptides, as well as compositions and methods for treating, ameliorating or preventing conditions...
US-9,745,357 Peptides used for treating cancers and, in particular, chronic lymphoid leukaemia
The invention relates to the A1 peptide of the sequence RRKYGRDFLLRF, as well as to certain variants thereof, for treating cancers, in particular malignant...
US-9,745,356 Treatment of ischemia
A system, including methods and compositions, for treatment of ischemia.
US-9,745,355 Binding-site modified lectins and uses thereof
In one aspect, the disclosure provides cross-linked materials that include multivalent lectins with at least two binding sites for glucose, wherein the lectins...
US-9,745,354 Compositions relating to a mutant Clostridium difficile toxin and methods thereof
In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile...
US-9,745,353 Production of anti-peptide antibodies
Anti-peptide antibodies (APAs) are extremely important tools for biomedical research. Many important techniques, such as immunoblots, ELISA immunoassays,...
US-9,745,352 Influenza treatment and/or characterization, human-adapted HA polypeptides; vaccines
The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza...
US-9,745,351 Truncated L1 protein of human papillomavirus type 6
The invention relates to a truncated L1 protein of the Human Papillomavirus Type 6, a virus-like particle consisting of the truncated L1 protein, a vaccine...
US-9,745,350 HER3 binding polypeptides
The present disclosure relates to polypeptides which bind to human epidermal growth factor receptor 3 (HER3) and to use of such polypeptides in imaging and...
US-9,745,349 Cyclic peptide and pharmaceutical product containing same
A cyclic peptide or a salt thereof of formula (1): X-Leu-Val-Y.sup.1-Y.sup.2 (1), where X is Lys, Arg, His, Ala, Gly, Ser, or Thr; and Y.sup.1 and Y.sup.2,...
US-9,745,348 Short designed peptides possessing selective actions against bacteria and cancer cells
The present invention relates to amphiphilic peptides having antibacterial and/or antitumor activity, and to therapeutic and non-therapeutic compositions...
US-9,745,347 PAR1 and PAR2 c-tail peptides and peptide mimetics
The present invention concerns isolated PAR1 cytoplasmic tail (c-tail) peptides and isolated PAR2 cytoplasmic tail (c-tail) peptides, as well as compositions...
US-9,745,346 Antimicrobial peptides and their application
The present invention relates to a compound of formula (I) and to compositions comprising said compound, as well as the use of said compound and/or said...
US-9,745,345 Anti-tumor polypeptides and method for preparing anti-tumor drugs comprisng the same
An anti-tumor polypeptide, having an amino acid sequence represented by FPGSDRF (SEQ ID NO: 15), X-FPGSDRF (SEQ ID NO: 16), FPGSDRF-Z (SEQ ID NO: 17), or...
US-9,745,344 NPR-B agonists
Disclosed are novel compounds having NPR-B agonistic activity. Preferred compounds are linear peptides containing 8-13 conventional or non-conventional L- or...
US-9,745,343 Method of inducing an immune response by administering WDRPUH epitope peptides
The present invention provides peptides containing the amino acid sequence of SEQ ID NOs: 1, 2, 3, 4, 16, 17, 30, 31, 34, 36, 37, 40, 41, 45, 49, 55, 57 and 61,...
US-9,745,342 NMDA receptor modulators and prodrugs, salts, and uses thereof
Disclosed are compounds having enhanced potency in the modulation of NMD A receptor activity. Such compounds are contemplated for use in the treatment of...
US-9,745,341 Tubulysins and processes for preparing
Processes are described for the preparation of tubulysins. The processes are useful for preparing predetermined mixtures of tubulysins, preparing single...
US-9,745,340 Method for the separation of proteins containing an albumin-binding
The disclosure provides a method of separation of at least one ABD-containing molecule present in a liquid from other constituents in the liquid, comprising a...
US-9,745,339 Ligands for antibody and Fc-fusion protein purification by affinity chromotography IV
The present invention relates to the use, for affinity purification of an antibody or an fragment of an antibody, of a ligand-substituted matrix comprising a...
US-9,745,338 Pro-drug forming compounds
Various prodrug compounds having the general structure: Active agent-(acid)-(linker)-SO.sub.2NR.sub.1R.sub.2 are described herein. Compounds having this general...
US-9,745,337 Complex compounds of germanium, methods for producing same, and drugs
The invention relates to the development of drugs intended for the prophylaxis and/or treatment of viral diseases caused, in particular, by herpes viruses. What...
US-9,745,336 Fluorescent dye compounds, conjugates and uses thereof
The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and...
US-9,745,335 N-substituted second generation derivatives of antifungal antibiotic amphotericin B and methods of their...
The invention provides semisynthetic N-substituted derivatives of the antifungal antibiotic Amphotericin B and water soluble salts and complexes, pharmaceutical...
US-9,745,334 Cytotoxic-drug delivering molecules targeting HIV (CDM-Hs), cytotoxic activity against the human...
The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to...
US-9,745,333 Optimization of separation for viscous suspensions
The present invention relates to methods and systems for optimization of dilution of a viscous starting material to isolate and/or concentrate the product of...
US-9,745,332 Catalysts and processes for the hydrogenation of amides
There is provided a process for the reduction of one or more amide moieties in a compound comprising contacting the compound with hydrogen gas and a transition...
US-9,745,331 Therapeutic bisphosphonates
The invention provides novel pyrophosphate synthase inhibitors of formula I and formula II as well salts thereof; the invention also provides compositions...
US-9,745,330 Oligomeric organosilanes, the production thereof and the use thereof in rubber mixtures
The present invention relates to oligomeric organosilanes containing at least two different structural units within a molecule, selected from the structural...
US-9,745,329 Method of preparing silylative-reduced N-heterocyclic compound using organoboron catalyst
Provided is a method of preparing a silylative-reduced N-heterocyclic compound by reducing an N-heteraromatic compound including a sp.sup.2 hybridized nitrogen...
US-9,745,328 Flap modulators
The present invention relates to compounds of Formula (I), or a form thereof wherein ring A.sub.1, R.sub.1, R.sub.2, R.sub.3, R.sub.3', L, W, and V are as...
US-9,745,326 Bridged alkaline earth metal alkylphenates
A bridged alkaline earth metal alkylphenate having reduced monomeric alkylphenol is prepared by reacting (a) a 4-alkylphenol, unsubstituted at the ortho...
US-9,745,325 Fused heterocyclic compound
The present invention provides a fused heterocyclic compound that has CDK 8 and/or CDK 19 inhibitory activity. The present invention provides a compound...
US-9,745,324 Iminothiadiazepane dioxide compounds as BACE inhibitors, compositions, and their use
In its many embodiments, the present invention provides certain iminothiadiazepane dioxide compounds, including compounds Formula (I): ##STR00001## or a...
US-9,745,323 Compound and pharmaceutical composition for neuropsychological disorder or malignant tumor
The present invention provides a compound and a pharmaceutical composition for neuropsychological disorders or malignant tumors, the use of the compound and the...
US-9,745,322 Compounds for the treatment of hepatitis C
The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The...
US-9,745,321 Fused pyrimidine compound, intermediate, preparation method therefor, and composition and application thereof
Disclosed are a fused pyrimidine compound, an intermediate, a preparation method therefor, and a composition and an application thereof. The present invention...
US-9,745,320 Five-and-six-membered heterocyclic compound, and preparation method, pharmaceutical composition and use thereof
A five-and-six-membered heterocyclic compound as represented by general formula I, pharmaceutically acceptable salt, metabolite, metabolic precursors or drug...
US-9,745,319 Irreversible covalent inhibitors of the GTPase K-Ras G12C
Irreversible inhibitors of K-Ras, H-Ras or N-ras protein comprising a G12C mutation are provided. Also disclosed are methods to regulate the activity of K-Ras,...
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