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Patent # Description
US-9,765,340 RNAi-mediated inhibition of phosphodiesterase type 4 for treatment of CAMP-related ocular disorders
RNA interference is provided for inhibition of phosphodiesterase type 4 mRNA expression for treating patients with a cAMP-related ocular disorder....
US-9,765,339 FLT3 receptor antagonists for the treatment or the prevention of pain disorders
The present invention relates to FLT3 receptor antagonists or inhibitors of FLT3 receptor gene expression for the treatment or the prevention of pain disorders.
US-9,765,338 Modulation of dystrophia myotonica-protein kinase (DMPK) expression
Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods,...
US-9,765,337 Phosphoribosyl pyrophosphate synthetase 2 (PRPS2) as a therapeutic target in cancer treatment
The present invention provides methods of selectively killing a cell, comprising contacting the cell with an agent that inhibits phospho-ribosyl...
US-9,765,336 Treatment of erythropoietin (EPO) related diseases by inhibition of natural antisense transcript to EPO
Oligonucleotide compounds modulate expression and/or function of Erythropoietin (EPO) polynucleotides and encoded products thereof. Methods for treating...
US-9,765,335 Gene nanocomposite, and cellular internalization method of gene using same
A gene nanocomposite and a cellular internalization method of a gene using the same are provided. More specifically provided is a gene nanocomposite including:...
US-9,765,334 Compositions and methods for prognosis of gastric cancer
Described herein are compositions and methods for survival prediction in gastric cancer patients after surgical operation. The compositions are microRNA...
US-9,765,333 Compositions and methods for silencing marburg virus gene expression
The present invention provides compositions comprising siRNA molecules that target Marburg virus (MARV) gene expression, lipid particles comprising one or more...
US-9,765,332 Oligonucleotides and methods for inhibiting or reducing bacterial biofilms
The present invention relates to oligonucleotides useful for inhibiting or reducing bacterial biofilms.
US-9,765,330 Compositions and methods for reduction of allograft recognition and rejection
Allograft recognition and rejection of donor cells in a host is reduced by limiting or even abrogating expression of the donor cell's MHC-I peptides to avoid...
US-9,765,329 Adipocyte-targeting non-viral gene delivery system
The present invention relates to a gene delivery system for targeting adipocytes and a treatment system for obesity and obesity-derived metabolic syndromes...
US-9,765,328 Nuclease-resistant DNA analogues
The present invention provides stable, nuclease-resistant TNA and TNA-DNA oligonucleotides, wherein the oligonucleotides are completely resistant to enzymatic...
US-9,765,327 Induction of hemogenic endothelium from pluripotent stem cells
Described herein are methods and related compositions for inducing differentiation of human pluripotent stem cells (hPSCs) into hemogenic endothelium with...
US-9,765,326 Apparatus and method for nucleic acid sequencing based on nanochannels
An apparatus for nucleic acid sequencing includes a nanochannel and a conveying device, configured to move a nucleic acid strand through the nanochannel. The...
US-9,765,325 Fabrication of hierarchical silica nanomembranes and uses thereof for solid phase extraction of nucleic acids
The present invention provides a novel method to fabricate silica nanostructures on thin polymer films based on silica deposition and self-wrinkling induced by...
US-9,765,324 Hierarchical magnetic nanoparticle enzyme mesoporous assemblies embedded in macroporous scaffolds
A hierarchical catalyst composition comprising a continuous or particulate macroporous scaffold in which is incorporated mesoporous aggregates of magnetic...
US-9,765,323 Thermally stable enzymes, compositions thereof and method of using same
Described herein are isolated recombinant proteins having lyase activity and nucleic acid sequences which code therefor; along with methods of expressing,...
US-9,765,322 Pectin degrading enzymes from macrophomina phaseolina and uses thereof
The present invention discloses isolated polynucleotide encoding enzymes, derived from the fungus Macrophomina phaseolina ("M. phaseolina"), responsible for...
US-9,765,321 P. pastoris pastoris promoters, and the use thereof to direct expression of proteins in yeast, preferably using...
Novel promoters which are derived from P. pastoris pastoris which are inducible or repressible under specific growth conditions are provided. These promoters...
US-9,765,320 Modified beta-lactamases and methods and uses related thereto
The present invention relates to pharmaceuticals and modified beta-lactamases. Specifically, the invention relates to novel recombinant beta-lactamases and...
US-9,765,319 Xylanases, nucleic acids encoding them and methods for making and using them
The invention relates to xylanases and to polynucleotides encoding the xylanases. In addition, methods of designing new xylanases and methods of use thereof are...
US-9,765,318 Glucoamylase variants and polynucleotides encoding same
The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the...
US-9,765,317 Alpha-amylases and polynucleotides encoding same
The present disclosure relates to isolated polypeptides having alpha-amylase activity, polynucleotides encoding the polypeptides, nucleic acid constructs,...
US-9,765,316 Alpha amylase variants and polynucleotides encoding same
The present invention relates to variants of alpha amylase. The present invention also relates to polynucleotides encoding the variants; nucleic acid...
US-9,765,315 Cellulose and/or hemicelluloses degrading enzymes from Macrophomina phaseolina and uses thereof
The present invention provides nucleotide sequences of Macrophomina phaseolina ("M. phaseolina") that encodes proteins/enzymes with cellulolytic activity,...
US-9,765,313 Method for producing a phytase variant with improved thermal stability, and a phytase variant and the use thereof
The present invention relates to the field of genetic engineering, in particular, the present invention relates to a method for producing a phytase variant with...
US-9,765,312 DNA polymerases with increased 3'-mismatch discrimination
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are...
US-9,765,311 DNA polymerases with increased 3'-mismatch discrimination
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are...
US-9,765,310 Nucleotide transient binding for sequencing methods
Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the...
US-9,765,309 Modified polymerases for improved incorporation of nucleotide analogues
Presented herein are polymerase enzymes for improved incorporation of nucleotide analogs, in particular nucleotides which are modified at the 3' sugar hydroxyl,...
US-9,765,308 Aromatic prenyltransferase from cannabis
Nucleic acid molecules from cannabis has been isolated and characterized and encode polypeptides having aromatic prenyltransferase activity. Expression or...
US-9,765,307 Cytochrome P450 polypeptide with increased enzyme activity
The present invention pertains to an isolated P450 enzyme comprising or consisting of an amino acid sequence at least 80% identical to SEQ ID NO: 1, wherein...
US-9,765,306 Biocatalysts and methods for the synthesis of armodafinil
The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods...
US-9,765,305 Mutant vaccinia virus strains, uses thereof and method of producing the same
The present disclosure provides mutant vaccinia virus strains that can selectively replicate in tumor cells. The present disclosure also provides use of the...
US-9,765,304 Synthetic viruses and uses thereof
The present invention relates to compositions and methods for producing an immune response or reaction, as well as to vaccines, kits, processes, cells and uses...
US-9,765,303 Method for the production of differentiated respiratory epithelial cells
The present invention relates to a method for the production of differentiated respiratory epithelial cells comprising: (a) providing a cell population...
US-9,765,302 Compositions and methods for differentiating stem cells into cell populations comprising beta-like cells
Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g.,...
US-9,765,301 Liver organoid, uses thereof and culture method for obtaining them
The invention relates to a liver organoid, uses thereof and method for obtaining them.
US-9,765,300 Hepatic cell lines and stem-like cells, methods of making and using the same
New cell lines designated as Hepa-SC and Hepa-RP, originating from human hepatoma line HEPARG.RTM. are disclosed. Methods of inducing stemness in parental cells...
US-9,765,299 Chemically defined albumin-free conditions for cardiomyocyte differentiation of human pluripotent stem cells
Methods for generating high-yield, high-purity cardiomyocyte progenitors or cardiomyocytes from pluripotent cells are described. Wnt/.beta.-catenin signaling is...
US-9,765,298 Methods and materials for providing cardiac cells
This document provides methods and materials relating to cardiac cells. For example, this document provides methods and materials that can be used to obtain...
US-9,765,297 Stem cell-based culture system for drug development
The present invention relates to culture systems comprising differentiated stem cells, that may be used for identifying agents useful in treating degenerative...
US-9,765,296 Method for preparing pluripotent stem cells
An object of the present invention is to provide a method capable of inexpensively and conveniently preparing cells having pluripotency and a very low risk of...
US-9,765,295 Composition for culturing sanal and sanal culturing method using the same
Provided are a sanal culturing composition and a method for culturing sanal using the same.
US-9,765,294 Chemically defined medium for the industrial scale culture of a species of Bordetella
Chemically defined media for the industrial-scale culture of Bordetella species.
US-9,765,293 Agglomerated microbiological media
A method of making a flowable, dried agglomerated nutrient medium is provided. The method comprises introducing a nutrient component comprising a powdered...
US-9,765,292 Bioreactor and rack for mounting bioreactors
A bioreactor for preferably three-dimensional cell culturing comprises a scaffold chamber, a first tube, a second tube and a first valve with a scaffold...
US-9,765,291 Array of micromolded structures for sorting adherent cells
An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a...
US-9,765,290 Solid soap fragment melting apparatus and method
An apparatus and method for melting soap fragments to create a soap bar from the soap fragments. The apparatus includes various replaceable molds to create soap...
US-9,765,288 Compositions for cleaning III-V semiconductor materials and methods of using same
Liquid compositions useful for the cleaning of residue and contaminants from a III-V microelectronic device material, such as InGaAs, without substantially...
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