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Patent # Description
US-9,771,610 Primers for melting analysis
Methods and kits are provided for nucleic acid analysis. In an illustrative method a target nucleic acid is amplified using a first primer and a second primer,...
US-9,771,609 Electrode for uric acid and method of producing the same
Embodiments of this invention disclose new second generation uric acid-sensing electrodes at least characterized by chemically bonding both uricase and the...
US-9,771,608 Fagopyritol synthase genes and uses thereof
The present invention relates to an isolated DNA molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an insulin...
US-9,771,607 Method of constructing a recombinant Bacillus subtilis that can produce specific-molecular-weight hyaluronic acids
The present invention relates to the field of biotechnology engineering. It provides a method of constructing a recombinant Bacillus subtilis that can produce...
US-9,771,606 UK-2 biosynthetic gene and method for improving UK-2 productivity using the same
The genomic DNA of Streptoverticillium sp. 3-7, which produces UK-2, was analyzed to identify a region expected to be a UK-2 biosynthetic gene cluster....
US-9,771,605 Enzyme directed oil biosynthesis in microalgae
The present invention is related to biosynthetic oil compositions and methods of making thereof. In some embodiments, the invention relates to the use of...
US-9,771,604 Genetically engineered yeast cell with enhanced EDC activity and capability of producing lactate, method of...
A genetically engineered yeast cell with enhanced activity of an EDC protein compared to that of a parent cell and capability of producing lactate, a method of...
US-9,771,603 Fermentation process
A methods for altering the metabolite profile of a fermentation, by increasing flux through acetolactate. The methods comprises increasing production of one or...
US-9,771,602 Competitive growth and/or production advantage for butanologen microorganism
Provided herein are recombinant yeast host cells and methods for their use for production of fermentation products. Host cells provided herein comprise a...
US-9,771,601 CRISPR hybrid DNA/RNA polynucleotides and methods of use
The present disclosure provides DNA-guided CRISPR systems; polynucleotides comprising DNA, RNA and mixtures thereof for use with CRISPR systems; and methods of...
US-9,771,600 Engineered nucleic acid-targeting nucleic acids
The present disclosure provides engineered polynucleotide sequences that form scaffolds and nucleoprotein complexes comprising such engineered polynucleotide...
US-9,771,599 Retroviral transduction using poloxamers
The present invention relates to a method for transducing a target cell, the method comprising the step of contacting a target cell with a retroviral vector and...
US-9,771,598 Isolated polynucleotides and polypeptides, construct and plants comprising same and methods of using same for...
Provided are isolated polypeptides which are at least 80% homologous to SEQ ID NOs: 496-794, 2898-3645, and 3647-4855, isolated polynucleotides which are at...
US-9,771,597 Methods and compositions for enhanced forage quality
The invention provides a method to select an alfalfa plant with enhanced feed value and increased flexibility in management either to increase quality of forage...
US-9,771,596 Use of auxin synthase for improving crop yield
Compositions and methods for increasing plant yield are provided. The methods comprise increasing the expression of an anxin synthase gene or coding sequence in...
US-9,771,595 Plant regulatory elements and uses thereof
The present invention provides novel DNA molecules and constructs, including their nucleotide sequences, useful for modulating gene expression in plants and...
US-9,771,594 Pharmaceutical composition consisting of RNA having alkali metal as counter ion and formulated with dications
A biologically active RNA-alkali metal-dication formulation, a pharmaceutical composition containing the complexes, and methods of producing the same. The...
US-9,771,593 Treatment of tumor necrosis factor receptor 2 (TNFR2) related diseases by inhibition of natural antisense...
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Tumor Necrosis Factor Receptor 2 (TNFR2), in...
US-9,771,592 Methods and compositions for treating or preventing pruritis
The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such...
US-9,771,591 Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ANGPTL3 gene, as well as methods of inhibiting expression of...
US-9,771,589 Treating hepatitis virus infection by modulating microRNAs miR-130a, miR-130b, miR-204, or miR-1236
Methods and pharmaceutical compositions for regulating hepatitis virus replication, involving a miR-130a RNA, a miR-130b RNA, a miR-204 RNA, a miR-1236 RNA, or...
US-9,771,588 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic...
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic,...
US-9,771,587 Compositions and methods to promote erythropoiesis
Described herein are compositions and methods for enhancing erythropoiesis in an individual in need thereof. Specifically agents that decrease the expression of...
US-9,771,586 RNAi targeting ZNF205
Efficient sequence specific gene silencing is possible through the use of RNAi technology. By selecting particular RNAi molecules by rational design, one can...
US-9,771,585 miR-155 inhibitors for treating cutaneous T cell lymphoma (CTCL)
The present invention provides oligonucleotide inhibitors of miR-155 and compositions thereof. The invention further provides methods for treating cancer such...
US-9,771,584 Methods for the prevention and the treatment of extracapillary glomerulonephritis
The present invention relates to the prevention and the treatment of extracapillary glomerulonephritis such as rapidly progressive glomerulonephritis and...
US-9,771,583 siRNA sequence-independent modification formats for reducing off-target phenotypic effects in RNAI, and...
Modification formats having modified nucleotides are provided for siRNA. Short interfering RNA having modification formats and modified nucleotides provided...
US-9,771,582 RNA interference compositions and methods for malignant tumors
This invention provides compositions for use in distributing active agents for treating a malignant tumor in a subject. The compositions contain RNAi molecules...
US-9,771,581 C-myc antisense oligonucleotides and methods for using the same to treat cell-proliferative disorders
Provided herein are antisense oligonucleotides that can effectively prevent or decrease c-myc protein expression as well as decrease overall rates of cell...
US-9,771,580 Antisense oligonucleotides for the treatment of Leber congenital amaurosis
The present invention relates to the fields of medicine and immunology. In particular, it relates to novel antisense oligonucleotides that may be used in the...
US-9,771,579 Treatment of sodium channel, voltage-gated, alpha subunit (SCNA) related diseases by inhibition of natural...
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Sodium channel, voltage-gated, alpha subunit...
US-9,771,578 Phosphorous-linked oligomeric compounds and their use in gene modulation
Oligonucleotide compositions comprising first and second oligonucleotides are provided wherein at least a portion of the first oligonucleotide is capable of...
US-9,771,577 Methods for analyzing lariat RNA
The present invention relates to compositions and methods useful for analyzing lariat RNA, which plays a role in the regulation of gene expression. A sample of...
US-9,771,576 Materials and methods for the synthesis of error-minimized nucleic acid molecules
The present invention provides materials and methods useful for error correction of nucleic acid molecules. In one embodiment of the invention, a first...
US-9,771,575 Methods for on-array fragmentation and barcoding of DNA samples
The present disclosure provides methods for barcoding a plurality of DNA samples using a microarray of barcode-containing transposase complexes. In some...
US-9,771,574 Apparatus for continuous directed evolution of proteins and nucleic acids
Aspects of the disclosure relate to an apparatus for continuous directed evolution of a gene of interest. In some embodiments, the apparatus comprises a...
US-9,771,573 Methods of quantitating heavy and light chain polypeptide pairs
Provided is a method of quantitatively determining the ability of individual IgG heavy chains to selectively pair with a particular IgG light chain when the...
US-9,771,572 Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde
Method, composition, kit and system for isolating amplifiable nucleic acid from specimens preserved in a liquid-based cytology preservative that contains...
US-9,771,571 Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde
Method, composition, kit and system for isolating amplifiable nucleic acid from specimens preserved in a liquid-based cytology preservative that contains...
US-9,771,570 Polypeptides having protease activity
The present invention relates to isolated polypeptides having protease activity and isolated nucleic acid sequences encoding the proteases. The invention also...
US-9,771,569 Polypeptides having xylanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also...
US-9,771,568 Polypeptides having beta-glucosidase activity and polynucleotides encoding same
Provided are isolated polypeptides having beta-glucosidase activity and polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs,...
US-9,771,567 Klotho variant polypeptides
Disclosed are Klotho variant proteins in which residue Glu414 and/or residue Asp238 is substituted with an amino acid different than L-Glu or L-Asp,...
US-9,771,566 Organophosphorous hydrolase variants
The present invention relates to organophosphorous hydrolase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid...
US-9,771,565 Thermostable reverse transcriptases and uses thereof
The present invention is in the fields of molecular and cellular biology. The invention is generally related to reverse transcriptase enzymes and methods for...
US-9,771,564 Influenza virus
The present invention provides a novel influenza virus wherein both the NS and the PB1 gene segments are modified and wherein the PB1-F2 open reading frame is...
US-9,771,563 Chemical approaches for generation of induced pluripotent stem cells
The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing...
US-9,771,562 Method for culture of human and mouse prostate organoids and uses thereof
The invention discloses a methodology for the culture of prostate tissue organoids from mouse and human prostate.
US-9,771,561 Method of making primate cells expressing apelin receptor that have mesangioblast potential
Methods for obtaining multipotent Apelin receptor-positive lateral plate mesoderm cells, mesenchymal stem cells, and mesangioblasts under serum-free conditions...
US-9,771,560 High-throughput image-based chemical screening in zebrafish blastomere cell culture
Disclosed are methods of inducing differentiation of stem into myogenic cells without gene manipulation and for inducing proliferation of satellite cells. The...
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