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Patent # Description
US-9,783,596 Humanized monoclonal antibodies that specifically bind and/or neutralize Japanese encephalitis virus (JEV) and...
Disclosed herein are isolated humanized monoclonal antibodies that specifically bind Japanese encephalitis virus (JEV) with a binding affinity of about 1.0 nM...
US-9,783,595 Neutralizing GP41 antibodies and their use
Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are...
US-9,783,594 Human immunodeficiency virus neutralizing antibodies and methods of use thereof
The invention provides broadly neutralizing antibodies directed to epitopes of Human Immunodeficiency Virus, or HIV. The invention further provides compositions...
US-9,783,593 Antibodies, variable domains and chains tailored for human use
The invention relates to the provision of antibody therapeutics and prophylactics that are tailored specifically for human use. The present invention provides...
US-9,783,592 Glucagon superfamily peptides exhibiting nuclear hormone receptor activity
Provided herein are glucagon superfamily peptides conjugated with NHR ligands that are capable of acting at a nuclear hormone receptor. Also provided herein are...
US-9,783,591 Use of the CD2 signaling domain in second-generation chimeric antigen receptors
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T...
US-9,783,590 Variants of human taste receptor genes
Identified herein are different forms of bitter receptor genes that occur in different humans. These alleles are generated by numerous coding single nucleotide...
US-9,783,589 Engineered antibody-interferon fusion molecules for treatment of autoimmune diseases
The field of the present invention relates to genetically engineered fusion molecules, methods of making said fusion molecules, and uses thereof for treatment...
US-9,783,588 Chemokine-immunoglobulin fusion polypeptides, compositions, method of making and use thereof
This application is directed to chemokine-immunoglobulin fusion polypeptides and chemokine-polymer conjugates. The fusion polypeptides and conjugates can be...
US-9,783,587 Synthetic foldable proteins generated from peptide segments of folding nuclei of reference proteins
A method of making a synthetic foldable having a tertiary structure emulating the tertiary structure of a reference foldable protein is described. The method...
US-9,783,586 Inhibitors of the linear ubiquitin chain assembly complex (LUBAC) and related methods
The invention relates to peptide inhibitors of linear ubiquitin chain assembly complex (LUBAC) and to methods of treating diseases including activated B-cell...
US-9,783,585 Compositions and methods for increasing the expression and signalling of proteins on cell surfaces
The present invention relates to the field of protein expression. More specifically, the present invention provides compositions and methods for increasing the...
US-9,783,584 Methods and compositions for expressing functional class XIV myosin
The invention, in part, includes methods and compounds useful to prepare and functional class XIV myosin. Functional class XIV myosin prepared using methods of...
US-9,783,583 Antigenic polypeptides of Trichinella and uses thereof
The invention relates to novel polypeptides which are recognized by anti-Trichinella antibodies. Said polypeptides can be used particularly for detecting...
US-9,783,582 Staphylococcus aureus leukocidins, therapeutic compositions, and uses thereof
Disclosed herein are isolated and purified Staphylococcus aureus bi-component leukocidin, referred to herein as LukAB, and its components LukA and LukB,...
US-9,783,581 Method for producing plastic raw material from blue-green algae
An object of the present invention is to construct a production system that enables efficient production of organic acids using blue-green algae, which are...
US-9,783,580 Treatment and prevention of Gardnerella vaginalis infections
The present invention is drawn to the nucleic and amino acid sequences encoding vaginolysin (VLY) toxin from Gardnerella vaginalis, and biologically active...
US-9,783,579 Compositions and methods for dengue virus chimeric constructs in vaccines
Embodiments herein report compositions, uses and manufacturing of dengue virus constructs and live attenuated dengue viruses. Some embodiments concern a...
US-9,783,578 Immunosuppression modulating compounds
The present invention provides immunosuppression compounds to inhibit the programmed cell death 1 (PD1) signalling pathway. The present invention further...
US-9,783,577 Hybrid cyclic libraries and screens thereof
Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to...
US-9,783,576 Compositions and methods for targeted endometriosis treatment
Disclosed are compositions and methods for selectively targeting an endometriosis cell. Also disclosed are compositions and methods for treating endometriosis.
US-9,783,575 Methyl degron peptide and methods of controlling protein lifespan
The present invention provides an isolated methyl degron peptide and a fusion protein comprising a methyl degron peptide. Also, the present invention provides...
US-9,783,574 Cardiovascular therapeutics
Compounds and compositions comprising a B-type natriuretic signal peptide fragment agent, and methods of use thereof, are provided for the treatment or...
US-9,783,573 IAP antagonists
There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds...
US-9,783,572 Synthesis of syrbactin proteasome inhibitors
The disclosure relates generally to methods for the preparation of a family of natural compounds, the syrbactins and their analogs.
US-9,783,571 Isolation of cysteine containing peptides
The disclosure provides a capture system and methods for isolating cysteine-containing peptides from biological fluid and proteolytic mixtures. The disclosure...
US-9,783,570 Method for separation of monomeric polypeptides from aggregated polypeptides
Herein is reported a method for obtaining a polypeptide in monomeric form comprising the steps of a) providing a solution comprising the polypeptide m monomeric...
US-9,783,569 Method for preparing 6-alkylated steroidal derivatives and corresponding alkylated...
The present invention concerns a method for preparing certain steroidal derivatives alkylated in position 6, comprising a step of alkylating the corresponding...
US-9,783,568 Salts of HIV inhibitor compounds
The invention is related to salts of anti-viral compounds, compositions containing such salts, and therapeutic methods that include the administration of such...
US-9,783,567 Processes and intermediates for preparing anti-HIV agents
The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.
US-9,783,566 Non-caloric sweeteners and methods for synthesizing
Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside...
US-9,783,565 Liquefaction of biomass at low pH
The present invention relates to regulation of the p H of a liquefaction process. Presented is a method for treatment of a biomass feedstock wherein the biomass...
US-9,783,564 Organic electroluminescent materials and devices
Novel phosphorescent tetradentate platinum compounds of Formula I are provided. The complexes contain a dibenzo moiety, which allows for the creation of OLED...
US-9,783,563 Synthesis and use of precursors for ALD of tellurium and selenium thin films
Atomic layer deposition (ALD) processes for forming Te-containing thin films, such as Sb--Te, Ge--Te, Ge--Sb--Te, Bi--Te, and Zn--Te thin films are provided....
US-9,783,562 Phytosphingosine-1-phosphate derivative, preparation method therefor, and composition for preventing and...
The present invention provides: O-cyclic phytospingosine-1-phosphate (O-C-P1P), N-cyclic phytospingosine-1-phosphate (N-C-P1P), a pharmaceutically acceptable...
US-9,783,561 Chiral imidodiphosphates and derivatives thereof
The invention relates to chiral imidodiphosphates and derivatives thereof having the general formula I, ##STR00001## The compounds are suitable as chiral...
US-9,783,560 Reagents useful for synthesizing rhodamine-labeled oligonucleotides
The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.
US-9,783,559 .beta.-Ketophosphonic acids and dental materials based thereon
.beta.-Ketophosphonic acid according to general formula I: ##STR00001## in which A=an aliphatic C.sub.1-C.sub.18 radical which can be interrupted by --O--,...
US-9,783,558 Composition and method for low temperature chemical vapor deposition of silicon-containing films including...
Silicon precursors for forming silicon-containing films in the manufacture of semiconductor devices, such as films including silicon carbonitride, silicon...
US-9,783,557 Metallocene catalyst for preparing a high molecular weight polyolefin and a preparation method thereof
The present invention relates to a metallocene compound having novel structure which can provide various selectivity and activity to polyolefin copolymers, a...
US-9,783,556 Kinase inhibitors
There are provided compounds of formula I, (I): ##STR00001## wherein R.sup.1 to R.sup.5, X.sup.1, X.sup.2, Ar, L, E, A, A1, G and G.sup.1 have meanings...
US-9,783,555 Beta-lactamase inhibitors
Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit...
US-9,783,554 Lanthanide ion complexes and imaging method
A lanthanide complex, method of forming and method of using the lanthanide complex as a near-infrared luminescent material are described. The complex includes...
US-9,783,553 Silver ion .alpha.-oxy carboxylate-oxime complexes
A non-hydroxylic-solvent soluble silver complex comprises a reducible silver ion complexed with an .alpha.-oxy carboxylate and an oxime compound. The...
US-9,783,552 Soluble guanylate cyclase activators
A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate...
US-9,783,551 Pyranochromenyl phenol derivative, and pharmaceutical composition for treating metabolic syndrome or...
Provided are a pyranochromenyl phenol derivative, a pharmaceutically acceptable salt thereof, or a solvate thereof. Also provided is a pharmaceutical...
US-9,783,550 Highly potent inhibitors of porcupine
The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such...
US-9,783,549 Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B
The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization...
US-9,783,548 Production method for epoxy compound using solid catalyst
A method for producing an epoxy compound by reacting a compound having a carbon-carbon double bond with hydrogen peroxide in the coexistence of the compound...
US-9,783,547 Water soluble 4-azapodophyllotoxin analogs
The present invention relates to 4-azapodophyllotoxin analogs of formula (I) in which X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and Ar are as defined in claim 1,...
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